Abstract：
:Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with 'peroxiporin' activity (AQP3, AQP8, AQP9). Here, we exploit different organelle-targeted H2O2-sensitive probes to show that also AQP11 efficiently conduits H2O2. Unlike other peroxiporins, AQP11 is localized in the endoplasmic reticulum (ER), accumulating partly in mitochondrial-associated ER membranes (MAM). Its downregulation severely perturbs the flux of H2O2 through the ER, but not through the mitochondrial or plasma membranes. These properties make AQP11 a potential regulator of ER redox homeostasis and signaling.
journal_name
Redox Bioljournal_title
Redox biologyauthors
Bestetti S,Galli M,Sorrentino I,Pinton P,Rimessi A,Sitia R,Medraño-Fernandez Idoi
10.1016/j.redox.2019.101326subject
Has Abstractpub_date
2020-01-01 00:00:00pages
101326issn
2213-2317pii
S2213-2317(19)30579-8journal_volume
28pub_type
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