Abstract:
Purpose:To ascertain wet AMD (wAMD) management patterns in Spain. Methods:A two-round Delphi study conducted through a questionnaire-based survey designed from literature review and validated by an independent Steering Committee. Results:Forty-nine retina specialists experienced in wAMD participated by answering the two-round study questionnaire. Retina specialists are the main responsible for wAMD diagnosis and monitoring, including visits and associated procedures, with a median time per visit of 15 minutes. Standard treatment strategies are based on anti-VEGF administration, including standard loading dose administration followed by maintenance with aflibercept or ranibizumab (81% of patients). Although treat and extend (T&E) dosing strategy is considered as optimal for wAMD management (78% of the panelists), the main routine healthcare limitations (i.e., visits overload, reduced staff, short visit time, coordination issues, lack of facilities) conduct to self-defined "flexible" strategies, based on T&E and pro-re-nata (PRN) protocols. Conclusion:Proactive treatment patterns (T&E) are the preferred ones by the retina specialists in Spain. However, their proper implementation is difficult due to healthcare resource limitations, as well as organisation and logistic issues. The use of anti-VEGF agents with longer duration of action could facilitate the use of strict T&E approaches according to routine clinical practices.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
García-Layana A,García-Arumí J,Figueroa MS,Arias Barquet L,Ruíz-Moreno JM,Monclús-Arbona L,The Spanish Amd Multicenter Groupdoi
10.1155/2019/9821509subject
Has Abstractpub_date
2019-09-30 00:00:00pages
9821509eissn
2090-004Xissn
2090-0058journal_volume
2019pub_type
杂志文章abstract::Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Oxidative stress plays a large role in the pathogenesis of AMD. The present study was to evaluate the effects of Fructus lycii ethanol extract on AMD in mice and to investigate whether combination of lutein and zeaxanthin, two carotenoid p...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/862806
更新日期:2013-01-01 00:00:00
abstract::Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/397495
更新日期:2015-01-01 00:00:00
abstract::We aimed to investigate the efficacy of frequency doubling technology (FDT) perimetry for glaucoma detection in comprehensive screening examinations. We performed a retrospective analysis of prospectively collected data of participants who underwent a comprehensive health checkup service. Participants with glaucoma we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/4687398
更新日期:2020-03-29 00:00:00
abstract::Purpose. To evaluate the outcome of combined vitrectomy with phacoemulsification without postoperative face-down positioning for idiopathic macular holes (MHs). Design. Retrospective, observational case series. Participants. Forty-two eyes of 42 patients with MH. Methods. We studied 42 eyes of 42 cases followed up for...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2012/571748
更新日期:2012-01-01 00:00:00
abstract:Purpose:To evaluate a new tangential map-based nomogram versus the axial map-based nomogram for ICRS in keratoconus. Methods:A prospective case series study including 64 eyes of 64 patients who underwent ICRS implantation. Cone location was determined for each eye with two maps: the axial and the tangential. Appropria...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/3983508
更新日期:2020-02-19 00:00:00
abstract::Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evalua...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2013/895147
更新日期:2013-01-01 00:00:00
abstract::Dry eye syndrome is a disease of the ocular surface and tear film that is prevalent in older adults. Even though the degree of visual acuity loss in dry eye patients is commonly mild-to-moderate, in the aging population, this minimal change in visual status can lead to a significant decrease in visual function and qua...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2014/781683
更新日期:2014-01-01 00:00:00
abstract:Purpose:To compare the outcomes of Ex-PRESS glaucoma filtration device and transscleral cyclophotocoagulation (TSCP) in the management of neovascular glaucoma (NVG). Patients and Methods. A total of 30 eyes (12 express shunts and 18 TSCP) of 28 patients were included. The eyes had NVG with intraocular pressure (IOP) mo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/3781249
更新日期:2020-05-17 00:00:00
abstract::Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measureme...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/193078
更新日期:2015-01-01 00:00:00
abstract::The ciliary body ablation is still considered as a last resort treatment to reduce the intraocular pressure (IOP) in uncontrolled glaucoma. Several ablation techniques have been proposed over the years, all presenting a high rate of complications, nonselectivity for the target organ, and unpredictable dose-effect rela...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2017/7136275
更新日期:2017-01-01 00:00:00
abstract::Familial exudative vitreoretinopathy (FEVR) is a hereditary ocular disorder characterized by incomplete vascularization/abnormality of peripheral retina. Four of the identified disease-causing genes of FEVR were NDP, FZD4, LRP5, and TSPAN12, the protein coded by which were the components of the Norrin/β-catenin signal...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/5782536
更新日期:2019-11-16 00:00:00
abstract::Purpose. The aim of this study is to investigate the etiology and the clinical, microbiological, histopathological, and radiological findings of acquired dacryocystoceles. Methods. In this retrospective study, we reviewed the clinical records of 10 eyes of 8 patients with dacryocystoceles who underwent external dacryo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/396782
更新日期:2014-01-01 00:00:00
abstract:Purpose:To describe a modified technique of white line advancement posterior ptosis surgery and to report the success rate of the procedure. Methods:A retrospective case series of 60 patients who presented with ptosis with good levator function. The success rate was defined as an MRD1 of greater than or equal to 3.5 m...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/9021848
