当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Fabrication of engineered nanoparticles on biological macromolecular (PEGylated chitosan) composite for bio-active hydrogel system in cardiac repair applications.

Fabrication of engineered nanoparticles on biological macromolecular (PEGylated chitosan) composite for bio-active hydrogel system in cardiac repair applications.

Abstract：

:The development of advanced nano-mediated biological macromolecular (PEGylated Chitosan) hydrogel materials is a vital approach to enhance the efficiency of cardiac tissue applications for treatment of cardiac tissue repair. Definite properties of PEG and chitosan hydrogel matrixes including swelling, mechanical stability and porosity need to be further improved with effective and non-toxic nanoparticles to promote the cell adhesion and organization of cardiac cells. In the current study, we fabricated engineered spherical TiO2 nanoparticles into the biologically active macromolecular (PEG/CTS) hydrogel matrixes with enhanced physico-chemical and biological properties. The morphological improved spherical TiO2 NPs have been highly dispersed in the porous hydrogel structure and effectively promoted young modulus and swelling properties and also exhibited favorable cell adhesion and organization with the cardiomyocytes cells. The stained fluorescence images of TiO2-PEG/CTS hydrogels on the cardiomyocytes cells show the excellent cell-hydrogel matrix interactions comparable to the PEG/CTS hydrogel in the absence of TiO2 NPs. Thus, the investigation results of the present study clearly suggested that efficient cardiac patches with superior bioactive and mechanical properties for cardiac tissue repair.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Liu N,Chen J,Zhuang J,Zhu P

doi

10.1016/j.ijbiomac.2018.04.196

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

553-558

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)30258-7

journal_volume

117

pub_type

杂志文章

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