Population Genomics of Francisella tularensis subsp. holarctica and its Implication on the Eco-Epidemiology of Tularemia in Switzerland.

abstract：:Bacteria of the Salmonella genus cause diseases ranging from gastroenteritis to life-threatening typhoid fever and are among the most successful intracellular pathogens known. After the invasion of the eukaryotic cell, Salmonella exhibits contrasting lifestyles with different replication rates and subcellular location...

journal_title：Frontiers in cellular and infection microbiology

authors： Castanheira S,García-Del Portillo F

更新日期：2017-10-04 00:00:00

abstract：:Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy. Although studies have shown the changes of this disease at clinical, pathological and other levels, the dynamic characteristics of local microbiome and metabolomics are hitherto unknown. We aimed to examine the multi-omics fea...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Yan H,Zhang Y,Li Q,Yu L,Li Q,Liu C,Xie Y,Chen K,Ye F,Wang K,Chen L,Ding Y

更新日期：2020-10-21 00:00:00

abstract：:Murid and cricetid rodents were previously believed to be the principal reservoir hosts of hantaviruses. Recently, however, multiple newfound hantaviruses have been discovered in shrews, moles, and bats, suggesting a complex evolutionary history. Little is known about the genetic diversity and geographic distribution ...

journal_title：Frontiers in cellular and infection microbiology

authors： Kikuchi F,Aoki K,Ohdachi SD,Tsuchiya K,Motokawa M,Jogahara T,Sơn NT,Bawm S,Lin KS,Thwe TL,Gamage CD,Ranorosoa MC,Omar H,Maryanto I,Suzuki H,Tanaka-Taya K,Morikawa S,Mizutani T,Suzuki M,Yanagihara R,Arai S

更新日期：2020-08-27 00:00:00

abstract：:Background:Staphylococcus aureus biofilms contribute negatively to a number of chronic conditions, including chronic rhinosinusitis (CRS). With the inherent tolerance of biofilm-bound bacteria to antibiotics and the global problem of bacterial antibiotic resistance, the need to develop novel therapeutics is paramount....

journal_title：Frontiers in cellular and infection microbiology

authors： Drilling AJ,Ooi ML,Miljkovic D,James C,Speck P,Vreugde S,Clark J,Wormald PJ

更新日期：2017-02-24 00:00:00

abstract：:Dermatophytoses account for nearly a quarter of all fungal infections worldwide. These difficult to treat infections of the skin, hair, and nails, are growing more resistant to conventional antifungal treatments, and when treatable, often require prolonged therapeutic regimens. For centuries, essential oils have been ...

journal_title：Frontiers in cellular and infection microbiology

authors： Parrish N,Fisher SL,Gartling A,Craig D,Boire N,Khuvis J,Riedel S,Zhang S

更新日期：2020-10-16 00:00:00

abstract：:Staphylococcus aureus is a major cause of infective endocarditis (IE) and sepsis. Both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains cause these illnesses. Common S. aureus strains include pulsed-field gel electrophoresis (PFGE) types USA200, 300, and 400 types where we hypothesize that secrete...

journal_title：Frontiers in cellular and infection microbiology

authors： Spaulding AR,Satterwhite EA,Lin YC,Chuang-Smith ON,Frank KL,Merriman JA,Schaefers MM,Yarwood JM,Peterson ML,Schlievert PM

更新日期：2012-02-21 00:00:00

abstract：:Porphyromonas gingivalis is a major etiological agent in chronic and aggressive forms of periodontal disease. The organism is an asaccharolytic anaerobe and is a constituent of mixed species biofilms in a variety of microenvironments in the oral cavity. P. gingivalis expresses a range of virulence factors over which i...

journal_title：Frontiers in cellular and infection microbiology

authors： Hirano T,Beck DA,Demuth DR,Hackett M,Lamont RJ

更新日期：2012-06-12 00:00:00

abstract：:Tularemia is an endemic zoonotic disease in many parts of the world including Asia. A cross-sectional study was conducted to determine genome-based prevalence of Francisella tularensis (Ft) in soil, assess an association between its occurrence in soil and likely predictors i.e., macro and micro-nutrients and several c...

journal_title：Frontiers in cellular and infection microbiology

authors： Muhammad J,Rabbani M,Shabbir MZ,Muhammad K,Ghori MT,Chaudhry HR,Ul Hassnain Z,Jamil T,Abbas T,Chaudhry MH,Haisem-Ur-Rasool M,Ali MA,Nisar M,Kirimanjeswara GS,Jayarao BM

更新日期：2019-04-05 00:00:00

abstract：:Pet and EspC are toxins secreted by enteroaggregative (EAEC) and enteropathogenic (EPEC) diarrheagenic Escherichia coli pathotypes, respectively. Both toxins are members of the Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) family. Pet and EspC are important virulence factors that produce cytotoxic an...

journal_title：Frontiers in cellular and infection microbiology

authors： Sanchez-Villamil JI,Navarro-Garcia F,Castillo-Romero A,Gutierrez-Gutierrez F,Tapia D,Tapia-Pastrana G

