当前位置： SCI文献检索 > Redox Biology期刊下所有文献 > A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations.

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations.

Abstract：

:NRF2 is a redox-responsive transcription factor that regulates expression of cytoprotective genes via its interaction with DNA sequences known as antioxidant response elements (AREs). NRF2 activity is induced by oxidative stress, but oxidative stress is not the only context in which NRF2 can be activated. Mutations that disrupt the interaction between NRF2 and KEAP1, an inhibitor of NRF2, lead to NRF2 hyperactivation and promote oncogenesis. The mechanisms underlying NRF2's oncogenic properties remain unclear, but likely involve aberrant expression of select NRF2 target genes. We tested this possibility using an integrative genomics approach to get a precise view of the direct NRF2 target genes dysregulated in tumors with NRF2 hyperactivating mutations. This approach revealed a core set of 32 direct NRF2 targets that are consistently upregulated in NRF2 hyperactivated tumors. This set of NRF2 "cancer target genes" includes canonical redox-related NRF2 targets, as well as target genes that have not been previously linked to NRF2 activation. Importantly, NRF2-driven upregulation of this gene set is largely independent of the organ system where the tumor developed. One key distinguishing feature of these NRF2 cancer target genes is that they are regulated by high affinity AREs that fall within genomic regions possessing a ubiquitously permissive chromatin signature. This implies that these NRF2 cancer target genes are responsive to oncogenic NRF2 in most tissues because they lack the regulatory constraints that restrict expression of most other NRF2 target genes. This NRF2 cancer target gene set also serves as a reliable proxy for NRF2 activity, and high NRF2 activity is associated with significant decreases in survival in multiple cancer types. Overall, the pervasive upregulation of these NRF2 cancer targets across multiple cancers, and their association with negative outcomes, suggests that these will be central to dissecting the functional implications of NRF2 hyperactivation in several cancer contexts.

journal_name

Redox Biol

journal_title

Redox biology

authors

Levings DC,Wang X,Kohlhase D,Bell DA,Slattery M

doi

10.1016/j.redox.2018.07.026

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

235-249

issn

2213-2317

pii

S2213-2317(18)30528-7

journal_volume

19

pub_type

杂志文章

相关文献

Redox Biology文献大全
  • Altered glucose metabolism and cell function in keloid fibroblasts under hypoxia.

    abstract：:Keloids exhibit metabolic reprogramming including enhanced glycolysis and attenuated oxidative phosphorylation. Hypoxia induces a series of protective responses in mammalian cells. However, the metabolic phenotype of keloid fibroblasts under hypoxic conditions remains to be elucidated. The present study aimed to inves...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101815

    authors： Wang Q,Wang P,Qin Z,Yang X,Pan B,Nie F,Bi H

    更新日期：2021-01-01 00:00:00

  • Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria.

    abstract：:Mitochondria are critical sources of hydrogen peroxide (H2O2), an important secondary messenger in mammalian cells. Recent work has shown that O2•-/H2O2 emission from individual sites of production in mitochondria is regulated by protein S-glutathionylation. Here, we conducted the first examination of O2•-/H2O2 releas...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2017.12.006

    authors： Chalker J,Gardiner D,Kuksal N,Mailloux RJ

    更新日期：2018-05-01 00:00:00

  • Oxidation of protein disulfide bonds by singlet oxygen gives rise to glutathionylated proteins.

    abstract：:Disulfide bonds play a key function in determining the structure of proteins, and are the most strongly conserved compositional feature across proteomes. They are particularly common in extracellular environments, such as the extracellular matrix and plasma, and in proteins that have structural (e.g. matrix) or bindin...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101822

    authors： Jiang S,Carroll L,Rasmussen LM,Davies MJ

    更新日期：2021-01-01 00:00:00

  • Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy.

    abstract：:Chronic alcoholism disrupts mitochondrial function and often results in alcoholic cardiomyopathy (ACM). Fas-activated serine/threonine kinase (FASTK) is newly recognized as a key post-transcriptional regulator of mitochondrial gene expression. However, the modulatory role of FASTK in cardiovascular pathophysiology rem...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101778

    authors： Zhang F,Wang K,Zhang S,Li J,Fan R,Chen X,Pei J

    更新日期：2021-01-01 00:00:00

  • Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer.

