Intrahaplotypic Variants Differentiate Complex Linkage Disequilibrium within Human MHC Haplotypes.

abstract：:Hyperactivated mTOR signaling in the developing brain has been implicated in multiple forms of pathology including tuberous sclerosis complex (TSC). To date, various phenotypic defects such as cortical lamination irregularity, subependymal nodule formation, dysmorphic astrocyte differentiation and dendritic malformati...

journal_title：Scientific reports

authors： Shin J,Kim M,Jung HJ,Cha HL,Suh-Kim H,Ahn S,Jung J,Kim Y,Jun Y,Lee S,Hwang D,Kim J

更新日期：2017-06-06 00:00:00

abstract：:Magnetic refrigeration is of great interest due to its high energy efficiency, environmental friendliness and low cost. However, undesired hysteresis losses, concentrated working temperature interval (WTI) and poor mechanical stability are vital drawbacks that hinder its practical application. Off-stoichiometric Ni-Mn...

journal_title：Scientific reports

authors： Qian M,Zhang X,Wei L,Martin P,Sun J,Geng L,Scott TB,Peng HX

更新日期：2018-11-08 00:00:00

abstract：:The definition of a precise illumination region is essential in many applications where the electromagnetic field should be confined in some specific volume. By using conventional structures, it is difficult to achieve an adequate confinement distance (or volume) with negligible levels of radiation leakage beyond it. ...

journal_title：Scientific reports

authors： Bonache J,Zamora G,Paredes F,Zuffanelli S,Aguilà P,Martín F

更新日期：2016-11-25 00:00:00

abstract：:People with normal hearing thresholds can nonetheless have difficulty with understanding speech in noisy backgrounds. The origins of such supra-threshold hearing deficits remain largely unclear. Previously we showed that the auditory brainstem response to running speech is modulated by selective attention, evidencing ...

journal_title：Scientific reports

authors： Saiz-Alía M,Forte AE,Reichenbach T

更新日期：2019-10-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Qiao Y,Berg AL,Wang P,Ge Y,Quan S,Zhou S,Wang H,Liu Z,Gong R

更新日期：2020-09-21 00:00:00

abstract：:Spectroscopic techniques combined with chemometrics methods have proven to be effective tools for the discrimination of objects with similar properties. In this work, terahertz time-domain spectroscopy (THz-TDS) combined with discriminate analysis (DA) and principal component analysis (PCA) with derivative pretreatmen...

journal_title：Scientific reports

authors： Xu W,Xie L,Ye Z,Gao W,Yao Y,Chen M,Qin J,Ying Y

更新日期：2015-07-08 00:00:00

abstract：:The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV serotypes (n = 20) within HAdV species D. Analysis of nucleotide seque...

journal_title：Scientific reports

authors： Robinson CM,Singh G,Lee JY,Dehghan S,Rajaiya J,Liu EB,Yousuf MA,Betensky RA,Jones MS,Dyer DW,Seto D,Chodosh J

更新日期：2013-01-01 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 k...

journal_title：Scientific reports

authors： Ishii A,Katsuura G,Imamaki H,Kimura H,Mori KP,Kuwabara T,Kasahara M,Yokoi H,Ohinata K,Kawanishi T,Tsuchida J,Nakamoto Y,Nakao K,Yanagita M,Mukoyama M,Mori K

更新日期：2017-11-14 00:00:00

abstract：:Axonal injury is a common feature of central nervous system insults that culminates with the death of the affected neurons, and an irreversible loss of function. Inflammation is an important component of the neurodegenerative process, where the microglia plays an important role by releasing proinflammatory factors as ...

journal_title：Scientific reports

authors： Nadal-Nicolás FM,Galindo-Romero C,Valiente-Soriano FJ,Barberà-Cremades M,deTorre-Minguela C,Salinas-Navarro M,Pelegrín P,Agudo-Barriuso M

更新日期：2016-12-08 00:00:00

abstract：:Converging evidence has proved the attentional bias of Internet addicts (IAs) on network information. However, previous studies have neither explained how characteristics of network information are detected by IAs with priority nor proved whether this advantage is in line with the unconscious and automatic process. To...

