Abstract：
:The recognition of the pathogenicity of Cutibacterium acnes in implant-associated infection is not always obvious. In this paper, we aimed to distinguish pathogenic and non-pathogenic C. acnes isolates. To reach this goal, we investigated the clonal complex (CC) of a large collection of C. acnes clinical isolates through Multi-Locus Sequence Typing (MLST), we established a Caenorhabditis elegans model to assess C. acnes virulence and we investigated the presence of virulence factors in our collection. Ours results showed that CC36 and CC53 C. acnes isolates were more frequently observed in prosthetic joint infections (PJI) than CC18 and CC28 C. acnes isolates (p = 0.021). The C. elegans model developed here showed two distinct virulence groups of C. acnes (p < 0.05). These groups were not correlated to CC or clinical origin. Whole genome sequencing allowed us to identify a putative gene linked to low virulent strains. In conclusion, MLST remains a good method to screen pathogenic C. acnes isolates according to their clinical context but mechanisms of C. acnes virulence need to be assess thought transcriptomic analysis to investigate regulatory process.
journal_name
Anaerobejournal_title
Anaerobeauthors
Aubin GG,Lavigne JP,Foucher Y,Dellière S,Lepelletier D,Gouin F,Corvec Sdoi
10.1016/j.anaerobe.2017.04.009subject
Has Abstractpub_date
2017-10-01 00:00:00pages
73-78eissn
1075-9964issn
1095-8274pii
S1075-9964(17)30076-8journal_volume
47pub_type
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