2010 HIV Diagnostics Conference.

abstract：:Chronic rhinosinusitis (CRS) is a common health care problem, yet many aspects of this diagnosis remain poorly understood. Its etiology is often debated and remains a significant area of research. The diagnosis of CRS is based on subjective symptoms, duration of symptoms and objective evidence of inflammation. Each of...

journal_title：Expert review of anti-infective therapy

authors： Manes RP,Batra PS

更新日期：2013-01-01 00:00:00

abstract：:Invasive candidiasis, including candidemia (IC/C), is a major cause of morbidity and mortality among hospitalized patients. While incidence is higher in intensive care units, the majority of cases of candidemia are documented in medical wards. Although Candida albicans is still the most frequently isolated species, IC...

journal_title：Expert review of anti-infective therapy

authors： Tagliaferri E,Menichetti F

更新日期：2015-06-01 00:00:00

abstract：:Ceftobiprole is among the first of a new generation of cephalosporins with activity against aerobic Gram-negative bacilli, which extends to cefepime-sensitive Pseudomonas aeruginosa, and activity against Gram-positive organisms, which includes methicillin-resistant Staphylococcus aureus. Ceftobiprole is currently unde...

journal_title：Expert review of anti-infective therapy

authors： Schirmer PL,Deresinski SC

更新日期：2009-09-01 00:00:00

abstract：:Inflammation represents a complex biologic and biochemical process involving cells of the immune system and a plethora of biologic mediators in response to mechanical, chemical or infectious injuries. When mobilization of effector cells and molecules becomes excessive, the beneficial aspect of this response--to limit ...

journal_title：Expert review of anti-infective therapy

authors： Labro MT

更新日期：2005-02-01 00:00:00

abstract：:The management of anaerobic infection needs to be prompt and appropriate in order to ensure recovery. Management includes the use of hyperbaric oxygen, surgical methods and antimicrobial therapy. Various factors, such as efficacy, bacterial antimicrobial resistance, ability to reach appropriate antimicrobial levels at...

journal_title：Expert review of anti-infective therapy

authors： Brook I

更新日期：2004-02-01 00:00:00

abstract：:Infections due to multidrug-resistant pathogens have an increasing impact on patients undergoing cardiac surgery. Preoperative infections, such as endocarditis, and postoperative infections, including wound and device infection, influence patient outcomes. Special interest needs to be taken in patients admitted to car...

journal_title：Expert review of anti-infective therapy

authors： Kanzler I,Weis F,Beiras-Fernandez A

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Pneumocystis pneumonia is a potentially life-threatening pulmonary infection that occurs in immunocompromised individuals and HIV-infected patients with a low CD4 cell count. Trimethoprim-sulfamethoxazole has been used as the first-line agent for treatment, but mutations within dihydropteroate synthase gen...

journal_title：Expert review of anti-infective therapy

authors： Huang YS,Yang JJ,Lee NY,Chen GJ,Ko WC,Sun HY,Hung CC

更新日期：2017-09-01 00:00:00

abstract：:Antibiotic resistance is an important factor influencing clinical outcome for patients in intensive care units. It is also associated with increased healthcare costs resulting from prolonged patient stays. The problem of antibiotic resistance is particularly acute in intensive care units because they house seriously i...

journal_title：Expert review of anti-infective therapy

authors： Johnson AP

更新日期：2003-08-01 00:00:00

abstract：:The fixed dose combination of abacavir with lamivudine represents a new treatment option for patients infected with HIV. Fixed dose combination abacavir/lamivudine has the convenience of one pill and once-daily dosing. It achieves comparable suppression of plasma HIV RNA with the pill's individual components dosed twi...

journal_title：Expert review of anti-infective therapy

authors： Anderson AM,Bartlett JA

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:Sepsis-associated encephalopathy (SAE) and septic encephalitis (SE) are associated with increased mortality, long-term cognitive impairment, and focal neurological deficits. AREAS COVERED:The PUBMED database was searched 2016-2020. The clinical manifestation of SAE is delirium, SE additionally is characte...

