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Distinct clinical features between acute and chronic progressive parenchymal neuro-Behçet disease: meta-analysis.

Abstract：

:Neuro-Behçet's disease (NBD) is subcategorized into parenchymal-NBD (P-NBD) and non-parenchymal-NBD types. Recently, P-NBD has been further subdivided into acute P-NBD (A-P-NBD) and chronic progressive P-NBD (CP-P-NBD). Although an increasing number of studies have reported the various clinical features of A-P-NBD and CP-P-NBD over the last two decades, there was a considerable inconsistency. Two investigators systematically searched four electrical databases to detect studies that provided sufficient data to assess the specific characteristics of A-P-NBD and CP-P-NBD. All meta-analysis was carried out by employing the random-model generic inverse variance method. We included 11 reports consisted of 184 A-P-NBD patients and 114 CP-P-NBD patients. While fever (42% for A-P-NBD, 5% for CP-P-NBD, p < 0.001, I2 = 93%) was more frequently observed in A-P-NBD cases; sphincter disturbances (9%, 34%, P = 0.005, I2 = 87%), ataxia (16%, 57%, P < 0.001, I2 = 92%), dementia (7%, 61%, P < 0.001, I2 = 97%), confusion (5%, 18%, P = 0.04, I2 = 76%), brain stem atrophy on MRI (4%, 75%, P < 0.001, I2 = 98%), and abnormal MRI findings in cerebellum (7%, 54%, P = 0.02, I2 = 81%) were more common in CP-P-NBD. Cerebrospinal fluid cell count (94/mm3, 11/mm3, P = 0.009, I2 = 85%) was higher in A-P-NBD cases. We demonstrated that A-P-NBD and CP-P-NBD had clearly different clinical features and believe that these data will help future studies investigating P-NBD.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ishido M,Horita N,Takeuchi M,Shibuya E,Yamane T,Kawagoe T,Ishido T,Minegishi K,Yoshimi R,Kirino Y,Hirohata S,Ishigatsubo Y,Takeno M,Kaneko T,Mizuki N

doi

10.1038/s41598-017-09938-z

subject

Has Abstract

pub_date

2017-08-31 00:00:00

pages

10196

issue

1

issn

2045-2322

pii

10.1038/s41598-017-09938-z

journal_volume

7

pub_type

杂志文章,meta分析

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