当前位置： SCI文献检索 > Redox Biology期刊下所有文献 > Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α.

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α.

Abstract：

:The widespread detection of elevated oxidative stress levels in many medical conditions has led to numerous efforts to design interventions to reduce its effects. Efforts have been wide-ranging, from dietary changes to administration of antioxidants, supplements, e.g., omega-3-fatty acids, and many medications. However, there is still no systemic assessment of the efficacy of treatments for oxidative stress reduction across a variety of medical conditions. The goal of this meta-analysis is, by combining multiple studies, to quantitate the change in the levels of the popular oxidative stress biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α) after a variety of treatment strategies in human populations. Nearly 350 unique publications with 180 distinct strategies were included in the analysis. For each strategy, the difference between pre- or placebo and post-treatment levels calculated using Hedges' g value of effect. In general, administration of antibiotics, antihyperlipidemic agents, or changes in lifestyle (g = - 0.63, - 0.54, and 0.56) had the largest effect. Administration of supplements, antioxidants, or changes in diet (g = - 0.09, - 0.28, - 0.12) had small quantitative effects. To fully interpret the effectiveness of these treatments, comparisons to the increase in g value for each medical condition is required. For example, antioxidants in populations with coronary artery disease (CAD) reduce the 8-iso-PGF2α levels by g = - 0.34 ± 0.1, which is quantitatively considered a small effect. However, CAD populations, in comparison to healthy populations, have an increase in 8-iso-PGF2α levels by g = 0.38 ± 0.04; therefore, the overall reduction of 8-iso-PGF2α levels is ≈ 90% by this treatment in this specific medical condition. In conclusion, 8-iso-PGF2α levels can be reduced not only by antioxidants but by many other strategies. Not all strategies are equally effective at reducing 8-iso-PGF2α levels. In addition, the effectiveness of any strategy can be assessed only in relation to the medical condition investigated.

journal_name

Redox Biol

journal_title

Redox biology

authors

van 't Erve TJ

doi

10.1016/j.redox.2018.05.003

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

284-296

issn

2213-2317

pii

S2213-2317(18)30296-9

journal_volume

17

pub_type

杂志文章,meta分析

相关文献

Redox Biology文献大全
  • Redox regulation of proteasome function.

    abstract：:Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades,...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2017.07.005

    authors： Lefaki M,Papaevgeniou N,Chondrogianni N

    更新日期：2017-10-01 00:00:00

  • Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease.

    abstract：:Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities, however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident, that advanced glycation end products (AGEs) tri...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101546

    authors： Sharma A,Weber D,Raupbach J,Dakal TC,Fließbach K,Ramirez A,Grune T,Wüllner U

    更新日期：2020-07-01 00:00:00

  • MZe786, a hydrogen sulfide-releasing aspirin prevents preeclampsia in heme oxygenase-1 haplodeficient pregnancy under high soluble flt-1 environment.

    abstract：:Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disea...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101768

    authors： Rezai H,Ahmad S,Alzahrani FA,Sanchez-Aranguren L,Dias IH,Agrawal S,Sparatore A,Wang K,Ahmed A

    更新日期：2021-01-01 00:00:00

  • Critical role of AMPK in redox regulation under glucose starvation.

    abstract：:Glucose starvation is one of the major forms of metabolic stress in cancer cells. Deprivation of glucose impairs glycolysis and the pentose phosphate pathway, which elicits oxidative stress due to enhanced production of reactive oxygen species (ROS) and impaired antioxidant system, leading to redox imbalance and cell ...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2019.101154

    authors： Ren Y,Shen HM

    更新日期：2019-07-01 00:00:00

  • Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression.

    abstract：:We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration. However, delivery of naked siRNA remains a formidable challenge...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.101085

    authors： Xu Y,Pang L,Wang H,Xu C,Shah H,Guo P,Shu D,Qian SY

    更新日期：2019-02-01 00:00:00

  • A review of redox signaling and the control of MAP kinase pathway in plants.

