Abstract：
:Epidemiological studies have shown that estrogens have protective effects in cardiovascular diseases, even though the results from human clinical trials remain controversial, while most of the animal experiments confirmed this effect, but the detailed mechanism remains unclear. In this study, we found that estradiol (E2) treatment significantly increases the expression of mitochondrial superoxide dismutase (SOD2) in mice and in vitro in human aorta endothelial cells. Further investigation shows that E2 up-regulates SOD2 through tethering of estrogen receptor (ER) to Sp1 and the increased binding of Sp1 to GC-box on the SOD2 promoter, where ERα responses E2-mediated gene activation, and ERβ maintains basal gene expression level. The E2/ER-mediated SOD2 up-regulation results in minimized ROS generation, which highly favors healthy cardiovascular function. Gene therapy through lentivirus-carried endothelium-specific delivery to the vascular wall in high-fat diet (HFT) mice shows that the SOD2 expression in endothelial cells normalizes E2 deficiency-induced ROS generation with ameliorated mitochondrial dysfunction and vascular damage, while SOD2 knockdown worsens the problem despite the presence of E2, indicating that E2-induced SOD2 expression plays an important vasculoprotective role. To our knowledge, this is the first report for the mechanism by which E2 improves cardiovascular function through up-regulation of SOD2 in endothelial cells. In turn, this suggests a novel gene therapy through lentivirus-carried gene delivery to vascular wall for E2 deficiency-induced cardiovascular damage in postmenopausal women.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Liu Z,Gou Y,Zhang H,Zuo H,Zhang H,Liu Z,Yao Ddoi
10.1016/j.redox.2014.11.001subject
Has Abstractpub_date
2014-01-01 00:00:00pages
88-99issn
2213-2317pii
S2213-2317(14)00113-Xjournal_volume
3pub_type
杂志文章相关文献
Redox Biology文献大全abstract：:Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintain proteostasis. Here, we report that hippocampal cells selected for f...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101181
更新日期：2019-06-01 00:00:00
abstract：:Alzheimer disease (AD) is an age-related neurodegenerative disease characterized by the presence of three pathological hallmarks: synapse loss, extracellular senile plaques (SP) and intracellular neurofibrillary tangles (NFTs). The major component of SP is amyloid β-peptide (Aβ), which has been shown to induce oxidati...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2013.01.002
更新日期：2013-01-30 00:00:00
abstract：:Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis characterized by its insensitivity to chemotherapy. Emerging evidence indicates that cytoprotective antioxidation is involved in drug resistance of various cancers; however, the underlying molecular mechanisms remain obscure. Here, we ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101149
更新日期：2019-04-01 00:00:00
abstract：:Transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress. Inhibitors of Keap1-Nrf2 interaction are promising in oxidative stress related inflamm...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101565
更新日期：2020-07-01 00:00:00
abstract：:Mitochondria are critical sources of hydrogen peroxide (H2O2), an important secondary messenger in mammalian cells. Recent work has shown that O2•-/H2O2 emission from individual sites of production in mitochondria is regulated by protein S-glutathionylation. Here, we conducted the first examination of O2•-/H2O2 releas...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.12.006
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The Ras family of small GTPases cycle between an inactive, GDP-bound state and an active, GTP-bound state. When bound to GTP, Ras engages and activates a number of effectors that mediate proliferative and survival signals. Ras is mutated in over 30% of human cancers, usually at codons 12, 13, or 61, to remai...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.09.015
更新日期：2015-08-01 00:00:00
abstract：:Premature senescence, a death escaping pathway for cells experiencing stress, is conducive to aging and cardiovascular diseases. The molecular switch between senescent and apoptotic fate remains, however, poorly recognized. Nrf2 is an important transcription factor orchestrating adaptive response to cellular stress. H...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101304
更新日期：2020-01-01 00:00:00
abstract：:Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), a redox-regulated p38MAPK family member was a negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated the function of VSMC-MAPK14 in vivo in injury-induced neointima hyperplasia and the under...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101137
更新日期：2019-04-01 00:00:00
abstract：:Dilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D5 dopamine receptor (D5R) gene knockout (D5-/-) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R regulates cardiac function, we generated cardiac-specific human D5...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.07.008
更新日期：2018-10-01 00:00:00
abstract：:Oxidative stress is reported to regulate several apoptotic and necrotic cell death pathways in auditory tissues. Poly(ADP-ribose) polymerase-1 (PARP-1) can be activated under oxidative stress, which is the hallmark of parthanatos. Autophagy, which serves either a pro-survival or pro-death function, can also be stimula...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.10.002
更新日期：2018-04-01 00:00:00
abstract：:Sporadic cases account for 90-95% of all patients with Parkinson's Disease (PD). Atypical Parkinsonism comprises approximately 20% of all patients with parkinsonism. Progressive Supranuclear Palsy (PSP) belongs to the atypical parkinsonian diseases and is histopathologically classified as a tauopathy. Here, we report ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.10.016
