Human cytomegalovirus encoded microRNAs: hitting targets.


:Human cytomegalovirus (HCMV) infection is of particular concern in immunodeficient individuals notably transplant recipients, leading to increased morbidity and mortality. HCMV is predicted to encode multiple microRNAs (miRNAs) and several have been characterized in vitro. Furthermore, these miRNAs have been shown to target human and viral mRNAs. Pathways involved in human cellular targets have key roles in vesicle trafficking, immune evasion and cell cycle control. This demonstration of viral miRNA targets provides novel insights into viral pathogenesis. This review details the evidence for the existence of HCMV-encoded miRNA and their targets. HCMV miRNA in blood and other tissues is a potential diagnostic tool and blocking the effects of specific HCMV-encoded miRNA with sequence specific antagomirs is a potential new therapy.


Ng KR,Li JY,Gleadle JM




Has Abstract


2015-01-01 00:00:00












  • Novel corona virus (COVID-19) pandemic: current status and possible strategies for detection and treatment of the disease.

    abstract:INTRODUCTION:In December 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak occurred and caused the coronavirus disease of 2019 (COVID-19), which affected ~ 190 countries. The World Health Organization (WHO) has declared COVID-19 a pandemic on 11 March 2020. AREA COVERED:In the review, a com...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Bhagat S,Yadav N,Shah J,Dave H,Swaraj S,Tripathi S,Singh S

    更新日期:2020-12-07 00:00:00

  • Prevention and treatment of viral diarrhea in pediatrics.

    abstract::Diarrhea is the second largest cause of mortality worldwide in children from the perinatal period to the age of 5 years. Rotavirus has been the most commonly identified viral cause of diarrhea in children. Norovirus is now recognized as the second most common viral pathogen. Adenovirus, astrovirus and sapovirus are th...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Anderson EJ

    更新日期:2010-02-01 00:00:00

  • Drug combinations for HIV: what's new?

    abstract::Since the advent of combined antiretroviral therapy there have been reductions in mortality and morbidity from HIV, transforming the disease into a chronic medical condition where newly diagnosed individuals can expect to live a near-normal life expectancy. When choosing therapy, probably the most important considerat...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Scourfield A,Waters L,Nelson M

    更新日期:2011-11-01 00:00:00

  • A cross-sectional study evaluating the knowledge and beliefs about, and the use of antibiotics amongst Malaysian university students.

    abstract:BACKGROUND:The introduction of antibiotics into modern medicine has changed clinical care by saving millions of lives. However, misuse of antibiotics has led to their benefits being overshadowed by the development of antimicrobial resistance. AIMS OF STUDY:This study aimed to assess university students' knowledge and ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Haque M,Rahman NAA,McKimm J,Binti Abdullah SL,Islam MZ,Zulkifli Z,Saidin NB,Azhar NIK,Binti Lutfi SNN,Binti Othman NSA

    更新日期:2019-04-01 00:00:00

  • A systematic literature review to assess the burden of herpes zoster disease in China.

    abstract:INTRODUCTION:Herpes zoster (HZ) or shingles occurs as a result of reactivation after a primary infection with varicella zoster virus (chickenpox). The burden of HZ in older adults in China is not well understood. We conducted a systematic literature review to understand the burden of disease related to HZ, its complica...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Yin D,Van Oorschot D,Jiang N,Marijam A,Saha D,Wu Z,Tang H,Diaz-Decaro J,Watson P,Xie X,Ren Y,He Y,Feng Y

    更新日期:2020-09-30 00:00:00

  • The effect of antivirals on COVID-19: a systematic review.

    abstract:INTRODUCTION:Coronavirus Disease 2019 is a contagious infection that has infected millions worldwide. The objective of this systematic review is to identify studies pertaining to antivirals, both as sole and combined therapies, in COVID-19 patients and review the clinical outcomes of these treatment methods. AREAS COV...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Hussain N,Yoganathan A,Hewage S,Alom S,Harky A

    更新日期:2020-10-20 00:00:00

  • Challenges with Diagnosing and Managing Sepsis in Older Adults.

    abstract::Sepsis in older adults has many challenges that affect rate of septic diagnosis, treatment, and monitoring parameters. Numerous age-related changes and comorbidities contribute to increased risk of infections in older adults, but also atypical symptomatology that delays diagnosis. Due to various pharmacokinetic/pharma...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Clifford KM,Dy-Boarman EA,Haase KK,Maxvill K,Pass SE,Alvarez CA

    更新日期:2016-01-01 00:00:00

  • Darunavir/cobicistat once daily for the treatment of HIV.

    abstract::A current focus in HIV management is improving adherence by minimizing pill burden with convenient formulations, including fixed-dose combinations (FDCs). Darunavir, a HIV protease inhibitor, co-administered with low-dose ritonavir (800/100 mg once daily), is recommended in guidelines in combination with other antiret...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Kakuda TN,Crauwels H,Opsomer M,Tomaka F,van de Casteele T,Vanveggel S,Iterbeke K,de Smedt G

    更新日期:2015-06-01 00:00:00

  • An updated approach to healthcare-associated meningitis.

