Abstract：
:Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K+ channels is the signal that triggers cell depolarization, transmitter release and activation of sensory fibers that stimulate the brainstem respiratory center to produce hyperventilation. The molecular mechanisms underlying O2 sensing by glomus cells have, however, remained elusive. Here we discuss recent data demonstrating that ablation of mitochondrial Ndufs2 gene selectively abolishes sensitivity of glomus cells to hypoxia, maintaining responsiveness to hypercapnia or hypoglycemia. These data suggest that reactive oxygen species and NADH generated in mitochondrial complex I during hypoxia are signaling molecules that modulate membrane K+ channels. We propose that the structural substrates for acute O2 sensing in CB glomus cells are "O2-sensing microdomains" formed by mitochondria and neighboring K+ channels in the plasma membrane.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Gao L,González-Rodríguez P,Ortega-Sáenz P,López-Barneo Jdoi
10.1016/j.redox.2017.04.033subject
Has Abstractpub_date
2017-08-01 00:00:00pages
908-915issn
2213-2317pii
S2213-2317(17)30102-7journal_volume
12pub_type
杂志文章,评审相关文献
Redox Biology文献大全abstract：:We present a new database, specifically devoted to ROS homeostasis regulated proteins. This database replaced our previous database, the PeroxiBase, which was focused only on various peroxidase families. The addition of 20 new protein families related with ROS homeostasis justifies the new name for this more complex a...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101247
更新日期：2019-09-01 00:00:00
abstract：:Redox signaling and oxidative stress are associated with tissue fibrosis and aging. Aging is recognized as a major risk factor for fibrotic diseases involving multiple organ systems, including that of the lung. A number of oxidant generating enzymes are upregulated while antioxidant defenses are deficient with aging a...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2016.06.005
更新日期：2016-10-01 00:00:00
abstract：:Manganese superoxide dismutase, encoded by the Sod2 gene, is a ubiquitously expressed mitochondrial antioxidant enzyme that is essential for mammalian life. Mice born with constitutive genetic knockout of Sod2 do not survive the neonatal stage, which renders the longitudinal study of the biochemical and metabolic effe...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2013.01.001
更新日期：2013-02-05 00:00:00
abstract：:Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis characterized by its insensitivity to chemotherapy. Emerging evidence indicates that cytoprotective antioxidation is involved in drug resistance of various cancers; however, the underlying molecular mechanisms remain obscure. Here, we ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101149
更新日期：2019-04-01 00:00:00
abstract：:Retinal tissue receives its supply of oxygen from two sources - the retinal and choroidal circulations. Decreases in retinal blood flow occur in the early stages of diabetes, with the eventual development of hypoxia thought to contribute to pathological neovascularization. Oxygen consumption in the retina has been fou...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2014.04.006
更新日期：2014-04-18 00:00:00
abstract：:Glutathione peroxidase 2 (GPx2) is one of the five selenoprotein GPxs having a selenocysteine in the active center. GPx2 is strongly expressed in the gastrointestinal epithelium, as is another isoform, GPx1, though with a different localization pattern. Both GPxs are redox-active enzymes that are important for the red...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101388
更新日期：2020-01-01 00:00:00
abstract：:In order to overcome intercellular variability and thereby effectively assess signal propagation in biological networks it is imperative to simultaneously quantify multiple biological observables in single living cells. While fluorescent biosensors have been the tool of choice to monitor the dynamics of protein intera...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.07.023
更新日期：2018-10-01 00:00:00
abstract：:For years, there have been studies based on the use of natural compounds plant-derived as potential therapeutic agents for various diseases in humans. Curcumin is a phenolic compound extracted from Curcuma longa rhizome commonly used in Asia as a spice, pigment and additive. In traditional medicine of India and China,...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2013.09.003
更新日期：2013-09-17 00:00:00
abstract：:Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in yeast cells. Although the mechanisms causing this activation are not completely understood, it is as...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.09.001
更新日期：2018-04-01 00:00:00
abstract：:Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by transla...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2015.05.008
更新日期：2015-08-01 00:00:00
abstract：:Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades,...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2017.07.005
更新日期：2017-10-01 00:00:00
abstract：:Tumorigenesis is commonly known as a complicated process, in which reactive oxygen species (ROS) plays a critical role to involve in signal transduction, metabolism, cell proliferation and differentiation. Previously, ribosomal protein L10 (RPL10) was suggested to possess extra-ribosomal functions in pancreatic cancer...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.08.016
更新日期：2018-10-01 00:00:00
abstract：:Premature senescence, a death escaping pathway for cells experiencing stress, is conducive to aging and cardiovascular diseases. The molecular switch between senescent and apoptotic fate remains, however, poorly recognized. Nrf2 is an important transcription factor orchestrating adaptive response to cellular stress. H...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101304
