Evaluation of 1,5-anhydro-d-glucitol in clinical and forensic urine samples.

Abstract:

:Because of the lack of characteristic morphological findings post mortem diagnosis of diabetes mellitus and identification of diabetic coma can be complicated. 1,5-Anhydroglucitol (1,5-AG), the 1-deoxy form of glucose, competes with glucose for renal reabsorption. Therefore low serum concentrations of 1,5-AG, reflect hyperglycemic excursions over the prior 1-2 weeks in diabetic patients. Next to clinical applications determination of 1,5-AG can also be used in forensic analysis. To investigate the elimination of 1,5-AG, a liquid chromatographic-mass spectrometric method for the determination of 1,5-AG and creatinine in urine was developed and validated according to international guidelines. To evaluate ante mortem concentrations of 1,5-AG spot urine samples of 30 healthy subjects, 46 type 1 and 46 type 2 diabetic patients were analyzed. 1,5-AG urine concentrations of diabetic patients were significantly (p<0.001) lower (mean: 1.54μg/ml, n=92) compared to concentrations of healthy subjects (mean: 4.76μg/ml, n=30) which led to the idea that 1,5-AG urine concentrations post mortem might help in the interpretation of a diabetic coma post mortem. Urine of 47 deceased non-diabetics, 37 deceased diabetic and 9 cases of diabetic coma were measured. Comparison of blood and urine 1,5-AG concentrations in clinic samples (linear, R2=0.13) and forensic samples (linear, R2=0.02) showed no correlation. Urinary levels of 1,5-AG in deceased diabetic (mean 6.9μg/ml) and in non-diabetic patients (mean 6.3μg/ml) did not show a significant difference (p=0.752). However, urinary 1,5-AG concentrations in deceased due to diabetic coma (mean: 1.7μg/ml) were significantly lower than in non-diabetic (mean: 6.3μg/ml, p=0.039) and lower than in diabetic cases (mean: 4.7μg/ml, p=0.058). The determination of a reliable cut-off for the differentiation of diabetic to diabetic coma cases was not possible. Normalization of urinary 1,5-AG concentrations with the respective creatinine concentrations did not show any gain of information. In clinical (serum) and forensic blood samples a significant difference between all groups could be detected (p<0.05). Comparison of blood and urine 1,5-AG concentrations in clinical samples (linear, R2=0.13) and forensic samples (linear, R2=0.02) showed no correlation.

journal_name

Forensic Sci Int

authors

Sydow K,Wiedfeld C,Musshoff F,Madea B,Tschoepe D,Stratmann B,Hess C

doi

10.1016/j.forsciint.2018.03.002

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

88-97

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(18)30088-4

journal_volume

287

pub_type

杂志文章
  • Search for fungi-specific metabolites of four model drugs in postmortem blood as potential indicators of postmortem fungal metabolism.

    abstract::Fungi colonizing cadavers are capable of drug metabolism and may thus change the metabolite pattern or concentration of drugs in forensic postmortem samples. The purpose of this study was to check for the presence of such changes by searching fungi-specific metabolites of four model drugs (amitriptyline, metoprolol, m...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.03.006

    authors: Martínez-Ramírez JA,Strien J,Walther G,Peters FT

    更新日期:2016-05-01 00:00:00

  • Retinal hemorrhages: replicating the clinician's view of the eye.

    abstract::The authors describe a technique for the gross examination of postmortem eyes of children who are suspected to have been the victims of deliberate trauma. By removing the anterior segment (cornea, iris, lens and pars plicata of the ciliary body) en bloc by a coronal incision through the pars plana just anterior to the...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(92)90149-q

    authors: Gilliland MG,Folberg R

    更新日期:1992-09-01 00:00:00

  • Fatal versus non-fatal heroin "overdose": blood morphine concentrations with fatal outcome in comparison to those of intoxicated drivers.

    abstract::The study was performed to distinguish fatal from non-fatal blood concentrations of morphine. For this purpose, blood levels of free morphine and total morphine (free morphine plus morphine conjugates) in 207 cases of heroin-related deaths were compared to those in 27 drivers surviving opiate intoxication. The majorit...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(02)00343-2

    authors: Meissner C,Recker S,Reiter A,Friedrich HJ,Oehmichen M

    更新日期:2002-11-05 00:00:00

  • An investigation into the suitability of some etching reagents to restoring obliterated stamped numbers on cast iron engine blocks of cars.

