The antibiotic pipeline: reviving research and development and speeding drugs to market.

abstract：INTRODUCTION:Pneumocystis pneumonia is a potentially life-threatening pulmonary infection that occurs in immunocompromised individuals and HIV-infected patients with a low CD4 cell count. Trimethoprim-sulfamethoxazole has been used as the first-line agent for treatment, but mutations within dihydropteroate synthase gen...

journal_title：Expert review of anti-infective therapy

authors： Huang YS,Yang JJ,Lee NY,Chen GJ,Ko WC,Sun HY,Hung CC

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:COVID-19 disease progresses through a number of distinct phases. The management of each phase is unique and specific. The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in seve...

journal_title：Expert review of anti-infective therapy

authors： Marik PE,Kory P,Varon J,Iglesias J,Meduri GU

更新日期：2020-08-18 00:00:00

abstract：:Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential...

journal_title：Expert review of anti-infective therapy

authors： Paragas J,Geisbert TW

更新日期：2006-02-01 00:00:00

abstract：:Use of nonsystemic antimicrobials with activity against enteropathogens is a promising approach for treatment of infectious diarrhea and other nonsystemic gastrointestinal infections. Rifaximin is approved by the US FDA for the treatment of travelers' diarrhea caused by noninvasive strains of Escherichia coli in patie...

journal_title：Expert review of anti-infective therapy

authors： Cottreau J,Baker SF,DuPont HL,Garey KW

更新日期：2010-07-01 00:00:00

abstract：:Accidents or violence can result in penetrating trauma in the adult population. Contaminated penetrating foreign bodies introduced at the time of wounding cause infection, especially high velocity projectiles, which result in cavitation. Surgical debridement reduces potential infection; however, perioperative antibiot...

journal_title：Expert review of anti-infective therapy

authors： Petersen K,Waterman P

更新日期：2011-01-01 00:00:00

abstract：:Chronic hepatitis C (CHC) virus infection affects more than 170 million people globally. The aim of treatment of CHC is to affect sustained elimination of the virus (a sustained virological response [SVR]). The success and duration of therapy with interferon is dependent on HCV genotype. The current standard of care c...

journal_title：Expert review of anti-infective therapy

authors： Trembling PM,Tanwar S,Dusheiko GM

更新日期：2012-03-01 00:00:00

abstract：:Invasive aspergillosis (IA) is currently an important cause of morbidity and mortality in hematopoietic stem cell transplant and solid organ transplant recipients. A high index of suspicion and careful clinical and radiological examinations are the keys to identifying infected patients early. Chest computerized axial ...

journal_title：Expert review of anti-infective therapy

authors： Salman N,Törün SH,Budan B,Somer A

更新日期：2011-03-01 00:00:00

abstract：:The constant new emergence of life-threatening human respiratory viral pathogens presents new challenges to clinicians who are left with no available therapeutic interventions. Highly pathogenic strains of influenza A virus (IAV) share an enhanced capacity to propagate to the lower airways and paralyze alveolar macrop...

journal_title：Expert review of anti-infective therapy

authors： Coulombe F,Divangahi M

更新日期：2014-11-01 00:00:00

abstract：:Human cytomegalovirus is a large DNA virus that is well-equipped to evade both innate and adaptive host immune responses and to establish lifelong latency. It is a major opportunistic pathogen in immunocompromised hosts. Following allogeneic transplantation, immune responses are often inadequate to inhibit viral react...

journal_title：Expert review of anti-infective therapy

authors： Peggs KS

更新日期：2004-08-01 00:00:00

abstract：:Drug resistance in HIV-infected children is one of the main contributors to antiretroviral treatment (ART) failure, especially in developing countries. Sub-Saharan Africa has the largest burden of pediatric HIV infection in the world. Herein, we systematically review the current status of ART failure in HIV-infected A...

journal_title：Expert review of anti-infective therapy

authors： Jenabian MA,Costiniuk CT,Mboumba Bouassa RS,Chapdeleine Mekue Mouafo L,Brogan TV,Bélec L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The introduction of antibiotics into modern medicine has changed clinical care by saving millions of lives. However, misuse of antibiotics has led to their benefits being overshadowed by the development of antimicrobial resistance. AIMS OF STUDY:This study aimed to assess university students' knowledge and ...

