Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines.

abstract：:Rift Valley fever (RVF) is endemic to sub-Saharan Africa, and has spread into Madagascar, Egypt, Saudi Arabia, and Yemen. Rift Valley fever virus (RVFV) of the family Bunyaviridae, genus Phlebovirus causes hemorrhagic fever, neurological disorders or blindness in humans, and high rate abortion and fetal malformation i...

journal_title：Frontiers in cellular and infection microbiology

authors： Indran SV,Ikegami T

更新日期：2012-10-26 00:00:00

abstract：:Metagenomic approaches applied to viruses have highlighted their prevalence in almost all microbial ecosystems investigated. In all ecosystems, notably those associated with humans or animals, the viral fraction is dominated by bacteriophages. Whether they contribute to dysbiosis, i.e., the departure from microbiota c...

journal_title：Frontiers in cellular and infection microbiology

authors： De Paepe M,Leclerc M,Tinsley CR,Petit MA

更新日期：2014-03-28 00:00:00

abstract：:Group A Streptococcus (GAS), also called Streptococcus pyogenes, is a Gram-positive beta-hemolytic human pathogen which causes a wide range of mostly self-limiting but also several life-threatening diseases. Innate immune responses are fundamental for defense against GAS, yet their activation by pattern recognition re...

journal_title：Frontiers in cellular and infection microbiology

authors： Fieber C,Kovarik P

更新日期：2014-10-02 00:00:00

abstract：:Cerebral malaria is a severe neuropathological complication of Plasmodium falciparum infection. It results in high mortality and post-recovery neuro-cognitive disorders in children, even after appropriate treatment with effective anti-parasitic drugs. While the complete landscape of the pathogenesis of cerebral malari...

journal_title：Frontiers in cellular and infection microbiology

authors： Sahu PK,Satpathi S,Behera PK,Mishra SK,Mohanty S,Wassmer SC

更新日期：2015-10-27 00:00:00

abstract：:Shiga toxin (Stx)-producing Escherichia coli (STEC) O157:H7 is an enteric pathogen that causes life-threatening disease in humans, with cattle being major natural reservoirs. A group of STEC O157:H7 with a dramatic combination of high virulence potentials and super-shedder bovine origin have been isolated. Here, an ST...

journal_title：Frontiers in cellular and infection microbiology

authors： Teng L,Lee S,Park D,Jeong KC

更新日期：2020-06-05 00:00:00

abstract：:Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in Francisella n...

journal_title：Frontiers in cellular and infection microbiology

authors： Dean SN,Milton ME,Cavanagh J,van Hoek ML

更新日期：2020-03-13 00:00:00

abstract：:Protein secretion systems are vital for prokaryotic life, as they enable bacteria to acquire nutrients, communicate with other species, defend against biological and chemical agents, and facilitate disease through the delivery of virulence factors. In this review, we will focus on the recently discovered type IX secre...

journal_title：Frontiers in cellular and infection microbiology

authors： Lasica AM,Ksiazek M,Madej M,Potempa J

更新日期：2017-05-26 00:00:00

abstract：:Virulent C. difficile toxins TcdA and TcdB invade host intestinal epithelia by endocytosis and use the acidic environment of intracellular vesicles for further processing and activation. We investigated the role of ClC-5, a chloride/proton exchanger expressed in the endosomes of gastrointestinal epithelial cells, in t...

journal_title：Frontiers in cellular and infection microbiology

authors： Ruhe F,Olling A,Abromeit R,Rataj D,Grieschat M,Zeug A,Gerhard R,Alekov A

更新日期：2017-03-13 00:00:00

abstract：:For decades, mass drug treatment with praziquantel (PZQ) has been utilized to treat schistosomiasis, yet reinfection and the risk of drug resistance are among the various factors precluding successful elimination of schistosomiasis. Tractable models that replicate "real world" field conditions are crucial to effective...

journal_title：Frontiers in cellular and infection microbiology

authors： Melkus MW,Le L,Siddiqui AJ,Molehin AJ,Zhang W,Lazarus S,Siddiqui AA

更新日期：2020-02-24 00:00:00

abstract：:Background: Intraocular tuberculosis (IOTB), an extrapulmonary manifestation of tuberculosis of the eye, has unique and varied clinical presentations with poorly understood pathogenesis. As it is a significant cause of inflammation and visual morbidity, particularly in TB endemic countries, it is essential to study th...

journal_title：Frontiers in cellular and infection microbiology

authors： Abhishek S,Saikia UN,Gupta A,Bansal R,Gupta V,Singh N,Laal S,Verma I

更新日期：2018-10-02 00:00:00

abstract：:Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism. While the T3SS represents an attractive drug target and dozens of compounds with T3SS inhibitory activity have been identified, few T3SS inhibito...

