Tropism and virulence of Cutibacterium (formerly Propionibacterium) acnes involved in implant-associated infection.


:The recognition of the pathogenicity of Cutibacterium acnes in implant-associated infection is not always obvious. In this paper, we aimed to distinguish pathogenic and non-pathogenic C. acnes isolates. To reach this goal, we investigated the clonal complex (CC) of a large collection of C. acnes clinical isolates through Multi-Locus Sequence Typing (MLST), we established a Caenorhabditis elegans model to assess C. acnes virulence and we investigated the presence of virulence factors in our collection. Ours results showed that CC36 and CC53 C. acnes isolates were more frequently observed in prosthetic joint infections (PJI) than CC18 and CC28 C. acnes isolates (p = 0.021). The C. elegans model developed here showed two distinct virulence groups of C. acnes (p < 0.05). These groups were not correlated to CC or clinical origin. Whole genome sequencing allowed us to identify a putative gene linked to low virulent strains. In conclusion, MLST remains a good method to screen pathogenic C. acnes isolates according to their clinical context but mechanisms of C. acnes virulence need to be assess thought transcriptomic analysis to investigate regulatory process.






Aubin GG,Lavigne JP,Foucher Y,Dellière S,Lepelletier D,Gouin F,Corvec S




Has Abstract


2017-10-01 00:00:00














  • Diversity of Clostridium difficile in pigs and other animals in Slovenia.

    abstract::A study of Clostridium difficile diversity in pigs, calves and horses in Slovenia was conducted. A total of 547 samples were collected and C. difficile was isolated from 247/485 (50.9%) piglet samples, from 4/42 (9.5%) calf samples, and 1/20 (5%) horse samples. The isolates were characterized by toxinotyping, PCR-ribo...


    pub_type: 杂志文章


    authors: Avbersek J,Janezic S,Pate M,Rupnik M,Zidaric V,Logar K,Vengust M,Zemljic M,Pirs T,Ocepek M

    更新日期:2009-12-01 00:00:00

  • Susceptibility profiles and resistance genes for carbapenems (cfiA) and metronidazole (nim) among Bacteroides species in a Turkish University Hospital.

    abstract::Sixty-six nonduplicate Bacteroides clinical isolates collected at Marmara University Hospital were tested to investigate carbapenem and metronidazole resistance profiles and to detect the resistance genes (cfiA and nim) and related insertion sequence (IS) elements. The study found that there were no strains resistant ...


    pub_type: 杂志文章


    authors: Toprak NU,Uzunkaya OD,Sóki J,Soyletir G

    更新日期:2012-02-01 00:00:00

  • In vitro comparative evaluation of the impact of lacto-N-biose I, a major building block of human milk oligosaccharides, on the fecal microbiota of infants.

    abstract::Lacto-N-biose I (LNB) is a potential factor for the selective growth of bifidobacteria. We previously reported that the species of bifidobacteria predominant in infant intestines might use LNB. We aimed to assess the prebiotic properties of LNB in comparison to other oligosaccharides using an in vitro fermentation sys...


    pub_type: 杂志文章


    authors: Satoh T,Odamaki T,Namura M,Shimizu T,Iwatsuki K,Nishimoto M,Kitaoka M,Xiao JZ

    更新日期:2013-02-01 00:00:00

  • Periodontal microflora of HIV infected patients with periodontitis.

    abstract::The aim of this study was to determine the microbial profile of periodontal lesions in HIV seropositive patients and to compare it with rapidly progressing periodontal lesions in systemically healthy patients. The subgingival microflora of 20 CDC II, 20 CDC III, 20 CDC IV/V and 20 systemically healthy patients with ra...


    pub_type: 杂志文章


    authors: Nakou M,Kamma J,Gargalianos P,Laskaris G,Mitsis F

    更新日期:1997-04-01 00:00:00

  • Characterization of a bacteriocin produced by Lactobacillus sakei R1333 isolated from smoked salmon.

    abstract::Strain R1333, isolated from commercially available smoked salmon, was identified as Lactobacillus sakei based on biochemical tests, sugar fermentation reactions (API 50 CHL), PCR with species-specific primers and sequencing of the 16S rRNA gene. Strain R1333 produces a 3811 kDa class IIa bacteriocin, active against St...


    pub_type: 杂志文章


    authors: Todorov SD,Rachman C,Fourrier A,Dicks LM,van Reenen CA,Prévost H,Dousset X

    更新日期:2011-02-01 00:00:00

  • A rare case of pleural effusion due to Prevotella dentalis.

