Molecular tools for rapid identification and novel effective therapy against MDRTB/XDRTB infections.

abstract：:Knowledge of the clinical and economic impact of antimicrobial resistance is useful to influence programs and behavior in healthcare facilities, to guide policy makers and funding agencies, to define the prognosis of individual patients and to stimulate interest in developing new antimicrobial agents and therapies. Th...

journal_title：Expert review of anti-infective therapy

authors： Maragakis LL,Perencevich EN,Cosgrove SE

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Syphilis continues to be a growing epidemic among men who have sex with men (MSM), particularly for those living with the human immunodeficiency virus (HIV). In 2016, MSM accounted for 80% of primary and secondary syphilis diagnoses in men in the United States; almost half of who were also HIV-infected. Th...

journal_title：Expert review of anti-infective therapy

authors： Refugio ON,Klausner JD

更新日期：2018-04-01 00:00:00

abstract：:Nosocomial infections are the most frequent complications observed in surgical patients. In colorectal surgery, the opening of the viscera causes the dissemination into the operative field of microorganisms originating from endogenous sources, increasing the chance of developing postoperative complications. It is repo...

journal_title：Expert review of anti-infective therapy

authors： Rovera F,Diurni M,Dionigi G,Boni L,Ferrari A,Carcano G,Dionigi R

更新日期：2005-10-01 00:00:00

abstract：:Evaluation of: Riedel S, Melendez JH, An AT, Rosenbaum JE, Zenilman JM. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am. J. Clin. Pathol. 135(2), 182-189 (2011). In a recent report, Riedel et al. proposed a procalcitonin cutoff of 0.1 ng/ml to rule out bacteremia in...

journal_title：Expert review of anti-infective therapy

authors： Albrich WC,Mueller B

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Due to increasing intensity and complexity of therapies and longer survivorship, many patients with haematologic malignancy (HM) are at risk of invasive fungal disease (IFD). Mortality from IFD is high and treatment of an episode of IFD results in an excess length of hospital stay and costs and delays deli...

journal_title：Expert review of anti-infective therapy

authors： Douglas AP,Slavin MA

更新日期：2016-12-01 00:00:00

abstract：:Chronic hepatitis C (CHC) virus infection affects more than 170 million people globally. The aim of treatment of CHC is to affect sustained elimination of the virus (a sustained virological response [SVR]). The success and duration of therapy with interferon is dependent on HCV genotype. The current standard of care c...

journal_title：Expert review of anti-infective therapy

authors： Trembling PM,Tanwar S,Dusheiko GM

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:Patients with C. difficile infection (CDI) experience intestinal microflora changes that can promote the overgrowth and subsequent translocation of gut resident pathogens into the blood. Consistently, CDI due to PCR-ribotype 027 strain, severe or relapsing CDI, and treatment with high-dosage vancomycin are...

journal_title：Expert review of anti-infective therapy

authors： Falcone M,Venditti M,Sanguinetti M,Posteraro B

更新日期：2016-07-01 00:00:00

abstract：:bla NDM is a major mechanism of resistance of Gram-negative bacteria to β-lactam antibiotics including the carbapenems. bla NDM has been acquired by a large range of Gram-negative bacilli, especially by the Enterobacteriaceae and Acinetobacter spp. The combination of human factors (suboptimal antibiotic stewardship an...

journal_title：Expert review of anti-infective therapy

authors： Wailan AM,Paterson DL

更新日期：2014-01-01 00:00:00

abstract：:Tinidazole has been used for bacterial vaginosis (BV) outside the USA for almost four decades. Tinidazole has recently been resurrected and FDA approved for trichomoniasis and BV in the USA and is being restudied as an alternative to metronidazole for BV. In vitro antimicrobial activity and pharmacokinetics studies in...

journal_title：Expert review of anti-infective therapy

authors： Nailor MD,Sobel JD

更新日期：2007-06-01 00:00:00

abstract：:Multidrug chemotherapy for 6-9-months is one of the primary treatments in effective control of tuberculosis, although the mechanisms underlying the persistence of its etiological agent, Mycobacterium tuberculosis, against antibiotics remain unclear. Ever-mounting evidence indicates that the survival of many environmen...

