New targets in the search for preventive and therapeutic agents for botulism.

abstract：INTRODUCTION:The emergence and spread of antibiotic resistance among pathogenic bacteria drives the search for alternative antimicrobial therapies. Bacteriocins represent a potential alternative to antibiotic treatment. In contrast to antibiotics, bacteriocins are peptides or proteins that have relatively narrow spectr...

journal_title：Expert review of anti-infective therapy

authors： Bosák J,Hrala M,Micenková L,Šmajs D

更新日期：2020-09-22 00:00:00

abstract：:Itraconazole (Sporanox) is a triazole antifungal agent with a broad activity spectrum and favorable pharmacokinetic and safety profiles. Numerous clinical trials have established the efficacy and safety of itraconazole in the treatment of superficial fungal infections. In this field, full exploitation of its pharmacok...

journal_title：Expert review of anti-infective therapy

authors： Caputo R

更新日期：2003-12-01 00:00:00

abstract：:As a consequence of antibiotic overuse and misuse, nosocomial infections caused by multidrug-resistant bacteria represent a physician's nightmare throughout the world. No newer antimicrobials active against Pseudomonas aeruginosa, the main multidrug-resistant nosocomial pathogen, are available or under investigation. ...

journal_title：Expert review of anti-infective therapy

authors： Giamarellou H

更新日期：2006-08-01 00:00:00

abstract：:Tuberculosis (TB) is mainly an intracellular infection of the lung alveolar macrophages, and any anti-TB agent must therefore be active at the macrophage. Among the available therapies, isoniazid and rifampicin are the most effective drugs against susceptible Mycobacterium tuberculosis, but they are ineffective agains...

journal_title：Expert review of anti-infective therapy

authors： Viveiros M,Martins M,Couto I,Rodrigues L,Machado D,Portugal I,Amaral L

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:We performed a meta-analysis to determine diagnostic accuracy of Xpert MTB/RIF for diagnosis of abdominal (intestinal or peritoneal) tuberculosis (TB) in various tissues (intestinal, omental/peritoneal tissue or ascitic fluid). METHODS:Electronic databases were searched for observational studies on use of X...

journal_title：Expert review of anti-infective therapy

authors： Sharma V,Soni H,Kumar-M P,Dawra S,Mishra S,Mandavdhare HS,Singh H,Dutta U

更新日期：2020-08-26 00:00:00

abstract：:Diarrhea is the second largest cause of mortality worldwide in children from the perinatal period to the age of 5 years. Rotavirus has been the most commonly identified viral cause of diarrhea in children. Norovirus is now recognized as the second most common viral pathogen. Adenovirus, astrovirus and sapovirus are th...

journal_title：Expert review of anti-infective therapy

authors： Anderson EJ

更新日期：2010-02-01 00:00:00

abstract：:The authors sought to study whether extended or continuous infusion of cephalosporins is associated with better clinical outcomes than short-term infusion. PubMed and Scopus databases were systematically searched. Studies reporting the clinical outcomes of patients receiving extended or continuous infusion (≥3 or 24 h...

journal_title：Expert review of anti-infective therapy

authors： Korbila IP,Tansarli GS,Karageorgopoulos DE,Vardakas KZ,Falagas ME

更新日期：2013-06-01 00:00:00

abstract：:Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans.Areas covered: This review assessed the scientific literature on phage therapy published between 1 Janu...

journal_title：Expert review of anti-infective therapy

authors： Caflisch KM,Suh GA,Patel R

更新日期：2019-12-01 00:00:00

abstract：:Although penicillin remains the first-choice treatment for Streptococcus pyogenes infection, macrolides are important alternatives for allergic patients and lincosamides are recommended together with β-lactams in invasive infections. S. pyogenes may exhibit macrolide resistance because of active efflux (mef genes) or ...

journal_title：Expert review of anti-infective therapy

authors： Silva-Costa C,Friães A,Ramirez M,Melo-Cristino J

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Rapid molecular diagnostic methods help in the detection of TB and Rifampicin resistance. These methods detect TB early, are accurate and play a crucial role in reducing the burden of drug resistant tuberculosis. Areas covered: This review analyses rapid molecular diagnostic tools used in the diagnosis of ...

