Human cytomegalovirus encoded microRNAs: hitting targets.


:Human cytomegalovirus (HCMV) infection is of particular concern in immunodeficient individuals notably transplant recipients, leading to increased morbidity and mortality. HCMV is predicted to encode multiple microRNAs (miRNAs) and several have been characterized in vitro. Furthermore, these miRNAs have been shown to target human and viral mRNAs. Pathways involved in human cellular targets have key roles in vesicle trafficking, immune evasion and cell cycle control. This demonstration of viral miRNA targets provides novel insights into viral pathogenesis. This review details the evidence for the existence of HCMV-encoded miRNA and their targets. HCMV miRNA in blood and other tissues is a potential diagnostic tool and blocking the effects of specific HCMV-encoded miRNA with sequence specific antagomirs is a potential new therapy.


Ng KR,Li JY,Gleadle JM




Has Abstract


2015-01-01 00:00:00












  • An overview of nanotechnology-based treatment approaches against Helicobacter Pylori.

    abstract::Introduction: Helicobacter Pylori (H.Pylori) is a pathogen that infects about 50% of the world's population and is known to be responsible for gastroduodenal diseases such as atrophic gastritis, peptic ulcer and stomach cancer. Nowadays, there is no treatment that ensures complete eradication. In addition, resistance ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Safarov T,Kiran B,Bagirova M,Allahverdiyev AM,Abamor ES

    更新日期:2019-10-01 00:00:00

  • Treatment options for multidrug-resistant bacteria.

    abstract::As a consequence of antibiotic overuse and misuse, nosocomial infections caused by multidrug-resistant bacteria represent a physician's nightmare throughout the world. No newer antimicrobials active against Pseudomonas aeruginosa, the main multidrug-resistant nosocomial pathogen, are available or under investigation. ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Giamarellou H

    更新日期:2006-08-01 00:00:00

  • The effect of antivirals on COVID-19: a systematic review.

    abstract:INTRODUCTION:Coronavirus Disease 2019 is a contagious infection that has infected millions worldwide. The objective of this systematic review is to identify studies pertaining to antivirals, both as sole and combined therapies, in COVID-19 patients and review the clinical outcomes of these treatment methods. AREAS COV...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Hussain N,Yoganathan A,Hewage S,Alom S,Harky A

    更新日期:2020-10-20 00:00:00

  • Hepatitis C-HIV coinfection: current and future therapy.

    abstract::Coinfection with hepatitis C in HIV-infected patients has been reported in 15-70% of patients depending on the mode of acquisition of both viruses. As recent advances in HIV-directed antiviral therapy have markedly delayed HIV progression and mortality, the incidence of complications arising from hepatitis C-associate...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Vyas JJ,Brown RS,Gaglio PJ

    更新日期:2003-10-01 00:00:00

  • Predicting bacteremia by procalcitonin levels in patients evaluated for sepsis in the emergency department.

    abstract::Evaluation of: Riedel S, Melendez JH, An AT, Rosenbaum JE, Zenilman JM. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am. J. Clin. Pathol. 135(2), 182-189 (2011). In a recent report, Riedel et al. proposed a procalcitonin cutoff of 0.1 ng/ml to rule out bacteremia in...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章


    authors: Albrich WC,Mueller B

    更新日期:2011-06-01 00:00:00

  • Severe influenza in children: incidence and risk factors.

    abstract:INTRODUCTION:The identification of factors that can predispose to the development of severe influenza is essential to enable the implementation of optimal prevention and control measures for vulnerable populations. AREAS COVERED:Unfortunately, data in the pediatric age group remain difficult to interpret. However, epi...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Principi N,Esposito S

    更新日期:2016-10-01 00:00:00

  • Elvitegravir: a once-daily, boosted, HIV-1 integrase inhibitor.

    abstract::The development of HIV-1 integrase strand transfer inhibitors (INSTIs) has been a major therapeutic breakthrough in the management of HIV-1 infection. The first HIV-1 integrase inhibitor, raltegravir, was licensed in 2007 and was subsequently approved for use in treatment-naive patients. Since then, newer members of t...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Lampiris HW

    更新日期:2012-01-01 00:00:00

  • Drug combinations for HIV: what's new?

    abstract::Since the advent of combined antiretroviral therapy there have been reductions in mortality and morbidity from HIV, transforming the disease into a chronic medical condition where newly diagnosed individuals can expect to live a near-normal life expectancy. When choosing therapy, probably the most important considerat...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Scourfield A,Waters L,Nelson M

    更新日期:2011-11-01 00:00:00

  • 6th meeting of the World Society for Pediatric Infectious Diseases.

    abstract::The 6th World Congress of the World Society for Pediatric Infectious Diseases (WSPID), which was recently held in Buenos Aires, Argentina, between 18 and 22 November 2009, attracted 2401 attendees from 90 countries representing six continents. The WSPID, founded in 1994 by Professor Saldana Gonzalez of the Mexican Ped...

