Abstract:
:Primary liver malignancies are rare in children. Hepatoblastoma and hepatocellular carcinoma (HCC) together represent the overwhelming majority of cases. Overall survival of hepatoblastoma approaches 80% with multimodal treatment approaches that include chemotherapy, surgery and transplantation. However, there remains a subset of children with hepatoblastoma in whom resection or transplantation is not possible. The 5-year survival for children diagnosed with HCC is less than 30% and remains a significant therapeutic challenge. The poor outcomes for children with primary liver tumors motivate investigation of new therapeutic alternatives. Interventional oncology offers a broad scope of percutaneous and transcatheter endovascular cancer therapies that might provide clinical benefits. Minimally invasive approaches are distinct from medical, surgical and radiation oncologic treatments, and in adults these approaches have been established as the fourth pillar of cancer care. Transarterial chemoembolization is a minimally invasive locoregional treatment option performed by interventional radiologists with level-I evidence as standard of care in adults with advanced liver malignancy; transarterial chemoembolization in adults has served to prolong disease-free progression, downstage and bridge patients for surgical and transplant interventions, and improve overall survival. However, while several groups have reported that transarterial chemoembolization is feasible in children, the published experience is limited primarily to small retrospective case series. The lack of prospective trial evidence has in part limited the utilization of transarterial chemoembolization in the pediatric patient population. The purpose of this article is to provide an overview of the role of interventional radiology in the diagnosis and endovascular management of hepatic malignancies in children.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Lungren MP,Towbin AJ,Roebuck DJ,Monroe EJ,Gill AE,Thakor A,Towbin RB,Cahill AM,Matthew Hawkins Cdoi
10.1007/s00247-018-4068-1subject
Has Abstractpub_date
2018-04-01 00:00:00pages
555-564issue
4eissn
0301-0449issn
1432-1998pii
10.1007/s00247-018-4068-1journal_volume
48pub_type
杂志文章,评审abstract::The mucopolysaccharidoses are a heterogeneous group of inherited lysosomal storage disorders, characterized by the accumulation of undegraded glycosaminoglycans in various organs, leading to tissue damage. Mucopolysaccharidoses include eight individual disorders (IS [Scheie syndrome], IH [Hurler syndrome], II, III, IV...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-018-4139-3
更新日期:2018-09-01 00:00:00
abstract::Purpose. To determine whether gadolinium-enhanced MR imaging can detect early reversible ischemia of the capital femoral epiphysis and physis induced by hip hyperabduction in piglets. Materials and methods. Thirteen 1- to 3-week-old piglets were placed in maximal abduction of both hips and studied with dynamic gadolin...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02011824
更新日期:1995-01-01 00:00:00
abstract::A cardiac fibroma in a newborn is reported. The infant had skeletal stigmata of Gorlin's syndrome and the mother had known Gorlin's syndrome. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02011059
更新日期:1991-01-01 00:00:00
abstract::Scrotal abscess in infancy is rare and, in an otherwise healthy infant, an unexpected pathology. We present a 2-week-old boy with a unilateral scrotal swelling, imaged by high-resolution sonography. Sonography with colour Doppler demonstrated an encapsulated heterogeneous mass in the left scrotum with surrounding hype...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-006-0273-4
更新日期:2006-11-01 00:00:00
abstract::Cutis verticis gyrata (CVG) is a skin condition characterized by thick folds and deep furrows, resembling a cortical gyral pattern. There is a recognized but rare association with Noonan syndrome. We report the antenatal imaging, including three-dimensional surface-rendered sonography and MRI, of a fetus with CVG who ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-008-0747-7
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:We present the case of an 8-year-old girl with acute onset of intermittent lower abdominal pain. The gray-scale US examination showed an enlarged right ovary with peripheral cysts, reflecting ovarian congestion and strongly suggesting the diagnosis of torsion. Normal arterial and venous flow, however, was fo...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-002-0739-y
更新日期:2002-08-01 00:00:00
abstract::Malignant metastasis to the breast, rare in adults, has occurred in children from hematologic malignancies and from neuroblastoma and rhabdomyosarcoma. We report a case of bilateral breast metastases in a 14-year-old girl with a prior nephrectomy for renal cell carcinoma; the breast masses were the first sign of recur...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050111
更新日期:1997-03-01 00:00:00
abstract::In early life, patients with sickle cell disease (SCD) can have acute, life-threatening emergencies related to splenic hypofunction (overwhelming bacterial sepsis), as well as anemic crises from acute splenic sequestration because of sudden pooling of blood in the spleen. The landmark penicillin prophylaxis study in 1...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-008-1049-9
更新日期:2009-01-01 00:00:00
abstract::Calcification of the upper respiratory tract is exceptional in persons aged under 15 years, and only 9 cases have been published so far in the English or French literature. We present a new case and analyse those already reported. ...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/BF02011495
更新日期:1991-01-01 00:00:00
abstract::In 200 unselected upper abdominal sonographies in children the hepatic venous anatomy was examined with special reference to caudal hepatic veins. In 42% of patients caudal hepatic veins could be demonstrated sonographically, while large caudal hepatic veins could be shown in 12.5% of patients. The large caudal hepati...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02343422
更新日期:1984-01-01 00:00:00
abstract::Image quality takes on different perspectives and meanings when associated with the concept of as low as reasonably achievable (ALARA), which is chiefly focused on radiation dose delivered as a result of a medical imaging procedure. ALARA is important because of the increased radiosensitivity of children to ionizing r...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-004-1268-7
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Laterality defects are quite common in thoracoileopagus and parapagus dicephalus but rare in other types of conjoined twins. OBJECTIVE:To present the presumed laterality defects in cephalothoracoileopagus and prosopothoracoileopagus conjoined twins, based on the unilateral or bilateral absence or duplicatio...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-011-2316-8