journal_title：Frontiers in cellular and infection microbiology

authors： Morgan JM,Lam HN,Delgado J,Luu J,Mohammadi S,Isberg RR,Wang H,Auerbuch V

更新日期：2018-11-22 00:00:00

abstract：:Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and, consequently, cell cycle arrest at the G2/M stage and apoptosis. Ra...

journal_title：Frontiers in cellular and infection microbiology

authors： Lin HJ,Liu HH,Lin CD,Kao MC,Chen YA,Chiang-Ni C,Jiang ZP,Huang MZ,Lin CJ,Lo UG,Lin LC,Lai CK,Lin H,Hsieh JT,Chiu CH,Lai CH

更新日期：2017-06-08 00:00:00

abstract：:Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy. Although studies have shown the changes of this disease at clinical, pathological and other levels, the dynamic characteristics of local microbiome and metabolomics are hitherto unknown. We aimed to examine the multi-omics fea...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Yan H,Zhang Y,Li Q,Yu L,Li Q,Liu C,Xie Y,Chen K,Ye F,Wang K,Chen L,Ding Y

更新日期：2020-10-21 00:00:00

abstract：:Ten bacteriophages were isolated from faeces and their lytic effects assayed on 103 pathogenic and non-pathogenic Enterobacteriaceae. Two phages (DT1 and DT6) were selected based on their host ranges, and their lytic effects on pathogenic E. coli strains inoculated on pieces of beef were determined. We evaluated the r...

journal_title：Frontiers in cellular and infection microbiology

authors： Tomat D,Migliore L,Aquili V,Quiberoni A,Balagué C

更新日期：2013-06-06 00:00:00

abstract：:Objectives: The emergence of carbapenem-resistant Enterobacteriaceae, especially Klebsiella pneumoniae, has become a major concern in clinic settings. Combination therapy is gaining momentum to counter the secondary resistance and potential suboptimal efficacy of monotherapy. The aim of this study was to evaluate the ...

journal_title：Frontiers in cellular and infection microbiology

authors： Yu W,Zhou K,Guo L,Ji J,Niu T,Xiao T,Shen P,Xiao Y

更新日期：2017-06-16 00:00:00

abstract：:Whole genome sequencing (WGS) methods provide new possibilities in the field of molecular epidemiology. This is particularly true for monomorphic organisms where the discriminatory power of traditional methods (e.g., restriction enzyme length polymorphism typing, multi locus sequence typing etc.) is inadequate to eluc...

journal_title：Frontiers in cellular and infection microbiology

authors： Wittwer M,Altpeter E,Pilo P,Gygli SM,Beuret C,Foucault F,Ackermann-Gäumann R,Karrer U,Jacob D,Grunow R,Schürch N

更新日期：2018-03-22 00:00:00

abstract：:The phenylacetic acid (PA) degradative pathway is the central pathway by which various aromatic compounds (e.g., styrene) are degraded. Upper pathways for different aromatic compounds converge at common intermediate phenylacetyl-CoA (PA-CoA), which is then metabolized to succinyl-CoA and acetyl-CoA. We previously made...

journal_title：Frontiers in cellular and infection microbiology

authors： Imolorhe IA,Cardona ST

更新日期：2011-12-14 00:00:00

abstract：Background and Aims:Schistosomiasis japonica is a widespread human zoonotic disease, and in China, there are many patients with schistosomiasis suffering from liver fibrosis. Many studies have shown that natural killer (NK) cells could reduce the progression of hepatic fibrosis by directly killing hepatic stellate cell...

journal_title：Frontiers in cellular and infection microbiology

authors： Hu Y,Wang X,Wei Y,Liu H,Zhang J,Shen Y,Cao J

更新日期：2020-11-19 00:00:00

abstract：:The human-specific pathogen Salmonella enterica serovar Typhi causes typhoid, a major public health issue in developing countries. Several aspects of its pathogenesis are still poorly understood. S. Typhi possesses 14 fimbrial gene clusters including 12 chaperone-usher fimbriae (stg, sth, bcf, fim, saf, sef, sta, stb,...

journal_title：Frontiers in cellular and infection microbiology

authors： Dufresne K,Saulnier-Bellemare J,Daigle F

更新日期：2018-02-08 00:00:00

abstract：:Murid and cricetid rodents were previously believed to be the principal reservoir hosts of hantaviruses. Recently, however, multiple newfound hantaviruses have been discovered in shrews, moles, and bats, suggesting a complex evolutionary history. Little is known about the genetic diversity and geographic distribution ...

journal_title：Frontiers in cellular and infection microbiology

authors： Kikuchi F,Aoki K,Ohdachi SD,Tsuchiya K,Motokawa M,Jogahara T,Sơn NT,Bawm S,Lin KS,Thwe TL,Gamage CD,Ranorosoa MC,Omar H,Maryanto I,Suzuki H,Tanaka-Taya K,Morikawa S,Mizutani T,Suzuki M,Yanagihara R,Arai S