    abstract：:Mechanistic/mammalian target of rapamycin (mTOR) has emerged as a new potential therapeutic target for gastric cancer. Rapamycin and rapamycin analogs are undergoing clinical trials and have produced clinical responses in a subgroup of cancer patients. However, monotherapy with rapamycin at safe dosage fails to induce...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2016.09.006

    authors： Chen W,Zou P,Zhao Z,Chen X,Fan X,Vinothkumar R,Cui R,Wu F,Zhang Q,Liang G,Ji J

    更新日期：2016-12-01 00:00:00

  • Persistent oxidative stress in human neural stem cells exposed to low fluences of charged particles.

    abstract：:Exposure to the space radiation environment poses risks for a range of deleterious health effects due to the unique types of radiation encountered. Galactic cosmic rays are comprised of a spectrum of highly energetic nuclei that deposit densely ionizing tracks of damage along the particle trajectory. These tracks are ...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2015.03.001

    authors： Baulch JE,Craver BM,Tran KK,Yu L,Chmielewski N,Allen BD,Limoli CL

    更新日期：2015-08-01 00:00:00

  • Single cell-based fluorescence lifetime imaging of intracellular oxygenation and metabolism.

    abstract：:Oxidation-reduction chemistry is fundamental to the metabolism of all living organisms, and hence quantifying the principal redox players is important for a comprehensive understanding of cell metabolism in normal and pathological states. In mammalian cells, this is accomplished by measuring oxygen partial pressure (p...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101549

    authors： Penjweini R,Roarke B,Alspaugh G,Gevorgyan A,Andreoni A,Pasut A,Sackett DL,Knutson JR

    更新日期：2020-07-01 00:00:00

  • Nitric Oxide And Oxygen: Actions And Interactions In Health And Disease.

    abstract：:Nitric oxide (NO) inhibits cell respiration reversibly and in competition with O2 through the inhibition of the mitochondrial cytochrome c oxidase (Complex IV). At concentrations lower than those required to inhibit respiration, endogenous NO enhances the reduction of the electron transport chain, thus enabling cells ...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2015.09.034

    authors： Moncada PS

    更新日期：2015-08-01 00:00:00

  • Redox regulation of proteasome function.

    abstract：:Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades,...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2017.07.005

    authors： Lefaki M,Papaevgeniou N,Chondrogianni N

    更新日期：2017-10-01 00:00:00

  • Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1.

    abstract：:Cigarette smoking remains a major health concern worldwide, and many of the adverse effects of cigarette smoke (CS) can be attributed to its abundant electrophilic aldehydes, such as acrolein (2-propenal). Previous studies indicate that acrolein readily reacts with thioredoxin reductase 1 (TrxR1), a critical enzyme in...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2013.02.001

    authors： Randall MJ,Spiess PC,Hristova M,Hondal RJ,van der Vliet A

    更新日期：2013-02-22 00:00:00

  • Mitochondrial dynamics and mitochondrial quality control.

    abstract：:Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis and function. Mitochondria are reticular organelles that have hi...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2014.11.006

    authors： Ni HM,Williams JA,Ding WX

    更新日期：2015-01-01 00:00:00

  • Oxygen delivery, consumption, and conversion to reactive oxygen species in experimental models of diabetic retinopathy.

    abstract：:Retinal tissue receives its supply of oxygen from two sources - the retinal and choroidal circulations. Decreases in retinal blood flow occur in the early stages of diabetes, with the eventual development of hypoxia thought to contribute to pathological neovascularization. Oxygen consumption in the retina has been fou...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2014.04.006

    authors： Eshaq RS,Wright WS,Harris NR

    更新日期：2014-04-18 00:00:00

  • Dynamic regulation of NADPH oxidase 5 by intracellular heme levels and cellular chaperones.