更新日期：2019-09-25 00:00:00

abstract：:The NLRP3 inflammasome and IL-1β release have recently been suggested to be important for the progression of urinary tract infection (UTI). However, much is still unknown regarding the interaction of UPEC and the NLRP3 inflammasome. The purpose of this study was to elucidate what virulence factors uropathogenic Escher...

journal_title：Frontiers in cellular and infection microbiology

authors： Demirel I,Persson A,Brauner A,Särndahl E,Kruse R,Persson K

更新日期：2018-03-14 00:00:00

abstract：:Meningitis, the inflammation of the protective membrane surrounding the brain and spinal cord (known as meninges), is a condition associated with high mortality rates and permanent neurological sequelae in a significant proportion of survivors. The opportunistic pathogen Streptococcus pneumoniae (SPN/pneumococcus) is ...

journal_title：Frontiers in cellular and infection microbiology

authors： Anil A,Banerjee A

更新日期：2020-11-03 00:00:00

abstract：:An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection against the disease may be useful for developing new treatment strategies. A mouse ENU-induced ...

journal_title：Frontiers in cellular and infection microbiology

authors： Schnider CB,Yang H,Starrs L,Ehmann A,Rahimi F,Di Pierro E,Graziadei G,Matthews K,De Koning-Ward T,Bauer DC,Foote SJ,Burgio G,McMorran BJ

更新日期：2020-09-03 00:00:00

abstract：:HIGHLIGHTS What is already known about this subject?Celiac disease (CD) has a high clinical and histological diversity and the mechanisms underlying this phenomenon remain elusive.H. pylori is a bacterium that chronically infect gastric and duodenal mucosa activating both a Th1/Th17 and T-reg pathways.The role of H. p...

journal_title：Frontiers in cellular and infection microbiology

authors： Lucero Y,Oyarzún A,O'Ryan M,Quera R,Espinosa N,Valenzuela R,Simian D,Alcalde E,Arce C,Farfán MJ,Vergara AF,Gajardo I,Mendez J,Carrasco J,Errázuriz G,Gonzalez M,Ossa JC,Maiza E,Perez-Bravo F,Castro M,Araya M

更新日期：2017-08-23 00:00:00

abstract：:Prompt and effective elicitation of protective immunity is highly relevant for cases of rapidly deteriorating fatal diseases, such as plague, which is caused by Yersinia pestis. Here, we assessed the potential of a live vaccine to induce rapid protection against this infection. We demonstrated that the Y. pestis EV76 ...

journal_title：Frontiers in cellular and infection microbiology

authors： Zauberman A,Vagima Y,Tidhar A,Aftalion M,Gur D,Rotem S,Chitlaru T,Levy Y,Mamroud E

更新日期：2017-06-21 00:00:00

abstract：:Invasive aspergillosis (IA) is a deep tissue infection with a high mortality occurring mostly in immunocompromised patients. To investigate the pathology of patients with IA it may be important to determine the genotype of the invasive isolate of Aspergillus, however available tissues for study are often formalin fixe...

journal_title：Frontiers in cellular and infection microbiology

authors： de Groot T,Hagen F,Vreuls W,Verweij PE,Chowdhary A,Meis JF

更新日期：2018-10-23 00:00:00

abstract：:Culture-independent metagenomic methodologies have enabled detection and identification of microorganisms in various biological systems and often revealed complex and unknown microbiomes. In many organisms, the microbiome outnumbers the host cells and greatly affects the host biology and fitness. Ticks are hematophago...

journal_title：Frontiers in cellular and infection microbiology

authors： Guizzo MG,Neupane S,Kucera M,Perner J,Frantová H,da Silva Vaz I,de Oliveira PL,Kopacek P,Zurek L

更新日期：2020-05-08 00:00:00

abstract：:Ticks modulate their hosts' defense responses by secreting a biopharmacopiea of hundreds to thousands of proteins and bioactive chemicals into the feeding site (tick-host interface). These molecules and their functions evolved over millions of years as ticks adapted to blood-feeding, tick lineages diverged, and host-s...

journal_title：Frontiers in cellular and infection microbiology

authors： Mans BJ,Featherston J,de Castro MH,Pienaar R

更新日期：2017-09-25 00:00:00

abstract：:Under unfavorable conditions such as host immune responses and environmental stresses, human pathogen Mycobacterium tuberculosis may acquire the dormancy phenotype characterized by "non-culturability" and a substantial decrease of metabolic activity and global transcription rates. Here, we found that the transition of...

journal_title：Frontiers in cellular and infection microbiology

authors： Salina EG,Grigorov AS,Bychenko OS,Skvortsova YV,Mamedov IZ,Azhikina TL,Kaprelyants AS

更新日期：2019-07-30 00:00:00

abstract：:Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further reduce the availability of metal nutrients by activating epithel...

journal_title：Frontiers in cellular and infection microbiology

authors： Diaz-Ochoa VE,Jellbauer S,Klaus S,Raffatellu M

更新日期：2014-01-24 00:00:00

abstract：:Studying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for non-model viruses an...