更新日期：2020-08-27 00:00:00

abstract：:The frequent emergence of azole-resistant strains has increasingly led azoles to fail in treating candidiasis. Combination with other drugs is a good option to effectively reduce or retard its incidence of resistance. Natural products are a promising synergist source to assist azoles in treating resistant candidiasis....

journal_title：Frontiers in cellular and infection microbiology

authors： Xu J,Liu R,Sun F,An L,Shang Z,Kong L,Yang M

更新日期：2019-06-20 00:00:00

abstract：:The intracellular pathogen Burkholderia pseudomallei, the etiological agent of melioidosis in humans and various animals, is capable of survival and movement within the cytoplasm of host cells by a process known as actin-based motility. The bacterial factor BimA is required for actin-based motility through its direct ...

journal_title：Frontiers in cellular and infection microbiology

authors： Srinon V,Chaiwattanarungruengpaisan S,Korbsrisate S,Stevens JM

更新日期：2019-03-22 00:00:00

abstract：:The type VI secretion system (T6SS) secretes numerous toxins for bacteria-bacteria competition. TplE is a newly identified trans-kingdom toxin secreted by the T6SS in Pseudomonas aeruginosa, while TplEi neutralizes the toxic effect of TplE to protect bacteria autointoxication. Blocking the interaction of TplE-TplEi co...

journal_title：Frontiers in cellular and infection microbiology

authors： Gao X,Mu Z,Qin B,Sun Y,Cui S

更新日期：2017-09-20 00:00:00

abstract：:Fusarium is an important genus of plant pathogenic fungi, and is widely distributed in soil and associated with plants worldwide. The diversity of mycoviruses in Fusarium is increasing continuously due to the development and extensive use of state-of-the-art RNA deep sequencing techniques. To date, fully-sequenced myc...

journal_title：Frontiers in cellular and infection microbiology

authors： Li P,Bhattacharjee P,Wang S,Zhang L,Ahmed I,Guo L

更新日期：2019-07-18 00:00:00

abstract：:Interferon (IFN)-sensitive and replication-incompetent influenza viruses are likely to be the alternatives to inactivated and attenuated virus vaccines. Some IFN-sensitive influenza vaccine candidates with modified non-structural protein 1 (NS1) are highly attenuated in IFN-competent hosts but induce robust antiviral ...

journal_title：Frontiers in cellular and infection microbiology

authors： Chen C,Fan W,Li J,Zheng W,Zhang S,Yang L,Liu D,Liu W,Sun L

更新日期：2018-05-01 00:00:00

abstract：:Cross talk occurs between the human gut and the lung through a gut-lung axis involving the gut microbiota. However, the signatures of the human gut microbiota after active Mycobacterium tuberculosis infection have not been fully understood. Here, we investigated changes in the gut microbiota in tuberculosis (TB) patie...

journal_title：Frontiers in cellular and infection microbiology

authors： Hu Y,Feng Y,Wu J,Liu F,Zhang Z,Hao Y,Liang S,Li B,Li J,Lv N,Xu Y,Zhu B,Sun Z

更新日期：2019-04-03 00:00:00

abstract：:Due to the importance of a rapid determination of patients infected by multidrug resistant bacteria, we evaluated two rapid diagnostic tests for the detection of third-generation cephalosporins (3GC)-resistant Enterobacterales directly from positive blood cultures within 1 h: BL-REDTM (electrochemical method) and β-LA...

journal_title：Frontiers in cellular and infection microbiology

authors： Durand C,Boudet A,Lavigne JP,Pantel A

更新日期：2020-09-11 00:00:00

abstract：:Background: Increasing evidence has shown that Helicobacter pylori is associated with coronary heart disease (CHD); however, the underlying mechanism remains unclear. Methods: The expression of miR-25 and mRNAs was measured using qRT-PCR. Protein levels were detected using western blotting and exosomes were assessed w...

journal_title：Frontiers in cellular and infection microbiology

authors： Li N,Liu SF,Dong K,Zhang GC,Huang J,Wang ZH,Wang TJ

更新日期：2019-10-29 00:00:00

abstract：:Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known about the effect of anthrax on the immune function of neutrophils,...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu JZ,Ali SR,Bier E,Nizet V

更新日期：2018-01-22 00:00:00

abstract：:Nocardia is one of the causing agents of bovine mastitis and increasing prevalence of nocardial mastitis in shape of serious outbreaks has been reported from many countries. However, the mechanisms by which this pathogen damages the bovine mammary epithelial cells (bMECs) is not yet studied. Therefore, this study was ...

journal_title：Frontiers in cellular and infection microbiology

authors： Chen W,Liu Y,Zhang L,Gu X,Liu G,Shahid M,Gao J,Ali T,Han B

更新日期：2017-05-18 00:00:00