    abstract：:NADPH oxidase 5 (NOX5) is a transmembrane signaling enzyme that produces superoxide in response to elevated cytosolic calcium. In addition to its association with numerous human diseases, NOX5 has recently been discovered to play crucial roles in the immune response and cardiovascular system. Details of NOX5 maturatio...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101656

    authors： Sweeny EA,Schlanger S,Stuehr DJ

    更新日期：2020-09-01 00:00:00

  • Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation.

    abstract：:Many physiological functions of hydrogen sulfide (H2S) have been reported in mammalian cells over the last 20 years. These physiological effects have been ascertained through in vitro treatment of cells with Na2S or NaHS, both of which are precursors of H2S. Since H2S exists as HS- in a neutral solution, a disulfide c...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2017.03.020

    authors： Koike S,Nishimoto S,Ogasawara Y

    更新日期：2017-08-01 00:00:00

  • Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy.

    abstract：:The massive production and activation of myofibroblasts (MFB) is key to the development of liver fibrosis. In many studies, it has been proven that hepatocytes are an important part of MFB, and can be transformed into MFB through epithelial-mesenchymal transition (EMT) during hepatic fibrogenesis. In our previous stud...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101600

    authors： Kong D,Zhang Z,Chen L,Huang W,Zhang F,Wang L,Wang Y,Cao P,Zheng S

    更新日期：2020-09-01 00:00:00

  • Green tea polyphenolic antioxidants oxidize hydrogen sulfide to thiosulfate and polysulfides: A possible new mechanism underpinning their biological action.

    abstract：:Matcha and green tea catechins such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG) have long been studied for their antioxidant and health-promoting effects. Using specific fluorophores for H2S (AzMC) and polysulfides (SSP4) as well as IC-MS and UPLC-MS/MS-based techniques ...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101731

    authors： Olson KR,Briggs A,Devireddy M,Iovino NA,Skora NC,Whelan J,Villa BP,Yuan X,Mannam V,Howard S,Gao Y,Minnion M,Feelisch M

    更新日期：2020-10-01 00:00:00

  • Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications.

    abstract：:Compared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defenses and a better mitochondrial function in females, which has been li...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2020.101505

    authors： Torrens-Mas M,Pons DG,Sastre-Serra J,Oliver J,Roca P

    更新日期：2020-04-01 00:00:00

  • HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress.

    abstract：:The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has not only resulted in a dramatic decrease in the peripheral viral load but has also led to increased life expectancy of the infected individuals. Paradoxically, increased lifespan is accompanied with higher prevalence of age-r...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101843

    authors： Thangaraj A,Chivero ET,Tripathi A,Singh S,Niu F,Guo ML,Pillai P,Periyasamy P,Buch S

    更新日期：2020-12-23 00:00:00

  • One-year follow-up of clinical, metabolic and oxidative stress profile of morbid obese patients after laparoscopic sleeve gastrectomy. 8-oxo-dG as a clinical marker.

    abstract：:Obesity has grown worldwide over the last few decades. In its different degrees, obesity is accompanied by many clinical and biochemical alterations reflecting the pathological condition of various body tissues. Among the mechanisms underlying the pathogenesis of obesity and associated complications, oxidative stress ...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2017.02.003

    authors： Monzo-Beltran L,Vazquez-Tarragón A,Cerdà C,Garcia-Perez P,Iradi A,Sánchez C,Climent B,Tormos C,Vázquez-Prado A,Girbés J,Estáñ N,Blesa S,Cortés R,Chaves FJ,Sáez GT

    更新日期：2017-08-01 00:00:00

  • Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.

    abstract：:Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stress that directly au...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101785

    authors： Lu Q,Zemskov EA,Sun X,Wang H,Yegambaram M,Wu X,Garcia-Flores A,Song S,Tang H,Kangath A,Cabanillas GZ,Yuan JX,Wang T,Fineman JR,Black SM

    更新日期：2021-01-01 00:00:00

  • The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness.

    abstract：:Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with h...

    journal_title：Redox biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.redox.2020.101585

    authors： Li H,Xia N

    更新日期：2020-10-01 00:00:00

  • Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration.

    abstract：:Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the main risk factors. Stress-induced premature cellular senescence (SIPS) is postulated to contribute to this c...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2015.11.011

    authors： Marazita MC,Dugour A,Marquioni-Ramella MD,Figueroa JM,Suburo AM

    更新日期：2016-04-01 00:00:00

  • Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation.