    abstract::Most of the automotive companies use cast iron for their engine blocks. Restoration of obliterated number on these iron surfaces by chemical etching is known to be quite difficult. Heating of the obliterated surface using oxyacetylene flame is an alternative recovery treatment suggested in literature and used in pract...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2012.07.020

    authors: Abdul Wahab MF,Mohamad Ghani NI,Kuppuswamy R

    更新日期:2012-11-30 00:00:00

  • Total body water is the preferred method to use in forensic blood-alcohol calculations rather than ethanol's volume of distribution.

    abstract::During the prosecution and defence of drink-driving cases, forensic practitioners are often required to engage in various blood-alcohol calculations, such as whether or not the statutory limit was exceeded (e.g. 80mg/100mL, 0.08g/100mL or 0.80g/L). For this purpose, most forensic scientists utilize the Widmark equatio...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2020.110532

    authors: Maskell PD,Jones AW,Heymsfield SB,Shapses S,Johnston A

    更新日期:2020-11-01 00:00:00

  • Experimental fragmentation of pipe bombs with varying case thickness.

    abstract::Among all the improvised explosive devices (IEDs) known, pipe bombs are one of the most popular devices used by terrorists. They are simple to use, easy to construct and materials are readily available. For this IED, fragmentation is the primary injury mechanism, which makes them a desirable weapon for terrorists aimi...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2019.110034

    authors: da Silva LA,Johnson S,Critchley R,Clements J,Norris K,Stennett C

    更新日期:2020-01-01 00:00:00

  • Social isolation and delayed discovery of bodies in houses: the value of forensic pathology, anthropology, odontology and entomology in the medico-legal investigation.

    abstract::The bodies of socially isolated people may remain undiscovered in their own houses for prolonged periods. Occasionally the body is in situ for sufficient time to become skeletonised, or partially so. Medico-legal investigation of these cases is complicated by degradation and contamination of evidence. Thus, a multidis...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2005.02.016

    authors: Archer MS,Bassed RB,Briggs CA,Lynch MJ

    更新日期:2005-07-16 00:00:00

  • HLA-DQA1 subtyping data in the Swiss population.

    abstract::Allele- and genotype frequencies for the polymerase chain reaction-based DNA genetic marker HLA-DQA1 were determined previously in a Swiss sample population (n = 200). In this study we subtyped the allele 4 in the same Swiss Caucasian population sample (distinguishing the 4.1 allele from the 4.2 and 4.3 alleles) using...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(96)02008-7

    authors: Gehrig C,Hochmeister MN,Budowle B,Reynolds R,Dirnhofer R

    更新日期:1996-11-11 00:00:00

  • Longitudinal brainstem laceration associated with complex basilar skull fractures due to a fall: an autopsy case.

    abstract::This report describes an autopsy case of a rare longitudinal brainstem laceration associated with complex basilar skull fractures. The victim was a 40-year-old male who died immediately after falling from a roof (9.2m in height) of a factory onto a concrete floor. The postmortem examination revealed an incomplete ring...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(02)00029-4

    authors: Zhu BL,Quan L,Ishida K,Taniguchi M,Oritani S,Fujita MQ,Maeda H

    更新日期:2002-03-28 00:00:00

  • Experimental study of the expansion dynamic of 9 mm Parabellum hollow point projectiles in ballistic gelatin.

    abstract::We study in this paper the expanding behaviour of hollow point 9 mm Parabellum projectiles (Hornady XTP(®) and Speer Gold Dot(®)). We defined a deformation rate that takes into account both the diameter increase and the length reduction. We plotted the behaviour of this parameter versus impact velocity (we refer to th...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2011.12.007

    authors: Bresson F,Ducouret J,Peyré J,Maréchal C,Delille R,Colard T,Demondion X

    更新日期:2012-06-10 00:00:00

  • Short range shooting distance estimation using variable pressure SEM images of the surroundings of bullet holes in textiles.

    abstract::Modifications of cotton and polyester textiles due to shots fired at short range were analyzed with a variable pressure scanning electron microscope (VP-SEM). Different mechanisms of fiber rupture as a function of fiber type and shooting distance were detected, namely fusing, melting, scorching, and mechanical breakag...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.12.033

    authors: Hinrichs R,Frank PRO,Vasconcellos MAZ

    更新日期:2017-03-01 00:00:00

  • Cuts and tears on a paper towel: a case report on an unusual examination of damage.

    abstract::The examination of damage to a paper towel, an item of evidence in a murder case, is described. Simulations performed with selected tools and the observation of the lacerations present on the towel permitted to infer that they were originated by cleaning of a pointed and sharp implement. Some marks, considered charact...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2004.04.078

    authors: Causin V,Marega C,Schiavone S

    更新日期:2005-03-10 00:00:00

  • Uncertainty about the true source. A note on the likelihood ratio at the activity level.

