Abstract:
:Drug resistance in HIV-infected children is one of the main contributors to antiretroviral treatment (ART) failure, especially in developing countries. Sub-Saharan Africa has the largest burden of pediatric HIV infection in the world. Herein, we systematically review the current status of ART failure in HIV-infected African children. A literature search for publications within 10 years was performed through PubMed to identify relevant articles. Included studies examined the impact of timing of ART initiation, criteria for diagnosing therapeutic failure, predictors of therapeutic failure, management strategies and future directions to minimize failure rates in these pediatric populations. Although there is scale-up of ART programs in Africa, novel therapeutic and management strategies are needed to overcome current challenges.
journal_name
Expert Rev Anti Infect Therjournal_title
Expert review of anti-infective therapyauthors
Jenabian MA,Costiniuk CT,Mboumba Bouassa RS,Chapdeleine Mekue Mouafo L,Brogan TV,Bélec Ldoi
10.1586/14787210.2015.1068117subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1213-23issue
10eissn
1478-7210issn
1744-8336journal_volume
13pub_type
杂志文章,评审abstract::Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of I...
journal_title:Expert review of anti-infective therapy
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doi:10.1080/14787210.2020.1697233
更新日期:2020-01-01 00:00:00
abstract::Post-exposure prophylaxis (PEP) with antiretrovirals is now widely used worldwide after either occupational contact (with blood or another blood-containing fluid), or nonoccupational contact (mainly sexual or injection-drug use). It is assumed to reduce the risk of HIV transmission by at least 80%, although its effica...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 指南,杂志文章,实务指引
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 历史文章,杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type:
doi:10.1586/eri.11.62
更新日期:2011-07-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
doi:10.1080/14787210.2020.1822736
更新日期:2020-09-20 00:00:00
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.09.54
更新日期:2009-09-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1080/14787210.2018.1544891
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
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更新日期:2020-08-18 00:00:00
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journal_title:Expert review of anti-infective therapy
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更新日期:2011-11-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
abstract::The vicious cycle is that hyperglycemia (≥11.1 mmol/l) or other diabetes-associated factors facilitate or worsen the development of infections and vice versa, the infections deteriorate the glycemic control of the patients. Diabetic patients are prone to some infections, infection recurrences and poor outcomes. Immuno...
journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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