Developing novel strategies to prevent parasitic infections.

Abstract:

:The 49th Annual Spring Meeting of the British Society of Parasitology was held at Nottingham University, UK, on 11-14 April 2011. Although a meeting of a national parasitological society, the meeting attracted approximately 375 delegates from 30 countries worldwide. Of the various themes at this meeting, two were focused on the biology, etiology and development of therapeutics for the parasitic diseases; malaria and schistosomiasis. Here we report on three aspects of this meeting that are focused on the development of novel therapeutics to address the significant health burden imposed by these tropical diseases.

authors

Staines HM,Croft SL,Horrocks PD

doi

10.1586/eri.11.62

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

783-5

issue

7

eissn

1478-7210

issn

1744-8336

journal_volume

9

pub_type

  • MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale.

    abstract:INTRODUCTION:COVID-19 disease progresses through a number of distinct phases. The management of each phase is unique and specific. The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in seve...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2020.1808462

    authors: Marik PE,Kory P,Varon J,Iglesias J,Meduri GU

    更新日期:2020-08-18 00:00:00

  • The effect of antivirals on COVID-19: a systematic review.

    abstract:INTRODUCTION:Coronavirus Disease 2019 is a contagious infection that has infected millions worldwide. The objective of this systematic review is to identify studies pertaining to antivirals, both as sole and combined therapies, in COVID-19 patients and review the clinical outcomes of these treatment methods. AREAS COV...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2021.1823832

    authors: Hussain N,Yoganathan A,Hewage S,Alom S,Harky A

    更新日期:2020-10-20 00:00:00

  • Prognostic markers of pediatric meningococcal sepsis.

    abstract::Having available tools to determine the prognosis of pediatric meningococcal sepsis at admission to the Intensive Care Unit or during the course of the disease constitutes a clinical necessity. Recently, new readily measurable circulating biomarkers have been described as an additional tool for severity classification...

    journal_title:Expert review of anti-infective therapy

    pub_type: 社论

    doi:10.1586/14787210.2014.945431

    authors: Briassoulis G,Galani A

    更新日期:2014-09-01 00:00:00

  • Nitazoxanide: a new broad spectrum antiparasitic agent.

    abstract::Nitazoxanide (Alinia, Romark Laboratories) was synthesized based on the structure of niclosamide. In vitro studies have demonstrated activity against a broad range of parasites as well as some bacteria. Three controlled trials demonstrated efficacy in cryptosporidiosis, however, the efficacy in advanced AIDS patients ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2.1.43

    authors: White CA Jr

    更新日期:2004-02-01 00:00:00

  • Malaria in pregnancy: diagnosing infection and identifying fetal risk.

    abstract::Despite increased malaria control efforts, recent reports indicate that over 1.2 million deaths due to malaria occurred in 2010. Pregnant women represent a particularly vulnerable risk group as malaria infection can lead to life-threatening disease for the mother and fetus. With 125 million women at risk of malaria in...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.12.123

    authors: Conroy AL,McDonald CR,Kain KC

    更新日期:2012-11-01 00:00:00

  • Efavirenz-based antiretroviral therapy versus nevirapine-including regimens for prevention of mother-to-child transmission of HIV option B plus in resource-limited settings: is there anything missing?

    abstract::In 2013, an estimated 1.5 million HIV-positive pregnant women gave birth, with 240,000 children worldwide acquiring HIV. More than 90% of new pediatric infections occurred in Sub-Saharan Africa. The latest WHO guidelines recommended efavirenz (EFV)-based antiretroviral therapy as the first-line regimen for prevention ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2016.1116383

    authors: De Nardo P,Gentilotti E,Nguhuni B,Vairo F,Chaula Z,Nicastri E,Ippolito G

    更新日期:2016-01-01 00:00:00

  • Darunavir/cobicistat once daily for the treatment of HIV.

    abstract::A current focus in HIV management is improving adherence by minimizing pill burden with convenient formulations, including fixed-dose combinations (FDCs). Darunavir, a HIV protease inhibitor, co-administered with low-dose ritonavir (800/100 mg once daily), is recommended in guidelines in combination with other antiret...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2015.1033400

    authors: Kakuda TN,Crauwels H,Opsomer M,Tomaka F,van de Casteele T,Vanveggel S,Iterbeke K,de Smedt G

    更新日期:2015-06-01 00:00:00

  • Procalcitonin-guided antibiotic therapy for chronic obstructive pulmonary disease exacerbations.

    abstract::The aim of this article is to review the current literature examining the use of procalcitonin-guided antibiotic therapy for management of chronic obstructive pulmonary disease (COPD) exacerbations. Procalcitonin is a serum marker that rises in response to bacterial infections, but remains low in nonbacterial infectio...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.11.45

    authors: Tokman S,Schuetz P,Bent S

    更新日期:2011-06-01 00:00:00

  • Characteristics of pathogenic fungi and antifungal therapy in cystic fibrosis.