journal_title：Expert review of anti-infective therapy

authors： Haque M,Rahman NAA,McKimm J,Binti Abdullah SL,Islam MZ,Zulkifli Z,Saidin NB,Azhar NIK,Binti Lutfi SNN,Binti Othman NSA

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Due to increasing intensity and complexity of therapies and longer survivorship, many patients with haematologic malignancy (HM) are at risk of invasive fungal disease (IFD). Mortality from IFD is high and treatment of an episode of IFD results in an excess length of hospital stay and costs and delays deli...

journal_title：Expert review of anti-infective therapy

authors： Douglas AP,Slavin MA

更新日期：2016-12-01 00:00:00

abstract：:Malaria is a curable disease, provided timely access to efficacious drugs is sought. Poor quality and, in particular, falsified antimalarial drugs harm the population of malaria endemic areas; they put lives in peril, cause economic losses to patients, families, industry, and generally undermine the trust in health sy...

journal_title：Expert review of anti-infective therapy

authors： Chaccour C,Kaur H,Del Pozo JL

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Influenza-Like Illness is a leading cause of hospitalization in children. Disease burden due to influenza and other respiratory viral infections is reported on a population level, but clinical scores measuring individual changes in disease severity are urgently needed. Areas covered: We present a composite...

journal_title：Expert review of anti-infective therapy

authors： Rath B,Conrad T,Myles P,Alchikh M,Ma X,Hoppe C,Tief F,Chen X,Obermeier P,Kisler B,Schweiger B

更新日期：2017-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is of particular concern in immunodeficient individuals notably transplant recipients, leading to increased morbidity and mortality. HCMV is predicted to encode multiple microRNAs (miRNAs) and several have been characterized in vitro. Furthermore, these miRNAs have been shown to ...

journal_title：Expert review of anti-infective therapy

authors： Ng KR,Li JY,Gleadle JM

更新日期：2015-01-01 00:00:00

abstract：:Management of anaerobic infections encompasses surgical procedures, antibacterial therapy and adjuncts. At present, metronidazole, penems, beta-lactam/beta-lactamase inhibitor combinations and chloramphenicol have the highest activity against obligate anaerobes. Tigecycline is a promising new agent. Other antibacteria...

journal_title：Expert review of anti-infective therapy

authors： Boyanova L,Kolarov R,Mitov I

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Neuraminidase inhibitors (NAIs) reduce influenza symptoms but clear evidence of relationships between viral titer reduction and symptom alleviation is lacking. This open-label, randomized study evaluated differences in viral dynamics between NAIs, and relationships between viral dynamics and influenza sympto...

journal_title：Expert review of anti-infective therapy

authors： Hirotsu N,Saisho Y,Hasegawa T,Shishido T

更新日期：2018-02-01 00:00:00

abstract：:The use of combination antiretroviral therapy for the prevention of mother to child transmission of HIV infection has achieved vertical HIV transmission rates of <1%. The use of these drugs is not without risk to the mother and infant. Pregnant women with HIV-infection are at high risk of preterm birth (PTB <37 weeks)...

journal_title：Expert review of anti-infective therapy

authors： Short CE,Taylor GP

更新日期：2014-03-01 00:00:00

abstract：:Chronic hepatitis C is a major worldwide health problem with an estimated prevalence of 1.6-2%. The prognosis of chronic hepatitis C depends on the rate of fibrosis progression which, over a 20-30-year time span, may determine the risk of developing cirrhosis and its complications, namely hepatocellular carcinoma, liv...

journal_title：Expert review of anti-infective therapy

authors： Aghemo A,Rumi MG,Colombo M

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Rapid molecular diagnostic methods help in the detection of TB and Rifampicin resistance. These methods detect TB early, are accurate and play a crucial role in reducing the burden of drug resistant tuberculosis. Areas covered: This review analyses rapid molecular diagnostic tools used in the diagnosis of ...

