Abstract:
OBJECTIVES:To compare the efficacy and safety of topical non-steroidal anti-inflammatory drugs (NSAIDs), including salicylate, for the treatment of osteoarthritis (OA). METHODS:PubMed, Embase, Cochrane Library and Web of Science were searched from 1966 to January 2017. Randomised controlled trials (RCTs) comparing topical NSAIDs with placebo or each other in patients with OA and observational studies comparing topical NSAIDs with no treatment or each other irrespective of disease were included. Two investigators identified studies and independently extracted data. Bayesian network and conventional meta-analyses were conducted. The primary outcomes were pain relief for RCTs and risk of adverse effects (AEs) for observational studies. RESULTS:43 studies, comprising 36 RCTs (7 900 patients with OA) and seven observational studies (218 074 participants), were included. Overall, topical NSAIDs were superior to placebo for relieving pain (standardised mean difference (SMD)=-0.30, 95% CI -0.40 to -0.20) and improving function (SMD=-0.35, 95% CI -0.45 to -0.24) in OA. Of all topical NSAIDs, diclofenac patches were most effective for OA pain (SMD=-0.81, 95% CI -1.12 to -0.52) and piroxicam was most effective for functional improvement (SMD=-1.04, 95% CI -1.60 to -0.48) compared with placebo. Although salicylate gel was associated with higher withdrawal rates due to AEs, the remaining topical NSAIDs were not associated with any increased local or systemic AEs. CONCLUSIONS:Topical NSAIDs were effective and safe for OA. Diclofenac patches may be the most effective topical NSAID for pain relief. No serious gastrointestinal and renal AEs were observed in trials or the general population. However, confirmation of the cardiovascular safety of topical NSAIDs still warrants further observational study.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
Zeng C,Wei J,Persson MSM,Sarmanova A,Doherty M,Xie D,Wang Y,Li X,Li J,Long H,Lei G,Zhang Wdoi
10.1136/bjsports-2017-098043subject
Has Abstractpub_date
2018-05-01 00:00:00pages
642-650issue
10eissn
0306-3674issn
1473-0480pii
bjsports-2017-098043journal_volume
52pub_type
杂志文章,meta分析,评审abstract:OBJECTIVES:A matched case-control study was carried out to evaluate biological risk indicators for recurrent non-specific low back pain in adolescents. METHODS:Adolescents with recurrent non-specific low back pain (symptomatic; n = 28; mean (SD) age 14.9 (0.7) years) and matched controls (asymptomatic; n = 28; age 14....
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.009951
更新日期:2005-03-01 00:00:00
abstract::Jogging is a form of physical exercise that has stimulated the imagination of the public as shown by recent appearance of its own journal (Jogging Magazine, Editor J. Bryant). We wish to report the unusual complication of an acute stroke sustained during jogging. ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.14.4.229
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Ankle sprains are highly prevalent with high risk of recurrence. Consequently, there are a significant number of research reports examining strategies for treating and preventing acute and recurrent sprains (otherwise known as chronic ankle instability (CAI)), with a coinciding proliferation of review articl...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2016-096178
更新日期:2017-01-01 00:00:00
abstract::Promoting physical activity has become a priority because of its role in preventing childhood obesity and chronic disease. Ecological approaches that recognise the interaction between individuals and the settings in which they spend their time are currently at the forefront of public health action. Schools have been i...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.2008.053447
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the differences in hip external rotation (ER) strength and inner, outer, and total hip ER range of motion (ROM) between dancers and non-dancers and between left and right sides in each group. METHODS:Seventy one subjects (34 dancers and 37 non-dancers) volunteered for this study. The strength (t...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.010827
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To compare cardiorespiratory responses between incremental treadmill (non-specific) and field (sport specific) tests in elite squash players. METHODS:Seven elite players (ranked 1 to 25 in their national federation including the World number 1) randomly performed an incremental treadmill test (TT) and a squ...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsm.2005.018101
更新日期:2005-12-01 00:00:00
abstract:AIM:The aim of this review is to summarise issues surrounding the measurement of physical activity (PA) by self-report and accelerometry in youth (2-18 years old). Current levels and temporal trends in PA and sport participation and the effect of assessment method on data interpretation will be summarised. METHODS:Rel...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2011-090190
更新日期:2011-09-01 00:00:00
abstract::In a one-year prospective study of 42 elite orienteers, 73 recent injuries (1.7 per runner per year) were found. Acute injuries totalled 52% and 48% were due to overuse. Ankle sprains made up 37% of acute injuries while the remaining were mainly contusions caused by falls or bumps against branches or rocks. Medial shi...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.20.3.125
更新日期:1986-09-01 00:00:00
abstract::Objective The purpose of this study was to describe the results of two treatment regimens for medial tibial stress syndrome (MTSS); a graded running programme and the same running programme with additional shockwave therapy (extracorporeal shockwave therapy; ESWT). Design A prospective observational controlled trial....
