Boceprevir: an oral protease inhibitor for the treatment of chronic HCV infection.

abstract：:Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans.Areas covered: This review assessed the scientific literature on phage therapy published between 1 Janu...

journal_title：Expert review of anti-infective therapy

authors： Caflisch KM,Suh GA,Patel R

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Onychomycosis is a chronic fungal infection of the nail bed, matrix or plate. It accounts for roughly 50% of all nail disease. As the prevalence of onychomycosis is increasing, a critical review of diagnostic techniques and treatment options is required. Areas covered: This review discusses the current dia...

journal_title：Expert review of anti-infective therapy

authors： Gupta AK,Mays RR,Versteeg SG,Shear NH,Piguet V

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Patients with C. difficile infection (CDI) experience intestinal microflora changes that can promote the overgrowth and subsequent translocation of gut resident pathogens into the blood. Consistently, CDI due to PCR-ribotype 027 strain, severe or relapsing CDI, and treatment with high-dosage vancomycin are...

journal_title：Expert review of anti-infective therapy

authors： Falcone M,Venditti M,Sanguinetti M,Posteraro B

更新日期：2016-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection spreads primarily via contact with infected blood and can establish a persistent infection in 80% of infected individuals, progressively causing chronic liver disease that can lead to hepatocellular carcinoma or end-stage liver disease requiring a transplant. There is no vaccine, and ...

journal_title：Expert review of anti-infective therapy

authors： Stamataki Z

更新日期：2010-09-01 00:00:00

abstract：:Lymphogranuloma venereum (LGV) is a sexually transmitted infection, previously only seen in tropical regions. This changed in 2003 when the first endemically acquired LGV cases were reported in Rotterdam, the Netherlands, among predominantly HIV positive men who have sex with men (MSM). Early diagnosis is important to...

journal_title：Expert review of anti-infective therapy

authors： de Vrieze NH,de Vries HJ

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Due to increasing intensity and complexity of therapies and longer survivorship, many patients with haematologic malignancy (HM) are at risk of invasive fungal disease (IFD). Mortality from IFD is high and treatment of an episode of IFD results in an excess length of hospital stay and costs and delays deli...

journal_title：Expert review of anti-infective therapy

authors： Douglas AP,Slavin MA

更新日期：2016-12-01 00:00:00

abstract：:Following the discovery of innate immune receptors, the topics of innate immunity and its role in defense against infective agents have recently blossomed into very active research fields, after several decades of neglect. Among innate immune cells, natural killer (NK) cells are endowed with the unique ability to reco...

journal_title：Expert review of anti-infective therapy

authors： Zucchini N,Crozat K,Baranek T,Robbins SH,Altfeld M,Dalod M

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:Microorganisms of clinical importance frequently develop resistance to drug therapy, now a growing problem. The experience with Mycobacterium tuberculosis is a representative example of increasing multi-drug resistance. To avoid reaching a crisis in which patients could be left without adequate treatment, ...

journal_title：Expert review of anti-infective therapy

authors： Guevara Salazar JA,Morán Díaz JR,Ramírez Segura E,Trujillo Ferrara JG

更新日期：2020-10-26 00:00:00

abstract：:Sertaconazole is an imidazole-type antifungal agent that has shown considerable in vitro activity against pathogenic fungi. Various studies carried out in animal models, clinical and toxicologic trials have confirmed the value of sertaconazole in the topical treatment of superficial mycoses in dermatology and gynecolo...

journal_title：Expert review of anti-infective therapy

authors： Carrillo-Muñoz AJ,Giusiano G,Ezkurra PA,Quindós G

更新日期：2005-06-01 00:00:00

abstract：:Post-exposure prophylaxis (PEP) with antiretrovirals is now widely used worldwide after either occupational contact (with blood or another blood-containing fluid), or nonoccupational contact (mainly sexual or injection-drug use). It is assumed to reduce the risk of HIV transmission by at least 80%, although its effica...

journal_title：Expert review of anti-infective therapy

authors： Rey D

更新日期：2011-04-01 00:00:00

abstract：:In this article we focus on the pathogenesis and clinical characteristics of schistosomiasis infection on the lung vasculature. Overall, the basic biology and understanding of Schistosoma immune responses and their effect on the cardiopulmonary system is limited in both animal and human models, which hinders clinical ...