    abstract::Among hospital-associated infections, healthcare-associated central nervous system infections are quite important because of high morbidity and mortality rates. The causative agents of healthcare-associated meningitis differ according to the status of immune systems and underlying diseases. The most frequent agents ar...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Bardak-Ozcem S,Sipahi OR

    更新日期:2014-03-01 00:00:00

  • Pulmonary bacterial coinfection in infants and children with viral respiratory infection.

    abstract::The true incidence of pulmonary bacterial coinfection in infants and children hospitalized with a viral respiratory infection is difficult to ascertain but can vary widely from under 1 to 44%. For the same patient group admitted to pediatric intensive care units and/or requiring ventilatory support, the evidence is mo...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Thorburn K,Riordan A

    更新日期:2012-08-01 00:00:00

  • Role of GB virus C in modulating HIV disease.

    abstract::GB virus C (GBV-C) is a member of the Flaviviridae family and the most closely related human virus to HCV. However, GBV-C does not replicate in hepatocytes, but rather in lymphocytes. GBV-C has a worldwide distribution and is transmitted sexually, parenterally and through mother-to-child transmission. Thus, co-infecti...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Schwarze-Zander C,Blackard JT,Rockstroh JK

    更新日期:2012-05-01 00:00:00

  • Pegylated IFN-alpha2a and ribavirin in the treatment of hepatitis C.

    abstract::Chronic hepatitis C is a major worldwide health problem with an estimated prevalence of 1.6-2%. The prognosis of chronic hepatitis C depends on the rate of fibrosis progression which, over a 20-30-year time span, may determine the risk of developing cirrhosis and its complications, namely hepatocellular carcinoma, liv...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Aghemo A,Rumi MG,Colombo M

    更新日期:2009-10-01 00:00:00

  • Hepatitis C-HIV coinfection: current and future therapy.

    abstract::Coinfection with hepatitis C in HIV-infected patients has been reported in 15-70% of patients depending on the mode of acquisition of both viruses. As recent advances in HIV-directed antiviral therapy have markedly delayed HIV progression and mortality, the incidence of complications arising from hepatitis C-associate...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Vyas JJ,Brown RS,Gaglio PJ

    更新日期:2003-10-01 00:00:00

  • Telaprevir for the treatment of chronic hepatitis C infection.

    abstract::Telaprevir is an NS3/4A protease inhibitor that has recently received US FDA approval for the treatment of chronic HCV infection. Telaprevir is given in combination with peg-IFN-α and ribavirin and is indicated for both treatment-naive and treatment-experienced patients with genotype 1 infection. Along with the other ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Muir AJ

    更新日期:2011-12-01 00:00:00

  • Is there really no benefit to combination therapy with colistin?

    abstract::Despite many theoretical and in vitro advantages, clinical data comparing combination therapy with colistin + rifampicin to colistin alone for infection due to extremely-drug resistant (XDR) Acinetobacter baumanni are scarce and limited by small numbers and/or low quality evidence. This article represents the first la...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章


    authors: Pogue JM,Kaye KS

    更新日期:2013-09-01 00:00:00

  • Toward the elimination of lymphatic filariasis by 2020: treatment update and impact assessment for the endgame.

    abstract::Lymphatic filariasis (LF) is an important public health problem endemic in 73 countries, where it is a major cause of acute and chronic morbidity and a significant impediment to socioeconomic development. It is targeted for elimination by 2020, through preventive chemotherapy using albendazole in combination with eith...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Rebollo MP,Bockarie MJ

    更新日期:2013-07-01 00:00:00

  • Intrapartum beta-lactam antibiotics for preventing group B streptococcal early-onset disease: can we abandon the concept of 'inadequate' intrapartum antibiotic prophylaxis?

    abstract::Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of I...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Berardi A,Spada C,Vaccina E,Boncompagni A,Bedetti L,Lucaccioni L

    更新日期:2020-01-01 00:00:00

  • Sertaconazole: updated review of a topical antifungal agent.

    abstract::Sertaconazole is an imidazole-type antifungal agent that has shown considerable in vitro activity against pathogenic fungi. Various studies carried out in animal models, clinical and toxicologic trials have confirmed the value of sertaconazole in the topical treatment of superficial mycoses in dermatology and gynecolo...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Carrillo-Muñoz AJ,Giusiano G,Ezkurra PA,Quindós G

    更新日期:2005-06-01 00:00:00

  • Management of bacteremia in patients undergoing hematopoietic stem cell transplantation.

    abstract::Bacteremias represent severe infectious complications following hematopoietic stem cell transplantation (HSCT). Frequency is highest during the pre-engraftment period, both in autologous and in allogeneic HSCT, when patients are granulocytopenic. In the postengraftment period, bacteremias are also frequent in the abse...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Castagnola E,Faraci M

    更新日期:2009-06-01 00:00:00

  • Is combination therapy for carbapenem-resistant Klebsiella pneumoniae the new standard of care?