journal_title：Expert review of anti-infective therapy

authors： Tauber SC,Djukic M,Gossner J,Eiffert H,Brück W,Nau R

更新日期：2020-09-14 00:00:00

abstract：:TB is typically caused by Mycobacterium tuberculosis, a symbiotic bacterium present in one-third of the world's population. There any many factors triggering overt clinical disease in a small proportion of humans. In our view the major role in the process is played by the host's immune response, especially self-direct...

journal_title：Expert review of anti-infective therapy

authors： Bourinbaiar AS,Mezentseva MV,Butov DA,Nyasulu PS,Efremenko YV,Jirathitikal V,Mishchenko VV,Kutsyna GA

更新日期：2012-03-01 00:00:00

abstract：:Diarrhoea is one of the most commonly occurring diseases. This article presents a review of the current state of the treatment of acute infectious diarrhoea, as well as of the most important pathogens. The general principles of the therapy of diarrhoea are exemplified, followed by a description of the targeted antimic...

journal_title：Expert review of anti-infective therapy

authors： Lübbert C

更新日期：2016-01-01 00:00:00

abstract：:Human cytomegalovirus is a large DNA virus that is well-equipped to evade both innate and adaptive host immune responses and to establish lifelong latency. It is a major opportunistic pathogen in immunocompromised hosts. Following allogeneic transplantation, immune responses are often inadequate to inhibit viral react...

journal_title：Expert review of anti-infective therapy

authors： Peggs KS

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an important emerging respiratory pathogen. MERS-CoV resulted in multiple hospital outbreaks within and outside the Arabian Peninsula. The disease has a high case fatality rate, with the need for a therapeutic option. Areas covered: In this rev...

journal_title：Expert review of anti-infective therapy

authors： Al-Tawfiq JA,Memish ZA

更新日期：2017-03-01 00:00:00

abstract：:The true incidence of pulmonary bacterial coinfection in infants and children hospitalized with a viral respiratory infection is difficult to ascertain but can vary widely from under 1 to 44%. For the same patient group admitted to pediatric intensive care units and/or requiring ventilatory support, the evidence is mo...

journal_title：Expert review of anti-infective therapy

authors： Thorburn K,Riordan A

更新日期：2012-08-01 00:00:00

abstract：:Mycobacterium caprae, a member of the Mycobacterium tuberculosis complex, causes tuberculosis (TB) in man and animals. Some features distinguish M. caprae from its epidemiological twin, Mycobacterium bovis: M. caprae is evolutionarily older, accounts for a smaller burden of zoonotic TB and is not globally distributed,...

journal_title：Expert review of anti-infective therapy

authors： Prodinger WM,Indra A,Koksalan OK,Kilicaslan Z,Richter E

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:The nervous system is involved in 10-15% of patients infected with B. burgdorferi, B. afzelii and B. garinii. This review will address widespread misconceptions about the clinical phenomenology, diagnostic approach and response to treatment of neuroborreliosis. Areas covered: Improvements in diagnostic tes...

journal_title：Expert review of anti-infective therapy

authors： Halperin JJ

更新日期：2018-01-01 00:00:00

abstract：:The constant new emergence of life-threatening human respiratory viral pathogens presents new challenges to clinicians who are left with no available therapeutic interventions. Highly pathogenic strains of influenza A virus (IAV) share an enhanced capacity to propagate to the lower airways and paralyze alveolar macrop...

journal_title：Expert review of anti-infective therapy

authors： Coulombe F,Divangahi M

更新日期：2014-11-01 00:00:00

abstract：:The development of HIV-1 integrase strand transfer inhibitors (INSTIs) has been a major therapeutic breakthrough in the management of HIV-1 infection. The first HIV-1 integrase inhibitor, raltegravir, was licensed in 2007 and was subsequently approved for use in treatment-naive patients. Since then, newer members of t...

journal_title：Expert review of anti-infective therapy

authors： Lampiris HW

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:The advent, more than two decades ago, of monoclonal antibodies and soluble receptors targeting tumor necrosis factor (TNF)-α has revolutionized the therapeutic approach to otherwise difficult-to-treat autoimmune and inflammatory diseases. However, due to the pleiotropic functions played by this pro-inflam...

