Incidence and risk factors of carbapenem-resistant Enterobacteriaceae infection in intensive care units: a matched case-control study.

Abstract:

BACKGROUND:Carbapenem-resistant Enterobacteriaceae (CRE) infection is associated with intensive care admissions, morbidity, and mortality. Our study aimed to determine the incidence, risk factors, and patient outcomes of CRE in the ICU units. METHODS:This was a retrospective matched case-control study of patients admitted to ICUs. Patients who have positive cultures of CRE and carbapenem-susceptible Enterobacteriaceae (CSE) were included in the study. Patients were randomly selected from a pool of CSE subjects in a ratio of 1:1 of CRE to CSE as control patients. RESULTS:The infection rate with CRE among all patients admitted to ICUs was 7.6% and the incidence of CRE infection was 5.6 per 1,000 person-day. The risk factors independently associated with CRE infection were: Higher Sequential Organ Failure Assessment (SOFA) and Nutrition Risk in Critically ill (NUTRIC) scores, prolonged ICU length of stay (LOS), previous surgery, dialysis and mechanical ventilation during ICU stay, and previous use of aminoglycoside and carbapenems. CONCLUSION:In this retrospective study, the incidence of CRE infection was relatively elevated in patients admitted to ICU. Patients with high SOFA and NUTRIC scores, prolonged ICU LOS, previous surgery, dialysis and mechanical ventilation, and prior aminoglycosides and carbapenems use, may have an increased risk of CRE infection.

authors

Aleidan FAS,Alkhelaifi H,Alsenaid A,Alromaizan H,Alsalham F,Almutairi A,Alsulaiman K,Abdel Gadir AG

doi

10.1080/14787210.2020.1822736

subject

Has Abstract

pub_date

2020-09-20 00:00:00

pages

1-6

eissn

1478-7210

issn

1744-8336

pub_type

杂志文章
  • Miltefosine: oral treatment of leishmaniasis.

    abstract::The well-known problems of classic treatment of the leishmaniases with pentavalent antimony (reduced efficacy), difficulties of administration and increasing frequency and severity of adverse events have stimulated the search for new drugs to treat these diseases. Other injectable, oral and topical drugs have not been...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.4.2.177

    authors: Soto J,Soto P

    更新日期:2006-04-01 00:00:00

  • Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility.

    abstract:INTRODUCTION:The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has brought aminoglycosides to the frontline since an aminoglycoside may be the only antimicrobial to which CRE isolates show in vitro susceptibility. The appropriateness of aminoglycoside-based therapies for severe infections by CRE is discuss...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2017.1316193

    authors: Zavascki AP,Klee BO,Bulitta JB

    更新日期:2017-06-01 00:00:00

  • The history and evolution of immigration medical screening for tuberculosis.

    abstract::Identifying and managing TB in immigrating populations has been an important aspect of immigration health for over a century, with the primary aim being protecting the host population by preventing the import of communicable diseases carried by the arriving migrants. This review describes the history and development o...

    journal_title:Expert review of anti-infective therapy

    pub_type: 历史文章,杂志文章

    doi:10.1586/eri.12.168

    authors: Dara M,Gushulak BD,Posey DL,Zellweger JP,Migliori GB

    更新日期:2013-02-01 00:00:00

  • Clinical management of women with listeriosis risk during pregnancy: a review of national guidelines.

    abstract:INTRODUCTION:Listeriosis is an uncommon foodborne infection that may cause moderate maternal illness, but can be extremely serious for the fetus and the newborn. Several guidelines have been elaborated in order to help clinicians on the care of pregnant women with known or suspected exposure to Listeria monocytogenes. ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2018.1417837

    authors: Pucci L,Massacesi M,Liuzzi G

    更新日期:2018-01-01 00:00:00

  • Sertaconazole: updated review of a topical antifungal agent.

    abstract::Sertaconazole is an imidazole-type antifungal agent that has shown considerable in vitro activity against pathogenic fungi. Various studies carried out in animal models, clinical and toxicologic trials have confirmed the value of sertaconazole in the topical treatment of superficial mycoses in dermatology and gynecolo...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.3.3.333

    authors: Carrillo-Muñoz AJ,Giusiano G,Ezkurra PA,Quindós G

    更新日期:2005-06-01 00:00:00

  • A systematic literature review to assess the burden of herpes zoster disease in China.

