Human cytomegalovirus encoded microRNAs: hitting targets.


:Human cytomegalovirus (HCMV) infection is of particular concern in immunodeficient individuals notably transplant recipients, leading to increased morbidity and mortality. HCMV is predicted to encode multiple microRNAs (miRNAs) and several have been characterized in vitro. Furthermore, these miRNAs have been shown to target human and viral mRNAs. Pathways involved in human cellular targets have key roles in vesicle trafficking, immune evasion and cell cycle control. This demonstration of viral miRNA targets provides novel insights into viral pathogenesis. This review details the evidence for the existence of HCMV-encoded miRNA and their targets. HCMV miRNA in blood and other tissues is a potential diagnostic tool and blocking the effects of specific HCMV-encoded miRNA with sequence specific antagomirs is a potential new therapy.


Ng KR,Li JY,Gleadle JM




Has Abstract


2015-01-01 00:00:00












  • Risk factors for West Nile virus infection and disease in populations and individuals.

    abstract::West Nile virus (WNV) is a mosquito-borne enveloped positive-strand RNA virus that emerged in North America in 1999 in New York City. Over the past 15 years, WNV has become established throughout the USA and has spread into Canada, Mexico and the Caribbean. CDC reports indicate >41,000 clinical cases, including more t...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Montgomery RR,Murray KO

    更新日期:2015-03-01 00:00:00

  • Commercially available assays for multiplex detection of alpha human papillomaviruses.

    abstract::Five main groups of commercial assays for the multiplex detection of alpha human papillomaviruses (HPVs) are currently available. DNA-based screening assays, which test for the presence of 13-14 HPVs without determination of HPV type, have been the standard for HPV detection in the last decade. Assays that combine tes...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Poljak M,Kocjan BJ

    更新日期:2010-10-01 00:00:00

  • Prognostic markers of meningococcal disease in children: recent advances and future challenges.

    abstract::Meningococcal disease is a life-threatening condition and a major cause of bacterial meningitis and sepsis worldwide. In many fatal cases, meningococcal disease is rapidly progressive and death occurs within hours of the initial symptoms. The early identification of patients at high risk of death would be useful in or...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,meta分析,评审


    authors: Montero-Martín M,Inwald DP,Carrol ED,Martinón-Torres F

    更新日期:2014-11-01 00:00:00

  • Is it time to revisit routine administration of antibiotic for preterm prelabor rupture of membranes?

    abstract::Preterm prelabor rupture of membranes (pPROM) is the precursor of up to 40% of preterm deliveries and an independent risk factor for neonatal disease, death and long-term pulmonary and neurodevelopmental deficits. A significant proportion of cases of pPROM are infection driven, although these are difficult to delineat...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章


    authors: Ugwumadu A

    更新日期:2007-08-01 00:00:00

  • Intrapartum beta-lactam antibiotics for preventing group B streptococcal early-onset disease: can we abandon the concept of 'inadequate' intrapartum antibiotic prophylaxis?

    abstract::Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of I...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Berardi A,Spada C,Vaccina E,Boncompagni A,Bedetti L,Lucaccioni L

    更新日期:2020-01-01 00:00:00

  • Necrobacillosis in humans.

    abstract::Necrobacillosis, often used synonymously with Lemierre's syndrome, is a form of abscess infection in the peritonsillar area associated with a thrombophlebitis and caused by the strict anaerobic species Fusobacterium necrophorum. The thrombosis formed affects the internal jugular vein, from which the bacteria are seede...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Dahlén G,Ebenfelt A

    更新日期:2011-02-01 00:00:00

  • Diagnostic accuracy of the Xpert MTB/RIF assay for abdominal tuberculosis: a systematic review and meta-analysis.

    abstract:BACKGROUND:We performed a meta-analysis to determine diagnostic accuracy of Xpert MTB/RIF for diagnosis of abdominal (intestinal or peritoneal) tuberculosis (TB) in various tissues (intestinal, omental/peritoneal tissue or ascitic fluid). METHODS:Electronic databases were searched for observational studies on use of X...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Sharma V,Soni H,Kumar-M P,Dawra S,Mishra S,Mandavdhare HS,Singh H,Dutta U

    更新日期:2020-08-26 00:00:00

  • Procalcitonin-guided antibiotic therapy for chronic obstructive pulmonary disease exacerbations.

    abstract::The aim of this article is to review the current literature examining the use of procalcitonin-guided antibiotic therapy for management of chronic obstructive pulmonary disease (COPD) exacerbations. Procalcitonin is a serum marker that rises in response to bacterial infections, but remains low in nonbacterial infectio...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Tokman S,Schuetz P,Bent S

    更新日期:2011-06-01 00:00:00

  • Severe influenza in children: incidence and risk factors.

    abstract:INTRODUCTION:The identification of factors that can predispose to the development of severe influenza is essential to enable the implementation of optimal prevention and control measures for vulnerable populations. AREAS COVERED:Unfortunately, data in the pediatric age group remain difficult to interpret. However, epi...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Principi N,Esposito S

