Role of pain in placebo analgesia.

abstract：:Malaria control is threatened by a limited pipeline of effective pharmaceuticals against drug-resistant strains of Plasmodium falciparum Components of the mitochondrial electron transport chain (ETC) are attractive targets for drug development, owing to exploitable differences between the parasite and human ETC. Disru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lane KD,Mu J,Lu J,Windle ST,Liu A,Sun PD,Wellems TE

更新日期：2018-06-12 00:00:00

abstract：:It has been recently shown that malignant activation of the c-has/bas proto-oncogene in T24 human bladder carcinoma cells was mediated by a single point mutation. A deoxyguanosine located at position 35 of the first exon of this proto-oncogene was substituted by thymidine. These findings predicted that the resulting o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santos E,Reddy EP,Pulciani S,Feldmann RJ,Barbacid M

更新日期：1983-08-01 00:00:00

abstract：:Neonicotinoid insecticides control crop pests based on their action as agonists at the insect nicotinic acetylcholine receptor, which accepts chloropyridinyl- and chlorothiazolyl-analogs almost equally well. In some cases, these compounds have also been reported to enhance plant vigor and (a)biotic stress tolerance, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ford KA,Casida JE,Chandran D,Gulevich AG,Okrent RA,Durkin KA,Sarpong R,Bunnelle EM,Wildermuth MC

更新日期：2010-10-12 00:00:00

abstract：:Yeast centromeric DNA (CEN DNA) binding factor 3 (CBF3) is a multisubunit protein complex that binds to the essential CDEIII element in CEN DNA. The four CBF3 proteins are required for accurate chromosome segregation and are considered to be core components of the yeast kinetochore. We have examined the structure of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pietrasanta LI,Thrower D,Hsieh W,Rao S,Stemmann O,Lechner J,Carbon J,Hansma H

更新日期：1999-03-30 00:00:00

abstract：:Design and synthesis of 3D metallic carbon that is stable under ambient conditions has been a long-standing dream. We predict the existence of such phases, T6- and T14-carbon, consisting of interlocking hexagons. Their dynamic, mechanical, and thermal stabilities are confirmed by carrying out a variety of state-of-the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang S,Wang Q,Chen X,Jena P

更新日期：2013-11-19 00:00:00

abstract：:Examples from various plant and animal groups indicate that there has been a general increase in potential versatility of form, determined by the number and range of independently varying morphogenetic parameters, among taxa appearing at successively younger stages in the fossil record. Taxa or body plans with higher ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vermeij GJ

更新日期：1973-07-01 00:00:00

abstract：:We recently found that the beta-adrenergic agonist 1-isoproterenol evokes a rapid (less than 5 min) Ca2+- and receptor-dependent stimulation of endocytosis, hexose transport, and amino acid transport in mouse renal cortex involving proximal tubule cells. This response is associated with increased Ca2+ fluxes and a mob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenig H,Goldstone AD,Lu CY

更新日期：1983-12-01 00:00:00

abstract：:Lateral mobility of an active fluorescent derivative of cytochrome c on the membranes of giant mitochondria was measured by fluorescence redistribution after photobleaching. A diffusion coefficient of 1.6 X 10(-10) cm2/sec was determined for the labeled cytochrome c on inner mitochondrial membranes under conditions wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hochman JH,Schindler M,Lee JG,Ferguson-Miller S

更新日期：1982-11-01 00:00:00

abstract：:In epidemiological studies, both positive and negative correlations have been found between cardiovascular disease and mortality and the presence of several inorganic ions in the drinking water. In an attempt to resolve this apparent disagreement, we exposed White Carneau pigeons to drinking water containing calcium (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Revis NW,Zinsmeister AR,Bull R

更新日期：1981-10-01 00:00:00

abstract：:The identification of genes contributing to the adaptation of local populations is of great biological interest. In an attempt to characterize functionally important differences among African and non-African Drosophila melanogaster populations, we surveyed neutral microsatellite variation in an 850-kb genomic sequence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harr B,Kauer M,Schlötterer C