journal_title：Expert review of anti-infective therapy

authors： Kolosionek E,Crosby A,Harhay MO,Morrell N,Butrous G

更新日期：2010-12-01 00:00:00

abstract：:The 49th Annual Spring Meeting of the British Society of Parasitology was held at Nottingham University, UK, on 11-14 April 2011. Although a meeting of a national parasitological society, the meeting attracted approximately 375 delegates from 30 countries worldwide. Of the various themes at this meeting, two were focu...

journal_title：Expert review of anti-infective therapy

authors： Staines HM,Croft SL,Horrocks PD

更新日期：2011-07-01 00:00:00

abstract：:Chronic hepatitis C is a major worldwide health problem with an estimated prevalence of 1.6-2%. The prognosis of chronic hepatitis C depends on the rate of fibrosis progression which, over a 20-30-year time span, may determine the risk of developing cirrhosis and its complications, namely hepatocellular carcinoma, liv...

journal_title：Expert review of anti-infective therapy

authors： Aghemo A,Rumi MG,Colombo M

更新日期：2009-10-01 00:00:00

abstract：:This report, completed in November 2003, is intended to serve as a resource for physicians, public health officials and organizations involved in the evaluation and treatment of Lyme disease. ...

journal_title：Expert review of anti-infective therapy

authors： Cameron D,Gaito A,Harris N,Bach G,Bellovin S,Bock K,Bock S,Burrascano J,Dickey C,Horowitz R,Phillips S,Meer-Scherrer L,Raxlen B,Sherr V,Smith H,Smith P,Stricker R,ILADS Working Group.

更新日期：2004-01-01 00:00:00

abstract：:Management of anaerobic infections encompasses surgical procedures, antibacterial therapy and adjuncts. At present, metronidazole, penems, beta-lactam/beta-lactamase inhibitor combinations and chloramphenicol have the highest activity against obligate anaerobes. Tigecycline is a promising new agent. Other antibacteria...

journal_title：Expert review of anti-infective therapy

authors： Boyanova L,Kolarov R,Mitov I

更新日期：2007-08-01 00:00:00

abstract：:Necrobacillosis, often used synonymously with Lemierre's syndrome, is a form of abscess infection in the peritonsillar area associated with a thrombophlebitis and caused by the strict anaerobic species Fusobacterium necrophorum. The thrombosis formed affects the internal jugular vein, from which the bacteria are seede...

journal_title：Expert review of anti-infective therapy

authors： Dahlén G,Ebenfelt A

更新日期：2011-02-01 00:00:00

abstract：:Evaluation of: Riedel S, Melendez JH, An AT, Rosenbaum JE, Zenilman JM. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am. J. Clin. Pathol. 135(2), 182-189 (2011). In a recent report, Riedel et al. proposed a procalcitonin cutoff of 0.1 ng/ml to rule out bacteremia in...

journal_title：Expert review of anti-infective therapy

authors： Albrich WC,Mueller B

更新日期：2011-06-01 00:00:00

abstract：:Linezolid is the first member of a new generation of antibiotics, the synthetic oxazolidinones, to become available, with a broad spectrum of in vitro activity against gram-positive organisms, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and vancomycin-resistant E. ...

journal_title：Expert review of anti-infective therapy

authors： Velissariou IM

更新日期：2006-12-01 00:00:00

abstract：:Knowledge of the clinical and economic impact of antimicrobial resistance is useful to influence programs and behavior in healthcare facilities, to guide policy makers and funding agencies, to define the prognosis of individual patients and to stimulate interest in developing new antimicrobial agents and therapies. Th...

journal_title：Expert review of anti-infective therapy

authors： Maragakis LL,Perencevich EN,Cosgrove SE

更新日期：2008-10-01 00:00:00

abstract：:Tinidazole has been used for bacterial vaginosis (BV) outside the USA for almost four decades. Tinidazole has recently been resurrected and FDA approved for trichomoniasis and BV in the USA and is being restudied as an alternative to metronidazole for BV. In vitro antimicrobial activity and pharmacokinetics studies in...

