Intrapartum beta-lactam antibiotics for preventing group B streptococcal early-onset disease: can we abandon the concept of 'inadequate' intrapartum antibiotic prophylaxis?

Abstract:

:Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of IAP may help in minimizing neonatal evaluation and unnecessary antibiotic use.Areas covered: In recent years, several studies on pharmacokinetics and clinical use of IAP have been published. Although penicillin and ampicillin are the most preferred antibiotics, the clinical efficacy of non-beta-lactam antibiotics, including clindamycin and vancomycin, used in cases of penicillin anaphylaxis-associated allergy, remains debatable. This is a narrative review of the literature regarding the impact of 'inadequate' IAP on the clinical management of women and newborns.Expert opinion: Recent evidence suggests that 'inadequate' IAP with beta-lactams is more effective in preventing vertical transmission of GBS than previously thought. Newborns exposed to intrapartum beta-lactams and who are asymptomatic at birth are likely uninfected, irrespective of IAP duration before delivery. Hence, we may abandon the concept of 'inadequate' IAP with beta-lactams in early-onset GBS sepsis, relying primarily on clinical signs observed at birth for managing IAP-exposed neonates.

authors

Berardi A,Spada C,Vaccina E,Boncompagni A,Bedetti L,Lucaccioni L

doi

10.1080/14787210.2020.1697233

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

37-46

issue

1

eissn

1478-7210

issn

1744-8336

journal_volume

18

pub_type

杂志文章
  • The epidemiology of pneumococcal carriage and infections in Malaysia.

    abstract::In Malaysia, various aspects of the epidemiology of pneumococcal carriage and disease remain largely unclear due to the lack of supporting data. Although a number of relevant studies have been documented, their individual discrete findings are not sufficient to inform experts on pneumococcal epidemiology at a national...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.12.54

    authors: Le CF,Jefferies JM,Yusof MY,Sekaran SD,Clarke SC

    更新日期:2012-06-01 00:00:00

  • Antibiotic exposure in hospitalized pediatric patients in the United States: prevalence and length of stay.

    abstract:BACKGROUND:Hospital antibiotic use is rising. We aimed to evaluate the antibiotic-use prevalence and length of stay. METHODS:We conducted a single-center retrospective study of patients < 18-years-old admitted to general pediatric services who received ≥ 1 antibiotic over six months. Demographics, culture results and ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2020.1787833

    authors: Gourishankar A,Agbasi A,Kain C,Lin E

    更新日期:2020-11-01 00:00:00

  • The glory of guidelines and the twilight of reality: controversies and challenges in the prevention and treatment of HIV in children.

    abstract::Since the discovery of HIV 30 years ago, we have learned much about HIV in children and adolescents. Dramatic declines have occurred in mother-to-child transmission of HIV in resource-rich countries. Resource-poor countries struggle with improving prevention of mother-to-child transmission due to the lack of universal...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.12.60

    authors: Anderson EJ,Yogev R

    更新日期:2012-07-01 00:00:00

  • Falsified antimalarials: a minireview.

    abstract::Malaria is a curable disease, provided timely access to efficacious drugs is sought. Poor quality and, in particular, falsified antimalarial drugs harm the population of malaria endemic areas; they put lives in peril, cause economic losses to patients, families, industry, and generally undermine the trust in health sy...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2015.1015990

    authors: Chaccour C,Kaur H,Del Pozo JL

    更新日期:2015-04-01 00:00:00

  • Natural killer cells in immunodefense against infective agents.

    abstract::Following the discovery of innate immune receptors, the topics of innate immunity and its role in defense against infective agents have recently blossomed into very active research fields, after several decades of neglect. Among innate immune cells, natural killer (NK) cells are endowed with the unique ability to reco...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.6.6.867

    authors: Zucchini N,Crozat K,Baranek T,Robbins SH,Altfeld M,Dalod M

    更新日期:2008-12-01 00:00:00

  • Evaluation and management of hepatitis B virus infection in hematopoietic stem cell transplantation: before and after transplantation.

    abstract::HBV infection remains a major global health problem and continues to be a common cause of liver-related morbidity and mortality in both immunocompetent and immunosuppressed individuals. Reactivation of HBV is a serious complication of chemotherapy/immunosuppressive therapy in patients with HBV infection. In this artic...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.11.79

    authors: Idilman R,Arat M

    更新日期:2011-08-01 00:00:00

  • Clinical and virologic effects of four neuraminidase inhibitors in influenza A virus-infected children (aged 4-12 years): an open-label, randomized study in Japan.

