The use of IV vitamin C for patients with COVID-19: a case series.

Abstract:

BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has affected almost 2.5 million people worldwide with almost 170,000 deaths reported to date. So far, there is scarce evidence for the current treatment options available for COVID-19. Vitamin C has previously been used for treatment of severe sepsis and septic shock. We reviewed the feasibility of using vitamin C in the setting of COVID-19 in a series of patients. METHODS:We sequentially identified a series of patients who were requiring at least 30% of FiO2 or more who received IV vitamin C as part of the COVID-19 treatment and analyzed their demographic and clinical characteristics. We compared inflammatory markers pre and post treatment including D-dimer and ferritin. RESULTS:We identified a total of 17 patients who received IV vitamin C for COVID-19. The inpatient mortality rate in this series was 12% with 17.6% rates of intubation and mechanical ventilation. We noted a significant decrease in inflammatory markers, including ferritin and D-dimer, and a trend to decreasing FiO2 requirements, after vitamin C administration. CONCLUSION:The use of IV vitamin C in patients with moderate to severe COVID-19 disease may be feasible.

authors

Hiedra R,Lo KB,Elbashabsheh M,Gul F,Wright RM,Albano J,Azmaiparashvili Z,Patarroyo Aponte G

doi

10.1080/14787210.2020.1794819

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1259-1261

issue

12

eissn

1478-7210

issn

1744-8336

journal_volume

18

pub_type

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