    更新日期:2016-10-01 00:00:00

  • Risk factors for hepatitis E virus infection and disease.

    abstract::Hepatitis E, caused by hepatitis E virus, is a disease of global significance, causing 20 million infections each year. Genotypes 1 and 2 have vastly different epidemiological patterns from genotypes 3 and 4. In genotype 1 and 2 endemic areas, most infections and illness occur in persons 15-30 years of age, with pregn...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Kmush BL,Nelson KE,Labrique AB

    更新日期:2015-01-01 00:00:00

  • Advances in the epidemiology, diagnosis and treatment of cryptosporidiosis.

    abstract::Cryptosporidiosis, the disease caused by protozoa of the genus Cryptosporidium, represents a major public health problem in both developing and developed countries. The infection can be severe and life threatening among immunocompromised individuals, particularly in AIDS patients and in those with primary immunodefici...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Cacciò SM,Pozio E

    更新日期:2006-06-01 00:00:00

  • Direct acting antivirals are associated with more liver stiffness regression than pegylated interferon therapy in chronic hepatitis C patients.

    abstract::Objectives: Extent of post-treatment fibrosis change in patients with different stages of fibrosis not fully known. We aimed to study changes in liver fibrosis in chronic hepatitis C patients who were treated with pegylated interferon/ribavirin (PEG/RBV) or direct acting antivirals (DAAs). Methods: Retrospective evalu...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Abdelsameea E,Alsebaey A,Abdel-Samiee M,Abdel-Razek W,Salama M,Waked I

    更新日期:2020-12-29 00:00:00

  • Development of treatment strategies to combat Ebola and Marburg viruses.

    abstract::Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Paragas J,Geisbert TW

    更新日期:2006-02-01 00:00:00

  • Macrolide-resistant Streptococcus pyogenes: prevalence and treatment strategies.

    abstract::Although penicillin remains the first-choice treatment for Streptococcus pyogenes infection, macrolides are important alternatives for allergic patients and lincosamides are recommended together with β-lactams in invasive infections. S. pyogenes may exhibit macrolide resistance because of active efflux (mef genes) or ...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Silva-Costa C,Friães A,Ramirez M,Melo-Cristino J

    更新日期:2015-05-01 00:00:00

  • Targeting eicosanoid pathways in the development of novel anti-influenza drugs.

    abstract::The constant new emergence of life-threatening human respiratory viral pathogens presents new challenges to clinicians who are left with no available therapeutic interventions. Highly pathogenic strains of influenza A virus (IAV) share an enhanced capacity to propagate to the lower airways and paralyze alveolar macrop...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Coulombe F,Divangahi M

    更新日期:2014-11-01 00:00:00

  • Diagnosis and management of Lyme neuroborreliosis.

    abstract:INTRODUCTION:The nervous system is involved in 10-15% of patients infected with B. burgdorferi, B. afzelii and B. garinii. This review will address widespread misconceptions about the clinical phenomenology, diagnostic approach and response to treatment of neuroborreliosis. Areas covered: Improvements in diagnostic tes...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Halperin JJ

    更新日期:2018-01-01 00:00:00

  • Antimicrobial resistance and the management of anaerobic infections.

    abstract::Management of anaerobic infections encompasses surgical procedures, antibacterial therapy and adjuncts. At present, metronidazole, penems, beta-lactam/beta-lactamase inhibitor combinations and chloramphenicol have the highest activity against obligate anaerobes. Tigecycline is a promising new agent. Other antibacteria...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Boyanova L,Kolarov R,Mitov I

    更新日期:2007-08-01 00:00:00

  • Targeting drug tolerance in mycobacteria: a perspective from mycobacterial biofilms.

    abstract::Multidrug chemotherapy for 6-9-months is one of the primary treatments in effective control of tuberculosis, although the mechanisms underlying the persistence of its etiological agent, Mycobacterium tuberculosis, against antibiotics remain unclear. Ever-mounting evidence indicates that the survival of many environmen...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Islam MS,Richards JP,Ojha AK

    更新日期:2012-09-01 00:00:00

  • Lopinavir plus ritonavir: a novel protease inhibitor combination for HIV infections.

    abstract::Lopinavir is a protease inhibitor (PI) for the treatment of HIV infection that was specifically designed to overcome the shortcomings of earlier agents in this class. It is the only PI coformulated with ritonavir, whose pharmacological boosting effect results in a highly potent, well-tolerated, clinically effective an...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Tan D,Walmsley S

    更新日期:2007-02-01 00:00:00

  • Micafungin: a therapeutic review.

    abstract::In recent decades, the incidence of aspergillosis, candidiasis and clinically important deep mycoses has been increasing, with advances in transplantation medicine and anticancer chemotherapy. Micafungin (FK463, Fujisawa Healthcare) has been developed as a novel type of antifungal agent, which inhibits 1,3-beta-D-gluc...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Higashiyama Y,Kohno S