    abstract:BACKGROUND:Neuraminidase inhibitors (NAIs) reduce influenza symptoms but clear evidence of relationships between viral titer reduction and symptom alleviation is lacking. This open-label, randomized study evaluated differences in viral dynamics between NAIs, and relationships between viral dynamics and influenza sympto...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/14787210.2018.1421945

    authors: Hirotsu N,Saisho Y,Hasegawa T,Shishido T

    更新日期:2018-02-01 00:00:00

  • Pulmonary bacterial coinfection in infants and children with viral respiratory infection.

    abstract::The true incidence of pulmonary bacterial coinfection in infants and children hospitalized with a viral respiratory infection is difficult to ascertain but can vary widely from under 1 to 44%. For the same patient group admitted to pediatric intensive care units and/or requiring ventilatory support, the evidence is mo...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.12.80

    authors: Thorburn K,Riordan A

    更新日期:2012-08-01 00:00:00

  • Lymphogranuloma venereum among men who have sex with men. An epidemiological and clinical review.

    abstract::Lymphogranuloma venereum (LGV) is a sexually transmitted infection, previously only seen in tropical regions. This changed in 2003 when the first endemically acquired LGV cases were reported in Rotterdam, the Netherlands, among predominantly HIV positive men who have sex with men (MSM). Early diagnosis is important to...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2014.901169

    authors: de Vrieze NH,de Vries HJ

    更新日期:2014-06-01 00:00:00

  • Influenza infection in human host: challenges in making a better influenza vaccine.

    abstract::Influenza is a ubiquitous infection with a spectrum ranging from mild to severe. The mystery regarding such variability in the clinical spectrum has not been fully unravelled, although a role for the complex interplay among virus characteristics, host immune response and environmental factors has been suggested. Antiv...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2016.1155450

    authors: Virk RK,Gunalan V,Tambyah PA

    更新日期:2016-01-01 00:00:00

  • 2010 HIV Diagnostics Conference.

    abstract::During the 2010 HIV Diagnostics Conference, which took place in Orlando (FL, USA) between 24 and 26 March 2010, salient new data related to three aspects of HIV testing (rapid point-of-care testing, laboratory assays and new technologies) were presented and discussed. A conundrum central to HIV diagnostics in the USA ...

    journal_title:Expert review of anti-infective therapy

    pub_type:

    doi:10.1586/eri.10.48

    authors: Pandori MW,Branson BM

    更新日期:2010-06-01 00:00:00

  • Is there really no benefit to combination therapy with colistin?

    abstract::Despite many theoretical and in vitro advantages, clinical data comparing combination therapy with colistin + rifampicin to colistin alone for infection due to extremely-drug resistant (XDR) Acinetobacter baumanni are scarce and limited by small numbers and/or low quality evidence. This article represents the first la...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章

    doi:10.1586/14787210.2013.827881

    authors: Pogue JM,Kaye KS

    更新日期:2013-09-01 00:00:00

  • Characteristics of pathogenic fungi and antifungal therapy in cystic fibrosis.

    abstract::A defective mucociliary clearance facilitates colonization with bacteria and fungal spores in cystic fibrosis patients. Yeasts and molds are cultured from the cystic fibrosis respiratory tract and often their clinical relevance is unknown. Candida spp. are the most commonly isolated yeasts, whereas Aspergillus spp., S...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/eri.10.72

    authors: Müller FM,Seidler M

    更新日期:2010-08-01 00:00:00

  • Rapid molecular diagnostics for multi-drug resistant tuberculosis in India.

    abstract:INTRODUCTION:Rapid molecular diagnostic methods help in the detection of TB and Rifampicin resistance. These methods detect TB early, are accurate and play a crucial role in reducing the burden of drug resistant tuberculosis. Areas covered: This review analyses rapid molecular diagnostic tools used in the diagnosis of ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2018.1438262

    authors: Ramachandran R,Muniyandi M

    更新日期:2018-03-01 00:00:00

  • Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV).

