Human cytomegalovirus encoded microRNAs: hitting targets.

Abstract:

:Human cytomegalovirus (HCMV) infection is of particular concern in immunodeficient individuals notably transplant recipients, leading to increased morbidity and mortality. HCMV is predicted to encode multiple microRNAs (miRNAs) and several have been characterized in vitro. Furthermore, these miRNAs have been shown to target human and viral mRNAs. Pathways involved in human cellular targets have key roles in vesicle trafficking, immune evasion and cell cycle control. This demonstration of viral miRNA targets provides novel insights into viral pathogenesis. This review details the evidence for the existence of HCMV-encoded miRNA and their targets. HCMV miRNA in blood and other tissues is a potential diagnostic tool and blocking the effects of specific HCMV-encoded miRNA with sequence specific antagomirs is a potential new therapy.

authors

Ng KR,Li JY,Gleadle JM

doi

10.1586/14787210.2015.1106939

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1469-79

issue

12

eissn

1478-7210

issn

1744-8336

journal_volume

13

pub_type

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