Abstract:
:The constant new emergence of life-threatening human respiratory viral pathogens presents new challenges to clinicians who are left with no available therapeutic interventions. Highly pathogenic strains of influenza A virus (IAV) share an enhanced capacity to propagate to the lower airways and paralyze alveolar macrophage antiviral capacity in order to replicate efficiently and cause pathologic inflammation. Following a century of using NSAIDs for the management of influenza symptoms, a number of studies have interrogated their function in the host response to IAV infection. We herein provide an overview of these studies as well as further insight of how pathogenic IAV hijacks the microsomal prostaglandin E synthase-1-dependent prostaglandin E2 pathway in order to evade host type I interferon-mediated antiviral immunity. We also reflect on the potential beneficial action of microsomal prostaglandin E synthase-1 inhibitory compounds in the treatment of IAV infections and potentially other RNA viruses.
journal_name
Expert Rev Anti Infect Therjournal_title
Expert review of anti-infective therapyauthors
Coulombe F,Divangahi Mdoi
10.1586/14787210.2014.966082subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1337-43issue
11eissn
1478-7210issn
1744-8336journal_volume
12pub_type
杂志文章,评审abstract:INTRODUCTION:The combination of growing antimicrobial resistance with a dry pipeline has resulted in infections that can no longer be treated. Specific reasons have led to companies' exit from the antibacterial space, however recent incentives are spurring interest to reinvigorate the pipeline. Areas covered: This arti...
journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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