Abstract：
:Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine β-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Dziegelewska M,Holtze S,Vole C,Wachter U,Menzel U,Morhart M,Groth M,Szafranski K,Sahm A,Sponholz C,Dammann P,Huse K,Hildebrandt T,Platzer Mdoi
10.1016/j.redox.2016.01.008subject
Has Abstractpub_date
2016-08-01 00:00:00pages
192-8issn
2213-2317pii
S2213-2317(16)30008-8journal_volume
8pub_type
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