Abstract:
:Hyperactivated mTOR signaling in the developing brain has been implicated in multiple forms of pathology including tuberous sclerosis complex (TSC). To date, various phenotypic defects such as cortical lamination irregularity, subependymal nodule formation, dysmorphic astrocyte differentiation and dendritic malformation have been described for patients and animal models. However, downstream networks affected in the developing brain by hyperactivated mTOR signaling have yet to be characterized. Here, we present an integrated analysis of transcriptomes and proteomes generated from wild-type and Tsc1/Emx1-Cre forebrains. This led to comprehensive lists of genes and proteins whose expression levels were altered by hyperactivated mTOR signaling. Further incorporation of TSC patient data followed by functional enrichment and network analyses pointed to changes in molecular components and cellular processes associated with neuronal differentiation and morphogenesis as the key downstream events underlying developmental and morphological defects in TSC. Our results provide novel and fundamental molecular bases for understanding hyperactivated mTOR signaling-induced brain defects which can in turn facilitate identification of potential diagnostic markers and therapeutic targets for mTOR signaling-related neurological disorders.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shin J,Kim M,Jung HJ,Cha HL,Suh-Kim H,Ahn S,Jung J,Kim Y,Jun Y,Lee S,Hwang D,Kim Jdoi
10.1038/s41598-017-02842-6subject
Has Abstractpub_date
2017-06-06 00:00:00pages
2826issue
1issn
2045-2322pii
10.1038/s41598-017-02842-6journal_volume
7pub_type
杂志文章abstract::Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients' quality of life. It is believed that the crosstalk between metastatic breast cancer cells and osteoclasts is critical for breast cancer-induced osteolysis. In this study, the effect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19074
更新日期:2016-01-08 00:00:00
abstract::A novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10179
更新日期:2015-07-10 00:00:00
abstract::Gas flow behavior in porous media with micro- and nanoscale pores has always been attracted great attention. Gas transport mechanism in such pores is a complex problem, which includes continuous flow, slip flow and transition flow. In this study, the microtubes of quartz microcapillary and nanopores alumina membrane w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46430-2
更新日期:2019-07-15 00:00:00
abstract::A previous randomized, controlled trial had demonstrated that complete intraureteral stent placement (CIU-SP) was superior to conventional stent placement (C-SP) in terms of improvement of stent-related urinary symptoms. However, it is unclear as to which subdomain symptom and cohort could benefit the most from CIU-SP...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-72937-0
更新日期:2020-09-28 00:00:00
abstract::A novel turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA (ssDNA) was established by combining Y-shaped DNA duplex and G-quadruplex-hemin DNAzyme. A G-rich single-stranded DNA (Oligo-1) displays peroxidase mimicking catalytic activity due to the specific binding with hemin in the pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30529-z
更新日期:2018-08-13 00:00:00
abstract::Understanding the behaviour of humpback whale mother-calf pairs and the acoustic environment on their breeding grounds is fundamental to assessing the biological and ecological requirements needed to ensure a successful migration and survival of calves. Therefore, on a breeding/resting ground, Exmouth Gulf, Western Au...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36870-7
更新日期:2019-01-25 00:00:00
abstract::The influenza A virus RNA polymerase cleaves the 5' end of host pre-mRNAs and uses the capped RNA fragments as primers for viral mRNA synthesis. We performed deep sequencing of the 5' ends of viral mRNAs from all genome segments transcribed in both human (A549) and mouse (M-1) cells infected with the influenza A/HongK...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06181
更新日期:2014-08-26 00:00:00
abstract::Ceramide (Cer) release from glucosylceramides (GlcCer) is critical for the formation of the skin permeability barrier. Changes in β-glucocerebrosidase (GlcCer'ase) activity lead to diminished Cer, GlcCer accumulation and structural defects in SC lipid lamellae; however, the molecular basis for this impairment is not c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06990-7
更新日期:2017-07-25 00:00:00
abstract::The interplay between spin states and metallization in compressed CoCl2 is investigated by combining diffraction, resistivity and spectroscopy techniques under high-pressure conditions and ab-initio calculations. A pressure-induced metallization along with a Co2+ high-spin (S = 3/2) to low-spin (S = 1/2) crossover tra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41337-4
更新日期:2019-04-01 00:00:00
abstract::Fusarium wilt is one of the major biotic stresses reducing chickpea productivity. The use of wilt-resistant cultivars is the most appropriate means to combat the disease and secure productivity. As a step towards understanding the molecular basis of wilt resistance in chickpea, we investigated the transcriptomes of wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07114-x
更新日期:2017-08-10 00:00:00
abstract::Parent selection is the core of hybrid breeding. The breeding strategy involving the parental identification of superior open-pollinated progeny of Populous tomentosa germplasm resources can significantly improve the efficiency of parental matching. However, due to some factors such as loose powdering time and pollen ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74941-w
更新日期:2020-10-29 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-54946-w
更新日期:2019-12-02 00:00:00
abstract::Several mosquito species have been described as vectors for the Zika virus (ZIKV), such as those in the Aedes, Anopheles, Mansonia and Culex genera. Our previous survey studies were found the ZIKV RNA positive in both male, female and larvae of Culex quinquefasciatus Say and Aedes aegypti (L.) mosquitoes collected fro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41727-8
更新日期:2019-03-27 00:00:00
abstract::Metabolomics has emerged as a powerful approach to comprehensively interrogate cellular biochemistry. As such, we applied an untargeted liquid chromatography-mass spectrometry metabolomic strategy to elucidate metabolome changes in the anthracnose-causing hemibiotrophic sorghum pathogen, Colletotrichum sublineolum. An...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38692-7