journal_title：Expert review of anti-infective therapy

authors： Islam MS,Richards JP,Ojha AK

更新日期：2012-09-01 00:00:00

abstract：:Ticks can transmit a variety of viruses, bacteria or parasites that can cause serious infections or conditions in humans and animals. While tick-borne diseases are becoming an increasing and serious problem in Europe, tick-borne diseases are also responsible for major depressions in livestock production and mortality ...

journal_title：Expert review of anti-infective therapy

authors： Heyman P,Cochez C,Hofhuis A,van der Giessen J,Sprong H,Porter SR,Losson B,Saegerman C,Donoso-Mantke O,Niedrig M,Papa A

更新日期：2010-01-01 00:00:00

abstract：:Objectives: Extent of post-treatment fibrosis change in patients with different stages of fibrosis not fully known. We aimed to study changes in liver fibrosis in chronic hepatitis C patients who were treated with pegylated interferon/ribavirin (PEG/RBV) or direct acting antivirals (DAAs). Methods: Retrospective evalu...

journal_title：Expert review of anti-infective therapy

authors： Abdelsameea E,Alsebaey A,Abdel-Samiee M,Abdel-Razek W,Salama M,Waked I

更新日期：2020-12-29 00:00:00

abstract：:Cryptosporidiosis, the disease caused by protozoa of the genus Cryptosporidium, represents a major public health problem in both developing and developed countries. The infection can be severe and life threatening among immunocompromised individuals, particularly in AIDS patients and in those with primary immunodefici...

journal_title：Expert review of anti-infective therapy

authors： Cacciò SM,Pozio E

更新日期：2006-06-01 00:00:00

abstract：:Diarrhea is the second largest cause of mortality worldwide in children from the perinatal period to the age of 5 years. Rotavirus has been the most commonly identified viral cause of diarrhea in children. Norovirus is now recognized as the second most common viral pathogen. Adenovirus, astrovirus and sapovirus are th...

journal_title：Expert review of anti-infective therapy

authors： Anderson EJ

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Drug concentrations in tuberculosis patients on standard regimens vary widely with clinically important consequences. Areas covered: We review the available literature identifying factors correlated with pharmacokinetic variability of antituberculosis drugs. Based on population pharmacokinetic models and t...

journal_title：Expert review of anti-infective therapy

authors： McIlleron H,Chirehwa MT

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Invasive fungal diseases (IFDs) have received attention as an emerging public health threat, are difficult to diagnose and to treat, and are associated with substantial morbidity and mortality. The standard of care in IFD management requires an early and targeted antifungal treatment, hence covers - amongs...

journal_title：Expert review of anti-infective therapy

authors： Knabl L,Lass-Flörl C

更新日期：2020-08-01 00:00:00

abstract：:Rodent-borne hantaviruses (family Bunyaviridae, genus Hantavirus) cause hantavirus pulmonary syndrome in the Americas and hemorrhagic fever with renal syndrome in Europe and Asia. The viruses are transmitted to humans mainly by inhalation of virus-contaminated aerosols of rodent excreta and secreta. Classic clinical h...

journal_title：Expert review of anti-infective therapy

authors： Mattar S,Guzmán C,Figueiredo LT

更新日期：2015-08-01 00:00:00

abstract：:Inflammation represents a complex biologic and biochemical process involving cells of the immune system and a plethora of biologic mediators in response to mechanical, chemical or infectious injuries. When mobilization of effector cells and molecules becomes excessive, the beneficial aspect of this response--to limit ...

journal_title：Expert review of anti-infective therapy

authors： Labro MT

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has affected almost 2.5 million people worldwide with almost 170,000 deaths reported to date. So far, there is scarce evidence for the current treatment options available for COVID-19. Vitamin C has previously been used for treatment of severe sepsis and septi...

journal_title：Expert review of anti-infective therapy

authors： Hiedra R,Lo KB,Elbashabsheh M,Gul F,Wright RM,Albano J,Azmaiparashvili Z,Patarroyo Aponte G

更新日期：2020-12-01 00:00:00

abstract：:Intracellular pathogens present a major health risk because of their innate ability to evade clearance. Their location within host cells and ability to react to the host environment by mutation or transcriptional changes often enables survival mechanisms to resist standard therapies. Host-directed drugs do not target ...