    abstract:INTRODUCTION:Herpes zoster (HZ) or shingles occurs as a result of reactivation after a primary infection with varicella zoster virus (chickenpox). The burden of HZ in older adults in China is not well understood. We conducted a systematic literature review to understand the burden of disease related to HZ, its complica...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2020.1792290

    authors: Yin D,Van Oorschot D,Jiang N,Marijam A,Saha D,Wu Z,Tang H,Diaz-Decaro J,Watson P,Xie X,Ren Y,He Y,Feng Y

    更新日期:2020-09-30 00:00:00

  • Darunavir/cobicistat once daily for the treatment of HIV.

    abstract::A current focus in HIV management is improving adherence by minimizing pill burden with convenient formulations, including fixed-dose combinations (FDCs). Darunavir, a HIV protease inhibitor, co-administered with low-dose ritonavir (800/100 mg once daily), is recommended in guidelines in combination with other antiret...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2015.1033400

    authors: Kakuda TN,Crauwels H,Opsomer M,Tomaka F,van de Casteele T,Vanveggel S,Iterbeke K,de Smedt G

    更新日期:2015-06-01 00:00:00

  • Treatment options for multidrug-resistant bacteria.

    abstract::As a consequence of antibiotic overuse and misuse, nosocomial infections caused by multidrug-resistant bacteria represent a physician's nightmare throughout the world. No newer antimicrobials active against Pseudomonas aeruginosa, the main multidrug-resistant nosocomial pathogen, are available or under investigation. ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.4.4.601

    authors: Giamarellou H

    更新日期:2006-08-01 00:00:00

  • Prognostic markers of pediatric meningococcal sepsis.

    abstract::Having available tools to determine the prognosis of pediatric meningococcal sepsis at admission to the Intensive Care Unit or during the course of the disease constitutes a clinical necessity. Recently, new readily measurable circulating biomarkers have been described as an additional tool for severity classification...

    journal_title:Expert review of anti-infective therapy

    pub_type: 社论

    doi:10.1586/14787210.2014.945431

    authors: Briassoulis G,Galani A

    更新日期:2014-09-01 00:00:00

  • Antibiotic prophylaxis in colorectal surgery.

    abstract::Nosocomial infections are the most frequent complications observed in surgical patients. In colorectal surgery, the opening of the viscera causes the dissemination into the operative field of microorganisms originating from endogenous sources, increasing the chance of developing postoperative complications. It is repo...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.3.5.787

    authors: Rovera F,Diurni M,Dionigi G,Boni L,Ferrari A,Carcano G,Dionigi R

    更新日期:2005-10-01 00:00:00

  • Pharmacodynamics of antibiotics to treat multidrug-resistant Gram-positive hospital infections.

    abstract::Hospital infection due to multidrug-resistant Gram-positive bacteria may often represent a life-threatening challenge; thus, to appropriately combat them, clinicians should be confident and systematically apply several important pharmacodynamic concepts. The concept of 'correct antibiotic treatment' should include, in...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.5.2.255

    authors: Pea F,Viale P

    更新日期:2007-04-01 00:00:00

  • Detection and diagnosis of Mycobacterium tuberculosis.

    abstract::Tuberculosis continues to be a major health problem worldwide, affecting millions of people each year. Accurate and rapid diagnosis is key to controlling the disease, yet the traditional tests for TB produce results that are either inaccurate or take too long to be definitive. A fast and reliable diagnostic method tha...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.09.92

    authors: Al-Zamel FA

    更新日期:2009-11-01 00:00:00

  • Procalcitonin-guided antibiotic therapy for chronic obstructive pulmonary disease exacerbations.

    abstract::The aim of this article is to review the current literature examining the use of procalcitonin-guided antibiotic therapy for management of chronic obstructive pulmonary disease (COPD) exacerbations. Procalcitonin is a serum marker that rises in response to bacterial infections, but remains low in nonbacterial infectio...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.11.45

    authors: Tokman S,Schuetz P,Bent S

    更新日期:2011-06-01 00:00:00

  • Antifungal susceptibility testing in Candida species: current methods and promising new tools for shortening the turnaround time.

