Abstract:
:Aim. To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG). Materials and Methods. We include 80 active chronic smokers and 80 age- and sex-matched healthy passive smokers. After a full ophthalmological examination, SD-OCT and PERG were tested for all participants. Urinary levels of cotinine and creatinine with subsequent calculation of the cotinine creatinine ratio (CCR). Results. Inferior and superior quadrants of RNFL were thinner in group I, but nasal and temporal quadrants did not show significant difference between the groups. There were no significant differences of GCC values between the two groups. There was no significant difference of PERG-P50 amplitude and latency; however, PERG-N95 showed significant difference between the two groups. Multiple regression analyses demonstrated that the number of cigarettes/day, urinary cotinine, and PERG-N95 amplitude are the most important determinants for both superior and inferior RNFL thicknesses. Conclusion. RNFL thickness decreases in chronic, healthy, heavy cigarette smokers, and this thinning is related to the number of cigarettes/day, urinary cotinine, and PERG-N95 latency and amplitude.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
El-Shazly AAE,Farweez YAT,Elewa LS,Elzankalony YA,Farweez BATdoi
10.1155/2017/6354025subject
Has Abstractpub_date
2017-01-01 00:00:00pages
6354025eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
杂志文章abstract:Purpose:Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis. Methods:A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epitheli...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/5830202
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abstract::Purpose. To assess the different check sizes of pattern visual evoked potential (PVEP) in diabetic patients without retinopathy according to HbA1c levels and diabetes duration. Methods. Fifty-eight eligible patients with type 2 diabetes mellitus and 26 age- and sex-matched healthy controls were included in the study. ...
journal_title:Journal of ophthalmology
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doi:10.1155/2017/8597629
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journal_title:Journal of ophthalmology
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abstract::Purpose. To analyze optical coherence tomography angiography (OCTA) findings in eyes with central serous chorioretinopathy (CSC) and to compare them with those obtained with multimodal imaging. Methods. A series of consecutive patients diagnosed with CSC, underwent OCTA and multimodal imaging, including spectral domai...
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pub_type: 杂志文章
doi:10.1155/2017/1842176
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journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2015/254260
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1155/2015/315281
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doi:10.1155/2018/2840246
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pub_type: 杂志文章,评审
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journal_title:Journal of ophthalmology
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doi:10.1155/2020/7217906
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abstract::[This corrects the article DOI: 10.1155/2016/3690140.]. ...
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