Abstract：
:Purpose. We report the effect of isotretinoin on corneal topography, corneal thickness, and biomechanical parameters in patients with acne vulgaris. Method. Fifty-four eyes of 54 patients who received oral isotretinoin for treatment of acne vulgaris were evaluated. All patients underwent a corneal topographical evaluation with a Scheimpflug camera combined with Placido-disk (Sirius), ultrasonic pachymetry measurements, and corneal biomechanical evaluation with an ocular response analyzer at baseline, in the 1st, 3rd, and 6th months of treatment, and 6 months after isotretinoin discontinuation. Results. The thinnest corneal thickness measured with Sirius differed significantly in the 1st, 3rd, and 6th months compared with the baseline measurement; there was no significant change in ultrasonic central corneal thickness measurements and biomechanical parameters (corneal hysteresis and corneal resistance factor) throughout the study. Average simulated keratometry and surface asymmetry index increased significantly only in the first month of treatment according to the baseline. All changes disappeared 6 months after the end of treatment. Conclusion. Basal tear secretion and corneal morphologic properties were significantly influenced during the systemic isotretinoin treatment and the changes were reversible after discontinuation. No statistical important biomechanical differences were found to be induced by isotretinoin.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Yildirim Y,Olcucu O,Agca A,Alagoz C,Demircan A,Basci A,Demirok A,Kutlubay Zdoi
10.1155/2014/701361subject
Has Abstractpub_date
2014-01-01 00:00:00pages
701361eissn
2090-004Xissn
2090-0058journal_volume
2014pub_type
杂志文章abstract：Background:Endoplasmic reticulum stress (ERS) in the retinal Müller cells is a key factor contributing to the retinal inflammation and vascular leakage in diabetic retinopathy (DR). This study was to investigate the underlying mechanisms through which the 3 main unfolded protein response (UPR) pathways regulate ERS and...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/9028483
更新日期：2019-02-24 00:00:00
abstract：Aims:To determine the accuracy and repeatability of new software to automatically quantify GA areas associated to age-related macular degeneration (AMD) by swept-source optical coherence tomography (SS-OCT). Settings and Design. Tertiary referral hospital in Spain. Cross-sectional and noninterventional. Methods and Mat...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/8204641
更新日期：2020-08-05 00:00:00
abstract：:Purpose. Randomized controlled trial aimed at comparing surgical outcomes in a group of patients suffering from hyperfunction of the inferior oblique (IO) muscle with abnormal head position (AHP). The surgical techniques being compared are Recession and (thread) Controlled Myotomy. Materials and Methods. The group of ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/1725484
更新日期：2016-01-01 00:00:00
abstract：:Purpose. To compare the clinical features of community-associated (CA) and healthcare-associated (HA) methicillin-resistant Staphylococcus aureus (MRSA) keratitis. Methods. Patients presenting with culture-proven MRSA keratitis between January 1, 2006, and December 31, 2010, at Chang Gung Memorial Hospital, Taiwan, we...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2015/923941
更新日期：2015-01-01 00:00:00
abstract：:The aim of this study was to assess the oxidative stress status in eyes affected by synchysis scintillans and to compare it to vitreoretinal disorders without synchysis scintillans. Human aqueous and vitreous humors were obtained during vitrectomy from thirty-seven otherwise healthy patients that were randomly chosen ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/7231015
更新日期：2019-10-30 00:00:00
abstract：Purpose:To evaluate contrast sensitivity (CS) changes in acute central serous chorioretinopathy (CSC). Methods:Visual acuity (VA), CS, and subretinal fluid (SRF) were evaluated monthly for 6 months. Treatment was considered at 3 months in case of persistent SRF. Results:Twelve of 20 eyes (60%) had spontaneous SRF res...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/9053932
更新日期：2017-01-01 00:00:00
abstract：:The costs for glaucoma care are rising worldwide. The main reason is the increase of life expectancy and the increasing variety of diagnostic tests and therapeutically options by implants and devices. How can we influence the increase in costs? Does a relationship exist between the rising costs and the behavior of pat...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2020/5901537
更新日期：2020-04-08 00:00:00
abstract：:Methylglyoxal (MG) is an intermediate of glucose metabolism and the precursor of advanced glycation end products (AGEs) found in high levels in blood or tissue of diabetic patients. MG and AGEs are thought to play a major role in the pathogenesis of diabetic retinopathy. In order to determine if zebrafish is valuable ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/2746735
更新日期：2019-04-17 00:00:00
abstract：Purpose:To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods:A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients wh...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/7419470
更新日期：2019-01-15 00:00:00
abstract：:Objective. To describe the clinicoradiological and histopathological findings in a case of lacrimal gland enlargement secondary to lymphomatoid granulomatosis (LG) and to review the literature. Design. Case report and systematic literature review. Methods. A 75-year-old woman presented with right ptosis. Computerised ...
