Abstract：
:Silk fibroin (SF) is a protein-based biomacromolecule with excellent biocompatibility, biodegradability and low immunogenicity. The development of SF-based nanoparticles for drug delivery have received considerable attention due to high binding capacity for various drugs, controlled drug release properties and mild preparation conditions. By adjusting the particle size, the chemical structure and properties, the modified or recombinant SF-based nanoparticles can be designed to improve the therapeutic efficiency of drugs encapsulated into these nanoparticles. Therefore, they can be used to deliver small molecule drugs (e.g., anti-cancer drugs), protein and growth factor drugs, gene drugs, etc. This paper reviews recent progress on SF-based nanoparticles, including chemical structure, properties, and preparation methods. In addition, the applications of SF-based nanoparticles as carriers for therapeutic drugs are also reviewed.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zhao Z,Li Y,Xie MBdoi
10.3390/ijms16034880subject
Has Abstractpub_date
2015-03-04 00:00:00pages
4880-903issue
3issn
1422-0067pii
ijms16034880journal_volume
16pub_type
杂志文章,评审abstract：:Antrodan, a unique protein-bound polysaccharide derived from the fungal mycelia of Antrodia cinnamomea, has been reported to exhibit antitumor and anti-metastatic effects on Lewis lung carcinoma (LLC) cells through direct action and immunomodulation in vitro. In this study, we investigated the combined treatment of an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061565
更新日期：2018-05-24 00:00:00
abstract：:Humans are exposed to phthalates released from plastics, cosmetics, or food on a daily basis. Phthalates have low acute liver toxicity, but their chronic exposures could induce molecular and cellular effects linked to adverse health outcomes, such as liver tumor promotion or chronic liver diseases. The alternation of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176069
更新日期：2020-08-23 00:00:00
abstract：:KRAS oncogenic mutations are widespread in lung cancer and, because direct targeting of KRAS has proven to be challenging, KRAS-driven cancers lack effective therapies. One alternative strategy for developing KRAS targeted therapies is to identify downstream targets involved in promoting important malignant features, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165806
更新日期：2020-08-13 00:00:00
abstract：:Recent studies have shown that free fatty acids are associated with chronic inflammation, which may be involved in vascular injury. The intake of eicosapentaenoic acid (EPA) can decrease cardiovascular disease risks, but the protective mechanisms of EPA on endothelial cells remain unclear. In this study, primary human...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150610334
更新日期：2014-06-10 00:00:00
abstract：:Wounds are a largely unrecognized, spiraling epidemic that affect millions of people world-wide [...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
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更新日期：2019-04-08 00:00:00
abstract：:This review highlights the added value of PET imaging in Central Nervous System (CNS) tumors, which is a tool that has rapidly evolved from a merely diagnostic setting to multimodal molecular diagnostics and the guidance of targeted therapy. PET is the method of choice for studying target expression and target binding...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21031029
更新日期：2020-02-04 00:00:00
abstract：:Merging targeted systemic gene delivery and systemic chemotherapy against cancer, chemovirotherapy, has the potential to improve chemotherapy and gene therapy treatments and overcome cancer resistance. We introduced a bacteriophage (phage) vector, named human adeno-associated virus (AAV)/phage or AAVP, for the systemi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217867
更新日期：2020-10-23 00:00:00
abstract：:Acyl activating enzyme 3 (AAE3) was identified as being involved in the acetylation pathway of oxalate degradation, which regulates the responses to biotic and abiotic stresses in various higher plants. Here, we investigated the role of Glycine sojaAAE3 (GsAAE3) in Cadmium (Cd) and Aluminum (Al) tolerances. The recomb...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228869
更新日期：2020-11-23 00:00:00
abstract：:Here is presented an investigation of the use of normal modes in protein-protein docking, both in theory and in practice. Upper limits of the ability of normal modes to capture the unbound to bound conformational change are calculated on a large test set, with particular focus on the binding interface, the subset of r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11103623
更新日期：2010-09-28 00:00:00
abstract：:Due to role of the Keap1-Nrf2 protein-protein interaction (PPI) in protecting cells from oxidative stress, the development of small molecule inhibitors that inhibit this interaction has arisen as a viable approach to combat maladies caused by oxidative stress, such as cancers, neurodegenerative disease and diabetes. T...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20184445
更新日期：2019-09-10 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18091993
更新日期：2017-09-16 00:00:00
abstract：:Receptor tyrosine kinases (RTKs) belong to a family of transmembrane receptors that display tyrosine kinase activity and trigger the activation of downstream signalling pathways mainly involved in cell proliferation and survival. RTK amplification or somatic mutations leading to their constitutive activation and oncog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18020383
更新日期：2017-02-11 00:00:00