更新日期:2019-03-01 00:00:00
abstract::In Australia, significant shifts in species distribution have occurred with the loss of megafauna, changes in indigenous Australian fire regime and land-use changes with European settlement. The emu, one of the last megafaunal species in Australia, has likely undergone substantial distribution changes, particularly ne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79551-0
更新日期:2021-01-13 00:00:00
abstract::High content of organic matter in the downstream of watersheds underscored the severity of non-point source (NPS) pollution. The major objectives of this study were to characterize and quantify dissolved organic matter (DOM) in watersheds affected by NPS pollution, and to apply self-organizing map (SOM) and parallel f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16079
更新日期:2015-11-03 00:00:00
abstract::Receipt of broad-spectrum antibiotics enhances Candida albicans colonization of the GI tract, a risk factor for haematogenously-disseminated candidiasis. To understand how antibiotics influence C. albicans colonization, we treated mice orally with vancomycin or a combination of penicillin, streptomycin, and gentamicin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08131
更新日期:2015-02-03 00:00:00
abstract::Highly efficient and specific biomolecular recognition requires both affinity and specificity. Previous quantitative descriptions of biomolecular recognition were mostly driven by improving the affinity prediction, but lack of quantification of specificity. We developed a novel method SPA (SPecificity and Affinity) ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00309
更新日期:2012-01-01 00:00:00
abstract::Transforming growth factor-β (TGF-β) signaling plays a key role in progression and metastasis of HCC. This study was undertaken to gain the proof of concept of a small-molecule inhibitor of TGF-β type I receptor kinase, EW-7197 as a potent anti-cancer therapy for HCC. We identified tissue inhibitors of metalloproteina...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16492
更新日期:2015-11-09 00:00:00
abstract::The proton exchange membrane fuel cells are the promising sustainable energy sources. The present study focuses on the enhancement the fuel cell performance and the protection of the stainless steel bipolar plate from the corrosion using polyaniline/Zn-Porphyrin composites coatings. The electrochemical properties (pol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60288-9
更新日期:2020-02-24 00:00:00
abstract::The annotation of protein function is a vital step to elucidate the essence of life at a molecular level, and it is also meritorious in biomedical and pharmaceutical industry. Developments of sequencing technology result in constant expansion of the gap between the number of the known sequences and their functions. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37179
更新日期:2016-11-16 00:00:00
abstract::The quest to 'forward-engineer' and fabricate biological machines remains a grand challenge. Towards this end, we have fabricated locomotive "bio-bots" from hydrogels and cardiomyocytes using a 3D printer. The multi-material bio-bot consisted of a 'biological bimorph' cantilever structure as the actuator to power the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00857
更新日期:2012-01-01 00:00:00
abstract::The reliable identification of diffuse large B-cell lymphoma (DLBCL)-specific targets owns huge implications for its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are implicated in DLBCL pathogenesis; however, circulating DLBCL-related lncRNAs are barely investigated. We investigated plasma lncRNAs; HOTAIR, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81715-5
更新日期:2021-01-22 00:00:00
abstract::OVGP1 is the major non-serum glycoprotein in the oviduct fluid at the time of fertilization and early embryo development. Its activity differs among species. Here, we show that the C-terminal region of recombinant OVGP1 regulates its binding to the extracellular zona pellucida and affects its activity during fertiliza...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32556
更新日期:2016-09-07 00:00:00
abstract::Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17997
更新日期:2015-12-09 00:00:00
abstract::Long non-coding RNAs (lncRNAs) form the largest transcript class in the human transcriptome. These lncRNA are expressed not only in the cells, but they are also present in the cell-derived extracellular vesicles such as exosomes. The function of these lncRNAs in cancer biology is not entirely clear, but they appear to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24922
更新日期:2016-04-22 00:00:00
abstract::Actinorhizal plants are ecologically and economically important. Symbiosis with nitrogen-fixing bacteria allows these woody dicotyledonous plants to colonise soils under nitrogen deficiency, water-stress or other extreme conditions. However, proteins involved in xerotolerance of symbiotic microorganisms have yet to be...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18839-0
更新日期:2018-01-15 00:00:00
abstract::In our experiment, it was observed that the emission of direct-gap band in germanium with Ge-GeSn layers on one-dimensional (1D) structure. The results of experiment and calculation demonstrate that the uniaxial tensile strain in the (111) and (110) direction can efficiently transform Ge to a direct bandgap material w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24802
更新日期:2016-04-21 00:00:00
abstract::Reperfusion alters post-myocardial infarction (MI) healing; however, very few systematic studies report the early molecular changes following ischemia/reperfusion (I/R). Alterations in the remote myocardium have also been neglected, disregarding its contribution to post-MI heart failure (HF) development. This study ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11985-5
更新日期:2017-09-27 00:00:00
abstract::Tumor necrosis factor (TNF) is best known for inducing a rapid but transient NF-κB-mediated inflammatory response. We investigated later phases of TNF signaling, after the initial transient induction of inflammatory genes has subsided, in primary human macrophages. TNF signaling induced expression of late response gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31959
更新日期:2016-08-25 00:00:00