journal_title：Journal of ophthalmology
pub_type：
doi：10.1155/2010/358121
更新日期：2010-01-01 00:00:00
abstract：Purpose:The aim of this work was to describe the ultrastructure and behavior of peeled internal limiting membrane (ILM) in macular hole (MH) surgery. Methods:Seven patients with MH were included, and vitrectomy with ILM peeling was performed in all patients. The ILM inverted flap technique was used. Two other flaps of...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/1345683
更新日期：2019-05-02 00:00:00
abstract：:Current data permit only speculations regarding sex differences in the prevalence of infectious uveitis between women and men because uveitis case surveys do not uniformly report gender data. Differences in prevalence that are reported in the literature could relate to simple differences in the number of women and men...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2014/683246
更新日期：2014-01-01 00:00:00
abstract：:Purpose. To examine causes as well as extent of delay in diagnosis and treatment of primary open angle glaucoma patients in a sample of Egyptians. Patients and Methods. 440 patients with primary open angle glaucoma were interviewed to evaluate delay in their diagnosis and treatment. The extent and cause of delay were ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/7012826
更新日期：2016-01-01 00:00:00
abstract：Purpose:Although optical coherence tomography (OCT) is essential for ophthalmologists, reading of findings requires expertise. The purpose of this study is to test deep learning with image augmentation for automated detection of chorioretinal diseases. Methods:A retina specialist diagnosed 1,200 OCT images. The diagno...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/6319581
更新日期：2019-04-09 00:00:00
abstract：Purpose:To investigate the refraction and ocular biometry characteristics and to examine the prevalence of refractive errors in preschool children aged 3 to 6 years in Shanghai, China. Methods:A school-based cross-sectional study was conducted in Jiading and Xuhui District, Shanghai, in 2013. We randomly selected 7 ki...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/5205946
更新日期：2018-03-05 00:00:00
abstract：:Here we review evidence that loss of photoreceptors due to degenerative retinal disease causes an increase in the rate of spontaneous ganglion spike discharge. Information about persistent spike activity is important since it is expected to add noise to the communication between the eye and the brain and thus impact t...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2011/507037
更新日期：2011-01-01 00:00:00
abstract：:Background. The effect of angiotensin converting enzyme inhibitors (ACEi) on regression of retinopathy in type 2 diabetics is still ill defined. Methods. We compared the incidence of retinopathy regression in 90 hypertensive type 2 diabetics randomized to at least 3-year blinded ACEi with trandolapril (2 mg/day) or no...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2010/106384
更新日期：2010-01-01 00:00:00
abstract：:Purpose. To compare fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) images of foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) with and without diabetic macular ischemia (DMI). Methods. The Wilcoxon signed-rank test was used to compare area measurements and p valu...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/3989310
更新日期：2016-01-01 00:00:00
abstract：:The new type implantable Collamer lens with a central hole (V4c-ICL) is widely used to treat myopia. However, halos occur in some patients after surgery. The aim is to evaluate the effect of V4c-ICL implantation on vision-related daily activities. This retrospective study included 42 patients. Uncorrected visual acuit...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/5717932
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:To evaluate the effect of preoperative intravitreal bevacizumab (IVB) injection on the surgical outcome of Ahmed glaucoma valve (AGV) implantation according to the angle status in neovascular glaucoma (NVG) eyes. MATERIALS AND METHODS:This retrospective study included 70 NVG patients who underwent AGV implanta...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/7672485