abstract：:To learn more about the structure-activity relationships of (E)-3-(5-styryl-1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives, which in our previous research displayed promising in vitro anticancer activity, we have synthesized a group of novel (E)-5-[(5-(2-arylvinyl)-1,3,4-oxadiazol-2-yl)]-4-chloro-2-R1-benzenesulf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062235
更新日期：2020-03-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145011
更新日期：2020-07-16 00:00:00
abstract：:Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2″,2″-dimethylpyrano (5″,6″:7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13067375
更新日期：2012-01-01 00:00:00
abstract：:The adult mammalian central nervous system (CNS) is generally considered as repair restricted organ with limited capacities to regenerate lost cells and to successfully integrate them into damaged nerve tracts. Despite the presence of endogenous immature cell types that can be activated upon injury or in disease cell ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20020455
更新日期：2019-01-21 00:00:00
abstract：:Nonobese diabetic (NOD) mice spontaneously develop lacrimal and salivary gland autoimmunity similar to human Sjögren syndrome. In both humans and NOD mice, the early immune response that drives T-cell infiltration into lacrimal and salivary glands is poorly understood. In NOD mice, lacrimal gland autoimmunity spontane...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103259
更新日期：2018-10-20 00:00:00
abstract：:It is widely accepted that chronic inflammation initiates and promotes carcinogenesis and tumor progression in various cell types. However, this paradigm has not been comprehensively investigated in melanoma. To investigate the effects of chronic inflammation on the progression of melanoma, we established a murine inf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20010169
更新日期：2019-01-04 00:00:00
abstract：:Jasmonic acid (JA) carboxyl methyltransferase (JMT), a key enzyme in jasmonate-regulated plant responses, may be involved in plant defense and development by methylating JA to MeJA, thus influencing the concentrations of MeJA in plant. In this study, we isolated the JMT gene from Salvia miltiorrhiza, an important medi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123788
更新日期：2018-11-28 00:00:00
abstract：:Phosphate (Pi) is a pivotal nutrient that constraints plant development and productivity in natural ecosystems. Land colonization by plants, more than 470 million years ago, evolved adaptive mechanisms to conquer Pi-scarce environments. However, little is known about the molecular basis underlying such adaptations at ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218354
更新日期：2020-11-07 00:00:00
abstract：:The circadian system is an endogenous timekeeping system that synchronizes physiology and behavior with the 24 h solar day. Mice with total deletion of the core circadian clock gene Bmal1 show circadian arrhythmicity, cognitive deficits, and accelerated age-dependent decline in adult neurogenesis as a consequence of i...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms21041394
更新日期：2020-02-19 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207578
更新日期：2020-10-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms141123086
更新日期：2013-11-21 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2017-11-11 00:00:00
abstract：:S-equol is a major bacterial metabolite of the soy isoflavone daidzein. It is known to be a phytoestrogen that acts by binding to the nuclear estrogen receptors (ERs) that are expressed in various brain regions, including the cerebellum. However, the effects of S-equol on cerebellar development and function have not y...
journal_title：International journal of molecular sciences
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更新日期：2019-10-18 00:00:00
abstract：:Omega-3 fatty acids are important to pregnancy and neonatal development and health. One mechanism by which omega-3 fatty acids exert their protective effects is through serving as substrates for the generation of specialized pro-resolving lipid mediators (SPM) that potently limit and resolve inflammatory processes. We...
journal_title：International journal of molecular sciences
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更新日期：2019-09-07 00:00:00
abstract：:Rho family GTPases belong to the Ras GTPase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. The three best-characterized Rho family members ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2013-03-28 00:00:00
abstract：:In higher organisms, epithelia separate compartments in order to guarantee their proper function. Such structures are able to seal but also to allow substances to pass. Within the paracellular pathway, a supramolecular structure, the tight junction transport is largely controlled by the temporospatial regulation of it...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-11-05 00:00:00
abstract：:Mechanical force is a key factor for the maintenance, adaptation, and function of tendons. Investigating the impact of mechanical loading in tenocytes and tendons might provide important information on in vivo tendon mechanobiology. Therefore, the study aimed at understanding if an in vitro loading set up of tenocytes...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-02-15 00:00:00
abstract：:The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges to the health care systems around the world. This is primarily because of the lack of vaccines to protect against the infe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155224
更新日期：2020-07-23 00:00:00
