Abstract：
:Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K+ channels is the signal that triggers cell depolarization, transmitter release and activation of sensory fibers that stimulate the brainstem respiratory center to produce hyperventilation. The molecular mechanisms underlying O2 sensing by glomus cells have, however, remained elusive. Here we discuss recent data demonstrating that ablation of mitochondrial Ndufs2 gene selectively abolishes sensitivity of glomus cells to hypoxia, maintaining responsiveness to hypercapnia or hypoglycemia. These data suggest that reactive oxygen species and NADH generated in mitochondrial complex I during hypoxia are signaling molecules that modulate membrane K+ channels. We propose that the structural substrates for acute O2 sensing in CB glomus cells are "O2-sensing microdomains" formed by mitochondria and neighboring K+ channels in the plasma membrane.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Gao L,González-Rodríguez P,Ortega-Sáenz P,López-Barneo Jdoi
10.1016/j.redox.2017.04.033subject
Has Abstractpub_date
2017-08-01 00:00:00pages
908-915issn
2213-2317pii
S2213-2317(17)30102-7journal_volume
12pub_type
杂志文章,评审相关文献
Redox Biology文献大全abstract：:Glutathione peroxidase 2 (GPx2) is one of the five selenoprotein GPxs having a selenocysteine in the active center. GPx2 is strongly expressed in the gastrointestinal epithelium, as is another isoform, GPx1, though with a different localization pattern. Both GPxs are redox-active enzymes that are important for the red...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101388
更新日期：2020-01-01 00:00:00
abstract：:The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are m...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2014.09.004
更新日期：2014-01-01 00:00:00
abstract：:Nitrite and nitrate restore deficient endogenous nitric oxide (NO) production as they are converted back to NO, and therefore complement the classic enzymatic NO synthesis. Circulating nitrate and nitrite must cross membrane barriers to produce their effects and increased nitrate concentrations may attenuate the nitri...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.03.003
更新日期：2017-08-01 00:00:00
abstract：:Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, leads to impaired mitochondrial complex I function, hypertension and ca...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.10.019
更新日期：2018-04-01 00:00:00
abstract：:The traditional Asian diet is rich in fruits, vegetables and soy, the latter representing a significant source of dietary isoflavones. The isoflavone prunetin was recently identified to improve intestinal epithelial barrier function in vitro and to ameliorate general survival and overall health state in vivo in male D...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.01.001
更新日期：2016-08-01 00:00:00
abstract：:Oxidative stress response in bacteria is mediated through coordination between the regulators of oxidant-remediation systems (e.g. OxyR, SoxR) and nucleoid condensation (e.g. Dps, Fis). However, these genetic factors are either absent or rendered non-functional in the human pathogen Mycobacterium tuberculosis (Mtb). T...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.08.006
更新日期：2018-10-01 00:00:00
abstract：:FUN14 domain-containing protein 1 (Fundc1)-dependent mitophagy, mainly activated by ischemic/hypoxic preconditioning, benefits acute myocardial reperfusion injury and chronic metabolic syndrome via sustaining mitochondrial homeostasis. Mitochondrial fission plays a pathogenic role in ischemic acute kidney injury (AKI)...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101415
更新日期：2020-02-01 00:00:00
abstract：:Cells employ multiple defence mechanisms to sustain a wide range of stress conditions associated with accumulation of modified self-biomolecules leading to lipo- and proteotoxicity. One of such mechanisms involves activation of the autophagy-lysosomal pathway for removal and degradation of modified lipids, proteins an...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101123
更新日期：2019-05-01 00:00:00
abstract：:Hydrogen peroxide appears to be the key reactive oxygen species involved in redox signalling, but comparisons of the low concentrations of hydrogen peroxide that are calculated to exist within cells with those previously shown to activate common signalling events in vitro indicate that direct oxidation of key thiol gr...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101484
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:The Ras family of small GTPases cycle between an inactive, GDP-bound state and an active, GTP-bound state. When bound to GTP, Ras engages and activates a number of effectors that mediate proliferative and survival signals. Ras is mutated in over 30% of human cancers, usually at codons 12, 13, or 61, to remai...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.09.015
更新日期：2015-08-01 00:00:00
abstract：:For years, there have been studies based on the use of natural compounds plant-derived as potential therapeutic agents for various diseases in humans. Curcumin is a phenolic compound extracted from Curcuma longa rhizome commonly used in Asia as a spice, pigment and additive. In traditional medicine of India and China,...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2013.09.003
更新日期：2013-09-17 00:00:00
abstract：:Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with h...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101585
更新日期：2020-10-01 00:00:00
abstract：:The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells. Understanding how the PTTRS integrates these functions requires tracing phenotypes to molecular...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.12.008
更新日期：2018-05-01 00:00:00
abstract：:Autophagy is an important cell recycling program responsible for the clearance of damaged or long-lived proteins and organelles. Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compoun...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.11.004
