Gradually Then Suddenly? Decline in Vision-Related Quality of Life as Glaucoma Worsens.

Abstract:

:Purpose. To evaluate the relationship between self-reported vision-related quality of life (VRQL) and visual field (VF) loss in people from glaucoma clinics. Methods. A postal survey using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was administered to people with a range of VF loss identified from a UK hospital-based glaucoma service database. Trends were assessed in a composite score from NEI VFQ-25 against better-eye mean deviation (BEMD) using linear regression and a spline-fitting method that can highlight where a monotonic relationship may have different stages. Results. A total of 636 patients (median [interquartile range] BEMD -2.1 [-5.2, -0.4] dB, median age 70 [60, 77] years) were analysed. Analysis of trends in the data revealed an average patient loses approximately 2 units (out of 100) on NEI VFQ-25 for every loss of 1 dB (BEMD) as VF defects first become bilateral, up to BEMD -5 dB. NEI VFQ-25 deterioration then appears to slow before a more rapid phase of change (4-5 units per 1 dB loss) after BEMD worsens beyond -15 dB. Conclusions. Relationship between decline in VRQL and VF worsening in glaucoma is unlikely to be linear; it more likely has different phases, and these should be further explored in longitudinal studies.

journal_name

J Ophthalmol

journal_title

Journal of ophthalmology

authors

Jones L,Bryan SR,Crabb DP

doi

10.1155/2017/1621640

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

1621640

eissn

2090-004X

issn

2090-0058

journal_volume

2017

pub_type

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