Effect of Active and Passive Smoking on Retinal Nerve Fibre Layer and Ganglion Cell Complex.


:Aim. To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG). Materials and Methods. We include 80 active chronic smokers and 80 age- and sex-matched healthy passive smokers. After a full ophthalmological examination, SD-OCT and PERG were tested for all participants. Urinary levels of cotinine and creatinine with subsequent calculation of the cotinine creatinine ratio (CCR). Results. Inferior and superior quadrants of RNFL were thinner in group I, but nasal and temporal quadrants did not show significant difference between the groups. There were no significant differences of GCC values between the two groups. There was no significant difference of PERG-P50 amplitude and latency; however, PERG-N95 showed significant difference between the two groups. Multiple regression analyses demonstrated that the number of cigarettes/day, urinary cotinine, and PERG-N95 amplitude are the most important determinants for both superior and inferior RNFL thicknesses. Conclusion. RNFL thickness decreases in chronic, healthy, heavy cigarette smokers, and this thinning is related to the number of cigarettes/day, urinary cotinine, and PERG-N95 latency and amplitude.


J Ophthalmol


Journal of ophthalmology


El-Shazly AAE,Farweez YAT,Elewa LS,Elzankalony YA,Farweez BAT




Has Abstract


2017-01-01 00:00:00










  • Ocular surface development and gene expression.

    abstract::The ocular surface-a continuous epithelial surface with regional specializations including the surface and glandular epithelia of the cornea, conjunctiva, and lacrimal and meibomian glands connected by the overlying tear film-plays a central role in vision. Molecular and cellular events involved in embryonic developme...

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    authors: Swamynathan SK

    更新日期:2013-01-01 00:00:00

  • Estimation of the Corneal Young's Modulus In Vivo Based on a Fluid-Filled Spherical-Shell Model with Scheimpflug Imaging.

    abstract::Current intraocular pressure (IOP) measurement using air puff could be erroneous without applying proper corrections. Although noncontact tonometry is not considered to be accurate, it is still popularly used by eye clinics. It is thus necessary to extract the correct information from their results. This study propose...

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    authors: Shih PJ,Huang CJ,Huang TH,Lin HC,Yen JY,Wang IJ,Cao HJ,Shih WP,Dai CA

    更新日期:2017-01-01 00:00:00

  • A Novel CRYBB2 Stopgain Mutation Causing Congenital Autosomal Dominant Cataract in a Chinese Family.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Zhou Y,Zhai Y,Huang L,Gong B,Li J,Hao F,Wu Z,Shi Y,Yang Y

    更新日期:2016-01-01 00:00:00

  • Assessment of Macular Parameter Changes in Patients with Keratoconus Using Optical Coherence Tomography.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Sahebjada S,Amirul Islam FM,Wickremasinghe S,Daniell M,Baird PN

    更新日期:2015-01-01 00:00:00

  • Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Shen X,Zhu M,Kang L,Tu Y,Li L,Zhang R,Qin B,Yang M,Guan H

    更新日期:2018-07-11 00:00:00

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    abstract::Purpose. Ischemic central retinal vein occlusion (CRVO) eyes are at high risk of developing neovascular glaucoma (NVG). Our purpose is to investigate the effect of anti-VEGF therapy for macular edema after CRVO on the development of neovascular glaucoma (NVG) in ischemic CRVO eyes. Methods. This is a retrospective cas...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Ryu CL,Elfersy A,Desai U,Hessburg T,Edwards P,Gao H

    更新日期:2014-01-01 00:00:00

  • ATF4 Involvement in TLR4 and LOX-1-Induced Host Inflammatory Response to Aspergillus fumigatus Keratitis.

    abstract:Purpose:Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis. Methods:A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epitheli...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Zhang S,Meng P,Liu G,Liu K,Che C

    更新日期:2018-12-13 00:00:00

  • Macular retinal ganglion cell complex thickness and its relationship to the optic nerve head topography in glaucomatous eyes with hemifield defects.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Takagi ST,Kita Y,Takeyama A,Tomita G

    更新日期:2011-01-01 00:00:00

  • Relative Contributions of Intracranial Pressure and Intraocular Pressure on Lamina Cribrosa Behavior.

    abstract:Purpose:To characterize the relative contributions of intraocular pressure (IOP) and intracranial pressure (ICP) on lamina cribrosa (LC) behavior, specifically LC depth (LCD) and LC peak strain. Methods:An axially symmetric finite element model of the posterior eye was constructed with an elongated optic nerve and ret...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Tong J,Ghate D,Kedar S,Gu L

    更新日期:2019-03-17 00:00:00

  • An extensive replication study on three new susceptibility Loci of primary angle closure glaucoma in han chinese: jiangsu eye study.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Shi H,Zhu R,Hu N,Shi J,Zhang J,Jiang L,Jiang H,Guan H

    更新日期:2013-01-01 00:00:00

  • Changes in Retinal Vasculature and Thickness after Small Incision Lenticule Extraction with Optical Coherence Tomography Angiography.

    abstract:Purpose:To evaluate the changes in retinal vessel density and thickness after small incision lenticule extraction (SMILE) with optical coherence tomography angiography (OCTA) in myopic patients. Methods:In this prospective study, SMILE surgeries were done in 46 eyes of 24 patients with spherical equivalent (SE) more t...

    journal_title:Journal of ophthalmology

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    authors: Chen M,Dai J,Gong L

    更新日期:2019-05-20 00:00:00

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    authors: Habroosh FA,Eatamadi H

    更新日期:2020-07-15 00:00:00

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    journal_title:Journal of ophthalmology

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    authors: Lourthai P,Bhurayanontachai P