journal_title：Expert review of anti-infective therapy

authors： Collier MA,Gallovic MD,Peine KJ,Duong AD,Bachelder EM,Gunn JS,Schlesinger LS,Ainslie KM

更新日期：2013-11-01 00:00:00

abstract：:In Malaysia, various aspects of the epidemiology of pneumococcal carriage and disease remain largely unclear due to the lack of supporting data. Although a number of relevant studies have been documented, their individual discrete findings are not sufficient to inform experts on pneumococcal epidemiology at a national...

journal_title：Expert review of anti-infective therapy

authors： Le CF,Jefferies JM,Yusof MY,Sekaran SD,Clarke SC

更新日期：2012-06-01 00:00:00

abstract：:HBV infection remains a major global health problem and continues to be a common cause of liver-related morbidity and mortality in both immunocompetent and immunosuppressed individuals. Reactivation of HBV is a serious complication of chemotherapy/immunosuppressive therapy in patients with HBV infection. In this artic...

journal_title：Expert review of anti-infective therapy

authors： Idilman R,Arat M

更新日期：2011-08-01 00:00:00

abstract：:Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of I...

journal_title：Expert review of anti-infective therapy

authors： Berardi A,Spada C,Vaccina E,Boncompagni A,Bedetti L,Lucaccioni L

更新日期：2020-01-01 00:00:00

abstract：:The 6th World Congress of the World Society for Pediatric Infectious Diseases (WSPID), which was recently held in Buenos Aires, Argentina, between 18 and 22 November 2009, attracted 2401 attendees from 90 countries representing six continents. The WSPID, founded in 1994 by Professor Saldana Gonzalez of the Mexican Ped...

journal_title：Expert review of anti-infective therapy

authors： Falade AG

更新日期：2010-03-01 00:00:00

abstract：:In recent decades, the incidence of aspergillosis, candidiasis and clinically important deep mycoses has been increasing, with advances in transplantation medicine and anticancer chemotherapy. Micafungin (FK463, Fujisawa Healthcare) has been developed as a novel type of antifungal agent, which inhibits 1,3-beta-D-gluc...

journal_title：Expert review of anti-infective therapy

authors： Higashiyama Y,Kohno S

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Neuraminidase inhibitors (NAIs) reduce influenza symptoms but clear evidence of relationships between viral titer reduction and symptom alleviation is lacking. This open-label, randomized study evaluated differences in viral dynamics between NAIs, and relationships between viral dynamics and influenza sympto...

journal_title：Expert review of anti-infective therapy

authors： Hirotsu N,Saisho Y,Hasegawa T,Shishido T

更新日期：2018-02-01 00:00:00

abstract：:Neurocysticercosis is the most common cause of late-onset epilepsy in developing countries. The larval stage of Taenia solium is the causative agent of the disease. Recent advances in neuroimaging and serologic diagnostic techniques have led to increased recognition of its importance, but its pathogenesis is just begi...

journal_title：Expert review of anti-infective therapy

authors： Serpa JA,Yancey LS,White AC Jr

更新日期：2006-12-01 00:00:00

abstract：:Neurocysticercosis is a major cause of neurologic disease worldwide. In India and other developing countries, single small enhancing computed tomographic lesions representing solitary cysticercus granuloma are a common cause of new-onset seizures. The interesting feature of these solitary enhancing lesions is their sp...

journal_title：Expert review of anti-infective therapy

authors： Garg RK

更新日期：2008-02-01 00:00:00

abstract：:Hepatitis E, caused by hepatitis E virus, is a disease of global significance, causing 20 million infections each year. Genotypes 1 and 2 have vastly different epidemiological patterns from genotypes 3 and 4. In genotype 1 and 2 endemic areas, most infections and illness occur in persons 15-30 years of age, with pregn...

journal_title：Expert review of anti-infective therapy

authors： Kmush BL,Nelson KE,Labrique AB

更新日期：2015-01-01 00:00:00

abstract：:Human enteritis resulting from the consumption of poultry products contaminated with serovars of Salmonella enterica remains a major public-health concern. Reducing food contamination by preventing or controlling infection in the chicken during rearing is an attractive solution. An accurate understanding of the mechan...

journal_title：Expert review of anti-infective therapy

authors： Beal RK,Smith AL

更新日期：2007-10-01 00:00:00