Abstract：
:Here we review evidence that loss of photoreceptors due to degenerative retinal disease causes an increase in the rate of spontaneous ganglion spike discharge. Information about persistent spike activity is important since it is expected to add noise to the communication between the eye and the brain and thus impact the design and effective use of retinal prosthetics for restoring visual function in patients blinded by disease. Patch-clamp recordings from identified types of ON and OFF retinal ganglion cells in the adult (36-210 d old) rd1 mouse show that the ongoing oscillatory spike activity in both cell types is driven by strong rhythmic synaptic input from presynaptic neurons that is blocked by CNQX. The recurrent synaptic activity may arise in a negative feedback loop between a bipolar cell and an amacrine cell that exhibits resonant behavior and oscillations in membrane potential when the normal balance between excitation and inhibition is disrupted by the absence of photoreceptor input.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Margolis DJ,Detwiler PBdoi
10.1155/2011/507037subject
Has Abstractpub_date
2011-01-01 00:00:00eissn
2090-004Xissn
2090-0058journal_volume
2011pub_type
杂志文章abstract：:Aim. To investigate the utility of fundus autofluorescence (FAF) and optical coherence tomography (OCT) in the evaluation of cystoid macular edema (CME) following cataract surgery. Materials and Methods. Forty eyes of 29 patients undergone phacoemulsification, with posterior chamber intraocular lens implantation surge...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2013/376013
更新日期：2013-01-01 00:00:00
abstract：Purpose:To evaluate contrast sensitivity (CS) changes in acute central serous chorioretinopathy (CSC). Methods:Visual acuity (VA), CS, and subretinal fluid (SRF) were evaluated monthly for 6 months. Treatment was considered at 3 months in case of persistent SRF. Results:Twelve of 20 eyes (60%) had spontaneous SRF res...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/9053932
更新日期：2017-01-01 00:00:00
abstract：:Purpose. To compare fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) images of foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) with and without diabetic macular ischemia (DMI). Methods. The Wilcoxon signed-rank test was used to compare area measurements and p valu...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/3989310
更新日期：2016-01-01 00:00:00
abstract：:Retinitis pigmentosa (RP) represents a clinically and genetically heterogeneous disease characterized by progressive photoreceptor loss. In recent years, research has been rarely made in blood flow affected in RP. The specific mechanism of blood flow affected in RP is not completely clear. A number of studies indicate...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2018/3249064
更新日期：2018-02-25 00:00:00
abstract：:Purpose. To evaluate intraobserver and interobserver agreement in locating the scleral spur landmark (SSL) and anterior chamber angle measurements obtained using Fourier Domain Anterior Segment Optical Coherence Tomography (ASOCT) images. Methods. Two independent, masked observers (SR and AZC) identified SSLs on ASOCT...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2012/487309
更新日期：2012-01-01 00:00:00
abstract：Purpose:To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27- AAU in the population of Slovenian patients. Methods:Retrospective study of hospitalized patients with AAU in the last 39 mo...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/6079146
更新日期：2020-09-19 00:00:00
abstract：Introduction:Hepatitis B virus (HBV) and hepatitis C virus (HCV) and their long-term sequelae are considered a major health issue in Egypt. The aim of this study is to determine the prevalence of undiagnosed hepatitis B virus (HBV) and hepatitis C virus (HCV) among patients admitted for elective eye surgery in a specia...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/3985865
更新日期：2019-07-01 00:00:00
abstract：Purpose:To ascertain wet AMD (wAMD) management patterns in Spain. Methods:A two-round Delphi study conducted through a questionnaire-based survey designed from literature review and validated by an independent Steering Committee. Results:Forty-nine retina specialists experienced in wAMD participated by answering the ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/9821509
更新日期：2019-09-30 00:00:00
abstract：Purpose:To investigate the refraction and ocular biometry characteristics and to examine the prevalence of refractive errors in preschool children aged 3 to 6 years in Shanghai, China. Methods:A school-based cross-sectional study was conducted in Jiading and Xuhui District, Shanghai, in 2013. We randomly selected 7 ki...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/5205946
更新日期：2018-03-05 00:00:00
abstract：:Purpose. This study retrospectively analyzed cataract surgeries to examine the usefulness of Surgical Media Center (SMC) (Abbott Medical Optics Inc.), a new cataract surgery recording device, for training of cataract surgery. Methods. We studied five hundred cataract surgeries conducted with a phacoemulsification syst...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/8435086
更新日期：2016-01-01 00:00:00
abstract：Purpose:To evaluate the outcomes of femtosecond laser-assisted implantation of a 355-degree intracorneal ring (ICR) (Keraring) in patients with keratoconus in the three-year follow-up. Setting:Future Femtolaser Center, Sohag, Egypt. Design:Prospective interventional case series. Patients and Methods:A prospective ca...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/6783181
更新日期：2019-10-09 00:00:00
abstract：:Purpose. To evaluate the effectiveness and safety of perfluorohexyloctane (F6H8) for intraoperative flattening of the retina and of F6H8/silicone oil (SO) 1000 cSt as a postoperative tamponade for inferior retinal detachment with inferior proliferative vitreoretinopathy. Methods. This is a retrospective review of 22 p...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/956831
更新日期：2014-01-01 00:00:00
abstract：:Purpose. We report the effect of isotretinoin on corneal topography, corneal thickness, and biomechanical parameters in patients with acne vulgaris. Method. Fifty-four eyes of 54 patients who received oral isotretinoin for treatment of acne vulgaris were evaluated. All patients underwent a corneal topographical evalua...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/701361
更新日期：2014-01-01 00:00:00