journal_title:British journal of sports medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/bjsm.2010.081992
更新日期:2012-03-01 00:00:00
abstract::The time that children and adults spend sedentary-put simply, doing too much sitting as distinct from doing too little physical activity-has recently been proposed as a population-wide, ubiquitous influence on health outcomes. It has been argued that sedentary time is likely to be additional to the risks associated wi...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2013-093107
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Physicians are increasingly being called upon to promote physical activity (PA) among patients. However, a paucity of exercise medicine teaching in the UK undergraduate medical curricula prevents students from acquiring the necessary knowledge and skills to do so. To address this issue, King's College London...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2013-092386
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:Patients with thoracic outlet syndrome (TOS) complain of many subjective symptoms that are difficult to measure and quantify. In this study we have tried to assess the weakness (muscle strength) and fatigue (endurance) of these patients with an objective measurement method, isokinetic muscle testing. METHOD...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2004.013706
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:Certain exercise prescriptions for patients with cancer may improve self-reported quality of life (QoL) and self-reported physical function (PF). We investigated the effects of exercise on QoL and PF in patients with cancer and studied differences in effects between different intervention-related and exercise...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2017-097891
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Older people are at high risk of physical inactivity. Activity trackers can facilitate physical activity. We aimed to investigate the effect of interventions using activity trackers on physical activity, mobility, quality of life and mental health among people aged 60+ years. METHODS:For this systematic rev...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析
doi:10.1136/bjsports-2018-100324
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:To study the long term effect of tibial shaft fractures treated by immobilisation in a long leg cast on the calf muscle bulk. METHODS:Computed tomography scans were performed at fixed points on the lower legs of 23 non-professional athletes who sustained closed tibial fractures 16 years previously. Length o...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.020743
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Exercise training has been shown to have beneficial effects on liver function in adults overweight or with fatty liver disease. To establish which exercise programme characteristics were likely to elicit optimal improvements. DESIGN:Systematic review and meta-analysis of randomised, controlled trials. DATA ...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2016-096197
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:To describe the current rugby playing status of a cohort of 1,169 men who had previously participated in an epidemiological survey of rugby injuries during the 1993-1994 season, and assess the consequences of rugby injuries sustained. METHODS:In May 1998, 911 (78%) men completed a questionnaire reporting th...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.35.1.38
更新日期:2001-02-01 00:00:00
abstract::The recovery pulse and respiration were analysed to determine the level of physical fitness among the physical education and medical students of Banaras Hindu University. The analysis of the data suggested that physical fitness as measured by recovery rate was better in physical education students than in medical stud...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.12.2.93
更新日期:1978-06-01 00:00:00
abstract:OBJECTIVES:To investigate the effects of two different regimens of androgenic-anabolic steroid (AAS) administration on serum lipid and lipoproteins, and recovery of these variables after drug cessation, as indicators of the risk for cardiovascular disease in healthy male strength athletes. METHODS:In a non-blinded stu...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/bjsm.2003.000199
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To describe the anthropometric and physical performance characteristics of a sample of senior A club rugby players and to highlight differences between the positional categories of the players within the forwards and backs. METHODS:94 senior A male rugby players were assessed on a number of anthropometric an...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.30.1.53
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Athletic groin pain (AGP) is an encompassing term for the multitude of chronic conditions presenting as pain in the inguinal region. The purpose of this review was to compare the return to play rates (RTPrate) and return to play times (RTPtime) between surgical and rehabilitation interventions in the treatme...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2014-093715
更新日期:2015-11-01 00:00:00
abstract::Mechanotransduction is the physiological process where cells sense and respond to mechanical loads. This paper reclaims the term "mechanotherapy" and presents the current scientific knowledge underpinning how load may be used therapeutically to stimulate tissue repair and remodelling in tendon, muscle, cartilage and b...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.2008.054239
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:When appraising the quality of randomised clinical trial (RCTs) on the merits of exercise therapy, we typically limit our assessment to the quality of the methods. However, heterogeneity across studies can also be caused by differences in the quality of the exercise interventions (ie, 'the potential effective...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2019-101630
更新日期:2020-11-03 00:00:00
abstract:OBJECTIVE:To examine the accuracy of the Caltrac accelerometer for estimating energy expenditure (EE) during three exercise modes. METHODS:A subset of 31 women (mean (SEM) age 22.6 (5) years) as selected from a training study comparing various physiological parameters during race walking, running, and stepping. Subjec...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.31.3.235
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:The relatively young sport of snowboarding exhibits high injury rates. The current efforts to characterise the injury pattern of snowboarders focus largely on the general snowboard population and upper extremity injuries, the most common injury site in snowboarders as a whole. METHODS:In an effort to descri...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-093019
更新日期:2014-01-01 00:00:00
abstract:AIM:To compare surgical and conservative treatment for high-risk stress fractures of the anterior tibial cortex, navicular and proximal fifth metatarsal. METHODS:Systematic searches of CENTRAL, MEDLINE, EMBASE, CINAHL, SPORTDiscus and PEDro were performed to identify relevant prospective and retrospective studies. Two...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-093246
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of inguinal canal posterior wall deficiency (sports hernia) in professional Australian Rules footballers using an ultrasound technique and correlate the results with the clinical symptom of groin pain. METHODS:Thirty five professional Australian footballers with and without gro...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章
doi:10.1136/bjsm.32.2.134
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:To systematically review evidence of primary outcomes from randomised controlled trials (RCTs) examining the effect of treatment strategies on quality of life (QoL) or psychosocial factors in individuals with knee osteoarthritis (OA). DESIGN:Systematic review with meta-analysis. DATA SOURCES:Medline, Embase...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2017-098099
更新日期:2018-08-01 00:00:00
abstract::The purpose of this study was to describe the anthropometric and physiological parameters that apply to a USA amateur rugby union club team. Fifteen players who were members of the club's first team were evaluated for body composition, muscular strength, power and endurance, flexibility, anaerobic power, anaerobic cap...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.17.1.16
更新日期:1983-03-01 00:00:00
abstract::Most humans observe an overnight fast on a daily basis, and the human body copes well with short duration fasting. Periodic fasting is widely practised for cultural, religious or health reasons. Fasting may take many different forms. Prolonged restriction of food and fluid is harmful to health and performance, and it ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2010.072157
更新日期:2010-06-01 00:00:00