Abstract:
:In Fig. 3c of this Letter, the the effects of CRISPR-Cas9-mediated deletion of NR3C1, TXNIP and CNR2 in patient-derived B-lineage leukaemia cells were shown. For curves depicting NR3C1 (left graph), data s for TXNIP (middle graph) were inadvertently plotted. This figure has been corrected online, and the original Fig. 3c is shown as Supplementary Information to this Amendment for transparency. The error does not affect the conclusions of the Letter. In addition, Source Data files have been added for the Figs. 1-4 and Extended Data Figs. 1-10 of the original Letter.
journal_name
Naturejournal_title
Natureauthors
Chan LN,Chen Z,Braas D,Lee JW,Xiao G,Geng H,Cosgun KN,Hurtz C,Shojaee S,Cazzaniga V,Schjerven H,Ernst T,Hochhaus A,Kornblau SM,Konopleva M,Pufall MA,Cazzaniga G,Liu GJ,Milne TA,Koeffler HP,Ross TS,Sánchez-Garcíadoi
10.1038/s41586-018-0164-5subject
Has Abstractpub_date
2018-06-01 00:00:00pages
E5issue
7711eissn
0028-0836issn
1476-4687pii
10.1038/s41586-018-0164-5journal_volume
558pub_type
杂志文章,已发布勘误相关文献
NATURE文献大全abstract::The dominant forcing factors for past large-scale changes in vegetation are widely debated. Changes in the distribution of C4 plants--adapted to warm, dry conditions and low atmospheric CO2 concentrations--have been attributed to marked changes in environmental conditions, but the relative impacts of changes in aridit...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01500
更新日期:2003-03-27 00:00:00
abstract::For more than 140 years, pollen tube guidance in flowering plants has been thought to be mediated by chemoattractants derived from target ovules. However, there has been no convincing evidence of any particular molecule being the true attractant that actually controls the navigation of pollen tubes towards ovules. Eme...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07882
更新日期:2009-03-19 00:00:00
abstract::Pathfinding by growing axons in the developing nervous system is guided by diffusible or bound factors that attract or repel the axonal growth cone. The cytoplasmic signalling mechanisms that trigger the responses of the growth cone to guidance factors are mostly unknown. Previous studies have shown that the level and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/47507
更新日期:2000-01-06 00:00:00
abstract::Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12912
更新日期:2014-01-23 00:00:00
abstract::Asexual reproduction by free-living invertebrate larvae is a rare and enigmatic phenomenon and, although it is known to occur in sea stars and brittle stars, it has not been detected in other echinoderms despite more than a century of intensive study. Here we describe spontaneous larval cloning in three species from t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/425146a
更新日期:2003-09-11 00:00:00
abstract::Mammal-like reptiles of the order Therapsida document the emergence of mammals from more primitive synapsids and are of unique zoological and palaeontological interest on that account. Therapsids, first appearing in the Early Permian, were thought to become extinct in the Middle Jurassic, soon after the Late Triassic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358233a0
更新日期:1992-07-16 00:00:00
abstract::Wilms' tumour (WT), a paediatric renal neoplasm, affect approximately 1 in 10,000 children. One or both kidneys can be affected and 5-10% of tumours are bilateral. Most tumours occur sporadically; however, around 1% of the cases are familial, with siblings or cousins most often being affected. Familial cases are more ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/336377a0
更新日期:1988-11-24 00:00:00
abstract::Developing an optical amplifier on silicon is essential for the success of silicon-on-insulator (SOI) photonic integrated circuits. Recently, optical gain with a 1-nm bandwidth was demonstrated using the Raman effect, which led to the demonstration of a Raman oscillator, lossless optical modulation and optically tunab...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04932
更新日期:2006-06-22 00:00:00
abstract::The neurohypophysial hormone vasopressin exerts antidiuretic, vasopressor and behavioural effects (for example, facilitation of memory processes). Vasopressin may alter animal behaviour via direct effect on brain processes. Recently, however, it has been suggested that vasopressin acts mainly at peripheral receptor sy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308276a0
更新日期:1984-03-15 00:00:00
abstract::Organocatalysis-catalysis mediated by small chiral organic molecules-is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature25175
更新日期:2018-01-31 00:00:00
abstract::Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03658
更新日期:2005-06-23 00:00:00
abstract::The 20S cyclosome complex (also known as the anaphase-promoting complex) has ubiquitin ligase activity and is required for mitotic cyclin destruction and sister chromatid separation. The formation and activation of the 20S cyclosome complex is regulated by an unknown mechanism. Here we show that Cut4 (ref. 6) is an es...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/384276a0
更新日期:1996-11-21 00:00:00
abstract::Clouds on Titan result from the condensation of methane and ethane and, as on other planets, are primarily structured by circulation of the atmosphere. At present, cloud activity mainly occurs in the southern (summer) hemisphere, arising near the pole and at mid-latitudes from cumulus updrafts triggered by surface hea...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08014
更新日期:2009-06-04 00:00:00
abstract::The complement system is a key part of the innate immune system, and is required for clearance of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convert...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05263
