Abstract：
:Ubiquitination is a reversible post-translational modification involved in a plethora of different physiological functions. Among the substrates that are ubiquitinated, neurotrophin receptors (TrkA, TrkB, TrkC, and p75NTR) have been studied recently. TrkA is the most studied receptor in terms of its ubiquitination, and different E3 ubiquitin ligases and deubiquitinases have been implicated in its ubiquitination, whereas not much is known about the other neurotrophin receptors aside from their ubiquitination. Additional studies are needed that focus on the ubiquitination of TrkB, TrkC, and p75NTR in order to further understand the role of ubiquitination in their physiological and pathological functions. Here we review what is currently known regarding the ubiquitination of neurotrophin receptors and its physiological and pathological relevance.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sánchez-Sánchez J,Arévalo JCdoi
10.3390/ijms18030630subject
Has Abstractpub_date
2017-03-14 00:00:00issue
3issn
1422-0067pii
ijms18030630journal_volume
18pub_type
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