journal_title：Scientific reports

authors： He J,Zheng Y,Nie Y,Zhou Z

更新日期：2018-06-12 00:00:00

abstract：:The controllability of a network is a theoretical problem of relevance in a variety of contexts ranging from financial markets to the brain. Until now, network controllability has been characterized only on isolated networks, while the vast majority of complex systems are formed by multilayer networks. Here we build a...

journal_title：Scientific reports

authors： Menichetti G,Dall'Asta L,Bianconi G

更新日期：2016-02-12 00:00:00

abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

journal_title：Scientific reports

authors： García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

更新日期：2016-02-10 00:00:00

abstract：:To overcome drug resistance caused by apoptosis deficiency in patients with non-small cell lung carcinoma (NSCLC), there is a need to identify other means of triggering apoptosis-independent cancer cell death. We are the first to report that isogambogenic acid (iso-GNA) can induce apoptosis-independent autophagic cell...

journal_title：Scientific reports

authors： Yang J,Zhou Y,Cheng X,Fan Y,He S,Li S,Ye H,Xie C,Wu W,Li C,Pei H,Li L,Wei Z,Peng A,Wei Y,Li W,Chen L

更新日期：2015-01-09 00:00:00

abstract：:Beaver have been referred to as ecosystem engineers because of the large impacts their dam building activities have on the landscape; however, the benefits they may provide to fluvial fish species has been debated. We conducted a watershed-scale experiment to test how increasing beaver dam and colony persistence in a ...

journal_title：Scientific reports

authors： Bouwes N,Weber N,Jordan CE,Saunders WC,Tattam IA,Volk C,Wheaton JM,Pollock MM

更新日期：2016-07-04 00:00:00

abstract：:Sex-dependent effects of mismatched prenatal-postnatal maternal conditions are predicted by combining two evolutionary hypotheses: that foetal conditions provide a forecast of likely postnatal environments (Predictive Adaptive Response), and that the female foetus is better adapted than the male to maternal adversity ...

journal_title：Scientific reports

authors： Hill J,Pickles A,Wright N,Braithwaite E,Sharp H

更新日期：2019-02-21 00:00:00

abstract：:Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain injury and stroke indicat...

journal_title：Scientific reports

authors： Deleglise B,Lassus B,Soubeyre V,Doulazmi M,Brugg B,Vanhoutte P,Peyrin JM

更新日期：2018-08-02 00:00:00

abstract：:While previous studies separately demonstrate EEG spectral modulations during speech preparation and ERP responses to the listened speech, it is unclear whether these responses are related on a trial-by-trial basis between a speaker and listener. In order to determine whether these responses are related in real-time, ...

journal_title：Scientific reports

authors： Bridwell DA,Henderson S,Sorge M,Plis S,Calhoun VD

更新日期：2018-08-27 00:00:00

abstract：:The increasing incidence of obesity accentuates the importance of identifying mechanisms and optimal therapeutic strategies for patients with heart failure (HF) in relation to obesity status. Here, we investigated the association between plasma level of apelin, an adipocyte-derived factor, and clinicopathological feat...

journal_title：Scientific reports

authors： Boal F,Roumegoux J,Alfarano C,Timotin A,Calise D,Anesia R,Drougard A,Knauf C,Lagente C,Roncalli J,Desmoulin F,Tronchere H,Valet P,Parini A,Kunduzova O

更新日期：2015-11-06 00:00:00

abstract：:A hypereutectic Al-Fe-Cu alloy with a high-volume fraction ferro-aluminum second phase (AlFe phases for short) was reheated in the solid-liquid region and the microstructure evolution was investigated. During semisolid heating, the high-melting AlFe phases in the Al-Fe-Cu alloy were demonstrated to stunt the grain gro...

journal_title：Scientific reports

authors： Wang W,Liu B

更新日期：2021-01-15 00:00:00

abstract：:Modern flow cytometry instruments have become vital tools for high-throughput analysis of single cells. However, as issues with the cellular labeling techniques often used in flow cytometry have become more of a concern, the development of label-free modalities for cellular analysis is increasingly desired. Non-linear...

