Alterations in voltage-sensing of the mitochondrial permeability transition pore in ANT1-deficient cells.

abstract：:The relationship between obstructive sleep apnea (OSA) and chronic rhinosinusitis (CRS) still remains unclear. This retrospective cohort study aimed to investigate the relationship between OSA and subsequent CRS using a population-based dataset. The study used data from the Taiwan Longitudinal Health Insurance Databas...

journal_title：Scientific reports

authors： Kao LT,Hung SH,Lin HC,Liu CK,Huang HM,Wu CS

更新日期：2016-02-10 00:00:00

abstract：:Etoposide (ETO) is a commonly used chemotherapeutic drug that inhibits topoisomerase II activity, thereby leading to genotoxicity and cytotoxicity. However, ETO has limited application due to its side effects on normal organs, especially the kidney. Here, we report the mechanism of ETO-induced cytotoxicity progression...

journal_title：Scientific reports

authors： Shin HJ,Kwon HK,Lee JH,Anwar MA,Choi S

更新日期：2016-09-26 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) patients have poor prognosis and poor response to treatment. This is largely due to PDAC being associated with a dense and active stroma and tumor fibrosis (desmoplasia). Desmoplasia is characterized by excessive degradation and formation of the extracellular matrix (ECM) genera...

journal_title：Scientific reports

authors： Willumsen N,Ali SM,Leitzel K,Drabick JJ,Yee N,Polimera HV,Nagabhairu V,Krecko L,Ali A,Maddukuri A,Moku P,Ali A,Poulose J,Menon H,Pancholy N,Costa L,Karsdal MA,Lipton A

更新日期：2019-12-24 00:00:00

abstract：:Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and...

journal_title：Scientific reports

authors： Ferrando B,Gomez-Cabrera MC,Salvador-Pascual A,Puchades C,Derbré F,Gratas-Delamarche A,Laparre L,Olaso-Gonzalez G,Cerda M,Viosca E,Alabajos A,Sebastiá V,Alberich-Bayarri A,García-Castro F,Viña J

更新日期：2018-02-23 00:00:00

abstract：:Distinct regions of long-range genetic fixation in the human MHC region, known as conserved extended haplotypes (CEHs), possess unique genomic characteristics and are strongly associated with numerous diseases. While CEHs appear to be homogeneous by SNP analysis, the nature of fine variations within their genomic stru...

journal_title：Scientific reports

authors： Lam TH,Tay MZ,Wang B,Xiao Z,Ren EC

更新日期：2015-11-23 00:00:00

abstract：:In this paper, we developed a new method to produce large-area single crystal arrays by using the organic semiconductor 9, 10-bis (phenylethynyl) anthracene (BPEA). This method involves an easy operation, is efficient, meets the demands of being low-cost and is independent of the substrate for large-area arrays fabric...

journal_title：Scientific reports

authors： Li Y,Ji D,Liu J,Yao Y,Fu X,Zhu W,Xu C,Dong H,Li J,Hu W

更新日期：2015-08-18 00:00:00

abstract：:A cobalt sulfide/PVDF(Polyvinylidene Fluoride) composite was prepared by a simple blending method, and the microstructure of the composite was investigated through X-ray diffraction, scanning electron microscopy, and field emission scanning electron microscopy. Increased absorption properties at frequencies ranging fr...

journal_title：Scientific reports

authors： Wu Q,Wu J,Wang GS,Zhang HZ,Gao HJ,Shui WJ

更新日期：2019-07-19 00:00:00

abstract：:Generation of flow is an important aspect in microfluidic applications and generally relies on external pumps or embedded moving mechanical parts which pose distinct limitations and protocols on the use of microfluidic systems. A possible approach to avoid moving mechanical parts is to generate flow by changing some s...

journal_title：Scientific reports

authors： Kos Ž,Ravnik M

更新日期：2020-01-29 00:00:00

abstract：:Although pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor for leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid (12-HHT), protects mice...

journal_title：Scientific reports

authors： Shigematsu M,Koga T,Ishimori A,Saeki K,Ishii Y,Taketomi Y,Ohba M,Jo-Watanabe A,Okuno T,Harada N,Harayama T,Shindou H,Li JD,Murakami M,Hoka S,Yokomizo T