journal_title：Expert review of anti-infective therapy

authors： Nailor MD,Sobel JD

更新日期：2007-06-01 00:00:00

abstract：:Having available tools to determine the prognosis of pediatric meningococcal sepsis at admission to the Intensive Care Unit or during the course of the disease constitutes a clinical necessity. Recently, new readily measurable circulating biomarkers have been described as an additional tool for severity classification...

journal_title：Expert review of anti-infective therapy

authors： Briassoulis G,Galani A

更新日期：2014-09-01 00:00:00

abstract：:Diarrhea is the second largest cause of mortality worldwide in children from the perinatal period to the age of 5 years. Rotavirus has been the most commonly identified viral cause of diarrhea in children. Norovirus is now recognized as the second most common viral pathogen. Adenovirus, astrovirus and sapovirus are th...

journal_title：Expert review of anti-infective therapy

authors： Anderson EJ

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Monkeypox is a re-emerging viral zoonosis that occurs naturally in heavily forested regions of West and Central Africa. Inter-human transmission of monkeypox virus, although limited, drives outbreaks, particularly in household and health-care settings. But the available evidence suggests that without repea...

journal_title：Expert review of anti-infective therapy

authors： Reynolds MG,Doty JB,McCollum AM,Olson VA,Nakazawa Y

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:Carbapenem-resistant Enterobacterales (CRE) represent a global public health problem. Precision medicine (PM) is a multicomponent medical approach that should be used to individualize the management of patients infected with CRE. AREAS COVERED:Here, we differentiate carbapenem-producing CRE (CP-CRE) from ...

journal_title：Expert review of anti-infective therapy

authors： Reyes S,Nicolau DP

更新日期：2020-08-01 00:00:00

abstract：:Despite significant advances in the day-to-day management of patients receiving hematopoietic stem cell transplantations, including the introduction of new antiviral drugs, cytomegalovirus (CMV) infection continues to be a major cause of morbidity and mortality. The aim of this article is to undertake a literature-bas...

journal_title：Expert review of anti-infective therapy

authors： Bacigalupo A,Boyd A,Slipper J,Curtis J,Clissold S

更新日期：2012-11-01 00:00:00

abstract：:Neurocysticercosis is the most common cause of late-onset epilepsy in developing countries. The larval stage of Taenia solium is the causative agent of the disease. Recent advances in neuroimaging and serologic diagnostic techniques have led to increased recognition of its importance, but its pathogenesis is just begi...

journal_title：Expert review of anti-infective therapy

authors： Serpa JA,Yancey LS,White AC Jr

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:Drug-resistant tuberculous meningitis has been reported worldwide. Isoniazid mono-resistance is the most frequent cause of drug-resistant tuberculous meningitis, a life-threatening disease. Extensive drug-resistant tuberculous meningitis has also been reported in some isolated case reports. Areas covered: ...

journal_title：Expert review of anti-infective therapy

authors： Garg RK,Rizvi I,Malhotra HS,Uniyal R,Kumar N

更新日期：2018-11-01 00:00:00

abstract：:Carbapenem-resistant Klebsiella pneumoniae causes serious nosocomial infections and therapeutic options are limited. There is increasing evidence suggesting that combination antibiotic therapy is more effective than monotherapy and leads to better outcomes. However, questions remain about which regimen is optimal and ...

journal_title：Expert review of anti-infective therapy

authors： Watkins RR,Deresinski S

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Latent tuberculosis infection (LTBI) accounts for almost a quarter of the world population, and, in 5-10% of the subjects with impaired immune-response against M. tuberculosis growth, it may progress to active tuberculosis (TB). In this review, we focus on the need to propose a screening for LTBI including...

journal_title：Expert review of anti-infective therapy

authors： Goletti D,Petrone L,Ippolito G,Niccoli L,Nannini C,Cantini F

更新日期：2018-06-01 00:00:00

abstract：:Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential...

journal_title：Expert review of anti-infective therapy

authors： Paragas J,Geisbert TW

更新日期：2006-02-01 00:00:00