    journal_title:Expert review of anti-infective therapy



    authors: Falade AG

    更新日期:2010-03-01 00:00:00

  • MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale.

    abstract:INTRODUCTION:COVID-19 disease progresses through a number of distinct phases. The management of each phase is unique and specific. The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in seve...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Marik PE,Kory P,Varon J,Iglesias J,Meduri GU

    更新日期:2020-08-18 00:00:00

  • Risk of infection associated with anti-TNF-α therapy.

    abstract:INTRODUCTION:The advent, more than two decades ago, of monoclonal antibodies and soluble receptors targeting tumor necrosis factor (TNF)-α has revolutionized the therapeutic approach to otherwise difficult-to-treat autoimmune and inflammatory diseases. However, due to the pleiotropic functions played by this pro-inflam...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Fernández-Ruiz M,Aguado JM

    更新日期:2018-12-01 00:00:00

  • Tocilizumab for patients with severe COVID-19: a retrospective, multi-center study.

    abstract:BACKGROUND:Tocilizumab, an inhibitor of the interleukin-6 receptor, may decrease the inflammatory response and control the symptoms of severe coronavirus disease 2019 (COVID-19), but the evidence is scarce. METHODS:This retrospective study included patients with severe COVID-19 requiring oxygen therapy who received to...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,多中心研究


    authors: Tomasiewicz K,Piekarska A,Stempkowska-Rejek J,Serafińska S,Gawkowska A,Parczewski M,Niścigorska-Olsen J,Łapiński TW,Zarębska-Michaluk D,Kowalska JD,Horban A,Flisiak R

    更新日期:2021-01-01 00:00:00

  • Management of bacteremia in patients undergoing hematopoietic stem cell transplantation.

    abstract::Bacteremias represent severe infectious complications following hematopoietic stem cell transplantation (HSCT). Frequency is highest during the pre-engraftment period, both in autologous and in allogeneic HSCT, when patients are granulocytopenic. In the postengraftment period, bacteremias are also frequent in the abse...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Castagnola E,Faraci M

    更新日期:2009-06-01 00:00:00

  • Implications and emerging control strategies for ventilator-associated infections.

    abstract::Ventilator-associated pneumonia (VAP) remains a major burden to the healthcare system and intubated patients in intensive care units. In fact, VAP is responsible for at least 50% of prescribed antibiotics to patients who need mechanical ventilation. One of the factors contributing to VAP pathogenesis is believed to be...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Loo CY,Lee WH,Young PM,Cavaliere R,Whitchurch CB,Rohanizadeh R

    更新日期:2015-03-01 00:00:00

  • Biological challenges of phage therapy and proposed solutions: a literature review.

    abstract::Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans.Areas covered: This review assessed the scientific literature on phage therapy published between 1 Janu...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Caflisch KM,Suh GA,Patel R

    更新日期:2019-12-01 00:00:00

  • 2010 HIV Diagnostics Conference.

    abstract::During the 2010 HIV Diagnostics Conference, which took place in Orlando (FL, USA) between 24 and 26 March 2010, salient new data related to three aspects of HIV testing (rapid point-of-care testing, laboratory assays and new technologies) were presented and discussed. A conundrum central to HIV diagnostics in the USA ...

    journal_title:Expert review of anti-infective therapy



    authors: Pandori MW,Branson BM

    更新日期:2010-06-01 00:00:00

  • Rapid molecular diagnostics for multi-drug resistant tuberculosis in India.

    abstract:INTRODUCTION:Rapid molecular diagnostic methods help in the detection of TB and Rifampicin resistance. These methods detect TB early, are accurate and play a crucial role in reducing the burden of drug resistant tuberculosis. Areas covered: This review analyses rapid molecular diagnostic tools used in the diagnosis of ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Ramachandran R,Muniyandi M

    更新日期:2018-03-01 00:00:00

  • Prognostic markers of meningococcal disease in children: recent advances and future challenges.

    abstract::Meningococcal disease is a life-threatening condition and a major cause of bacterial meningitis and sepsis worldwide. In many fatal cases, meningococcal disease is rapidly progressive and death occurs within hours of the initial symptoms. The early identification of patients at high risk of death would be useful in or...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,meta分析,评审


    authors: Montero-Martín M,Inwald DP,Carrol ED,Martinón-Torres F

    更新日期:2014-11-01 00:00:00

  • Post-exposure prophylaxis for HIV infection.

    abstract::Post-exposure prophylaxis (PEP) with antiretrovirals is now widely used worldwide after either occupational contact (with blood or another blood-containing fluid), or nonoccupational contact (mainly sexual or injection-drug use). It is assumed to reduce the risk of HIV transmission by at least 80%, although its effica...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Rey D

    更新日期:2011-04-01 00:00:00

  • Risk factors and prophylaxis against invasive fungal disease for haematology and stem cell transplant recipients: an evolving field.