更新日期：2002-10-01 00:00:00

abstract：:The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic "pseudo-loxP" sites in mammalian genomes, to date there have been no reports of loxP-site infidelity in tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt EE,Taylor DS,Prigge JR,Barnett S,Capecchi MR

更新日期：2000-12-05 00:00:00

abstract：:Mammalian CLC proteins function as Cl(-) channels or as electrogenic Cl(-)/H(+) exchangers and are present in the plasma membrane and intracellular vesicles. We now show that the ClC-6 protein is almost exclusively expressed in neurons of the central and peripheral nervous systems, with a particularly high expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poët M,Kornak U,Schweizer M,Zdebik AA,Scheel O,Hoelter S,Wurst W,Schmitt A,Fuhrmann JC,Planells-Cases R,Mole SE,Hübner CA,Jentsch TJ

更新日期：2006-09-12 00:00:00

abstract：:Extreme animal movements are usually associated with a single, high-performance behavior. However, the remarkably rapid mandible strikes of the trap-jaw ant, Odontomachus bauri, can yield multiple functional outcomes. Here we investigate the biomechanics of mandible strikes in O. bauri and find that the extreme mandib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patek SN,Baio JE,Fisher BL,Suarez AV

更新日期：2006-08-22 00:00:00

abstract：:The Prisoner's Dilemma (PD) is a widely employed metaphor for problems associated with the evolution of cooperative behavior. We have recently proposed an alternative approach to the PD, by exploring "spatial games" in which players--who are either pure cooperators, C, or pure defectors, D--interact with neighbors in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowak MA,Bonhoeffer S,May RM

更新日期：1994-05-24 00:00:00

abstract：:Forkhead box class O (FoxO) transcription factors are key regulators of growth, metabolism, life span, and stress resistance. FoxOs integrate signals from different pathways and guide the cellular response to varying energy and stress conditions. FoxOs are modulated by several signaling pathways, e.g., the insulin-TOR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mattila J,Kallijärvi J,Puig O

更新日期：2008-09-30 00:00:00

abstract：:We present molecular dating analyses for land plants that incorporate 33 fossil calibrations, permit rates of molecular evolution to be uncorrelated across the tree, and take into account uncertainties in phylogenetic relationships and the fossil record. We attached a prior probability to each fossil-based minimum age...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith SA,Beaulieu JM,Donoghue MJ

更新日期：2010-03-30 00:00:00

abstract：:The gamma-aminobutyrate-synthesizing enzyme glutamate decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.1.15) is a major target of autoantibodies associated with both early and late stages of pancreatic beta-cell destruction and development of type 1 diabetes. We have used five monoclonal anti-islet-cell antibod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter W,Shi Y,Baekkeskov S

更新日期：1993-04-01 00:00:00

abstract：:We have constructed yeast strains that secrete functional mouse-human chimeric antibody and its Fab fragment into the culture medium. For chimeric whole antibody, cDNA copies of the chimeric light-chain and heavy-chain genes of an anti-tumor antibody were inserted into vectors containing the yeast phosphoglycerate kin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horwitz AH,Chang CP,Better M,Hellstrom KE,Robinson RR

更新日期：1988-11-01 00:00:00

abstract：:In herpes simplex virus 1 (HSV-1) DNA, a small sequence, designated the a sequence, flanks the reiterated sequences at the ends of both the L and S components. The a sequence is the only sequence shared by the termini of all isomeric arrangements of HSV-1 DNA that arise from inversions of the covalently linked L and S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knipe DM,Ruyechan WT,Honess RW,Roizman B

更新日期：1979-09-01 00:00:00

abstract：:Recent findings suggest that neurons can efficiently repair oxidatively damaged DNA, and that both DNA damage and repair are enhanced by activation of excitatory glutamate receptors. However, in pathological conditions such as ischemic stroke, excessive DNA damage can trigger the death of neurons. Oxidative DNA damage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canugovi C,Yoon JS,Feldman NH,Croteau DL,Mattson MP,Bohr VA

