Abstract：
:Obesity is among the most pressing health concerns in the world since it is increasingly common even in the developing world, and is clearly associated with increased risk for chronic debilitating diseases and death. Furthermore, obesity can influence the pathogenesis of infectious diseases by affecting the balance of pathogen clearance and pathological inflammation. The mechanisms that result in enhanced inflammation in obese individuals are poorly understood. Clostridium difficile is a major cause of nosocomial infections worldwide. Recent studies have shown that obesity is associated with increased risk of C. difficile infections. In this review, we will discuss our current knowledge of the role of obesity in determining risk of C. difficile infections, and focus on the role of the adipose tissue-derived cytokine leptin in C. difficile infections.
journal_name
Anaerobejournal_title
Anaerobeauthors
Madan R,Petri WA Jrdoi
10.1016/j.anaerobe.2014.12.009subject
Has Abstractpub_date
2015-08-01 00:00:00pages
182-6eissn
1075-9964issn
1095-8274pii
S1075-9964(15)00013-Xjournal_volume
34pub_type
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