    abstract:INTRODUCTION:Invasive fungal diseases (IFDs) have received attention as an emerging public health threat, are difficult to diagnose and to treat, and are associated with substantial morbidity and mortality. The standard of care in IFD management requires an early and targeted antifungal treatment, hence covers - amongs...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2020.1760841

    authors: Knabl L,Lass-Flörl C

    更新日期:2020-08-01 00:00:00

  • Efficacy of telavancin, a lipoglycopeptide antibiotic, in experimental models of Gram-positive infection.

    abstract::Telavancin is a parenteral lipoglycopeptide antibiotic with a dual mechanism of action contributing to bactericidal activity against multidrug-resistant Gram-positive pathogens. It has been approved for the treatment of complicated skin and skin structure infections due to susceptible Gram-positive bacteria and hospit...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2014.979789

    authors: Hegde SS,Janc JW

    更新日期:2014-12-01 00:00:00

  • Extended or continuous versus short-term intravenous infusion of cephalosporins: a meta-analysis.

    abstract::The authors sought to study whether extended or continuous infusion of cephalosporins is associated with better clinical outcomes than short-term infusion. PubMed and Scopus databases were systematically searched. Studies reporting the clinical outcomes of patients receiving extended or continuous infusion (≥3 or 24 h...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,meta分析

    doi:10.1586/eri.13.44

    authors: Korbila IP,Tansarli GS,Karageorgopoulos DE,Vardakas KZ,Falagas ME

    更新日期:2013-06-01 00:00:00

  • Post-exposure prophylaxis for HIV infection.

    abstract::Post-exposure prophylaxis (PEP) with antiretrovirals is now widely used worldwide after either occupational contact (with blood or another blood-containing fluid), or nonoccupational contact (mainly sexual or injection-drug use). It is assumed to reduce the risk of HIV transmission by at least 80%, although its effica...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.11.20

    authors: Rey D

    更新日期:2011-04-01 00:00:00

  • Hepatitis C-HIV coinfection: current and future therapy.

    abstract::Coinfection with hepatitis C in HIV-infected patients has been reported in 15-70% of patients depending on the mode of acquisition of both viruses. As recent advances in HIV-directed antiviral therapy have markedly delayed HIV progression and mortality, the incidence of complications arising from hepatitis C-associate...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.1.3.433

    authors: Vyas JJ,Brown RS,Gaglio PJ

    更新日期:2003-10-01 00:00:00

  • Pertussis in Latin America: epidemiology and control strategies.

    abstract::Pertussis is a serious respiratory disease in infants that can also affect children and adults. Vaccination against pertussis was introduced in the 1950s and in the 1990s a resurgence of pertussis was observed worldwide. The aim of this work is to summarize the recent data concerning pertussis disease in different cou...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2014.948846

    authors: Falleiros Arlant LH,de Colsa A,Flores D,Brea J,Avila Aguero ML,Hozbor DF

    更新日期:2014-10-01 00:00:00

  • Levofloxacin for the treatment of community-acquired pneumonia.

    abstract::New respiratory fluoroquinolones (FQs), such as levofloxacin, offer many improved qualities over older agents, such as ciprofloxacin. These include retaining excellent Gram-negative bacilli activity, with improved Gram-positive activity. New FQ-like levofloxacin possesses greater bioavailabilty and a longer serum half...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.4.5.725

    authors: Lynch JP 3rd,File TM Jr,Zhanel GG

    更新日期:2006-10-01 00:00:00

  • Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections.

    abstract::The acyclic nucleoside phosphonates [HPMPC: cidofovir, Vistide; PMEA: adefovir dipivoxil, Hepsera; and PMPA: tenofovir, Viread] have proven to be effective in vitro (cell culture systems) and in vivo (animal models and clinical studies) against a wide variety of DNA virus and retrovirus infections, for example, cidofo...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.1.1.21

    authors: De Clercq E

    更新日期:2003-06-01 00:00:00

  • Prevention of influenza in healthy children.