更新日期：2012-09-11 00:00:00

abstract：:Waves and patterns in living systems are often driven by biochemical reactions with enzymes as catalysts and regulators. We present a reaction-diffusion system catalyzed by the enzyme glucose oxidase that exhibits traveling wave patterns in a spatially extended medium. Fronts and pulses propagate as a result of the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Míguez DG,Vanag VK,Epstein IR

更新日期：2007-04-24 00:00:00

abstract：:Synaptic vesicles release neurotransmitter by following a process of vesicle docking and exocytosis. Although these steps are well established, it has been difficult to observe and measure these rates directly in living synapses. Here, by combining the direct imaging of single synaptic vesicles and synaptic ribbons, I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zenisek D

更新日期：2008-03-25 00:00:00

abstract：:We have determined the amino acid sequence of the first constant (C) region domain (C delta 1) and the hinge region of the delta heavy chain of human IgD WAH and also the sequence of the adjacent COOH-terminal portion of the variable (V) region, including the JH region. Together with the sequence of the Fc fragment al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Putnam FW,Takahashi N,Tetaert D,Debuire B,Lin LC

更新日期：1981-10-01 00:00:00

abstract：:Break-induced replication (BIR) refers to recombination-dependent DNA synthesis initiated from one end of a DNA double-strand break and can extend for more than 100 kb. BIR initiates by Rad51-catalyzed strand invasion, but the mechanism for DNA synthesis is not known. Here, we used BrdU incorporation to track DNA synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donnianni RA,Symington LS

更新日期：2013-08-13 00:00:00

abstract：:A major question in plant physiology is how the large amount of sucrose made in leaves is transported to the rest of the plant. Although physiological, biochemical, and anatomical investigations have been performed in this field, to date there have been very few genetic studies. Using a reverse genetic screen, we have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gottwald JR,Krysan PJ,Young JC,Evert RF,Sussman MR

更新日期：2000-12-05 00:00:00

abstract：:Cells in the brain act as components of extended networks. Therefore, to understand neurobiological processes in a physiological context, it is essential to study them in vivo. Super-resolution microscopy has spatial resolution beyond the diffraction limit, thus promising to provide structural and functional insights ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turcotte R,Liang Y,Tanimoto M,Zhang Q,Li Z,Koyama M,Betzig E,Ji N

更新日期：2019-05-07 00:00:00

abstract：:Anaerobic beta-galactoside transport in whole cells and membrane vesicles from E. coli ML 308-225 is coupled to the oxidation of alpha-glycerol-P or D-lactate with fumarate as an electron acceptor. Alternatively, anaerobic beta-galactoside transport may be coupled to the oxidation of formate utilizing nitrate as elect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Konings WN,Kaback HR

更新日期：1973-12-01 00:00:00

abstract：:Previous studies have demonstrated that mutation in the forkhead domain of the forkhead box P2 (FOXP2) protein (R553H) causes speech-language disorders. To further analyze FOXP2 function in speech learning, we generated a knockin (KI) mouse for Foxp2 (R552H) [Foxp2 (R552H)-KI], corresponding to the human FOXP2 (R553H)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujita E,Tanabe Y,Shiota A,Ueda M,Suwa K,Momoi MY,Momoi T

更新日期：2008-02-26 00:00:00

abstract：:Cyclic AMP (cAMP) and calcium are ubiquitous, interdependent second messengers that regulate a wide range of cellular processes. During development of neuronal networks they are critical for the first step of circuit formation, transducing signals required for axon pathfinding. Surprisingly, the spatial and temporal c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicol X,Hong KP,Spitzer NC

更新日期：2011-08-16 00:00:00

abstract：:Cytochromes P450 play key roles in drug metabolism and disease by oxidizing a wide variety of natural and xenobiotic compounds. High-resolution crystal structures of P450cam bound to ruthenium sensitizer-linked substrates reveal an open conformation of the enzyme that allows substrates to access the active center via ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn AR,Dmochowski IJ,Bilwes AM,Gray HB,Crane BR

更新日期：2001-10-23 00:00:00