    abstract:INTRODUCTION:The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an important emerging respiratory pathogen. MERS-CoV resulted in multiple hospital outbreaks within and outside the Arabian Peninsula. The disease has a high case fatality rate, with the need for a therapeutic option. Areas covered: In this rev...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2017.1271712

    authors: Al-Tawfiq JA,Memish ZA

    更新日期:2017-03-01 00:00:00

  • Diagnostic accuracy of the Xpert MTB/RIF assay for abdominal tuberculosis: a systematic review and meta-analysis.

    abstract:BACKGROUND:We performed a meta-analysis to determine diagnostic accuracy of Xpert MTB/RIF for diagnosis of abdominal (intestinal or peritoneal) tuberculosis (TB) in various tissues (intestinal, omental/peritoneal tissue or ascitic fluid). METHODS:Electronic databases were searched for observational studies on use of X...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2020.1816169

    authors: Sharma V,Soni H,Kumar-M P,Dawra S,Mishra S,Mandavdhare HS,Singh H,Dutta U

    更新日期:2020-08-26 00:00:00

  • What are the origins of growing microbial resistance? Both Lamarck and Darwin were right.

    abstract:INTRODUCTION:Microorganisms of clinical importance frequently develop resistance to drug therapy, now a growing problem. The experience with Mycobacterium tuberculosis is a representative example of increasing multi-drug resistance. To avoid reaching a crisis in which patients could be left without adequate treatment, ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2021.1839418

    authors: Guevara Salazar JA,Morán Díaz JR,Ramírez Segura E,Trujillo Ferrara JG

    更新日期:2020-10-26 00:00:00

  • Antibiotic prophylaxis in colorectal surgery.

    abstract::Nosocomial infections are the most frequent complications observed in surgical patients. In colorectal surgery, the opening of the viscera causes the dissemination into the operative field of microorganisms originating from endogenous sources, increasing the chance of developing postoperative complications. It is repo...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.3.5.787

    authors: Rovera F,Diurni M,Dionigi G,Boni L,Ferrari A,Carcano G,Dionigi R

    更新日期:2005-10-01 00:00:00

  • Treatment of Pneumocystis jirovecii pneumonia in HIV-infected patients: a review.

    abstract:INTRODUCTION:Pneumocystis pneumonia is a potentially life-threatening pulmonary infection that occurs in immunocompromised individuals and HIV-infected patients with a low CD4 cell count. Trimethoprim-sulfamethoxazole has been used as the first-line agent for treatment, but mutations within dihydropteroate synthase gen...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2017.1364991

    authors: Huang YS,Yang JJ,Lee NY,Chen GJ,Ko WC,Sun HY,Hung CC

    更新日期:2017-09-01 00:00:00

  • Antiretroviral therapy and preterm birth in HIV-infected women.

    abstract::The use of combination antiretroviral therapy for the prevention of mother to child transmission of HIV infection has achieved vertical HIV transmission rates of <1%. The use of these drugs is not without risk to the mother and infant. Pregnant women with HIV-infection are at high risk of preterm birth (PTB <37 weeks)...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2014.885837

    authors: Short CE,Taylor GP

    更新日期:2014-03-01 00:00:00

  • Does lopinavir/ritonavir alter the primary gingival epithelium?

    abstract::In clinical practice, a significant proportion of HIV-infected patients receive lopinavir/ritonavir (LPV/r) as a component of highly active antiretroviral therapy (HAART). The study by Israr et al. was designed to evaluate the effects of the HIV protease inhibitor LPV/r on gingival epithelium growth and differentiatio...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1586/eri.10.138

    authors: Rivero A,Pérez-Camacho I

    更新日期:2010-12-01 00:00:00

  • Hepatitis C infection of B lymphocytes: more tools to address pending questions.

    abstract::Hepatitis C virus (HCV) infection spreads primarily via contact with infected blood and can establish a persistent infection in 80% of infected individuals, progressively causing chronic liver disease that can lead to hepatocellular carcinoma or end-stage liver disease requiring a transplant. There is no vaccine, and ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章

    doi:10.1586/eri.10.86

    authors: Stamataki Z

    更新日期:2010-09-01 00:00:00

  • Multidrug-resistant Escherichia coli in Asia: epidemiology and management.