journal_title：Frontiers in cellular and infection microbiology

authors： Petit MJ,Shah PS

更新日期：2019-01-07 00:00:00

abstract：:The oral microbiome can play a role in the instigation and progression of oral diseases that can manifest into other systemic conditions. These associations encourage the exploration of oral dysbiosis leading to the pathogenesis of cancers. In this study, oral rinse was used to characterize the oral microbiome fluctua...

journal_title：Frontiers in cellular and infection microbiology

authors： Lim Y,Fukuma N,Totsika M,Kenny L,Morrison M,Punyadeera C

更新日期：2018-08-03 00:00:00

abstract：:Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of pro- and anti-inflammatory responses to Plasmodium infection, en...

journal_title：Frontiers in cellular and infection microbiology

authors： Dunst J,Kamena F,Matuschewski K

更新日期：2017-07-20 00:00:00

abstract：:Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. The host immune system produces interferon-γ (IFN-γ) to inhibit T. gondii proliferation. IFN-γ-inducible indole-2,3-dioxygenase 1 (IDO1), which mediates tryptophan degradation, has a major role in anti-T. gondii imm...

journal_title：Frontiers in cellular and infection microbiology

authors： Bando H,Lee Y,Sakaguchi N,Pradipta A,Sakamoto R,Tanaka S,Ma JS,Sasai M,Yamamoto M

更新日期：2019-05-01 00:00:00

abstract：:Entamoeba histolytica is a protozoan parasite and a major cause of dysentery and diarrheal disease in developing countries. Disease transmission from one host to another occurs via cysts which can survive in environmental extremes and are transmitted through contaminated food and water. Recent studies in our lab ident...

journal_title：Frontiers in cellular and infection microbiology

authors： Manna D,Lozano-Amado D,Ehrenkaufer G,Singh U

更新日期：2020-07-17 00:00:00

abstract：:Objectives: To evaluate metagenomic next-generation sequencing (mNGS) as a diagnostic tool in detecting pathogens from osteoarticular infection (OAI) samples. Methods: 130 samples of joint fluid, sonicate fluid, and tissue were prospectively collected from 92 patients with OAI. The performance of mNGS and microbiology...

journal_title：Frontiers in cellular and infection microbiology

authors： Huang ZD,Zhang ZJ,Yang B,Li WB,Zhang CJ,Fang XY,Zhang CF,Zhang WM,Lin JH

更新日期：2020-09-17 00:00:00

abstract：:Deposition of Burkholderia pseudomallei within either the lungs or nasal passages of the Balb/c murine model resulted in different infection kinetics. The infection resulting from the inhalation of B. pseudomallei within a 12 μm particle aerosol was prolonged compared to a 1 μm particle aerosol with a mean time-to-dea...

journal_title：Frontiers in cellular and infection microbiology

authors： Thomas RJ,Davies C,Nunez A,Hibbs S,Eastaugh L,Harding S,Jordan J,Barnes K,Oyston P,Eley S

更新日期：2012-07-23 00:00:00

abstract：:The intracellular bacterial pathogen Francisella tularensis causes serious infectious disease in humans and animals. Moreover, F. tularensis, a highly infectious pathogen, poses a major concern for the public as a bacterium classified under Category A of bioterrorism agents. Unfortunately, research has so far failed t...

journal_title：Frontiers in cellular and infection microbiology

authors： Krocova Z,Macela A,Kubelkova K

更新日期：2017-10-16 00:00:00

abstract：:Platycodin D, extract from the root of Platycodon grandiflorum, is one of the most important monomers of the Qinbaiqingfei pellets (Qinbai) that has already been approved as the first Traditional Chinese Medicine for clinic use as an anti-M. pneumoniae agent. Qinbai constituents Scutellaria baicalensis and Platycodon ...

journal_title：Frontiers in cellular and infection microbiology

authors： Meng Y,Yang Y,Lu W,Wang Y,Qian F,Wang X,Zhang Z,Wang W

更新日期：2015-01-13 00:00:00

abstract：:Due to increased travel, climatic, and environmental changes, the incidence of tick-borne disease in both humans and animals is increasing throughout Europe. Therefore, extended surveillance tools are desirable. To accurately screen tick-borne pathogens (TBPs), a large scale epidemiological study was conducted on 7050...

journal_title：Frontiers in cellular and infection microbiology

authors： Michelet L,Delannoy S,Devillers E,Umhang G,Aspan A,Juremalm M,Chirico J,van der Wal FJ,Sprong H,Boye Pihl TP,Klitgaard K,Bødker R,Fach P,Moutailler S

更新日期：2014-07-29 00:00:00

abstract：:Virulent C. difficile toxins TcdA and TcdB invade host intestinal epithelia by endocytosis and use the acidic environment of intracellular vesicles for further processing and activation. We investigated the role of ClC-5, a chloride/proton exchanger expressed in the endosomes of gastrointestinal epithelial cells, in t...

journal_title：Frontiers in cellular and infection microbiology

authors： Ruhe F,Olling A,Abromeit R,Rataj D,Grieschat M,Zeug A,Gerhard R,Alekov A

更新日期：2017-03-13 00:00:00