    abstract::Carbapenem-resistant Klebsiella pneumoniae causes serious nosocomial infections and therapeutic options are limited. There is increasing evidence suggesting that combination antibiotic therapy is more effective than monotherapy and leads to better outcomes. However, questions remain about which regimen is optimal and ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 社论


    authors: Watkins RR,Deresinski S

    更新日期:2015-04-01 00:00:00

  • Incidence and risk factors of carbapenem-resistant Enterobacteriaceae infection in intensive care units: a matched case-control study.

    abstract:BACKGROUND:Carbapenem-resistant Enterobacteriaceae (CRE) infection is associated with intensive care admissions, morbidity, and mortality. Our study aimed to determine the incidence, risk factors, and patient outcomes of CRE in the ICU units. METHODS:This was a retrospective matched case-control study of patients admi...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Aleidan FAS,Alkhelaifi H,Alsenaid A,Alromaizan H,Alsalham F,Almutairi A,Alsulaiman K,Abdel Gadir AG

    更新日期:2020-09-20 00:00:00

  • HIV-1/hepatitis B coinfection.

    abstract::Reviews the epidemiology, natural history and the current status of treatment of HIV/hepatitis B coinfection. ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Benhamou Y

    更新日期:2005-04-01 00:00:00

  • Immune approaches in tuberculosis therapy: a brief overview.

    abstract::TB is typically caused by Mycobacterium tuberculosis, a symbiotic bacterium present in one-third of the world's population. There any many factors triggering overt clinical disease in a small proportion of humans. In our view the major role in the process is played by the host's immune response, especially self-direct...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Bourinbaiar AS,Mezentseva MV,Butov DA,Nyasulu PS,Efremenko YV,Jirathitikal V,Mishchenko VV,Kutsyna GA

    更新日期:2012-03-01 00:00:00

  • Evaluation and management of hepatitis B virus infection in hematopoietic stem cell transplantation: before and after transplantation.

    abstract::HBV infection remains a major global health problem and continues to be a common cause of liver-related morbidity and mortality in both immunocompetent and immunosuppressed individuals. Reactivation of HBV is a serious complication of chemotherapy/immunosuppressive therapy in patients with HBV infection. In this artic...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Idilman R,Arat M

    更新日期:2011-08-01 00:00:00

  • Precision medicine for the diagnosis and treatment of carbapenem-resistant Enterobacterales: time to think from a different perspective.

    abstract:INTRODUCTION:Carbapenem-resistant Enterobacterales (CRE) represent a global public health problem. Precision medicine (PM) is a multicomponent medical approach that should be used to individualize the management of patients infected with CRE. AREAS COVERED:Here, we differentiate carbapenem-producing CRE (CP-CRE) from ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Reyes S,Nicolau DP

    更新日期:2020-08-01 00:00:00

  • Targeting eicosanoid pathways in the development of novel anti-influenza drugs.

    abstract::The constant new emergence of life-threatening human respiratory viral pathogens presents new challenges to clinicians who are left with no available therapeutic interventions. Highly pathogenic strains of influenza A virus (IAV) share an enhanced capacity to propagate to the lower airways and paralyze alveolar macrop...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Coulombe F,Divangahi M

    更新日期:2014-11-01 00:00:00

  • Diagnostic accuracy of the Xpert MTB/RIF assay for abdominal tuberculosis: a systematic review and meta-analysis.

    abstract:BACKGROUND:We performed a meta-analysis to determine diagnostic accuracy of Xpert MTB/RIF for diagnosis of abdominal (intestinal or peritoneal) tuberculosis (TB) in various tissues (intestinal, omental/peritoneal tissue or ascitic fluid). METHODS:Electronic databases were searched for observational studies on use of X...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Sharma V,Soni H,Kumar-M P,Dawra S,Mishra S,Mandavdhare HS,Singh H,Dutta U

    更新日期:2020-08-26 00:00:00

  • Developing novel strategies to prevent parasitic infections.

    abstract::The 49th Annual Spring Meeting of the British Society of Parasitology was held at Nottingham University, UK, on 11-14 April 2011. Although a meeting of a national parasitological society, the meeting attracted approximately 375 delegates from 30 countries worldwide. Of the various themes at this meeting, two were focu...

    journal_title:Expert review of anti-infective therapy



    authors: Staines HM,Croft SL,Horrocks PD

    更新日期:2011-07-01 00:00:00

  • Management of candidemia in patients with Clostridium difficile infection.

    abstract:INTRODUCTION:Patients with C. difficile infection (CDI) experience intestinal microflora changes that can promote the overgrowth and subsequent translocation of gut resident pathogens into the blood. Consistently, CDI due to PCR-ribotype 027 strain, severe or relapsing CDI, and treatment with high-dosage vancomycin are...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Falcone M,Venditti M,Sanguinetti M,Posteraro B

    更新日期:2016-07-01 00:00:00

  • Delivery of host cell-directed therapeutics for intracellular pathogen clearance.

    abstract::Intracellular pathogens present a major health risk because of their innate ability to evade clearance. Their location within host cells and ability to react to the host environment by mutation or transcriptional changes often enables survival mechanisms to resist standard therapies. Host-directed drugs do not target ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Collier MA,Gallovic MD,Peine KJ,Duong AD,Bachelder EM,Gunn JS,Schlesinger LS,Ainslie KM

    更新日期:2013-11-01 00:00:00