journal_title：Expert review of anti-infective therapy

authors： Ramachandran R,Muniyandi M

更新日期：2018-03-01 00:00:00

abstract：:Lymphogranuloma venereum (LGV) is a sexually transmitted infection, previously only seen in tropical regions. This changed in 2003 when the first endemically acquired LGV cases were reported in Rotterdam, the Netherlands, among predominantly HIV positive men who have sex with men (MSM). Early diagnosis is important to...

journal_title：Expert review of anti-infective therapy

authors： de Vrieze NH,de Vries HJ

更新日期：2014-06-01 00:00:00

abstract：:Over the last few decades, various extended-spectrum β-lactamases (ESBLs), which are remotely related to the classical TEM and SHV families, have emerged. Among these, CTX-M, VEB and PER variants are of particular interest due to their widespread dissemination. This article will focus on these emerging ESBLs. CTX-M wa...

journal_title：Expert review of anti-infective therapy

authors： Akinci E,Vahaboglu H

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an important emerging respiratory pathogen. MERS-CoV resulted in multiple hospital outbreaks within and outside the Arabian Peninsula. The disease has a high case fatality rate, with the need for a therapeutic option. Areas covered: In this rev...

journal_title：Expert review of anti-infective therapy

authors： Al-Tawfiq JA,Memish ZA

更新日期：2017-03-01 00:00:00

abstract：:In this article we focus on the pathogenesis and clinical characteristics of schistosomiasis infection on the lung vasculature. Overall, the basic biology and understanding of Schistosoma immune responses and their effect on the cardiopulmonary system is limited in both animal and human models, which hinders clinical ...

journal_title：Expert review of anti-infective therapy

authors： Kolosionek E,Crosby A,Harhay MO,Morrell N,Butrous G

更新日期：2010-12-01 00:00:00

abstract：:Introduction: Helicobacter Pylori (H.Pylori) is a pathogen that infects about 50% of the world's population and is known to be responsible for gastroduodenal diseases such as atrophic gastritis, peptic ulcer and stomach cancer. Nowadays, there is no treatment that ensures complete eradication. In addition, resistance ...

journal_title：Expert review of anti-infective therapy

authors： Safarov T,Kiran B,Bagirova M,Allahverdiyev AM,Abamor ES

更新日期：2019-10-01 00:00:00

abstract：:The advent of highly active antiretroviral therapy (HAART) has revolutionized the treatment of HIV. A wide variety of antiretroviral agents are now available, allowing patients and physicians a choice of effective therapy. However, drug resistance and toxicities are emerging as major treatment challenges in the HAART ...

journal_title：Expert review of anti-infective therapy

authors： Jones R,Gazzard B

更新日期：2006-04-01 00:00:00

abstract：:Nosocomial infections are the most frequent complications observed in surgical patients. In colorectal surgery, the opening of the viscera causes the dissemination into the operative field of microorganisms originating from endogenous sources, increasing the chance of developing postoperative complications. It is repo...

journal_title：Expert review of anti-infective therapy

authors： Rovera F,Diurni M,Dionigi G,Boni L,Ferrari A,Carcano G,Dionigi R

更新日期：2005-10-01 00:00:00

abstract：:Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans.Areas covered: This review assessed the scientific literature on phage therapy published between 1 Janu...

journal_title：Expert review of anti-infective therapy

authors： Caflisch KM,Suh GA,Patel R

更新日期：2019-12-01 00:00:00

abstract：:Introduction: Ceftobiprole is a fifth-generation cephalosporin with a broad spectrum of antimicrobial activity, including also methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole is approved for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), excluding ventilator...

journal_title：Expert review of anti-infective therapy

authors： Giacobbe DR,De Rosa FG,Del Bono V,Grossi PA,Pea F,Petrosillo N,Rossolini GM,Tascini C,Tumbarello M,Viale P,Bassetti M

更新日期：2019-09-01 00:00:00

abstract：:Ventilator-associated pneumonia (VAP) remains a major burden to the healthcare system and intubated patients in intensive care units. In fact, VAP is responsible for at least 50% of prescribed antibiotics to patients who need mechanical ventilation. One of the factors contributing to VAP pathogenesis is believed to be...

journal_title：Expert review of anti-infective therapy

authors： Loo CY,Lee WH,Young PM,Cavaliere R,Whitchurch CB,Rohanizadeh R

更新日期：2015-03-01 00:00:00