    abstract：:Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved modules among eukaryotic species that range from yeast, plants, flies to mammals. In eukaryotic cells, reactive oxygen species (ROS) has both physiological and toxic effects. Both MAPK cascades and ROS signaling are involved in plant respons...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2016.12.009

    authors： Liu Y,He C

    更新日期：2017-04-01 00:00:00

  • Green tea polyphenolic antioxidants oxidize hydrogen sulfide to thiosulfate and polysulfides: A possible new mechanism underpinning their biological action.

    abstract：:Matcha and green tea catechins such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG) have long been studied for their antioxidant and health-promoting effects. Using specific fluorophores for H2S (AzMC) and polysulfides (SSP4) as well as IC-MS and UPLC-MS/MS-based techniques ...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101731

    authors： Olson KR,Briggs A,Devireddy M,Iovino NA,Skora NC,Whelan J,Villa BP,Yuan X,Mannam V,Howard S,Gao Y,Minnion M,Feelisch M

    更新日期：2020-10-01 00:00:00

  • Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence.

    abstract：:Cellular senescence plays essential roles in tissue homeostasis as well as a host of diseases ranging from cancers to age-related neurodegeneration. Various molecular pathways can induce senescence and these different pathways dictate the phenotypic and metabolic changes that accompany the transition to, and maintenan...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.05.008

    authors： Plafker KS,Zyla K,Berry W,Plafker SM

    更新日期：2018-07-01 00:00:00

  • Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo.

    abstract：:Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH utilization during development remains understudied. Monochlorobimane (MCB), a dye conjugated with GSH by glutathione-s-transferase (GST) to form a fluorescen...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2019.101235

    authors： Rastogi A,Clark CW,Conlin SM,Brown SE,Timme-Laragy AR

    更新日期：2019-09-01 00:00:00

  • Redox signaling in acute oxygen sensing.

    abstract：:Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K+ channels is the signal that tri...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2017.04.033

    authors： Gao L,González-Rodríguez P,Ortega-Sáenz P,López-Barneo J

    更新日期：2017-08-01 00:00:00

  • Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.

    abstract：:Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stress that directly au...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101785

    authors： Lu Q,Zemskov EA,Sun X,Wang H,Yegambaram M,Wu X,Garcia-Flores A,Song S,Tang H,Kangath A,Cabanillas GZ,Yuan JX,Wang T,Fineman JR,Black SM

    更新日期：2021-01-01 00:00:00

  • Evaluating The Role Of Nitric Oxide Synthase In Oncogenic Ras-Driven Tumorigenesis.

    abstract：:We previously reported that oncogenic KRAS activation of the PI3K/AKT pathway stimulates the remaining wild-type HRAS and NRAS proteins in a manner dependent upon both eNOS expression and C118 in HRAS and NRAS, which promoted tumor growth. Interestingly however, we recently found that loss of wild-type HRAS, NRAS, and...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2015.09.023

    authors： Counter C

    更新日期：2015-08-01 00:00:00

  • Artesunate-induced mitophagy alters cellular redox status.

    abstract：:Artesunate (ART) is a prominent anti-malarial with significant anti-cancer properties. Our previous studies showed that ART enhances lysosomal function and ferritin degradation, which was necessary for its anti-cancer properties. ART targeting to mitochondria also significantly improved its efficacy, but the effect of...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.07.025

    authors： Zhang J,Sun X,Wang L,Wong YK,Lee YM,Zhou C,Wu G,Zhao T,Yang L,Lu L,Zhong J,Huang D,Wang J

    更新日期：2018-10-01 00:00:00

  • Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.

    abstract：:Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintain proteostasis. Here, we report that hippocampal cells selected for f...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2019.101181

    authors： Chakraborty D,Felzen V,Hiebel C,Stürner E,Perumal N,Manicam C,Sehn E,Grus F,Wolfrum U,Behl C