更新日期:2006-11-09 00:00:00
abstract::Understanding cellular response to environmental stress has broad implications for human disease. AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and -consuming pathways, and protects the heart against ischaemic injury and apoptosis. A role for circulating hormones such as adiponec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06504
更新日期:2008-01-31 00:00:00
abstract::Tumour cells become addicted to the expression of initiating oncogenes like Ras, such that loss of oncogene expression in established tumours leads to tumour regression. HRas, NRas or KRas are mutated to remain in the active GTP-bound oncogenic state in many cancers. Although Ras activates several proteins to initiate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06778
更新日期:2008-04-03 00:00:00
abstract::Electric-field-induced charge separation (polarization) is the most fundamental manifestation of the interaction of light with matter and a phenomenon of great technological relevance. Nonlinear optical polarization produces coherent radiation in spectral ranges inaccessible by lasers and constitutes the key to ultima...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17650
更新日期:2016-06-02 00:00:00
abstract::Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08240
更新日期:2009-08-13 00:00:00
abstract::Cocaine is believed to work by blocking the dopamine transporter (DAT) and thereby increasing the availability of free dopamine within the brain. Although this concept is central to current cocaine research and to treatment development, a direct relationship between DAT blockade and the subjective effects of cocaine h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386827a0
更新日期:1997-04-24 00:00:00
abstract::In vitro studies of muscle mitochondrial metabolism in patients with mitochondrial myopathy have identified a variety of functional defects of the mitochondrial respiratory chain, predominantly affecting complex I (NADH-CoQ reductase) or complex III (ubiquinol-cytochrome c reductase) in adult cases. These two enzymes ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/331717a0
更新日期:1988-02-25 00:00:00
abstract::A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic u...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337525a0
更新日期:1989-02-09 00:00:00
abstract::Water availability limits plant growth and production in almost all terrestrial ecosystems. However, biomes differ substantially in sensitivity of aboveground net primary production (ANPP) to between-year variation in precipitation. Average rain-use efficiency (RUE; ANPP/precipitation) also varies between biomes, supp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02561
更新日期:2004-06-10 00:00:00
abstract::Complementary DNA cloning of the transcripts of the Drosophila clock gene period reveals three distinct transcripts. These result from unusual splicing pathways, one involving a CG 3' splice site and one resulting in the use of two different reading frames in one exon, and they predict three separate proteins. Two of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326042a0
更新日期:1987-03-05 00:00:00
abstract::It is thought that immunity depends on naive CD4 T cells that proliferate in response to microbial antigens, differentiate into memory cells that produce anti-microbial lymphokines, and migrate to sites of infection. Here we use immunohistology to enumerate individual naive CD4 T cells, specific for a model antigen, i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35065111
更新日期:2001-03-01 00:00:00
abstract::The Suzuki-Miyaura cross-coupling of organoboron nucleophiles with aryl halide electrophiles is one of the most widely used carbon-carbon bond-forming reactions in organic and medicinal chemistry1,2. A key challenge associated with these transformations is that they generally require the addition of an exogenous base,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0628-7
更新日期:2018-11-01 00:00:00
abstract::The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14366
更新日期:2015-04-30 00:00:00
abstract::To artists, the face is a mirror of the soul. To biologists, the face reflects remarkable structural diversity--think of bulldogs and wolfhounds or galapagos finches. How do such variations in skeletal form arise? Do the same mechanisms control skeletogenesis elsewhere in the body? The answers lie in the molecular mac...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature01656
更新日期:2003-05-15 00:00:00
abstract::Analogous to the progression of events in the opiate receptor-enkaphalin area, the first reports that benzodiazepines have selective and specific high-affinity binding sites in brain have stimulated a search for the endogenous 'ligand' or substance that might normally act at these sites. Braestrup and co-workers have ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288609a0
更新日期:1980-12-11 00:00:00
abstract::Recently, a class of protein antigens of high relative molecular mass (Mt) which can induce protective immunity against blood-stage malaria has been identified. In Plasmodium falciparum the protein has a Mr of approximately 195,000 (P195). It is the precursor of three proteins of Mr 83,000 (83K), 42K and 19K which are...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317270a0
更新日期:1985-09-19 00:00:00
abstract::Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III tumours (sometimes referred to as lower-grade gliomas). Genetic tumour profiling is used to classify disease and guide therapy1,2, but involves brain surgery for ti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0882-3
更新日期:2019-01-01 00:00:00