    abstract::Prevotella dentalis is a Gram-negative anaerobic rod involved in various human diseases, especially oral infections. We report a rare case of a pleural effusion due to this microorganism in an elderly patient. An 88-year-old man with chronic respiratory disease presented with a left pleural effusion for more than 1 mo...


    pub_type: 杂志文章


    authors: Cobo F,Calatrava E,Rodríguez-Granger J,Sampedro A,Aliaga-Martínez L,Navarro-Marí JM

    更新日期:2018-12-01 00:00:00

  • An in vitro time-kill assessment of linezolid and anaerobic bacteria.

    abstract::Linezolid is a novel oxazolidinone antibacterial agent active against staphylococci (including methicillin-resistant strains), enterococci (including vancomycin-resistant strains), streptococci (including penicillin-intermediate and -resistant Streptococcus pneumoniae), and other aerobic and facultative bacteria. The ...


    pub_type: 杂志文章


    authors: Yagi BH,Zurenko GE

    更新日期:2003-02-01 00:00:00

  • Antimicrobial susceptibility profiles of oral Treponema species.

    abstract::Treponemes occur in the microflora of the dental plaque. Certain Treponema species that are frequently isolated from chronic periodontitis lesions are involved in its initiation and progression. In addition to mechanical instrumentation, antimicrobial agents are used as an adjunctive treatment modality for periodontit...


    pub_type: 杂志文章


    authors: Okamoto-Shibayama K,Sekino J,Yoshikawa K,Saito A,Ishihara K

    更新日期:2017-12-01 00:00:00

  • ent-Copalic acid antibacterial and anti-biofilm properties against Actinomyces naeslundii and Peptostreptococcus anaerobius.

    abstract::Diterpenes are an important class of plant metabolites that can be used in the search for new antibacterial agents. ent-Copalic acid (CA), the major diterpene in Copaifera species exudates, displays several pharmacological properties. This study evaluates the CA antibacterial potential against the anaerobic bacteria P...


    pub_type: 杂志文章


    authors: Souza MGM,Leandro LF,Moraes TDS,Abrão F,Veneziani RCS,Ambrosio SR,Martins CHG

    更新日期:2018-08-01 00:00:00

  • A Europe-wide assessment of antibiotic resistance rates in Bacteroides and Parabacteroides isolates from intestinal microbiota of healthy subjects.

    abstract::Here, we sought to assess the levels of antibiotic resistance among intestinal Bacteroides and Parabacteroides strains collected between 2014 and 2016 in Europe and also attempted to compare resistance levels between clinical and commensal isolates. Bacteroides and Parabacteroides isolates were recovered from faecal s...


    pub_type: 杂志文章


    authors: Sóki J,Wybo I,Hajdú E,Toprak NU,Jeverica S,Stingu CS,Tierney D,Perry JD,Matuz M,Urbán E,Nagy E,ESCMID Study Group on Anaerobic Infections.

    更新日期:2020-04-01 00:00:00

  • An indirect ELISA for serodiagnosis of cattle footrot caused by Fusobacterium necrophorum.

    abstract::A serodiagnostic ELISA (rL-ELISA) using recombinant truncated leukotoxin protein PL2 (aa 311-644) of Fusobacterium necrophorum as antigen was developed for detection of antibodies against F. necrophorum from cattle footrot. In rL-ELISA, the recombinant diagnostic antigen showed no cross-reaction with antisera against ...


    pub_type: 杂志文章


    authors: Guo DH,Sun DB,Wu R,Yang HM,Zheng JS,Fan CL,Sun B,Wang JF

    更新日期:2010-08-01 00:00:00

  • Detection of resistance genes and susceptibility patterns in Bacteroides and Parabacteroides strains.

    abstract::Susceptibility to five antimicrobials was determined for Bacteroides spp. (n = 52) and Parabacteroides distasonis (n = 8). All isolates were susceptible to metronidazole. The resistance rates to ampicillin, cefoxitin, tetracycline and clindamycin were 98%, 9.6%, 65.3% and 19.2% of the Bacteroides strains, respectively...


    pub_type: 杂志文章


    authors: Boente RF,Ferreira LQ,Falcão LS,Miranda KR,Guimarães PL,Santos-Filho J,Vieira JM,Barroso DE,Emond JP,Ferreira EO,Paula GR,Domingues RM

    更新日期:2010-06-01 00:00:00

  • Diagnosis of Clostridium perfringens intestinal infections in sheep and goats.

    abstract::Clostridium perfringens produces disease in sheep, goats and other animal species, most of which are generically called enterotoxemias. This micro-organism can be a normal inhabitant of the intestine of most animal species including humans, but when the intestinal environment is altered by sudden changes in diet or ot...