journal_title：Expert review of anti-infective therapy

authors： Ramachandran R,Muniyandi M

更新日期：2018-03-01 00:00:00

abstract：:The true incidence of pulmonary bacterial coinfection in infants and children hospitalized with a viral respiratory infection is difficult to ascertain but can vary widely from under 1 to 44%. For the same patient group admitted to pediatric intensive care units and/or requiring ventilatory support, the evidence is mo...

journal_title：Expert review of anti-infective therapy

authors： Thorburn K,Riordan A

更新日期：2012-08-01 00:00:00

abstract：:Human cytomegalovirus is a large DNA virus that is well-equipped to evade both innate and adaptive host immune responses and to establish lifelong latency. It is a major opportunistic pathogen in immunocompromised hosts. Following allogeneic transplantation, immune responses are often inadequate to inhibit viral react...

journal_title：Expert review of anti-infective therapy

authors： Peggs KS

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has brought aminoglycosides to the frontline since an aminoglycoside may be the only antimicrobial to which CRE isolates show in vitro susceptibility. The appropriateness of aminoglycoside-based therapies for severe infections by CRE is discuss...

journal_title：Expert review of anti-infective therapy

authors： Zavascki AP,Klee BO,Bulitta JB

更新日期：2017-06-01 00:00:00

abstract：:Diarrhoea is one of the most commonly occurring diseases. This article presents a review of the current state of the treatment of acute infectious diarrhoea, as well as of the most important pathogens. The general principles of the therapy of diarrhoea are exemplified, followed by a description of the targeted antimic...

journal_title：Expert review of anti-infective therapy

authors： Lübbert C

更新日期：2016-01-01 00:00:00

abstract：:Hepatitis C virus infection is the leading cause of chronic liver disease in the western world. Chronic liver diseases may cause, through portal hypertension, the development of gastroesophageal varices, which can then bleed. We assess the findings of a study aimed at identifying the incidence of de novo varix develop...

journal_title：Expert review of anti-infective therapy

authors： Gentile I,Borgia G

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:The advent, more than two decades ago, of monoclonal antibodies and soluble receptors targeting tumor necrosis factor (TNF)-α has revolutionized the therapeutic approach to otherwise difficult-to-treat autoimmune and inflammatory diseases. However, due to the pleiotropic functions played by this pro-inflam...

journal_title：Expert review of anti-infective therapy

authors： Fernández-Ruiz M,Aguado JM

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:In December 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak occurred and caused the coronavirus disease of 2019 (COVID-19), which affected ~ 190 countries. The World Health Organization (WHO) has declared COVID-19 a pandemic on 11 March 2020. AREA COVERED:In the review, a com...

journal_title：Expert review of anti-infective therapy

authors： Bhagat S,Yadav N,Shah J,Dave H,Swaraj S,Tripathi S,Singh S

更新日期：2020-12-07 00:00:00

abstract：:Rodent-borne hantaviruses (family Bunyaviridae, genus Hantavirus) cause hantavirus pulmonary syndrome in the Americas and hemorrhagic fever with renal syndrome in Europe and Asia. The viruses are transmitted to humans mainly by inhalation of virus-contaminated aerosols of rodent excreta and secreta. Classic clinical h...

journal_title：Expert review of anti-infective therapy

authors： Mattar S,Guzmán C,Figueiredo LT

更新日期：2015-08-01 00:00:00

abstract：:Identifying and managing TB in immigrating populations has been an important aspect of immigration health for over a century, with the primary aim being protecting the host population by preventing the import of communicable diseases carried by the arriving migrants. This review describes the history and development o...

journal_title：Expert review of anti-infective therapy

authors： Dara M,Gushulak BD,Posey DL,Zellweger JP,Migliori GB

更新日期：2013-02-01 00:00:00

abstract：:A current focus in HIV management is improving adherence by minimizing pill burden with convenient formulations, including fixed-dose combinations (FDCs). Darunavir, a HIV protease inhibitor, co-administered with low-dose ritonavir (800/100 mg once daily), is recommended in guidelines in combination with other antiret...

journal_title：Expert review of anti-infective therapy

authors： Kakuda TN,Crauwels H,Opsomer M,Tomaka F,van de Casteele T,Vanveggel S,Iterbeke K,de Smedt G

更新日期：2015-06-01 00:00:00

abstract：:Use of nonsystemic antimicrobials with activity against enteropathogens is a promising approach for treatment of infectious diarrhea and other nonsystemic gastrointestinal infections. Rifaximin is approved by the US FDA for the treatment of travelers' diarrhea caused by noninvasive strains of Escherichia coli in patie...