    abstract::This paper focuses on likelihood ratio based evaluations of fibre evidence in cases in which there is uncertainty about whether or not the reference item available for analysis - that is, an item typically taken from the suspect or seized at his home - is the item actually worn at the time of the offence. A likelihood...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2012.02.021

    authors: Taroni F,Biedermann A,Bozza S,Comte J,Garbolino P

    更新日期:2012-07-10 00:00:00

  • Experimental and theoretical studies of the spreading of bloodstains on painted surfaces.

    abstract::The spreading of bloodstains on matt, vinyl silk and gloss painted surfaces, following both perpendicular and non-perpendicular impact, has been studied with a view to understanding whether surface-specific properties affect the size and shape of the final stain. In all cases the dimensions of the stains on the roughe...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2013.03.044

    authors: Adam CD

    更新日期:2013-06-10 00:00:00

  • HLA DQ alpha typing of forensic specimens by amplification restriction fragment polymorphism (ARFP) analysis.

    abstract::The alleles present at the HLA DQ alpha locus may be typed by either allele specific oligonucleotide (ASO) probing or by restriction mapping, referred to here as amplification restriction fragment polymorphism (ARFP) analysis. ASO typing relies upon hybridization principles, whereas ARFP typing relies upon restriction...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(91)90215-5

    authors: Harrington CS,Dunaiski V,Williams KE,Fowler C

    更新日期:1991-10-01 00:00:00

  • The histopathological structures of the extrapleural hematoma wall: A case report.

    abstract::Extrapleural hematoma is a rare condition in which blood is present in the extrapleural space, which sometimes causes death due to respiratory failure. Although a single low-density stripe, called a "displaced extrapleural fat sign," can be detected in chest computed tomographic (CT) scans, no reports have confirmed t...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.05.021

    authors: Ezaki J,Ro A,Kibayashi K

    更新日期:2016-09-01 00:00:00

  • Adulterants encountered in the illicit cocaine market.

    abstract::Illicit cocaine samples (156), seized on Rome's illegal market between January 1996 and June 1997, were examined. Both the purity of the cocaine and the presence of substances employed for dilution were determined for each sample. Adulterants were found in many of the street samples analysed. Lidocaine (average 14.7%)...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(98)00102-9

    authors: Fucci N,De Giovanni N

    更新日期:1998-08-12 00:00:00

  • Visualization of the air ejected from the temporary cavity in brain and tissue simulants during gunshot wounding.

    abstract::One hypothesis for the physical mechanism responsible for backspatter during cranial gunshot wounding is that air is ejected by the collapse of the temporary cavity formed around the bullet path. Using bovine and ovine heads and simulant materials, evidence of this ejection was sought by measuring the velocity of the ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2014.11.005

    authors: Lazarjan MS,Geoghegan PH,Taylor MC,Jermy MC

    更新日期:2015-01-01 00:00:00

  • Unidentified bodies and human remains: an Italian glimpse through a European problem.

    abstract::The identification of cadavers (the main activity of forensic odontologists and anthropologists) is a crucial issue in forensic pathology, but the official entity of this problem is still poorly known in most countries, apart from a few American reports. In this article the authors present a descriptive study of unide...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2009.11.008

    authors: Cattaneo C,Porta D,De Angelis D,Gibelli D,Poppa P,Grandi M

    更新日期:2010-02-25 00:00:00

  • Biological organisms as volatile compound detectors: a review.

    abstract::The detection and identification of volatile compounds is essential to the successful undertaking of numerous forensic analyses. Biological olfactory systems possess the extraordinary ability to not only detect many thousands of distinct volatile compounds (odors) but also to discriminate between them. Whole-organism ...

    journal_title:Forensic science international

    pub_type: 杂志文章,评审

    doi:10.1016/j.forsciint.2013.07.004

    authors: Leitch O,Anderson A,Kirkbride KP,Lennard C

    更新日期:2013-10-10 00:00:00

  • Delimitation of the time of death by immunohistochemical detection of insulin in pancreatic beta-cells.

    abstract::To improve the possibilities to delimitate the time of death after longer laytime, it was examined if this is possible by immunohistochemical insulin detection. The results show that in our examination material, the pancreatic beta-cells of up to 12-day-old corpses produce a positive immunoreaction towards insulin in ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(99)00124-3

    authors: Wehner F,Wehner HD,Schieffer MC,Subke J

    更新日期:1999-11-08 00:00:00

  • On the theory and practice of Essen-Möller's W value and Gürtler's paternity index (PI).