    更新日期:2004-06-01 00:00:00

  • TB diagnostic tests: how do we figure out their costs?

    abstract::Tuberculosis continues to be a major global health problem. Lack of accurate, rapid and cost-effective diagnostic tests poses a huge obstacle to global TB control. While several new diagnostic tools are being developed and evaluated for TB, it is important that new tools are introduced for widespread use only after ca...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Sohn H,Minion J,Albert H,Dheda K,Pai M

    更新日期:2009-08-01 00:00:00

  • An updated approach to healthcare-associated meningitis.

    abstract::Among hospital-associated infections, healthcare-associated central nervous system infections are quite important because of high morbidity and mortality rates. The causative agents of healthcare-associated meningitis differ according to the status of immune systems and underlying diseases. The most frequent agents ar...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Bardak-Ozcem S,Sipahi OR

    更新日期:2014-03-01 00:00:00

  • Risk factors and prophylaxis against invasive fungal disease for haematology and stem cell transplant recipients: an evolving field.

    abstract:INTRODUCTION:Due to increasing intensity and complexity of therapies and longer survivorship, many patients with haematologic malignancy (HM) are at risk of invasive fungal disease (IFD). Mortality from IFD is high and treatment of an episode of IFD results in an excess length of hospital stay and costs and delays deli...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Douglas AP,Slavin MA

    更新日期:2016-12-01 00:00:00

  • Antibiotics in the first hour: is there new evidence?

    abstract:INTRODUCTION:International guidelines have recommended for many years to start antimicrobials as early as possible in sepsis and shock. This concept has been challenged by the controversial results of experimental studies and clinical cohorts and resulted in intense debate in the literature. This review aims to summari...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Dupuis C,Timsit JF

    更新日期:2021-01-01 00:00:00

  • Predicting bacteremia by procalcitonin levels in patients evaluated for sepsis in the emergency department.

    abstract::Evaluation of: Riedel S, Melendez JH, An AT, Rosenbaum JE, Zenilman JM. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am. J. Clin. Pathol. 135(2), 182-189 (2011). In a recent report, Riedel et al. proposed a procalcitonin cutoff of 0.1 ng/ml to rule out bacteremia in...

    journal_title:Expert review of anti-infective therapy

    pub_type: 评论,杂志文章


    authors: Albrich WC,Mueller B

    更新日期:2011-06-01 00:00:00

  • Diagnosis of hantavirus infection in humans.

    abstract::Rodent-borne hantaviruses (family Bunyaviridae, genus Hantavirus) cause hantavirus pulmonary syndrome in the Americas and hemorrhagic fever with renal syndrome in Europe and Asia. The viruses are transmitted to humans mainly by inhalation of virus-contaminated aerosols of rodent excreta and secreta. Classic clinical h...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Mattar S,Guzmán C,Figueiredo LT

    更新日期:2015-08-01 00:00:00

  • The effect of antivirals on COVID-19: a systematic review.

    abstract:INTRODUCTION:Coronavirus Disease 2019 is a contagious infection that has infected millions worldwide. The objective of this systematic review is to identify studies pertaining to antivirals, both as sole and combined therapies, in COVID-19 patients and review the clinical outcomes of these treatment methods. AREAS COV...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章


    authors: Hussain N,Yoganathan A,Hewage S,Alom S,Harky A

    更新日期:2020-10-20 00:00:00

  • Treatment of invasive candidiasis: between guidelines and daily clinical practice.

    abstract::Invasive candidiasis, including candidemia (IC/C), is a major cause of morbidity and mortality among hospitalized patients. While incidence is higher in intensive care units, the majority of cases of candidemia are documented in medical wards. Although Candida albicans is still the most frequently isolated species, IC...

    journal_title:Expert review of anti-infective therapy

    pub_type: 社论


    authors: Tagliaferri E,Menichetti F

    更新日期:2015-06-01 00:00:00

  • Etiology, diagnosis and management of chronic rhinosinusitis.

    abstract::Chronic rhinosinusitis (CRS) is a common health care problem, yet many aspects of this diagnosis remain poorly understood. Its etiology is often debated and remains a significant area of research. The diagnosis of CRS is based on subjective symptoms, duration of symptoms and objective evidence of inflammation. Each of...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Manes RP,Batra PS

    更新日期:2013-01-01 00:00:00

  • Syphilis incidence in men who have sex with men with human immunodeficiency virus comorbidity and the importance of integrating sexually transmitted infection prevention into HIV care.

    abstract:INTRODUCTION:Syphilis continues to be a growing epidemic among men who have sex with men (MSM), particularly for those living with the human immunodeficiency virus (HIV). In 2016, MSM accounted for 80% of primary and secondary syphilis diagnoses in men in the United States; almost half of who were also HIV-infected. Th...

    journal_title:Expert review of anti-infective therapy

    pub_type: 杂志文章,评审


    authors: Refugio ON,Klausner JD

    更新日期:2018-04-01 00:00:00