更新日期：2017-04-01 00:00:00
abstract：:Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm at the wound site are known to compromise SM regeneration. Recently, we reported that abrogation of Nrf2/antioxidant signaling promotes oxidative stress and im...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101492
更新日期：2020-07-01 00:00:00
abstract：:Cardiovascular disease is the leading cause of death and disability worldwide with increased oxidative stress and reduced NO bioavailability serving as key risk factors. For decades, elevation in protein abundance and enzymatic activity of xanthine oxidoreductase (XOR) under hypoxic/inflammatory conditions has been as...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101447
更新日期：2020-07-01 00:00:00
abstract：:The biological functions of N6-methyladenosine (m6A) RNA methylation are mainly dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we have demonstrated that the m6A reader YT521-B homology domain containing 2 (YTHDC2) is frequently suppressed in lung adenocarcinoma (LUAD). Downregu...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101801
更新日期：2021-01-01 00:00:00
abstract：:A reliable and fast liquid chromatography-tandem mass spectrometry method has been developed for the simultaneous determination of three oxidized nucleic acid damage products in urine, 8-oxoguanine (8-oxoGua), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo). We applied this me...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.11.016
更新日期：2019-01-01 00:00:00
abstract：:Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disea...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101768
更新日期：2021-01-01 00:00:00
abstract：:Exposure to the space radiation environment poses risks for a range of deleterious health effects due to the unique types of radiation encountered. Galactic cosmic rays are comprised of a spectrum of highly energetic nuclei that deposit densely ionizing tracks of damage along the particle trajectory. These tracks are ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.03.001
更新日期：2015-08-01 00:00:00
abstract：:Hypertension is one of the major predisposing factors for neurodegenerative disease characterized with activated renin-angiotensin system (RAS) in both periphery and brain. Vitamin D (VitD) is recently recognized as a pleiotropic hormone with strong neuroprotective properties. While multiple lines of evidence suggest ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101295
更新日期：2019-09-01 00:00:00
abstract：:The diphthamide modification of translation elongation factor 2 is highly conserved in eukaryotes and archaebacteria. Nevertheless, cells lacking diphthamide can carry out protein synthesis and are viable. We have analyzed the phenotypes of diphthamide deficient cells and found that diphthamide deficiency reduces sele...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.09.015
更新日期：2019-01-01 00:00:00
abstract：:Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signal transduction. Both intracellular and extracellular sources of H2O2 have been implicated in eNOS regulation, yet the specific endothelial pathways rema...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101605
更新日期：2020-09-01 00:00:00
abstract：:NRF2 is a redox-responsive transcription factor that regulates expression of cytoprotective genes via its interaction with DNA sequences known as antioxidant response elements (AREs). NRF2 activity is induced by oxidative stress, but oxidative stress is not the only context in which NRF2 can be activated. Mutations th...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.07.026
更新日期：2018-10-01 00:00:00
abstract：:Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces GA biosynthesis by increasing ROS production, and further research fo...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.03.018
更新日期：2018-06-01 00:00:00
abstract：:Superoxide dismutase (SOD) is known to be protective against oxidative stress-mediated skin dysfunction. Here we explore the potential therapeutic activities of RM191A, a novel SOD mimetic, on skin. RM191A is a water-soluble dimeric copper (Cu2+-Cu3+)-centred polyglycine coordination complex. It displays 10-fold highe...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101790
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The oxidation of the methionine adenosyltransferase (MAT) by the combined impact of peroxides contaminating parenteral nutrition (PN) and oxidized redox potential of glutathione is suspected to explain its inhibition observed in animals. A modification of MAT activity is suspected to be at origin of the PN-a...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.12.003
更新日期：2016-08-01 00:00:00
abstract：:The massive production and activation of myofibroblasts (MFB) is key to the development of liver fibrosis. In many studies, it has been proven that hepatocytes are an important part of MFB, and can be transformed into MFB through epithelial-mesenchymal transition (EMT) during hepatic fibrogenesis. In our previous stud...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101600
更新日期：2020-09-01 00:00:00
abstract：:Oxidation-reduction chemistry is fundamental to the metabolism of all living organisms, and hence quantifying the principal redox players is important for a comprehensive understanding of cell metabolism in normal and pathological states. In mammalian cells, this is accomplished by measuring oxygen partial pressure (p...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101549
更新日期：2020-07-01 00:00:00
abstract：:In order to overcome intercellular variability and thereby effectively assess signal propagation in biological networks it is imperative to simultaneously quantify multiple biological observables in single living cells. While fluorescent biosensors have been the tool of choice to monitor the dynamics of protein intera...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.07.023
更新日期：2018-10-01 00:00:00