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Head computed tomography (CT) is the current standard of care for evaluating infants at high risk of abusive head trauma. OBJECTIVE:To both assess the feasibility of using a previously developed magnetic resonance imaging (MRI) brain injury screen (MRBRscreen) in the acute care setting in place of head CT t...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-019-04506-1
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:During the course of our routine renal ultrasound examinations, we noticed that some children who developed dilatation of a renal pelvis following voiding had reflux found on voiding cystourethrography (VCUG). PURPOSE:To determine if increase in renal pelvic size on post-void ultrasound is an accurate predi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050591
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:A new children's hospital provided the impetus to investigate radiation dose and image quality in a fluoroscope that was specially engineered for pediatric fluoroscopy. Radiation protection management recommends radiation exposures that are as low as reasonably achievable, while still maintaining diagnostic ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050728
更新日期:2000-04-01 00:00:00
abstract::We report the US and MR appearances in a case of persistent Müllerian duct syndrome, a rare form of inherited male pseudohermaphroditism characterised by the presence of uterus and fallopian tubes in a normally virilised 46XY male. ...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s002470050484
更新日期:1998-11-01 00:00:00
abstract::The imaging procedures utilized at presentation in the diagnostic work-up of 19 children with Burkitt lymphoma were reviewed. The distribution of disease was compared to other tumors of childhood so that the most valuable modalities could be identified. Burkitt lymphoma is a rapidly growing tumor in the child, making ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388718
更新日期:1985-01-01 00:00:00
abstract::The experience from 123 pediatric MRI examinations disclosed several different types of artifacts and age-related variants that could have caused pitfalls in MRI interpretation. Artifacts were caused by metallic objects, patient touching the RF coil, and patient motion. The potential pitfalls are caused by the MRI var...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388605
更新日期:1985-01-01 00:00:00
abstract::A neonate with reversible, nonobstructive common hepatic duct enlargement secondary to intravenous morphine administration is presented. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02390403
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Accurate diagnosis of hepatic vein (HV) stenosis by real-time and color Doppler US (CD-US) after segmental liver transplantation in children can decrease morbidity because it allows unnecessary biopsy, obstruction or thrombosis and loss of the graft to be avoided. OBJECTIVE:To evaluate CD-US parameters to p...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-007-0731-7
更新日期:2008-04-01 00:00:00
abstract::Rwanda is a country of 12 million people with 41% of its population under the age of 14 years. Despite major improvements in health care since the 1994 genocide, pediatric neuroimaging in Rwanda remains challenging. Prenatal and advanced imaging techniques, such as magnetic resonance imaging (MRI), are not widespread....
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-018-4315-5
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Food allergy may be partly due to impairment of the intestinal barrier and is frequently associated with atopic dermatitis (AD) in early life. OBJECTIVE:To determine whether bowel wall thickening, as demonstrated by US, is useful for the identification of food allergy. MATERIALS AND METHODS:We used US to s...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-001-0593-3
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Alveolar rhabdomyosarcoma commonly arises in the extremities and is characterized by aggressive biology and high frequency of metastases. Whole-body imaging is increasingly employed in pediatric oncology but not recommended as standard in the staging of soft-tissue sarcomas. OBJECTIVE:After observing patien...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-017-4066-8
更新日期:2018-05-01 00:00:00
abstract::Hydranencephaly is an encephaloclastic central nervous system disorder characterised by severe destruction of the cerebral hemispheres with preservation of posterior fossa structures. We present MRI and neurosonography features of a unique case of hydranencephaly involving cerebellum (in the form of complete liquefact...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-010-1749-9
更新日期:2011-02-01 00:00:00
abstract::Limb-sparing procedures utilizing endoprostheses improve both the quality of life and functional level of patients treated for primary bone sarcomas. Herein, we present the imaging findings of an uncommon cause of prosthetic failure, i. e., foreign body reaction, manifested by progressive multifocal osteolysis along t...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/BF01372099
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Dual-energy absorptiometry (DXA) is the current reference standard for assessing pediatric osteoporosis; however due to its areal nature, it has limitations. Thus, quantitative ultrasound (QUS), a modality free of ionizing radiation, has been proposed as a potential surrogate for DXA. OBJECTIVE:To semi-quan...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-014-3041-x
更新日期:2014-12-01 00:00:00
abstract::The logistic approach in diagnosis of focal nodular hyperplasia (FNH) of the liver is discussed, based on the experience with three children. In only one child could the diagnosis be made without angiography. In that child the combination of hypervascularity on the radionuclide angiogram and uptake of the radiocolloid...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02390106
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Shielding of the gonads is a dose-saving strategy in pediatric radiography and its use is the law in New York and the majority of other states. However, routine use of gonadal shields is controversial because of concerns that important diagnostic information can be obscured. OBJECTIVE:The purpose of this st...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-013-2700-7
更新日期:2013-10-01 00:00:00
abstract::A 4-year-old boy with bilateral optic sheath enlargement and progressive optic atrophy and blindness is presented. Computed tomography demonstrated hydrocephalus and enlargement of the optic nerve sheath complex. The child died during an attempted repair of hypoplastic atrioventricular valves. Autopsy demonstrated a p...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050518
更新日期:1998-12-01 00:00:00
abstract::Intussusception in the pediatric patient may have a varied clinical presentation depending on its location, presence of lead point, intermittent occurrence, or underlying systemic disease. Computed tomography (CT) may be used at times in the evaluation of children with complicated presentations. The purpose of this in...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01403699
更新日期:1996-01-01 00:00:00