    abstract::Escherichia coli has become multiresistant by way of production of a variety of β-lactamases. The prevalence of CTX-M-producing E. coli has reached 60-79% in certain parts of Asia. The acquisition of CTX-M plasmids by E. coli sequence type 131, a successful clone of E. coli, has caused further dissemination of CTX-M-p...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2015.1028365

    authors: Sidjabat HE,Paterson DL

    更新日期:2015-05-01 00:00:00

  • Alternative mechanisms of action of cationic antimicrobial peptides on bacteria.

    abstract::Cationic antimicrobial peptides are a novel type of antibiotic offering much potential in the treatment of microbial-related diseases. They offer many advantages for commercial development, including a broad spectrum of action and modest size. However, despite the identification or synthetic production of thousands of...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.5.6.951

    authors: Hale JD,Hancock RE

    更新日期:2007-12-01 00:00:00

  • Addressing antimicrobial resistance in Nigerian hospitals: exploring physicians prescribing behavior, knowledge, and perception of antimicrobial resistance and stewardship programs.

    abstract:INTRODUCTION:We assessed the knowledge of, attitude toward antimicrobial resistance (AMR) and practice of antimicrobial stewardship (AMS) among physicians in Nigeria to provide future guidance to the Nigerian National Action Plan for AMR. METHODS:A descriptive cross-sectional questionnaire-based study explored the phy...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2021.1829474

    authors: Babatola AO,Fadare JO,Olatunya OS,Obiako R,Enwere O,Kalungia A,Ojo TO,Sunmonu TA,Desalu O,Godman B

    更新日期:2020-11-02 00:00:00

  • Antimicrobial therapy of acute diarrhoea: a clinical review.

    abstract::Diarrhoea is one of the most commonly occurring diseases. This article presents a review of the current state of the treatment of acute infectious diarrhoea, as well as of the most important pathogens. The general principles of the therapy of diarrhoea are exemplified, followed by a description of the targeted antimic...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1586/14787210.2016.1128824

    authors: Lübbert C

    更新日期:2016-01-01 00:00:00

  • Developing novel strategies to prevent parasitic infections.

    abstract::The 49th Annual Spring Meeting of the British Society of Parasitology was held at Nottingham University, UK, on 11-14 April 2011. Although a meeting of a national parasitological society, the meeting attracted approximately 375 delegates from 30 countries worldwide. Of the various themes at this meeting, two were focu...

    journal_title:Expert review of anti-infective therapy

    pub_type:

    doi:10.1586/eri.11.62

    authors: Staines HM,Croft SL,Horrocks PD

    更新日期:2011-07-01 00:00:00

  • Ceftobiprole: drug evaluation and place in therapy.

    abstract::Introduction: Ceftobiprole is a fifth-generation cephalosporin with a broad spectrum of antimicrobial activity, including also methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole is approved for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), excluding ventilator...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审

    doi:10.1080/14787210.2019.1667229

    authors: Giacobbe DR,De Rosa FG,Del Bono V,Grossi PA,Pea F,Petrosillo N,Rossolini GM,Tascini C,Tumbarello M,Viale P,Bassetti M

    更新日期:2019-09-01 00:00:00

  • Evidence-based guidelines for the management of Lyme disease.

    abstract::This report, completed in November 2003, is intended to serve as a resource for physicians, public health officials and organizations involved in the evaluation and treatment of Lyme disease. ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 指南,杂志文章,实务指引

    doi:10.1586/14789072.2.1.s1

    authors: Cameron D,Gaito A,Harris N,Bach G,Bellovin S,Bock K,Bock S,Burrascano J,Dickey C,Horowitz R,Phillips S,Meer-Scherrer L,Raxlen B,Sherr V,Smith H,Smith P,Stricker R,ILADS Working Group.

    更新日期:2004-01-01 00:00:00

  • Novel corona virus (COVID-19) pandemic: current status and possible strategies for detection and treatment of the disease.

    abstract:INTRODUCTION:In December 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak occurred and caused the coronavirus disease of 2019 (COVID-19), which affected ~ 190 countries. The World Health Organization (WHO) has declared COVID-19 a pandemic on 11 March 2020. AREA COVERED:In the review, a com...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章

    doi:10.1080/14787210.2021.1835469

    authors: Bhagat S,Yadav N,Shah J,Dave H,Swaraj S,Tripathi S,Singh S

    更新日期:2020-12-07 00:00:00