更新日期：2018-04-01 00:00:00
abstract：:Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet, overcoming it with other xenobiotics impose additional risks. In this study, we consider the use of natural-occurring and purified Vitamin E analogs as hepatoprotective agents. Vitamin E is well-known for its intrinsic antioxida...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.01.013
更新日期：2015-01-01 00:00:00
abstract：:Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with 'peroxiporin' activity (AQP3, AQP8, AQP9). Here, we exploit different organelle-targeted H2O2-sensitive probes to show that also A...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101326
更新日期：2020-01-01 00:00:00
abstract：:This review focuses on the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths. A disproportionately higher number of African Americans are afflicted with autoimmune and inflammatory diseases (e.g., diabetes, hypertension, obesity), a...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101721
更新日期：2020-10-01 00:00:00
abstract：:The system (PTTRS) formed by typical 2-Cys peroxiredoxins (Prx), thioredoxin (Trx), Trx reductase (TrxR), and sulfiredoxin (Srx) is central in antioxidant protection and redox signaling in the cytoplasm of eukaryotic cells. Understanding how the PTTRS integrates these functions requires tracing phenotypes to molecular...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.12.008
更新日期：2018-05-01 00:00:00
abstract：:Neonatal hypoxic-ischemic (HI) injury is a major cause of neonatal death and neurological dysfunction. H2S has been shown to protect against hypoxia-induced injury and apoptosis of neurons. L-Cysteine is catalyzed by cystathionine-β-synthase (CBS) in the brain and sequentially produces endogenous H2S. The present stud...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.06.007
更新日期：2017-10-01 00:00:00
abstract：:Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by transla...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2015.05.008
更新日期：2015-08-01 00:00:00
abstract：:The nuclear protein HMGB1 (high mobility group box 1) is secreted by monocytes-macrophages in response to inflammatory stimuli and serves as a danger-associated molecular pattern. Acetylation and phosphorylation of HMGB1 are implicated in the regulation of its nucleocytoplasmic translocation for secretion, although in...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101203
更新日期：2019-06-01 00:00:00
abstract：:Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101440
更新日期：2020-02-01 00:00:00
abstract：:Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with h...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101585
更新日期：2020-10-01 00:00:00
abstract：:Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral a...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2017.04.040
更新日期：2017-08-01 00:00:00
abstract：:Autophagy is an important cell recycling program responsible for the clearance of damaged or long-lived proteins and organelles. Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compoun...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.11.004
更新日期：2017-04-01 00:00:00
abstract：:Red blood cells (RBC) have been considered almost exclusively as a transporter of metabolic gases and nutrients for the tissues. It is an accepted dogma that RBCs take up and inactivate endothelium-derived NO via rapid reaction with oxyhemoglobin to form methemoglobin and nitrate, thereby limiting NO available for vas...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2013.12.027
更新日期：2014-01-09 00:00:00
abstract：:Muscle mass and strength are very important for exercise performance. Training-induced musculoskeletal injuries usually require periods of complete immobilization to prevent any muscle contraction of the affected muscle groups. Disuse muscle wasting will likely affect every sport practitioner in his or her lifetime. E...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101531
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidate...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.12.009
更新日期：2016-08-01 00:00:00
abstract：:Mitochondrial derived reactive oxygen species (mtROS) are known for their signaling qualities in both physiology and pathology. To elucidate mitochondrial complex I-dependent ROS-signaling after lipopolysaccharide (LPS)-stimulation THP-1 macrophages with a knockdown of the transmembrane protein TMEM126B were generated...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.10.007
更新日期：2019-01-01 00:00:00
abstract：:We previously reported that the highly reactive cell-free heme (CFH) is increased in the plasma of patients with chronic lung injury and causes pulmonary edema in animal model of acute respiratory distress syndrome (ARDS) post inhalation of halogen gas. However, the mechanisms by which CFH causes pulmonary edema are u...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101592
更新日期：2020-09-01 00:00:00
abstract：:Ischemia heart disease is the leading cause of death world-widely and has increased prevalence and exacerbated myocardial infarction with aging. Sestrin2, a stress-inducible protein, declines with aging in the heart and the rescue of Sestrin2 in the aged mouse heart improves the resistance to ischemic insults caused b...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101556
更新日期：2020-07-01 00:00:00
abstract：:Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular dise...
journal_title：Redox biology
pub_type： 临床试验,杂志文章
doi：10.1016/j.redox.2016.12.014
更新日期：2017-04-01 00:00:00
abstract：:Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. H...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.01.008
更新日期：2016-08-01 00:00:00