    abstract::A defective mucociliary clearance facilitates colonization with bacteria and fungal spores in cystic fibrosis patients. Yeasts and molds are cultured from the cystic fibrosis respiratory tract and often their clinical relevance is unknown. Candida spp. are the most commonly isolated yeasts, whereas Aspergillus spp., S...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.10.72

    authors: Müller FM,Seidler M

    更新日期:2010-08-01 00:00:00

  • Sulfadiazine and pyrimethamine in the postnatal treatment of congenital toxoplasmosis: what are the options?

    abstract::Pre- and neonatal screening for congenital toxoplasmosis rests upon the assumption that treatment is beneficial on either acute symptoms or in preventing later reactivation. Postpartum treatment of congenital toxoplasmosis with sulfadiazine and pyrimethamine has remained almost unchanged for 50 years. More recently, s...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.1.1.175

    authors: Petersen E,Schmidt DR

    更新日期:2003-06-01 00:00:00

  • Levofloxacin for the treatment of community-acquired pneumonia.

    abstract::New respiratory fluoroquinolones (FQs), such as levofloxacin, offer many improved qualities over older agents, such as ciprofloxacin. These include retaining excellent Gram-negative bacilli activity, with improved Gram-positive activity. New FQ-like levofloxacin possesses greater bioavailabilty and a longer serum half...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.4.5.725

    authors: Lynch JP 3rd,File TM Jr,Zhanel GG

    更新日期:2006-10-01 00:00:00

  • Late HIV presentation: epidemiology, clinical implications and management.

    abstract::Late presentation of HIV is common and is associated with several adverse outcomes including an increased risk of clinical progression, blunted immune recovery on highly active antiretroviral therapy and a greater risk of drug toxicity. Late presenters may have higher rates of poor adherence, exacerbated by the same f...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.11.106

    authors: Waters L,Sabin CA

    更新日期:2011-10-01 00:00:00

  • Invasive pulmonary aspergillosis.

    abstract::In susceptible patients, invasive aspergillosis has a high incidence and a mortality of up to 80%. The diagnosis of this condition is difficult, especially in the early stages of the disease and, as a consequence, antifungal therapy, despite its expense and toxicity, is often initiated empirically. Until recently, the...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.3.4.613

    authors: Doffman SR,Agrawal SG,Brown JS

    更新日期:2005-08-01 00:00:00

  • Use of linezolid in children: an overview of recent advances.

    abstract::Linezolid is the first member of a new generation of antibiotics, the synthetic oxazolidinones, to become available, with a broad spectrum of in vitro activity against gram-positive organisms, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and vancomycin-resistant E. ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.4.6.947

    authors: Velissariou IM

    更新日期:2006-12-01 00:00:00

  • Lymphogranuloma venereum among men who have sex with men. An epidemiological and clinical review.

    abstract::Lymphogranuloma venereum (LGV) is a sexually transmitted infection, previously only seen in tropical regions. This changed in 2003 when the first endemically acquired LGV cases were reported in Rotterdam, the Netherlands, among predominantly HIV positive men who have sex with men (MSM). Early diagnosis is important to...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2014.901169

    authors: de Vrieze NH,de Vries HJ

    更新日期:2014-06-01 00:00:00

  • The glory of guidelines and the twilight of reality: controversies and challenges in the prevention and treatment of HIV in children.

    abstract::Since the discovery of HIV 30 years ago, we have learned much about HIV in children and adolescents. Dramatic declines have occurred in mother-to-child transmission of HIV in resource-rich countries. Resource-poor countries struggle with improving prevention of mother-to-child transmission due to the lack of universal...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.12.60

    authors: Anderson EJ,Yogev R

    更新日期:2012-07-01 00:00:00

  • Recent progress in the repurposing of drugs/molecules for the management of COVID-19.

    abstract::Introduction: In the current scenario, COVID-19 is a clinical and public health problem globally. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains the causative agent, emerged in China and continuously spreading across the globe. Until now, no efficient therapeutics have been approved, which combat...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2021.1860020

    authors: Sharma D,Kunamneni A

    更新日期:2020-12-10 00:00:00

  • Mycobacterium caprae infection in humans.

    abstract::Mycobacterium caprae, a member of the Mycobacterium tuberculosis complex, causes tuberculosis (TB) in man and animals. Some features distinguish M. caprae from its epidemiological twin, Mycobacterium bovis: M. caprae is evolutionarily older, accounts for a smaller burden of zoonotic TB and is not globally distributed,...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2014.974560

    authors: Prodinger WM,Indra A,Koksalan OK,Kilicaslan Z,Richter E

    更新日期:2014-12-01 00:00:00

  • Antibiotics in the first hour: is there new evidence?

    abstract:INTRODUCTION:International guidelines have recommended for many years to start antimicrobials as early as possible in sepsis and shock. This concept has been challenged by the controversial results of experimental studies and clinical cohorts and resulted in intense debate in the literature. This review aims to summari...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2020.1810567

    authors: Dupuis C,Timsit JF

    更新日期:2021-01-01 00:00:00

  • Treatment of Pneumocystis jirovecii pneumonia in HIV-infected patients: a review.

