Abstract:
BACKGROUND:Human skin aging is caused by several factors, such as UV irradiation, stress, hormone, and pollution. Wrinkle formation and skin pigmentation are representative features of skin aging. Although EGF and arbutin are used as anti-wrinkle and skin whitening agents, respectively, they have adverse effects on skin. When more cosmeceutical ingredients are added to cosmetic product, adverse effects are also accumulated. For these reasons, multifunctional and safe cosmetic ingredients are in demand. The aim of the present study is to investigate the novel anti-aging agents, AIMP1-derived peptide (AdP, INCI name: sh-oligopeptide-5/sh-oligopeptide SP) for cosmetic products. METHODS:To assess the anti-wrinkle effect of AdP, collagen type I synthesis and fibroblast proliferation were determined on human fibroblasts. The anti-wrinkle effect of AdP was examined by ELISA and cell titer glo assay. To assess the whitening, melanin content and tyrosinase activity were determined on melanocytes. The whitening effect of AdP was examined by melanin measurement and enzyme activity assay. The safety of AdP was determined by cytotoxicity and immunogenicity, CCK-8 and TNF-α ELISA assay, respectively. RESULTS:AdP treatment induced the collagen type I synthesis and fibroblast proliferation. Also, AdP treatment inhibited melanin synthesis by regulating tyrosinase activity. The anti-aging effect of AdP is more potent than EGF and albutin. AdP did not show adverse effects. CONCLUSION:These results show that AdP can be dual functional and safe cosmeceutical agent to prevent skin aging.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Kim J,Kang S,Kwon H,Moon H,Park MCdoi
10.1111/jocd.12671subject
Has Abstractpub_date
2019-02-01 00:00:00pages
251-257issue
1eissn
1473-2130issn
1473-2165journal_volume
18pub_type
杂志文章abstract::We report the case of a woman who presented with several facial scars following a road accident. Treatment was carried out using combined laser treatment with pulsed dye laser (PDL) and Q-switched neodymium:yttrium-aluminum-garnet laser (QS Nd:YAG laser). No side effects or complications from treatment were noted or r...
journal_title:Journal of cosmetic dermatology
pub_type: 信件
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pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:BACKGROUND:Acne vulgaris is a highly prevalent skin condition associated with considerable psychological burden. Acne and its sequelae can affect many domains of life leading to social dysfunction, psychiatric issues and educational shortcomings. Psychiatric conditions like depression is found to be more prevalent in a...
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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更新日期:2011-09-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-08-04 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13735
更新日期:2020-09-26 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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journal_title:Journal of cosmetic dermatology
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更新日期:2016-06-01 00:00:00
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更新日期:2006-06-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
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更新日期:2008-06-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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更新日期:2018-10-01 00:00:00