abstract：:Purpose. To evaluate the corneal higher-order aberrations (HOA), contrast sensitivity function (CSF), and light distortion (LD) in patients undergoing orthokeratology (OK). Methods. Twenty healthy subjects (mean age: 21.40 ± 8 years) with mean spherical equivalent refractive error M = -2.19 ± 0.97 D were evaluated at ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/8453462
更新日期：2016-01-01 00:00:00
abstract：:Idiopathic full-thickness macular hole is a severe visual impairment disease. Pars plana vitrectomy remains the primary treatment option for idiopathic full-thickness macular holes, and over 90% idiopathic full-thickness macular holes are closed by vitrectomy surgery. However, the full-thickness macular hole may close...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2019/4793764
更新日期：2019-03-13 00:00:00
abstract：Purpose:The iStent provides a direct pathway for aqueous outflow from the anterior chamber to Schlemm's canal in patients with open-angle glaucoma (OAG). We performed a meta-analysis to evaluate the effectiveness of iStent as a standalone operation in patients with OAG in reducing the intraocular pressure (IOP) and the...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2020/8754730
更新日期：2020-05-24 00:00:00
abstract：:Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/397495
更新日期：2015-01-01 00:00:00
abstract：Background:To evaluate the outcome and complications of transscleral suture-fixated posterior chamber intraocular lens (PCIOL) implantation combined with Ahmed glaucoma valve (AGV) surgery in Asian eyes. Design:This was a retrospective study that included 22 eyes from 22 participants. The surgeries were performed at S...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/9824035
更新日期：2018-03-25 00:00:00
abstract：:Objective. To describe the clinicoradiological and histopathological findings in a case of lacrimal gland enlargement secondary to lymphomatoid granulomatosis (LG) and to review the literature. Design. Case report and systematic literature review. Methods. A 75-year-old woman presented with right ptosis. Computerised ...
journal_title：Journal of ophthalmology
pub_type：
doi：10.1155/2010/358121
更新日期：2010-01-01 00:00:00
abstract：Purpose:To compare two calculators for toric intraocular lens (IOL) calculation and to evaluate the prediction of refractive outcome. Methods:Sixty-four eyes of forty-five patients underwent cataract surgery followed by implantation of a toric intraocular lens (Zeiss Torbi 709 M) calculated by a standard industry calc...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/2840246
更新日期：2018-01-10 00:00:00
abstract：:Purpose. To report a new clinical finding related to Fabry disease. Methods. Fabry subjects were enrolled in the study, matched for age and sex with healthy individuals as a control group. This is a prospective review of all upper lid pictures taken for every subject at their last visit. A 4-step grading scale is prop...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2013/207573
更新日期：2013-01-01 00:00:00
abstract：Background:Uveal melanoma (UM) is the most common primary intraocular tumor in adults and arises from the uvea. Marital status was a vital factor among physical conditions and social networks of cancer patients. Our study aimed to evaluate the impact of marital status on the outcomes among patients with UM. Methods:Pa...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/7012940
更新日期：2020-12-04 00:00:00
abstract：:Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evalua...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2013/895147
更新日期：2013-01-01 00:00:00
abstract：:Purpose. To evaluate the anterior chamber volume in cataract patients with Swept-Source Optical Coherence Tomography (SS-OCT) and its influencing factors. Methods. Anterior chamber volume of 92 cataract patients was evaluated with SS-OCT in this cross-sectional study. Univariate analyses and multiple linear regression...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/8656301
更新日期：2016-01-01 00:00:00
abstract：:Purpose. To measure central corneal thickness (CCT) in patients with history of nonarteritic anterior ischemic optic neuropathy (NAION). Patients and Methods. Patients older than 40 years with a history of NAION (group 1) were prospectively evaluated including full eye examination and central corneal thickness (CCT) p...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2014/904373
更新日期：2014-01-01 00:00:00
abstract：Background:The advantage of using an autostereoscopic smartphone is that it can achieve 3D effects without the need for glasses. The purpose of this study was to evaluate whether this technology could be utilized to detect stereoacuity. Methods:An autostereoscopic smartphone was used to imitate Lang stereotest I & II,...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/1570309
更新日期：2019-10-31 00:00:00
abstract：Objective:To evaluate optical coherence tomography (OCT) findings of pediatric Alport syndrome (AS) patients with no retinal pathology on fundus examination. Materials and Methods:Twenty-one patients being followed up with the diagnosis of AS (Group 1) and 24 age- and sex-matched healthy volunteers (Group 2) were pros...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/6741930
更新日期：2019-01-21 00:00:00
abstract：:Objective. Compare glaucoma medication costs between the United States (USA) and Canada. Methods. We modelled glaucoma brand name and generic medication annual costs in the USA and Canada based on October 2013 Costco prices and previously reported bottle overfill rates, drops per mL, and wastage adjustment. We also ca...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/547960
更新日期：2015-01-01 00:00:00
abstract：:Aim. The aim of this study was to determine the intra- and interobserver variability of two Scheimpflug based camera systems, Pentacam and Sirius. In addition, the comparability of the measurements was tested in healthy subjects, subjects with regular astigmatism, and keratoconus patients. Methods. Intra- and interobs...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/315281
更新日期：2015-01-01 00:00:00
abstract：Purpose:To determine the significance of any association between intersessional changes in ocular residual astigmatism (RA) and astigmatism at corneal front (FSA) and back (BSA) surfaces following uneventful routine phacoemulsification. Methods:Astigmatism was evaluated by autorefractometry and subjective refraction a...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/7395081
更新日期：2020-07-22 00:00:00