journal_title：Expert review of anti-infective therapy

authors： Fernández-Ruiz M,Aguado JM

更新日期：2018-12-01 00:00:00

abstract：:Human rickettsioses caused by intracellular bacteria of the genus Rickettsia are distributed worldwide and are transmitted by arthropod vectors such as ticks, fleas, mites and lice. They have a wide range of manifestations from benign to life-threatening diseases. Mortality rates of up to 30% have been reported for so...

journal_title：Expert review of anti-infective therapy

authors： Botelho-Nevers E,Socolovschi C,Raoult D,Parola P

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Neuraminidase inhibitors (NAIs) reduce influenza symptoms but clear evidence of relationships between viral titer reduction and symptom alleviation is lacking. This open-label, randomized study evaluated differences in viral dynamics between NAIs, and relationships between viral dynamics and influenza sympto...

journal_title：Expert review of anti-infective therapy

authors： Hirotsu N,Saisho Y,Hasegawa T,Shishido T

更新日期：2018-02-01 00:00:00

abstract：:Since the advent of combined antiretroviral therapy there have been reductions in mortality and morbidity from HIV, transforming the disease into a chronic medical condition where newly diagnosed individuals can expect to live a near-normal life expectancy. When choosing therapy, probably the most important considerat...

journal_title：Expert review of anti-infective therapy

authors： Scourfield A,Waters L,Nelson M

更新日期：2011-11-01 00:00:00

abstract：:Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans.Areas covered: This review assessed the scientific literature on phage therapy published between 1 Janu...

journal_title：Expert review of anti-infective therapy

authors： Caflisch KM,Suh GA,Patel R

更新日期：2019-12-01 00:00:00

abstract：:Over the last few decades, various extended-spectrum β-lactamases (ESBLs), which are remotely related to the classical TEM and SHV families, have emerged. Among these, CTX-M, VEB and PER variants are of particular interest due to their widespread dissemination. This article will focus on these emerging ESBLs. CTX-M wa...

journal_title：Expert review of anti-infective therapy

authors： Akinci E,Vahaboglu H

更新日期：2010-11-01 00:00:00

abstract：:Antifungal susceptibility testing should identify in vitro resistance among a normally susceptible population or should detect the development of resistance during therapy. The Clinical and Laboratory Standards Institute (CLSI; formerly the National Committee for Clinical Laboratory Standards [NCCLS]) has developed re...

journal_title：Expert review of anti-infective therapy

authors： Cantón E,Espinel-Ingroff A,Pemán J

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:Invasive fungal diseases (IFDs) have received attention as an emerging public health threat, are difficult to diagnose and to treat, and are associated with substantial morbidity and mortality. The standard of care in IFD management requires an early and targeted antifungal treatment, hence covers - amongs...

journal_title：Expert review of anti-infective therapy

authors： Knabl L,Lass-Flörl C

更新日期：2020-08-01 00:00:00

abstract：:Coinfection with hepatitis C in HIV-infected patients has been reported in 15-70% of patients depending on the mode of acquisition of both viruses. As recent advances in HIV-directed antiviral therapy have markedly delayed HIV progression and mortality, the incidence of complications arising from hepatitis C-associate...

journal_title：Expert review of anti-infective therapy

authors： Vyas JJ,Brown RS,Gaglio PJ

更新日期：2003-10-01 00:00:00

abstract：:The advent of highly active antiretroviral therapy (HAART) has revolutionized the treatment of HIV. A wide variety of antiretroviral agents are now available, allowing patients and physicians a choice of effective therapy. However, drug resistance and toxicities are emerging as major treatment challenges in the HAART ...

journal_title：Expert review of anti-infective therapy

authors： Jones R,Gazzard B

更新日期：2006-04-01 00:00:00

abstract：:A current focus in HIV management is improving adherence by minimizing pill burden with convenient formulations, including fixed-dose combinations (FDCs). Darunavir, a HIV protease inhibitor, co-administered with low-dose ritonavir (800/100 mg once daily), is recommended in guidelines in combination with other antiret...

journal_title：Expert review of anti-infective therapy

authors： Kakuda TN,Crauwels H,Opsomer M,Tomaka F,van de Casteele T,Vanveggel S,Iterbeke K,de Smedt G

更新日期：2015-06-01 00:00:00