    abstract::In cases of disputed parentage the biostatistical information is contained in the frequencies X and Y (as defined by Essen-M oller ); X denotes the hypothesis "paternity", Y the hypothesis "non-paternity". Essen-M oller proposed a probability of paternity which includes both values: W = X/(X + Y) (where X + Y becomes ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(84)90010-0

    authors: Hummel K

    更新日期:1984-05-01 00:00:00

  • In vitro metabolism of desomorphine.

    abstract::Desomorphine is reported to be the principal pharmacologically active opioid in Krokodil, a homemade injectable drug that is perceived to be a cheaper alternative to heroin. There have been limited studies regarding its pharmacology or detection in biological matrices. The goal of this study was to contribute further ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2018.05.017

    authors: Winborn J,Haines D,Kerrigan S

    更新日期:2018-08-01 00:00:00

  • Evaluation of the correlation between time corpses spent in in-ground graves and findings at exhumation.

    abstract::To determine how long pathological findings persist after burial and which factors play a role in decomposition of a corpse, we evaluated all bodies exhumed under the auspices of the Institute of Legal Medicine at the Hannover Medical School between 1978 and 1997. A total of 87 exhumations (54 men, 33 women) were perf...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2004.11.018

    authors: Breitmeier D,Graefe-Kirci U,Albrecht K,Weber M,Tröger HD,Kleemann WJ

    更新日期:2005-11-25 00:00:00

  • Accuracy and reliability of breath alcohol testing by handheld electrochemical analysers.

    abstract::Usefulness of portable, handheld breath analysers equipped with electrochemical sensor was assessed. Breath- and blood-alcohol concentrations in drunken drivers were taken from 370 expert opinions elaborated at the Institute of Forensic Research between January 1st 2002 and February 28th 2007. The results of second an...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2008.03.002

    authors: Zuba D

    更新日期:2008-07-04 00:00:00

  • Development of "Quick-DB forensic": A total workflow from QuEChERS-dSPE method to GC-MS/MS quantification of forensically relevant drugs and pesticides in whole blood.

    abstract::Trends in forensic toxicology show the advancement of rapid and sensitive analytical methods for qualitative and quantitative analysis of drugs of abuse. However, forensic toxicologists are continuously faced with the challenges of identifying and quantifying drug blood concentration while simultaneously struggling wi...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2019.03.048

    authors: Kusano M,Sakamoto Y,Natori Y,Miyagawa H,Tsuchihashi H,Ishii A,Zaitsu K

    更新日期:2019-07-01 00:00:00

  • Synthesis and impurity profiling of MDMA prepared from commonly available starting materials.

    abstract::This work examines the synthesis of 3,4-methylenedioxy-N-methylamphetamine (MDMA) from common starting materials that may be utilised by clandestine laboratory operators. Piperonal was prepared from two common starting materials, piperine (from pepper) and vanillin (a common flavouring). Piperine was converted to pipe...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2012.10.006

    authors: Gallagher R,Shimmon R,McDonagh AM

    更新日期:2012-11-30 00:00:00

  • The effectiveness of strong afterglow phosphor powder in the detection of fingermarks.

    abstract::There are numerous types of fluorescent fingermark powders or reagents used with the visualization of latent fingermarks deposited on multicolored substrate surfaces that can present a contrast problem if developed with regular fingermark powders. The developed fingermarks can show bright fluorescence upon exposure to...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2008.10.008

    authors: Liu L,Zhang Z,Zhang L,Zhai Y

    更新日期:2009-01-10 00:00:00

  • Methamphetamine-related fatalities in forensic autopsy during 5 years in the southern half of Osaka city and surrounding areas.

    abstract::To outline the recent features of methamphetamine-related fatalities from the medico-legal point of view, a retrospective investigation of forensic autopsy cases involving methamphetamine during a 5-year period (1994-1998) in the southern half of Osaka city and surrounding areas (about 1.57 million population) was und...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(00)00281-4

    authors: Zhu BL,Oritani S,Shimotouge K,Ishida K,Quan L,Fujita MQ,Ogawa M,Maeda H

    更新日期:2000-09-11 00:00:00

  • Validation of a standard forensic anthropology examination protocol by measurement of applicability and reliability on exhumed and archive samples of known biological attribution.

    abstract::Forensic anthropology makes an important contribution to human identification and assessment of the causes and mechanisms of death and body disposal in criminal and civil investigations, including those related to atrocity, disaster and trafficking victim identification. The methods used are comparative, relying on as...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2017.08.015

    authors: Francisco RA,Evison MP,Costa Junior MLD,Silveira TCP,Secchieri JM,Guimarães MA

    更新日期:2017-10-01 00:00:00