更新日期:2020-07-15 00:00:00
abstract:Purpose:To analyze the results of three-year outcomes of combined epithelium-on cross-linking with femtosecond laser ICRS (cross-linking PLUS) for keratoconus management. Design:A retrospective multicenter clinical study. Methods:43 eyes of 38 patients were subjected to preoperative and postoperative UCVA, BCVA, refr...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6907573
更新日期:2018-01-17 00:00:00
abstract::Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), for treatment of amblyopia in adult patients. Methods. Visual stimuli were presented anaglyphically...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/615213
更新日期:2014-01-01 00:00:00
abstract::Objective. The purpose of this study was to examine how patient, physician, and situational factors are associated with the extent to which providers educate patients about glaucoma and glaucoma medications, and which patient and provider characteristics are associated with whether providers educate patients about gla...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/238939
更新日期:2014-01-01 00:00:00
abstract:Purpose:To analyze the "in vitro" aberrometric pattern of a refractive IOL and two extended depth of focus IOLs. Methods:A special optical bench with a Shack-Hartmann wavefront sensor (SH) was designed for the measurement. Three presbyopia correction IOLs were analyzed: Mini WELL (MW), TECNIS Symfony ZXR00 (SYM), and ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/7095734
更新日期:2017-01-01 00:00:00
abstract:Background:Endoplasmic reticulum stress (ERS) in the retinal Müller cells is a key factor contributing to the retinal inflammation and vascular leakage in diabetic retinopathy (DR). This study was to investigate the underlying mechanisms through which the 3 main unfolded protein response (UPR) pathways regulate ERS and...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9028483
更新日期:2019-02-24 00:00:00
abstract::Background. The aim of this study is to investigate the ocular thermographic profiles in age-related macular degeneration (AMD) eyes and age-matched controls to detect possible hemodynamic abnormalities, which could be involved in the pathogenesis of the disease. Methods. 32 eyes with early AMD, 37 eyes with atrophic ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/281010
更新日期:2014-01-01 00:00:00
abstract::Central retinal vein occlusion (CRVO) is a common retinal disease. Recent works mentioned spontaneous retinal arterial pulsations (SRAPs) as a feature of some CRVOs. This is a retrospective study on patients presenting with CRVO who were followed up for at least 6 months. The objective was to identify SRAP in the acut...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/3107472
更新日期:2020-06-09 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/3690140.]. ...
journal_title:Journal of ophthalmology
pub_type: 已发布勘误
doi:10.1155/2019/6212745
更新日期:2019-06-11 00:00:00
abstract::Objective. We aimed to assess peripheral vascular endothelial function in open-angle glaucoma (POAG) by measuring flow-mediated dilatation (FMD). Materials and Methods. The study included 20 cases with POAG (group 1, mean age 58.68 ± 13.3 years) and 30 healthy individuals (group 2, mean age 58.68 ± 13.6 years). In all...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/529082
更新日期:2014-01-01 00:00:00
abstract::Purpose. To describe the SD-OCT findings in patients with diffuse unilateral subacute neuroretinitis (DUSN) and evaluate CRT and RNFL thickness. Methods. Patients with clinical diagnosis of DUSN who were submitted to SD-OCT were included in the study. Complete ophthalmologic examination and SD-OCT were performed. Cirr...
journal_title:Journal of ophthalmology
pub_type:
doi:10.1155/2011/285296
更新日期:2011-01-01 00:00:00
abstract:Purpose:To determine the significance of any association between intersessional changes in ocular residual astigmatism (RA) and astigmatism at corneal front (FSA) and back (BSA) surfaces following uneventful routine phacoemulsification. Methods:Astigmatism was evaluated by autorefractometry and subjective refraction a...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/7395081
更新日期:2020-07-22 00:00:00
abstract:Purpose:Activating transcription factor 4 (ATF4) is induced by various stressors. Here, we investigated the expression of ATF4 in the host inflammatory response to Aspergillus fumigatus (A. fumigatus) keratitis. Methods:A. fumigatus keratitis mouse models developed by intrastromal injection as well as corneal epitheli...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/5830202
更新日期:2018-12-13 00:00:00
abstract::Purpose. To evaluate the anterior chamber volume in cataract patients with Swept-Source Optical Coherence Tomography (SS-OCT) and its influencing factors. Methods. Anterior chamber volume of 92 cataract patients was evaluated with SS-OCT in this cross-sectional study. Univariate analyses and multiple linear regression...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8656301
更新日期:2016-01-01 00:00:00
abstract:Purpose:To evaluate the effect of corneal cap thickness on visual acuity and corneal biomechanics in small incision lenticule extraction (SMILE) for the treatment of myopia. Methods:Forty eyes of 20 patients undergoing SMILE for the treatment of myopia were enrolled in this prospective controlled study. The patients w...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6040873
更新日期:2018-06-28 00:00:00
abstract:Purpose:To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods:A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients wh...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/7419470
更新日期:2019-01-15 00:00:00
abstract:Purpose:The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods:We searched a number of electronic databases, including MEDLINE, EMBA...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/7697416
更新日期:2019-05-02 00:00:00
abstract:Purpose:To evaluate the response of intravitreal aflibercept injection (IAI) in eyes with detachment of retinal pigment epithelium (DEP) secondary to nAMD refractory to monthly ranibizumab. Patients and Methods:This is a retrospective, multicenter study. All patients received 3 IAI then treated as needed every 4 weeks...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/8984313
更新日期:2017-01-01 00:00:00