journal_title：Expert review of anti-infective therapy

authors： Cottreau J,Baker SF,DuPont HL,Garey KW

更新日期：2010-07-01 00:00:00

abstract：:Influenza is a ubiquitous infection with a spectrum ranging from mild to severe. The mystery regarding such variability in the clinical spectrum has not been fully unravelled, although a role for the complex interplay among virus characteristics, host immune response and environmental factors has been suggested. Antiv...

journal_title：Expert review of anti-infective therapy

authors： Virk RK,Gunalan V,Tambyah PA

更新日期：2016-01-01 00:00:00

abstract：:Ticks can transmit a variety of viruses, bacteria or parasites that can cause serious infections or conditions in humans and animals. While tick-borne diseases are becoming an increasing and serious problem in Europe, tick-borne diseases are also responsible for major depressions in livestock production and mortality ...

journal_title：Expert review of anti-infective therapy

authors： Heyman P,Cochez C,Hofhuis A,van der Giessen J,Sprong H,Porter SR,Losson B,Saegerman C,Donoso-Mantke O,Niedrig M,Papa A

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Onychomycosis is a chronic fungal infection of the nail bed, matrix or plate. It accounts for roughly 50% of all nail disease. As the prevalence of onychomycosis is increasing, a critical review of diagnostic techniques and treatment options is required. Areas covered: This review discusses the current dia...

journal_title：Expert review of anti-infective therapy

authors： Gupta AK,Mays RR,Versteeg SG,Shear NH,Piguet V

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Tocilizumab, an inhibitor of the interleukin-6 receptor, may decrease the inflammatory response and control the symptoms of severe coronavirus disease 2019 (COVID-19), but the evidence is scarce. METHODS:This retrospective study included patients with severe COVID-19 requiring oxygen therapy who received to...

journal_title：Expert review of anti-infective therapy

authors： Tomasiewicz K,Piekarska A,Stempkowska-Rejek J,Serafińska S,Gawkowska A,Parczewski M,Niścigorska-Olsen J,Łapiński TW,Zarębska-Michaluk D,Kowalska JD,Horban A,Flisiak R

更新日期：2021-01-01 00:00:00

abstract：:Endobronchial tuberculosis is defined as tuberculous infection of the tracheobronchial tree. Although clinical features differ between various types and stages of endobronchial tuberculosis, common symptoms are cough, hemoptysis, sputum production, wheezing, chest pain, fever and dyspnea. Endobronchial tuberculosis is...

journal_title：Expert review of anti-infective therapy

authors： Rikimaru T

更新日期：2004-04-01 00:00:00

abstract：:Hospital infection due to multidrug-resistant Gram-positive bacteria may often represent a life-threatening challenge; thus, to appropriately combat them, clinicians should be confident and systematically apply several important pharmacodynamic concepts. The concept of 'correct antibiotic treatment' should include, in...

journal_title：Expert review of anti-infective therapy

authors： Pea F,Viale P

更新日期：2007-04-01 00:00:00

abstract：:Drug resistance in HIV-infected children is one of the main contributors to antiretroviral treatment (ART) failure, especially in developing countries. Sub-Saharan Africa has the largest burden of pediatric HIV infection in the world. Herein, we systematically review the current status of ART failure in HIV-infected A...

journal_title：Expert review of anti-infective therapy

authors： Jenabian MA,Costiniuk CT,Mboumba Bouassa RS,Chapdeleine Mekue Mouafo L,Brogan TV,Bélec L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Hospital antibiotic use is rising. We aimed to evaluate the antibiotic-use prevalence and length of stay. METHODS:We conducted a single-center retrospective study of patients < 18-years-old admitted to general pediatric services who received ≥ 1 antibiotic over six months. Demographics, culture results and ...

journal_title：Expert review of anti-infective therapy

authors： Gourishankar A,Agbasi A,Kain C,Lin E

更新日期：2020-11-01 00:00:00

abstract：:Preterm prelabor rupture of membranes (pPROM) is the precursor of up to 40% of preterm deliveries and an independent risk factor for neonatal disease, death and long-term pulmonary and neurodevelopmental deficits. A significant proportion of cases of pPROM are infection driven, although these are difficult to delineat...

journal_title：Expert review of anti-infective therapy

authors： Ugwumadu A

更新日期：2007-08-01 00:00:00