Abstract:
:Following the discovery of innate immune receptors, the topics of innate immunity and its role in defense against infective agents have recently blossomed into very active research fields, after several decades of neglect. Among innate immune cells, natural killer (NK) cells are endowed with the unique ability to recognize and kill cells infected with a variety of pathogens, irrespective of prior sensitization to these microbes. NK cells have a number of other functions, including cytokine production and immunoregulatory activities. Major advances have recently been made in the understanding of the role of NK cells in the physiopathology of infectious diseases. The cellular and molecular mechanisms regulating the acquisition of effector functions by NK cells and their triggering upon pathogenic encounters are being unraveled. The possibility that the power of NK cells could be harnessed for the design of innovative treatments against infections is a major incentive for biologists to further explore NK cell subset complexity and to identify the ligands that activate NK cell receptors.
journal_name
Expert Rev Anti Infect Therjournal_title
Expert review of anti-infective therapyauthors
Zucchini N,Crozat K,Baranek T,Robbins SH,Altfeld M,Dalod Mdoi
10.1586/14787210.6.6.867subject
Has Abstractpub_date
2008-12-01 00:00:00pages
867-85issue
6eissn
1478-7210issn
1744-8336journal_volume
6pub_type
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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更新日期:2007-04-01 00:00:00
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journal_title:Expert review of anti-infective therapy
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更新日期:2012-12-01 00:00:00
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journal_title:Expert review of anti-infective therapy
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1586/14787210.5.5.873
更新日期:2007-10-01 00:00:00
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journal_title:Expert review of anti-infective therapy
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更新日期:2004-04-01 00:00:00
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journal_title:Expert review of anti-infective therapy
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更新日期:2014-09-01 00:00:00
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