更新日期：2017-01-01 00:00:00
abstract：:Purpose. To evaluate the effectiveness of deep sclerectomy with T-flux implant (DS T-flux) in patients with pseudoexfoliation glaucoma (PExG). Methods. 20 eyes of 18 patients with medically uncontrolled PExG have undergone DS T-flux implantation. Postoperatively we evaluated the IOP values and the frequency of complic...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2017/6923208
更新日期：2017-01-01 00:00:00
abstract：:Purpose. To compare the surgically induced astigmatism from clear corneal and square posterior limbal incisions at the time of cataract surgery. Methods. Surgically induced astigmatism was calculated for a set of eyes after cataract surgery using a temporal 2.2 mm square posterior limbal incision. Results were compare...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2011/243170
更新日期：2011-01-01 00:00:00
abstract：Purpose:To assess anterior corneal surface stability 12 months following hyperopic LASIK correction with a light propagation algorithm. Setting:Vissum Instituto Oftalmológico de Alicante, Universidad Miguel Hernández, Alicante, Spain. Methods:This retrospective consecutive observational study includes 37 eyes of 37 p...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/3060939
更新日期：2018-03-28 00:00:00
abstract：:Purpose. To investigate tear function, ocular manifestations, and squamous metaplasia of the conjunctival epithelium (SMCE) in children with end stage renal failure (ESRF) on dialysis. Methods. Thirty children with ESRF and 20 age and sex matched controls during the period from January 2014 to May 2015 underwent full ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2016/4767819
更新日期：2016-01-01 00:00:00
abstract：:Central retinal vein occlusion (CRVO) is a common retinal disease. Recent works mentioned spontaneous retinal arterial pulsations (SRAPs) as a feature of some CRVOs. This is a retrospective study on patients presenting with CRVO who were followed up for at least 6 months. The objective was to identify SRAP in the acut...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2020/3107472
更新日期：2020-06-09 00:00:00
abstract：Purpose:To ascertain wet AMD (wAMD) management patterns in Spain. Methods:A two-round Delphi study conducted through a questionnaire-based survey designed from literature review and validated by an independent Steering Committee. Results:Forty-nine retina specialists experienced in wAMD participated by answering the ...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/9821509
更新日期：2019-09-30 00:00:00
abstract：:The ciliary body ablation is still considered as a last resort treatment to reduce the intraocular pressure (IOP) in uncontrolled glaucoma. Several ablation techniques have been proposed over the years, all presenting a high rate of complications, nonselectivity for the target organ, and unpredictable dose-effect rela...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2017/7136275
更新日期：2017-01-01 00:00:00
abstract：Purpose:To evaluate the outcomes of femtosecond laser-assisted implantation of a 355-degree intracorneal ring (ICR) (Keraring) in patients with keratoconus in the three-year follow-up. Setting:Future Femtolaser Center, Sohag, Egypt. Design:Prospective interventional case series. Patients and Methods:A prospective ca...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2019/6783181
更新日期：2019-10-09 00:00:00
abstract：Background:Chromatic contrast may affect stereopsis. Daltonism is a common color deficiency in which the colors red and green are incorrectly detected. The aim of this study was to evaluate the stereoacuity of color-defective individuals presented with color symbols that they see defectively. Methods:Ten students diag...
journal_title：Journal of ophthalmology
pub_type： 杂志文章
doi：10.1155/2018/1926736
更新日期：2018-08-01 00:00:00
abstract：Purpose:The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods:We searched a number of electronic databases, including MEDLINE, EMBA...
journal_title：Journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1155/2019/7697416
更新日期：2019-05-02 00:00:00