    pub_type: 杂志文章


    authors: Uzal FA

    更新日期:2004-04-01 00:00:00

  • Low antibiotic resistance among anaerobic Gram-negative bacteria in periodontitis 5 years following metronidazole therapy.

    abstract::The objective of this study was to assess antibiotic susceptibility among predominant Gram-negative anaerobic bacteria isolated from periodontitis patients who 5 years prior had been subject to mechanical therapy with or without adjunctive metronidazole. One pooled sample was taken from the 5 deepest sites of each of ...


    pub_type: 杂志文章,随机对照试验


    authors: Dahlen G,Preus HR

    更新日期:2017-02-01 00:00:00

  • Real-time PCR quantification of the predominant bacterial divisions in the distal gut of Meishan and Landrace pigs.

    abstract::Firmicutes and Bacteroidetes are closely related to body fat in humans and mice, which are the two dominant bacterial divisions of gut microbiota in mammals. Here real-time PCR analysis indicated that Meishan pigs had a 34% reduction in percentage Bacteroidetes (P = 0.008) and a significantly lower proportion of Bacte...


    pub_type: 杂志文章


    authors: Guo X,Xia X,Tang R,Wang K

    更新日期:2008-10-01 00:00:00

  • Arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota.

    abstract::Rheumatoid arthritis (RA) and periodontitis (PD) are chronic inflammatory disorders that cause bone loss. PD tends to be more prevalent and severe in RA patients. Previous experimental studies demonstrated that RA triggers alveolar bone loss similarly to PD. The aim of this study was to investigate if arthritis-induce...


    pub_type: 杂志文章


    authors: Corrêa JD,Saraiva AM,Queiroz-Junior CM,Madeira MF,Duarte PM,Teixeira MM,Souza DG,da Silva TA

    更新日期:2016-06-01 00:00:00

  • Taxonomy--General comments and update on taxonomy of Clostridia and Anaerobic cocci.

    abstract::Since such things as sites of normal carriage, type and severity of infections produced, and antimicrobial susceptibility patterns may vary according to the particular species involved, accurate taxonomy for differentiation of species is important. For example, reclassification of the 'Bacteroides gracilis group' reve...


    pub_type: 杂志文章


    authors: Finegold SM,Song Y,Liu C

    更新日期:2002-10-01 00:00:00

  • Toxic effects of zinc on anaerobic microbiota from Zimapán Reservoir (Mexico).

    abstract::The toxic effects of heavy metals have been extensively documented in different organisms. Nevertheless, a lack of information exists with regard to this topic in the case of autochthonous microorganism communities. The aim of this study was to evaluate the toxic effects of zinc on the anaerobic microorganisms present...


    pub_type: 杂志文章


    authors: Vega-López A,Amora-Lazcano E,López-López E,Terrón O,Proal-Nájera JB

    更新日期:2007-04-01 00:00:00

  • Evaluation of the routine antimicrobial susceptibility testing results of clinically significant anaerobic bacteria in a Slovenian tertiary-care hospital in 2015.

    abstract::The aim of our study was to determined antimicrobial susceptibility profiles of 2673 clinically significant anaerobic bacteria belonging to the major genera, isolated in 2015 in a large tertiary-care hospital in Slovenia. The species identification was performed by MALDI-TOF mass spectrometry. Antimicrobial susceptibi...


    pub_type: 杂志文章


    authors: Jeverica S,Kolenc U,Mueller-Premru M,Papst L

    更新日期:2017-10-01 00:00:00

  • Effect of the corn silage to grass silage ratio and feed particle size of diets for ruminants on the ruminal Bacteroides-Prevotella community in vitro.

    abstract::This study examined whether different corn silage to grass silage ratios in ruminant rations and different grinding levels of the feed affect the composition of the ruminal Bacteroides-Prevotella community in vitro. Three diets, composed of 10% soybean meal as well as of different corn silage and grass silage proporti...


    pub_type: 杂志文章


    authors: Witzig M,Boguhn J,Kleinsteuber S,Fetzer I,Rodehutscord M

    更新日期:2010-08-01 00:00:00

  • Relationship between gastrointestinal dysbiosis and Clostridium botulinum in dairy cows.

    abstract::The gastrointestinal tract is a balanced ecosystem that can get out of balance and predisposed to clostridial diseases or other pathological conditions. The objective of the present study was to evaluate the gut microbiota in dairy cows suffering from chronic botulism. Cows were investigated for Clostridium (C.) botul...


    pub_type: 杂志文章


    authors: Krüger M,Shehata AA,Grosse-Herrenthey A,Ständer N,Schrödl W

    更新日期:2014-06-01 00:00:00

  • The role of anaerobic bacteria in acute and chronic mastoiditis.

