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Neurodevelopmental outcome in survivors of hypoxic ischemic encephalopathy without cerebral palsy.

Abstract：

:To access outcome following hypoxic ischemic encephalopathy (HIE), survivors without cerebral palsy were invited for formal developmental assessment. Children aged ≥ 42 months were assessed using the NEPSY-2, Movement Assessment Battery for Children 2 (Movement ABC-2), Behavior Rating Inventory of Executive Function, and the Child Behavior Checklist. Children aged < 42 months were assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (BSITD-3). One hundred forty-six children attended for assessments [Grade 1 (112), Grade 2 (33), and Grade 3 (1)]. BSITD-3 did not identify significant rates of impairment on cognitive, motor, or language subtests. A significant proportion of children scored < 3rd percentile on the adaptive behavior scale. In older age groups, difficulties were seen in 16/24 NEPSY-2 subtests and on timed assessments using Movement ABC-2. Difficulties arose especially in the "control" aspects of cognition and behavior. Behavioral difficulties were common with internalizing problems predominating. There was a graded effect with grade 2 cases differing significantly from grade 1 cases. CONCLUSION:Following HIE, children may experience attention, memory, and behavior difficulties which are not always evident at a young age. The adaptive behavior questionnaire may be a useful tool to select children requiring developmental surveillance beyond 2 years of age. What is known: • Diversity of outcome across grades of HIE is reported and few studies have looked at the milder consequences of HIE at school age. What is new: • Following HIE children may experience attention, memory, and behavior difficulties which are not always evident at a young age. • The adaptive behavior questionnaire may be a useful tool to select children requiring developmental surveillance beyond 2 years of age.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Hayes BC,Doherty E,Grehan A,Madigan C,McGarvey C,Mulvany S,Matthews TG,King MD

doi

10.1007/s00431-017-3028-3

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

19-32

issue

eissn

0340-6199

issn

1432-1076

pii

10.1007/s00431-017-3028-3

journal_volume

177

pub_type

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Neurodevelopmental outcome in survivors of hypoxic ischemic encephalopathy without cerebral palsy.