更新日期：2016-10-05 00:00:00

abstract：:The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis c...

journal_title：Scientific reports

authors： Chang HH,Chang YK,Lu CW,Huang CT,Chien CT,Hung KY,Huang KC,Hsu CC

更新日期：2016-02-23 00:00:00

abstract：:Concurrent spread of Tomato yellow leaf curl virus (TYLCV) with invasion of Bemisia tabaci Q rather than B in China suggests a more mutualistic relationship between TYLCV and Q than B. To assess this hypothesis, we quantified the impacts of TYLCV on the performance and competitiveness of B and Q in the laboratory. The...

journal_title：Scientific reports

authors： Pan H,Chu D,Liu B,Shi X,Guo L,Xie W,Carrière Y,Li X,Zhang Y

更新日期：2013-01-01 00:00:00

abstract：:Endovascular sealing is a new technique for the repair of abdominal aortic aneurysms. Commercially available in Europe since 2013, it takes a revolutionary approach to aneurysm repair through minimally invasive techniques. Although aneurysm sealing may be thought as more stable than conventional endovascular stent gra...

journal_title：Scientific reports

authors： Argani LP,Torella F,Fisher RK,McWilliams RG,Wall ML,Movchan AB

更新日期：2017-12-18 00:00:00

abstract：:Bisacylphosphane oxides (BAPOs) are established as photoinitiators for industrial applications. Light irradiation leads to their photolysis, producing radicals. Radical species induce oxidative stress in cells and may cause cell death. Hence, BAPOs may be suitable as photolatent cytotoxic agents, but such applications...

journal_title：Scientific reports

authors： Beil A,Steudel FA,Bräuchle C,Grützmacher H,Möckl L

更新日期：2019-04-12 00:00:00

abstract：:This study examines the analytical and numerical solution of electromagnetic surface waves supported by a resistive metasurface-covered grounded metamaterial structure. To simulate the metamaterial, the Kramers-Kronig relation based on the causality principle is used, while the modeling of the resistive metasurface ha...

journal_title：Scientific reports

authors： Yaqoob MZ,Ghaffar A,Alkanhal MAS,Naz MY,Alqahtani AH,Khan Y

更新日期：2020-09-23 00:00:00

abstract：:Cyanobacteria harbor unique photoreceptors, designated as cyanobacteriochromes (CBCRs). In this study, we attempted to engineer the chromatic acclimation sensor CcaS, a CBCR derived from the cyanobacterium Synechocystis sp. PCC 6803. The wild-type CcaS induces gene expression under green light illumination and repress...

journal_title：Scientific reports

authors： Nakajima M,Ferri S,Rögner M,Sode K

更新日期：2016-11-24 00:00:00

abstract：:We evaluated surgical outcomes of bilateral rectus (BLR) recession in patients with intermittent exotropia who underwent diagnostic monocular occlusion. Records of patients with intermittent exotropia who were preoperatively examined one-hour monocular occlusion and underwent BLR recession were reviewed retrospectivel...

journal_title：Scientific reports

authors： Lee JY,Song JE,Chang HR,Choi CY,Han SY

更新日期：2020-05-08 00:00:00

abstract：:Giant magnetoresistive (GMR) biosensors consisting of many rectangular stripes are being developed for high sensitivity medical diagnostics of diseases at early stages, but many aspects of the sensing mechanism remain to be clarified. Using e-beam patterned masks on the sensors, we showed that the magnetic nanoparticl...

journal_title：Scientific reports

authors： Lee JR,Sato N,Bechstein DJ,Osterfeld SJ,Wang J,Gani AW,Hall DA,Wang SX

更新日期：2016-01-05 00:00:00

abstract：:To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...

journal_title：Scientific reports

authors： Zhang Q,Ma J,Liu H,He D,Chen L,Wu H,Jiang H,Lu Q,Bai S

更新日期：2018-01-09 00:00:00

abstract：:This study was to investigate effects of progesterone vaginal sustained-release gel and intramuscular injection of progesterone on frozen-thawed embryos transfer in 3013 patients receiving vaginal progesterone sustained-release gel and progesterone injection in artificial cycle for frozen-thawed embryo transfer. All p...