    更新日期：2019-06-01 00:00:00

  • Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone.

    abstract：:Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species ...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101440

    authors： Torrente L,Prieto-Farigua N,Falzone A,Elkins CM,Boothman DA,Haura EB,DeNicola GM

    更新日期：2020-02-01 00:00:00

  • Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences.

    abstract：:Fibrosis is one of the most prevalent features of age-related diseases like obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, or cardiomyopathy and affects millions of people in all countries. Although the understanding about the pathophysiology of fibrosis has improved a lot during the rec...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2015.08.015

    authors： Richter K,Konzack A,Pihlajaniemi T,Heljasvaara R,Kietzmann T

    更新日期：2015-12-01 00:00:00

  • Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress.

    abstract：:Ischemia/reperfusion injury (I/R) is one of the leading causes of acute kidney injury (AKI) that typically occurs in renal surgeries. However, renal I/R still currently lacks effective therapeutic targets. In this study, we proved that inhibition of Brd4 with its selective inhibitor, JQ1, could exert a protective role...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2019.101195

    authors： Liu H,Wang L,Weng X,Chen H,Du Y,Diao C,Chen Z,Liu X

    更新日期：2019-06-01 00:00:00

  • Quantifying intracellular hydrogen peroxide perturbations in terms of concentration.

    abstract：:Molecular level, mechanistic understanding of the roles of reactive oxygen species (ROS) in a variety of pathological conditions is hindered by the difficulties associated with determining the concentration of various ROS species. Here, we present an approach that converts fold-change in the signal from an intracellul...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2014.08.001

    authors： Huang BK,Sikes HD

    更新日期：2014-01-01 00:00:00

  • The aryl hydrocarbon receptor as a target of environmental stressors - Implications for pollution mediated stress and inflammatory responses.

    abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor regulating the expression of genes, for instance encoding the monooxygenases cytochrome P450 (CYP) 1A1 and CYP1A2, which are important enzymes in metabolism of xenobiotics. The AHR is activated upon binding of polycyclic aromatic hydrocarbo...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2020.101530

    authors： Vogel CFA,Van Winkle LS,Esser C,Haarmann-Stemmann T

    更新日期：2020-07-01 00:00:00

  • Genome-wide transcriptional effects of deletions of sulphur metabolism genes in Drosophila melanogaster.

    abstract：:In recent years, the gasotransmitter hydrogen sulphide (H2S), produced by the transsulphuration pathway, has been recognized as a biological mediator playing an important role under normal conditions and in various pathologies in both eukaryotes and prokaryotes. The transsulphuration pathway (TSP) includes the convers...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101654

    authors： Zatsepina O,Karpov D,Chuvakova L,Rezvykh A,Funikov S,Sorokina S,Zakluta A,Garbuz D,Shilova V,Evgen'ev M

    更新日期：2020-09-01 00:00:00

  • Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.

    abstract：:Isolated hepatocytes from young (4-6mo) and old (24-26mo) F344 rats were exposed to increasing concentrations of menadione, a vitamin K derivative and redox cycling agent, to determine whether the age-related decline in Nrf2-mediated detoxification defenses resulted in heightened susceptibility to xenobiotic insult. A...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2016.09.010

    authors： Thomas NO,Shay KP,Kelley AR,Butler JA,Hagen TM

    更新日期：2016-12-01 00:00:00

  • Statin treatment, oxidative stress and inflammation in a Danish population.

    abstract：BACKGROUND:While statins may have anti-inflammatory effects, anti-oxidative effects are controversial. We investigated if statin treatment is associated with differences in oxidatively generated nucleotide damage and chronic inflammation, and the relationship between nucleotide damage and chronic inflammation. METHODS...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.101088

    authors： Sørensen AL,Hasselbalch HC,Nielsen CH,Poulsen HE,Ellervik C

    更新日期：2019-02-01 00:00:00

  • Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall.