    更新日期:2017-01-01 00:00:00

  • Local Relationship between Global-Flash Multifocal Electroretinogram Optic Nerve Head Components and Visual Field Defects in Patients with Glaucoma.

    abstract::Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...

    journal_title:Journal of ophthalmology

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    authors: Moon CH,Han J,Ohn YH,Park TK

    更新日期:2015-01-01 00:00:00

  • Agreement between Gonioscopic Examination and Swept Source Fourier Domain Anterior Segment Optical Coherence Tomography Imaging.

    abstract::Purpose. To evaluate interobserver, intervisit, and interinstrument agreements for gonioscopy and Fourier domain anterior segment optical coherence tomography (FD ASOCT) for classifying open and narrow angle eyes. Methods. Eighty-six eyes with open or narrow anterior chamber angles were included. The superior angle wa...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Rigi M,Bell NP,Lee DA,Baker LA,Chuang AZ,Nguyen D,Minnal VR,Feldman RM,Blieden LS

    更新日期:2016-01-01 00:00:00

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    authors: Huang L,Sun L,Wang Z,Li S,Chen C,Luo X,Ding X

    更新日期:2021-01-06 00:00:00

  • Reporting the Undiagnosed Cases of Hepatitis B and Hepatitis C Viruses among Patients Undergoing Elective Eye Surgery in a Specialized Eye Hospital in Egypt.

    abstract:Introduction:Hepatitis B virus (HBV) and hepatitis C virus (HCV) and their long-term sequelae are considered a major health issue in Egypt. The aim of this study is to determine the prevalence of undiagnosed hepatitis B virus (HBV) and hepatitis C virus (HCV) among patients admitted for elective eye surgery in a specia...

    journal_title:Journal of ophthalmology

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    authors: Dahab AA,Youssef MM,Eid HM,Elsadi KW

    更新日期:2019-07-01 00:00:00

  • Correlation of Myopia with Physical Exercise and Sleep Habits among Suburban Adolescents.

    abstract:Purpose:To analyse the correlation of myopia with physical exercise and sleep habits to explore the possible risk or protective factors of juvenile myopia. Methods:This study was a retrospective cross-sectional study. A total of 1831 students aged 11-18 years from five schools in Qingpu completed questionnaires from 2...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Qu Y,Yu J,Xia W,Cai H

    更新日期:2020-07-25 00:00:00

  • Measurement of the Orbital Soft Tissue Volume in Chinese Adults Based on Three-Dimensional CT Reconstruction.

    abstract::Quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases. The purpose of this study is to establish a computed tomography- (CT-) based three-dimensional (3D) reconstruction model and measure the orbital soft tissue volume in Chinese adults. We collected da...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Du Y,Lu BY,Chen J,He JF

    更新日期:2019-07-02 00:00:00

  • Double Retinal Tamponade for Treatment of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy and Inferior Breaks.

    abstract:Purpose:To evaluate the efficacy and safety of the simultaneous use of short-term perfluoro-n-octane (PFO) with perfluoropropane (C3F8) gas to achieve retinal reattachment in eyes with rhegmatogenous retinal detachment (RRD) with proliferative vitreoretinopathy (PVR) grade C and multiple retinal breaks including inferi...

    journal_title:Journal of ophthalmology

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  • Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea?

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    authors: Satue M,Idoipe M,Gavin A,Romero-Sanz M,Liarakos VS,Mateo A,Garcia-Martin E,Blasco-Martinez A,Sanchez-Perez A

    更新日期:2018-09-23 00:00:00

  • A Novel Device to Exploit the Smartphone Camera for Fundus Photography.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Russo A,Morescalchi F,Costagliola C,Delcassi L,Semeraro F

    更新日期:2015-01-01 00:00:00

  • Femtosecond Laser Implantation of a 355-Degree Intrastromal Corneal Ring Segment in Keratoconus: A Three-Year Follow-Up.

    abstract:Purpose:To evaluate the outcomes of femtosecond laser-assisted implantation of a 355-degree intracorneal ring (ICR) (Keraring) in patients with keratoconus in the three-year follow-up. Setting:Future Femtolaser Center, Sohag, Egypt. Design:Prospective interventional case series. Patients and Methods:A prospective ca...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Abdellah MM,Ammar HG

    更新日期:2019-10-09 00:00:00

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    abstract::Methylglyoxal (MG) is an intermediate of glucose metabolism and the precursor of advanced glycation end products (AGEs) found in high levels in blood or tissue of diabetic patients. MG and AGEs are thought to play a major role in the pathogenesis of diabetic retinopathy. In order to determine if zebrafish is valuable ...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Li Y,Zhao Y,Sang S,Leung T

    更新日期:2019-04-17 00:00:00

  • The Role of RPGR and Its Interacting Proteins in Ciliopathies.

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    更新日期:2015-01-01 00:00:00

  • Effect of trandolapril on regression of retinopathy in hypertensive patients with type 2 diabetes: a prespecified analysis of the benedict trial.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


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    更新日期:2010-01-01 00:00:00

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Sachdev N,Aquino MC,Loon SC,Chan YH,Chew P,Koh V

    更新日期:2018-03-25 00:00:00

  • The Degeneration and Apoptosis Patterns of Cone Photoreceptors in rd11 Mice.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Zhang H,Li X,Dai X,Han J,Zhang Y,Qi Y,He Y,Liu Y,Chang B,Pang JJ

    更新日期:2017-01-01 00:00:00

  • A Cross-Knotted Suture Basket Technique for Large Nonmagnetic Intraocular Foreign Body Removal.

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    journal_title:Journal of ophthalmology

    pub_type: 杂志文章


    authors: Cao J,Chen B,Li Y

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    pub_type: 杂志文章


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    更新日期:2018-02-04 00:00:00