    abstract:INTRODUCTION:Pneumocystis pneumonia is a potentially life-threatening pulmonary infection that occurs in immunocompromised individuals and HIV-infected patients with a low CD4 cell count. Trimethoprim-sulfamethoxazole has been used as the first-line agent for treatment, but mutations within dihydropteroate synthase gen...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2017.1364991

    authors: Huang YS,Yang JJ,Lee NY,Chen GJ,Ko WC,Sun HY,Hung CC

    更新日期:2017-09-01 00:00:00

  • Control of influenza virus infection by immunity to conserved viral features.

    abstract::Influenza has circulated among humans for centuries and kills more people than many newly emerging diseases. The present methods for control of influenza are not adequate, especially for dealing with a pandemic. In the face of a rapidly spreading outbreak, a race to isolate the virus and prepare a vaccine would probab...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.1.4.627

    authors: Epstein SL

    更新日期:2003-12-01 00:00:00

  • Antiparasitic treatment for solitary cysticercus granuloma: to treat or not to treat?

    abstract::Neurocysticercosis is a major cause of neurologic disease worldwide. In India and other developing countries, single small enhancing computed tomographic lesions representing solitary cysticercus granuloma are a common cause of new-onset seizures. The interesting feature of these solitary enhancing lesions is their sp...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章

    doi:10.1586/14787210.6.1.15

    authors: Garg RK

    更新日期:2008-02-01 00:00:00

  • Prevention of influenza in healthy children.

    abstract::Healthy children are high transmitters of influenza and can experience poor influenza outcomes. Many questions remain about the efficacy and impect of preventive measures because most existing studies report imprecise proxies of influenza incidence, do not follow subjects throughout the entire influenza season and acr...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.12.106

    authors: Lee BY,Shah M

    更新日期:2012-10-01 00:00:00

  • Ceftobiprole: a new cephalosporin for the treatment of skin and skin structure infections.

    abstract::Ceftobiprole is among the first of a new generation of cephalosporins with activity against aerobic Gram-negative bacilli, which extends to cefepime-sensitive Pseudomonas aeruginosa, and activity against Gram-positive organisms, which includes methicillin-resistant Staphylococcus aureus. Ceftobiprole is currently unde...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.09.54

    authors: Schirmer PL,Deresinski SC

    更新日期:2009-09-01 00:00:00

  • 6th meeting of the World Society for Pediatric Infectious Diseases.

    abstract::The 6th World Congress of the World Society for Pediatric Infectious Diseases (WSPID), which was recently held in Buenos Aires, Argentina, between 18 and 22 November 2009, attracted 2401 attendees from 90 countries representing six continents. The WSPID, founded in 1994 by Professor Saldana Gonzalez of the Mexican Ped...

    journal_title:Expert review of anti-infective therapy

    pub_type:

    doi:10.1586/eri.10.6

    authors: Falade AG

    更新日期:2010-03-01 00:00:00

  • Antifungal susceptibility testing in Candida species: current methods and promising new tools for shortening the turnaround time.

    abstract:INTRODUCTION:Invasive fungal diseases (IFDs) have received attention as an emerging public health threat, are difficult to diagnose and to treat, and are associated with substantial morbidity and mortality. The standard of care in IFD management requires an early and targeted antifungal treatment, hence covers - amongs...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2020.1760841

    authors: Knabl L,Lass-Flörl C

    更新日期:2020-08-01 00:00:00

  • HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and management.

    abstract::HIV-associated nephropathy (HIVAN) is the most well-known and aggressive kidney disease in HIV-1-infected patients. A variant of focal segmental glomerulosclerosis, it is characterized by the collapse of the glomerular tuft with podocyte hypertrophy/hyperplasia and foot process effacement, often with concurrent tubula...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.6.3.365

    authors: Atta MG,Lucas GM,Fine DM

    更新日期:2008-06-01 00:00:00

  • Pertussis in Latin America: epidemiology and control strategies.

    abstract::Pertussis is a serious respiratory disease in infants that can also affect children and adults. Vaccination against pertussis was introduced in the 1950s and in the 1990s a resurgence of pertussis was observed worldwide. The aim of this work is to summarize the recent data concerning pertussis disease in different cou...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2014.948846

    authors: Falleiros Arlant LH,de Colsa A,Flores D,Brea J,Avila Aguero ML,Hozbor DF

    更新日期:2014-10-01 00:00:00

  • Optimizing the management of children with latent tuberculosis infection.

    abstract:INTRODUCTION:The management of latent tuberculosis (LTBI) in children represents an important issue for paediatricians because of the disease burden, the lack of a gold standard for the diagnosis and the high annual risk of progression to active disease. Areas covered: A review of English language articles on LTBI in c...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2017.1279541

    authors: Venturini E,Tersigni C,Chiappini E,de Martino M,Galli L

    更新日期:2017-04-01 00:00:00

  • HIV and malaria interactions: where do we stand?

    abstract::Reversing the spread of HIV infection and the incidence of malaria constitute two of the Millenium Development Goals. However, despite recent achievements, both diseases still entail global heath problems. Furthermore, their overlapping geographical distribution raises concerns and challenges for potential immunologic...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.11.167

    authors: González R,Ataíde R,Naniche D,Menéndez C,Mayor A

    更新日期:2012-02-01 00:00:00