    abstract：:Epidemiological studies have shown that estrogens have protective effects in cardiovascular diseases, even though the results from human clinical trials remain controversial, while most of the animal experiments confirmed this effect, but the detailed mechanism remains unclear. In this study, we found that estradiol (...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2014.11.001

    authors： Liu Z,Gou Y,Zhang H,Zuo H,Zhang H,Liu Z,Yao D

    更新日期：2014-01-01 00:00:00

  • Critical role of vascular peroxidase 1 in regulating endothelial nitric oxide synthase.

    abstract：:Vascular peroxidase 1 (VPO1) is a member of the peroxidase family which aggravates oxidative stress by producing hypochlorous acid (HOCl). Our previous study demonstrated that VPO1 plays a critical role in endothelial dysfunction through dimethylarginine dimethylaminohydrolase2 (DDAH2)/asymmetric Dimethylarginine (ADM...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2017.02.022

    authors： Liu Z,Liu Y,Xu Q,Peng H,Tang Y,Yang T,Yu Z,Cheng G,Zhang G,Shi R

    更新日期：2017-08-01 00:00:00

  • Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity.

    abstract：:Yeast Sir2 is an NAD-dependent histone deacetylase related to oxidative stress and aging. In a previous study, we showed that Sir2 is regulated by S-glutathionylation of key cysteine residues located at the catalytic domain. Mutation of these residues results in strains with increased resistance to disulfide stress. I...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2019.101229

    authors： Vall-Llaura N,Mir N,Garrido L,Vived C,Cabiscol E

    更新日期：2019-06-01 00:00:00

  • Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.

    abstract：:Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species. Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maintained in a reduced state by glutathione reductase (GR). Nitro oleic acid (NO2-OA) is an el...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.11.008

    authors： Jobbagy S,Vitturi DA,Salvatore SR,Turell L,Pires MF,Kansanen E,Batthyany C,Lancaster JR Jr,Freeman BA,Schopfer FJ

    更新日期：2019-02-01 00:00:00

  • Clinical relevance of guanine-derived urinary biomarkers of oxidative stress, determined by LC-MS/MS.

    abstract：:A reliable and fast liquid chromatography-tandem mass spectrometry method has been developed for the simultaneous determination of three oxidized nucleic acid damage products in urine, 8-oxoguanine (8-oxoGua), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo). We applied this me...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.11.016

    authors： Shih YM,Cooke MS,Pan CH,Chao MR,Hu CW

    更新日期：2019-01-01 00:00:00

  • Altered glucose metabolism and cell function in keloid fibroblasts under hypoxia.

    abstract：:Keloids exhibit metabolic reprogramming including enhanced glycolysis and attenuated oxidative phosphorylation. Hypoxia induces a series of protective responses in mammalian cells. However, the metabolic phenotype of keloid fibroblasts under hypoxic conditions remains to be elucidated. The present study aimed to inves...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101815

    authors： Wang Q,Wang P,Qin Z,Yang X,Pan B,Nie F,Bi H

    更新日期：2021-01-01 00:00:00

  • Formation of electrophilic oxidation products from mitochondrial cardiolipin in vitro and in vivo in the context of apoptosis and atherosclerosis.

    abstract：:Emerging evidence indicates that mitochondrial cardiolipins (CL) are prone to free radical oxidation and this process appears to be intimately associated with multiple biological functions of mitochondria. Our previous work demonstrated that a significant amount of potent lipid electrophiles including 4-hydroxy-nonena...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2014.04.003

    authors： Zhong H,Lu J,Xia L,Zhu M,Yin H

    更新日期：2014-04-13 00:00:00

  • Redox regulation of ischemic limb neovascularization - What we have learned from animal studies.

    abstract：:Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral a...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2017.04.040

    authors： Matsui R,Watanabe Y,Murdoch CE

    更新日期：2017-08-01 00:00:00