    abstract::Healthy children are high transmitters of influenza and can experience poor influenza outcomes. Many questions remain about the efficacy and impect of preventive measures because most existing studies report imprecise proxies of influenza incidence, do not follow subjects throughout the entire influenza season and acr...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.12.106

    authors: Lee BY,Shah M

    更新日期:2012-10-01 00:00:00

  • Drug combinations for HIV: what's new?

    abstract::Since the advent of combined antiretroviral therapy there have been reductions in mortality and morbidity from HIV, transforming the disease into a chronic medical condition where newly diagnosed individuals can expect to live a near-normal life expectancy. When choosing therapy, probably the most important considerat...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.11.125

    authors: Scourfield A,Waters L,Nelson M

    更新日期:2011-11-01 00:00:00

  • Ceftobiprole: drug evaluation and place in therapy.

    abstract::Introduction: Ceftobiprole is a fifth-generation cephalosporin with a broad spectrum of antimicrobial activity, including also methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole is approved for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), excluding ventilator...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2019.1667229

    authors: Giacobbe DR,De Rosa FG,Del Bono V,Grossi PA,Pea F,Petrosillo N,Rossolini GM,Tascini C,Tumbarello M,Viale P,Bassetti M

    更新日期:2019-09-01 00:00:00

  • Treatment of Rickettsia spp. infections: a review.

    abstract::Human rickettsioses caused by intracellular bacteria of the genus Rickettsia are distributed worldwide and are transmitted by arthropod vectors such as ticks, fleas, mites and lice. They have a wide range of manifestations from benign to life-threatening diseases. Mortality rates of up to 30% have been reported for so...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.12.139

    authors: Botelho-Nevers E,Socolovschi C,Raoult D,Parola P

    更新日期:2012-12-01 00:00:00

  • HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and management.

    abstract::HIV-associated nephropathy (HIVAN) is the most well-known and aggressive kidney disease in HIV-1-infected patients. A variant of focal segmental glomerulosclerosis, it is characterized by the collapse of the glomerular tuft with podocyte hypertrophy/hyperplasia and foot process effacement, often with concurrent tubula...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.6.3.365

    authors: Atta MG,Lucas GM,Fine DM

    更新日期:2008-06-01 00:00:00

  • Diagnostic accuracy of the Xpert MTB/RIF assay for abdominal tuberculosis: a systematic review and meta-analysis.

    abstract:BACKGROUND:We performed a meta-analysis to determine diagnostic accuracy of Xpert MTB/RIF for diagnosis of abdominal (intestinal or peritoneal) tuberculosis (TB) in various tissues (intestinal, omental/peritoneal tissue or ascitic fluid). METHODS:Electronic databases were searched for observational studies on use of X...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2020.1816169

    authors: Sharma V,Soni H,Kumar-M P,Dawra S,Mishra S,Mandavdhare HS,Singh H,Dutta U

    更新日期:2020-08-26 00:00:00

  • HIV and malaria interactions: where do we stand?

    abstract::Reversing the spread of HIV infection and the incidence of malaria constitute two of the Millenium Development Goals. However, despite recent achievements, both diseases still entail global heath problems. Furthermore, their overlapping geographical distribution raises concerns and challenges for potential immunologic...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.11.167

    authors: González R,Ataíde R,Naniche D,Menéndez C,Mayor A

    更新日期:2012-02-01 00:00:00

  • Influenza infection in human host: challenges in making a better influenza vaccine.

    abstract::Influenza is a ubiquitous infection with a spectrum ranging from mild to severe. The mystery regarding such variability in the clinical spectrum has not been fully unravelled, although a role for the complex interplay among virus characteristics, host immune response and environmental factors has been suggested. Antiv...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2016.1155450

    authors: Virk RK,Gunalan V,Tambyah PA

    更新日期:2016-01-01 00:00:00

  • Development and progression of gastroesophageal varices in patients with chronic hepatitis C.

    abstract::Hepatitis C virus infection is the leading cause of chronic liver disease in the western world. Chronic liver diseases may cause, through portal hypertension, the development of gastroesophageal varices, which can then bleed. We assess the findings of a study aimed at identifying the incidence of de novo varix develop...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章

    doi:10.1586/eri.10.71

    authors: Gentile I,Borgia G

    更新日期:2010-08-01 00:00:00