    abstract：:Oxidative modification of cysteine residues has been shown to regulate the activity of several protein-tyrosine kinases. We explored the possibility that Fms-like tyrosine kinase 3 (FLT3), a hematopoietic receptor-tyrosine kinase, is subject to this type of regulation. An underlying rationale was that the FLT3 gene is...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2019.101325

    authors： Böhmer A,Barz S,Schwab K,Kolbe U,Gabel A,Kirkpatrick J,Ohlenschläger O,Görlach M,Böhmer FD

    更新日期：2020-01-01 00:00:00

  • C/EBPβ mediates NQO1 and GSTP1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation.

    abstract：:Glioblastoma (GBM) is the most common and most aggressive brain tumor, associated with high levels of reactive oxidative species (ROS) due to metabolic and signaling aberrations. High ROS levels are detrimental to cells, but it remains incompletely understood how cancer cells cope with the adverse effects. Here we sho...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101578

    authors： Lei K,Xia Y,Wang XC,Ahn EH,Jin L,Ye K

    更新日期：2020-07-01 00:00:00

  • MZe786, a hydrogen sulfide-releasing aspirin prevents preeclampsia in heme oxygenase-1 haplodeficient pregnancy under high soluble flt-1 environment.

    abstract：:Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disea...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2020.101768

    authors： Rezai H,Ahmad S,Alzahrani FA,Sanchez-Aranguren L,Dias IH,Agrawal S,Sparatore A,Wang K,Ahmed A

    更新日期：2021-01-01 00:00:00

  • Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy.

    abstract：:Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. An increase of PM2.5 of 10 μg per cubic meter was associated with a 76% increase in the ris...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2019.101161

    authors： Yue W,Tong L,Liu X,Weng X,Chen X,Wang D,Dudley SC,Weir EK,Ding W,Lu Z,Xu Y,Chen Y

    更新日期：2019-04-01 00:00:00

  • Co-imaging extrinsic, intrinsic and effector caspase activity by fluorescence anisotropy microscopy.

    abstract：:In order to overcome intercellular variability and thereby effectively assess signal propagation in biological networks it is imperative to simultaneously quantify multiple biological observables in single living cells. While fluorescent biosensors have been the tool of choice to monitor the dynamics of protein intera...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.07.023

    authors： Corbat AA,Schuermann KC,Liguzinski P,Radon Y,Bastiaens PIH,Verveer PJ,Grecco HE

    更新日期：2018-10-01 00:00:00

  • Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer.

    abstract：:PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attrib...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.03.016

    authors： Hou D,Liu Z,Xu X,Liu Q,Zhang X,Kong B,Wei JJ,Gong Y,Shao C

    更新日期：2018-07-01 00:00:00

  • Redox-dependent condensation of the mycobacterial nucleoid by WhiB4.

    abstract：:Oxidative stress response in bacteria is mediated through coordination between the regulators of oxidant-remediation systems (e.g. OxyR, SoxR) and nucleoid condensation (e.g. Dps, Fis). However, these genetic factors are either absent or rendered non-functional in the human pathogen Mycobacterium tuberculosis (Mtb). T...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2018.08.006

    authors： Chawla M,Mishra S,Anand K,Parikh P,Mehta M,Vij M,Verma T,Singh P,Jakkala K,Verma HN,AjitKumar P,Ganguli M,Narain Seshasayee AS,Singh A

    更新日期：2018-10-01 00:00:00

  • Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid.

    abstract：:Neuroblastoma is the most common extra-cranial solid tumor in childhood; and patients in stage IV of the disease have a high propensity for tumor recurrence. Retinoid therapy has been utilized as a means to induce differentiation of tumor cells and to inhibit relapse. In this study, the expression of a common neuronal...

    journal_title：Redox biology

    pub_type： 杂志文章

    doi：10.1016/j.redox.2015.11.012

    authors： Silvis AM,McCormick ML,Spitz DR,Kiningham KK

    更新日期：2016-04-01 00:00:00