更新日期：2020-01-01 00:00:00
abstract：:Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have indicated that Mas receptor activation initiates an anti-oxidative and anti-apoptotic role in the brain. However, whether Mas activation can attenuate...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.09.022
更新日期：2019-01-01 00:00:00
abstract：:Mitochondria are critical sources of hydrogen peroxide (H2O2), an important secondary messenger in mammalian cells. Recent work has shown that O2•-/H2O2 emission from individual sites of production in mitochondria is regulated by protein S-glutathionylation. Here, we conducted the first examination of O2•-/H2O2 releas...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.12.006
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The oxidation of the methionine adenosyltransferase (MAT) by the combined impact of peroxides contaminating parenteral nutrition (PN) and oxidized redox potential of glutathione is suspected to explain its inhibition observed in animals. A modification of MAT activity is suspected to be at origin of the PN-a...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.12.003
更新日期：2016-08-01 00:00:00
abstract：:Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic agents. Previously, we discovered one novel synthetic compound, tanshinol borneol ester (DBZ), possesses anti-inflammatory and anti-ath...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101644
更新日期：2020-09-01 00:00:00
abstract：:Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular defense mechanisms as well as physiological functions, and intracellular signaling. However, excessive ROS generation (endogenous and exogenous) can create a state of redox imbalance leading to cellular and tissue damage (Ma and H...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2018.11.017
更新日期：2019-02-01 00:00:00
abstract：:FUN14 domain-containing protein 1 (Fundc1)-dependent mitophagy, mainly activated by ischemic/hypoxic preconditioning, benefits acute myocardial reperfusion injury and chronic metabolic syndrome via sustaining mitochondrial homeostasis. Mitochondrial fission plays a pathogenic role in ischemic acute kidney injury (AKI)...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101415
更新日期：2020-02-01 00:00:00
abstract：:Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. An increase of PM2.5 of 10 μg per cubic meter was associated with a 76% increase in the ris...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101161
更新日期：2019-04-01 00:00:00
abstract：:Necroptosis has been discovered as a new paradigm of cell death and may play a key role in heart disease and selenium (Se) deficiency. Hence, we detected the specific microRNA (miRNA) in response to Se-deficient heart using microRNAome analysis. For high-throughput sequencing using Se-deficient chicken cardiac tissue,...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.11.025
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Macrophages regulate the inflammatory response and affect re-endothelialization. Inflammation and macrophages play important roles in promoting tissue repair, but p38α mitogen-activated protein kinase's role in re-endothelialization is unknown. METHODS AND RESULTS:Wire injuries of carotid arteries and Evans...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101775
更新日期：2021-01-01 00:00:00
abstract：:Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disea...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101768
更新日期：2021-01-01 00:00:00
abstract：:Bupivacaine is frequently administered for diagnosing and controlling spine-related pain in interventional spine procedures. However, the potential cytotoxic effects of bupivacaine on intervertebral disc (IVD) cells and the underlying molecular mechanisms have not yet been fully established. Here, we showed that bupiv...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.06.010
更新日期：2018-09-01 00:00:00
abstract：:The massive production and activation of myofibroblasts (MFB) is key to the development of liver fibrosis. In many studies, it has been proven that hepatocytes are an important part of MFB, and can be transformed into MFB through epithelial-mesenchymal transition (EMT) during hepatic fibrogenesis. In our previous stud...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101600
更新日期：2020-09-01 00:00:00
abstract：:Vascular peroxidase 1 (VPO1) is a member of the peroxidase family which aggravates oxidative stress by producing hypochlorous acid (HOCl). Our previous study demonstrated that VPO1 plays a critical role in endothelial dysfunction through dimethylarginine dimethylaminohydrolase2 (DDAH2)/asymmetric Dimethylarginine (ADM...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.02.022
更新日期：2017-08-01 00:00:00
abstract：:Muscle mass and strength are very important for exercise performance. Training-induced musculoskeletal injuries usually require periods of complete immobilization to prevent any muscle contraction of the affected muscle groups. Disuse muscle wasting will likely affect every sport practitioner in his or her lifetime. E...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101531
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Vitamin D status [25(OH)D] has recently been reported to be associated with altered cellular bioenergetic profiles of peripheral blood mononuclear cells (PBMCs). No study has tracked the seasonal variation of 25(OH)D and its putative influence on whole body energy metabolism, cellular bioenergetic profiles, ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.04.009
更新日期：2017-08-01 00:00:00
abstract：:PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attrib...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.03.016
更新日期：2018-07-01 00:00:00
abstract：:Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stress that directly au...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101785
更新日期：2021-01-01 00:00:00