journal_title：Scientific reports

authors： Jiang L,Luo ZY,Hao GM,Gao BL

更新日期：2019-10-24 00:00:00

abstract：:Aryl nitriles are versatile compounds that can be synthesized via transition-metal-mediated cyanation of aryl halides. Most of the supported-heterogeneous catalysts are noble-metals based and there are very limited numbers of efficient non-noble metal based catalysts demonstrated for the cyanation of aryl halides. Her...

journal_title：Scientific reports

authors： Mayakrishnan G,Elayappan V,Kim IS,Chung IM

更新日期：2020-01-20 00:00:00

abstract：:Ferroelectric tunneling junctions (FTJs) with tunable tunneling electroresistance (TER) are promising for many emerging applications, including non-volatile memories and neurosynaptic computing. One of the key challenges in FTJs is the balance between the polarization value and the tunneling current. In order to achie...

journal_title：Scientific reports

authors： Ryu H,Wu H,Rao F,Zhu W

更新日期：2019-12-31 00:00:00

abstract：:Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in ...

journal_title：Scientific reports

authors： Sharma P,Yi R,Nayak AP,Wang N,Tang F,Knight MJ,Pan S,Oliver B,Deshpande DA

更新日期：2017-04-11 00:00:00

abstract：:Endometrial cancer is the most common gynecologic cancer in the United States and its incidence and mortality has been rising over the past decade. Few treatment options are available for patients with advanced and recurring endometrial cancers. Novel therapies, which are frequently toxic, are difficult to establish i...

journal_title：Scientific reports

authors： Wen W,Lowe G,Roberts CM,Finlay J,Han ES,Glackin CA,Dellinger TH

更新日期：2017-10-06 00:00:00

abstract：:Southern hemisphere humpback whales are classified as high-fidelity Antarctic krill consumers and as such are vulnerable to variability and long-term changes in krill biomass. Evidence of heterogeneous feeding patterns of east coast of Australia migrating humpback whales has been observed, warranting a comprehensive a...

journal_title：Scientific reports

authors： Groß J,Virtue P,Nichols PD,Eisenmann P,Waugh CA,Bengtson Nash S

更新日期：2020-10-26 00:00:00

abstract：:Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/-); Notch3(-/-) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction with the endothelium a...

journal_title：Scientific reports

authors： Kofler NM,Cuervo H,Uh MK,Murtomäki A,Kitajewski J

更新日期：2015-11-13 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graft is a critical concern for clinical application. Here, we hypothesized that brentuximab vedotin, which target...

journal_title：Scientific reports

authors： Sougawa N,Miyagawa S,Fukushima S,Kawamura A,Yokoyama J,Ito E,Harada A,Okimoto K,Mochizuki-Oda N,Saito A,Sawa Y

更新日期：2018-02-27 00:00:00

abstract：:Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing tracking algorithms are most effective for relatively low numbers of particles that undergo displacements smaller than their typical interparticle separation distance....

journal_title：Scientific reports

authors： Patel M,Leggett SE,Landauer AK,Wong IY,Franck C

更新日期：2018-04-03 00:00:00

abstract：:A frequency reconfigurable dipole antenna based on a silicon radiator is presented. The silicon radiator is activated with the aid of highly dense solid-state plasma by injecting carriers into the intrinsic region of p-i-n diodes. The fabrication and design guideline of the reconfigurable dipole antenna with this plas...

journal_title：Scientific reports

authors： Kim DJ,Jo ES,Cho YK,Hur J,Kim CK,Kim CH,Park B,Kim D,Choi YK

更新日期：2018-10-09 00:00:00

abstract：:The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. Here, we examined the pH-dependency of NFEPP binding to brain MOR and it...

journal_title：Scientific reports

authors： Baamonde A,Menéndez L,González-Rodríguez S,Lastra A,Seitz V,Stein C,Machelska H

更新日期：2020-10-29 00:00:00

abstract：:Antibody based bio-molecular drugs are an exciting, new avenue of drug development as an alternative to the more traditional small chemical compounds. However, the binding mechanism and the effect on the conformational ensembles of a therapeutic antibody to its peptide or protein antigen have not yet been well studied...

journal_title：Scientific reports

authors： Bekker GJ,Fukuda I,Higo J,Kamiya N

更新日期：2020-01-29 00:00:00