journal_title：Scientific reports

authors： Collier BB,Awasthi S,Lieu DK,Chan JW

更新日期：2015-05-29 00:00:00

abstract：:We study a minimal model of the stress-driven p53 regulatory network that includes competition between active and mutant forms of the tumor-suppressor gene p53. Depending on the nature and level of the external stress signal, four distinct dynamical states of p53 are observed. These states can be distinguished by diff...

journal_title：Scientific reports

authors： Jangid A,Malik MZ,Ramaswamy R,Singh RKB

更新日期：2021-01-27 00:00:00

abstract：:We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others' cooperation. Furthermore, we establish a general model for this kind of quantum secret sharing schemes and then ...

journal_title：Scientific reports

authors： Wang TY,Liu YZ,Wei CY,Cai XQ,Ma JF

更新日期：2017-05-30 00:00:00

abstract：:Determination of the absolute configrations for natural products is one of the most important and challenging tasks, especially when the molecules display high conformational flexibility. In this paper, eight new prenylxanthones, aspergixanthones A-H (1-8), and one known analogue (9), were isolated from the marine-der...

journal_title：Scientific reports

authors： Zhu A,Yang MY,Zhang YH,Shao CL,Wang CY,Hu LD,Cao F,Zhu HJ

更新日期：2018-07-13 00:00:00

abstract：:Heterogeneity is inherent to biology, thus it is imperative to realize methods capable of obtaining spatially-resolved genomic and transcriptomic profiles of heterogeneous biological samples. Here, we present a new method for local lysis of live adherent cells for nucleic acid analyses. This method addresses bottlenec...

journal_title：Scientific reports

authors： Kashyap A,Autebert J,Delamarche E,Kaigala GV

更新日期：2016-07-14 00:00:00

abstract：:Although microbes influence plant growth, little is known about the impact of microbial diversity on plant fitness trade-offs, intraspecific-interactions, and soil nutrient dynamics in the context of biodiversity-ecosystem functioning (BEF) research. The BEF theory states that higher species richness can enhance ecosy...

journal_title：Scientific reports

authors： Sahib MR,Pervaiz ZH,Williams MA,Saleem M,DeBolt S

更新日期：2020-09-22 00:00:00

abstract：:The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...

journal_title：Scientific reports

authors： Eilebrecht S,Hotz-Wagenblatt A,Sarachaga V,Burk A,Falida K,Chakraborty D,Nikitina E,Tessmer C,Whitley C,Sauerland C,Gunst K,Grewe I,Bund T

更新日期：2018-02-12 00:00:00

abstract：:The prognostic factors for survival among patients with secondary osteosarcoma remain unclear. The aim of this study was to develop a practical nomogram for predicting cancer-specific survival (CSS) in patients with osteosarcoma as a secondary malignancy. The surveillance, epidemiology, and end results database was us...

journal_title：Scientific reports

authors： He Y,Liu H,Wang S,Zhang J

更新日期：2020-07-30 00:00:00

abstract：:The objective of this study was to assess the diagnosis value of urinary inflammatory index (UII) and systemic immune-inflammation index (SII) for UTI. Nine inflammatory indexes including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, SII and six UIIs were calculated for Receiver operating characteristi...

journal_title：Scientific reports

authors： Gu W,Huang W,Zhang J,Qian S,Cao H,Ge L

更新日期：2020-11-09 00:00:00

abstract：:The micro-capillary condensation of a new high boiling point organic reagent (HBPO), is studied in a periodic mesoporous oxide (PMO) with ∼34 % porosity and k-value ∼2.3. At a partial pressure of 3 mT, the onset of micro-capillary condensation occurs around +20 °C and the low-k matrix is filled at -20 °C. The condense...

journal_title：Scientific reports

authors： Chanson R,Zhang L,Naumov S,Mankelevich YA,Tillocher T,Lefaucheux P,Dussart R,Gendt S,Marneffe JF

更新日期：2018-01-30 00:00:00

abstract：:Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked...

journal_title：Scientific reports

authors： Cisneros E,di Marco F,Rueda-Carrasco J,Lillo C,Pereyra G,Martín-Bermejo MJ,Vargas A,Sanchez R,Sandonís Á,Esteve P,Bovolenta P

更新日期：2020-03-20 00:00:00