    abstract:INTRODUCTION:Due to increasing intensity and complexity of therapies and longer survivorship, many patients with haematologic malignancy (HM) are at risk of invasive fungal disease (IFD). Mortality from IFD is high and treatment of an episode of IFD results in an excess length of hospital stay and costs and delays deli...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Douglas AP,Slavin MA

    更新日期:2016-12-01 00:00:00

  • Efficacy of telavancin, a lipoglycopeptide antibiotic, in experimental models of Gram-positive infection.

    abstract::Telavancin is a parenteral lipoglycopeptide antibiotic with a dual mechanism of action contributing to bactericidal activity against multidrug-resistant Gram-positive pathogens. It has been approved for the treatment of complicated skin and skin structure infections due to susceptible Gram-positive bacteria and hospit...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Hegde SS,Janc JW

    更新日期:2014-12-01 00:00:00

  • Addressing antimicrobial resistance in Nigerian hospitals: exploring physicians prescribing behavior, knowledge, and perception of antimicrobial resistance and stewardship programs.

    abstract:INTRODUCTION:We assessed the knowledge of, attitude toward antimicrobial resistance (AMR) and practice of antimicrobial stewardship (AMS) among physicians in Nigeria to provide future guidance to the Nigerian National Action Plan for AMR. METHODS:A descriptive cross-sectional questionnaire-based study explored the phy...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Babatola AO,Fadare JO,Olatunya OS,Obiako R,Enwere O,Kalungia A,Ojo TO,Sunmonu TA,Desalu O,Godman B

    更新日期:2020-11-02 00:00:00

  • Extended or continuous versus short-term intravenous infusion of cephalosporins: a meta-analysis.

    abstract::The authors sought to study whether extended or continuous infusion of cephalosporins is associated with better clinical outcomes than short-term infusion. PubMed and Scopus databases were systematically searched. Studies reporting the clinical outcomes of patients receiving extended or continuous infusion (≥3 or 24 h...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,meta分析


    authors: Korbila IP,Tansarli GS,Karageorgopoulos DE,Vardakas KZ,Falagas ME

    更新日期:2013-06-01 00:00:00

  • Detection and diagnosis of Mycobacterium tuberculosis.

    abstract::Tuberculosis continues to be a major health problem worldwide, affecting millions of people each year. Accurate and rapid diagnosis is key to controlling the disease, yet the traditional tests for TB produce results that are either inaccurate or take too long to be definitive. A fast and reliable diagnostic method tha...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Al-Zamel FA

    更新日期:2009-11-01 00:00:00

  • Antibiotic resistance in the intensive care unit setting.

    abstract::Antibiotic resistance is an important factor influencing clinical outcome for patients in intensive care units. It is also associated with increased healthcare costs resulting from prolonged patient stays. The problem of antibiotic resistance is particularly acute in intensive care units because they house seriously i...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Johnson AP

    更新日期:2003-08-01 00:00:00

  • An updated approach to healthcare-associated meningitis.

    abstract::Among hospital-associated infections, healthcare-associated central nervous system infections are quite important because of high morbidity and mortality rates. The causative agents of healthcare-associated meningitis differ according to the status of immune systems and underlying diseases. The most frequent agents ar...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Bardak-Ozcem S,Sipahi OR

    更新日期:2014-03-01 00:00:00

  • Antiparasitic treatment for solitary cysticercus granuloma: to treat or not to treat?

    abstract::Neurocysticercosis is a major cause of neurologic disease worldwide. In India and other developing countries, single small enhancing computed tomographic lesions representing solitary cysticercus granuloma are a common cause of new-onset seizures. The interesting feature of these solitary enhancing lesions is their sp...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章


    authors: Garg RK

    更新日期:2008-02-01 00:00:00

  • Late HIV presentation: epidemiology, clinical implications and management.

    abstract::Late presentation of HIV is common and is associated with several adverse outcomes including an increased risk of clinical progression, blunted immune recovery on highly active antiretroviral therapy and a greater risk of drug toxicity. Late presenters may have higher rates of poor adherence, exacerbated by the same f...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Waters L,Sabin CA

    更新日期:2011-10-01 00:00:00

  • HIV-1/hepatitis B coinfection.

    abstract::Reviews the epidemiology, natural history and the current status of treatment of HIV/hepatitis B coinfection. ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Benhamou Y

    更新日期:2005-04-01 00:00:00

  • Micafungin: a therapeutic review.

    abstract::In recent decades, the incidence of aspergillosis, candidiasis and clinically important deep mycoses has been increasing, with advances in transplantation medicine and anticancer chemotherapy. Micafungin (FK463, Fujisawa Healthcare) has been developed as a novel type of antifungal agent, which inhibits 1,3-beta-D-gluc...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Higashiyama Y,Kohno S

    更新日期:2004-06-01 00:00:00