    abstract::Mastoiditis (M) is the most common intratemporal complication of otitis media. The incidence of M has decreased since the advent of antimicrobial agents. In the last decade, however, there has been a marked increased in the incidence of acute M in several communities, sometimes in association with the growing resistan...


    pub_type: 杂志文章


    authors: Brook I

    更新日期:2005-10-01 00:00:00

  • Use of fluorescent staining and flow cytometry for monitoring physiological changes in solventogenic clostridia.

    abstract::Physiological changes in populations of Clostridium beijerinckii and Clostridium tetanomorphum were monitored by fluorescence staining and flow cytometry. To estimate the number of metabolically active cells in exponential growth, a combination of the dyes propidium iodide and carboxy fluorescein diacetate appeared to...


    pub_type: 杂志文章


    authors: Patakova P,Linhova M,Vykydalova P,Branska B,Rychtera M,Melzoch K

    更新日期:2014-10-01 00:00:00

  • Antimicrobial susceptibilities of clinical isolates of the anaerobic bacteria which can cause aspiration pneumonia.

    abstract::Aspiration pneumonia is an infectious disease of the lungs caused by inhalation of saliva or foods, associated with swallowing dysfunction. Therefore, the major causative organisms are oral or gastric bacteria. In this study, we evaluated the antimicrobial susceptibility patterns of the anaerobic bacteria which can ca...


    pub_type: 杂志文章


    authors: Fujita K,Takata I,Sugiyama H,Suematsu H,Yamagishi Y,Mikamo H

    更新日期:2019-06-01 00:00:00

  • Ultrastructure of Clostridium difficile colonies.

    abstract::The ultrastructural colony architecture of six Clostridium difficile strains belonging to four different ribotypes (001, 027, 078/126 and 036) was studied by scanning electron microscopy (SEM). In 2-day-old colonies several microareas differing in cell length and organization could be differentiated. Some cells at col...


    pub_type: 杂志文章


    authors: Lipovsek S,Leitinger G,Rupnik M

    更新日期:2013-12-01 00:00:00

  • The association of anaerobic bacteria with infectious mononucleosis.

    abstract::This review summarizes the information that supports the potential importance of anaerobic bacteria in the pharyngo-tonsillitis (PT) associated with infectious mononucleosis (IM). Evidence supportive of the potential of involvement of bacteria in IM was provided by several studies that showed increased recovery of bac...


    pub_type: 杂志文章


    authors: Brook I

    更新日期:2005-12-01 00:00:00

  • Postanginal sepsis syndrome with metastatic lung abscess in a young man.

    abstract::A postanginal Sepsis Syndrome with metastatic lung abscess caused by Fusobacterium necrophorumin a 25-year-old previously healthy man is described. The incomplete and ineffective antibiotic treatment at onset of angina ended progressively in septicaemia and metastatic infections in a 3-week time period. The early pare...


    pub_type: 杂志文章


    authors: Avlami A,Schina M,Tzivra M,Stefanou I,Papaparaskevas N,Sakellaropoulos N

    更新日期:1997-04-01 00:00:00

  • Intestinal microbiota diversity and expression of pattern recognition receptors in newly weaned piglets.

    abstract::This study evaluated the gastrointestinal microbial diversity and the expression of pattern recognition receptors (PRRs) of the small intestine during the first week post-weaning in newly weaned piglets. Sixteen piglets were sacrificed on days 0, 1, 4, and 7 post-weaning. Luminal contents from the stomach, ileum, and ...


    pub_type: 杂志文章


    authors: Tao X,Xu Z,Wan J

    更新日期:2015-04-01 00:00:00

  • The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

    abstract::Sporulation during Clostridioides difficile infection (CDI) contributes to recurrent disease. Cell division and sporulation both require peptidoglycan biosynthesis. We show C. difficile growth and sporulation is attenuated by antisenses to murA and murC or the MurA inhibitor fosfomycin. Thus, targeting the early steps...


    pub_type: 杂志文章


    authors: Sapkota M,Marreddy RKR,Wu X,Kumar M,Hurdle JG

    更新日期:2020-02-01 00:00:00

  • Prevalence of CTGCAG recognizing restriction and modification systems in ruminal selenomonades.

    abstract::Analysis of restriction and modification activities in natural population of Selenomonas ruminantium have revealed the prevalence of CTGCAG (Pst I isoschizomers) recognizing restriction and/or modification systems in these bacteria. Pst I isoschizomeric restriction endonucleases were detected in 4 out of 15 strains te...


    pub_type: 杂志文章


    authors: Molnarova V,Pristas P,Javorsky P

    更新日期:1999-02-01 00:00:00