Abstract:
BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has affected almost 2.5 million people worldwide with almost 170,000 deaths reported to date. So far, there is scarce evidence for the current treatment options available for COVID-19. Vitamin C has previously been used for treatment of severe sepsis and septic shock. We reviewed the feasibility of using vitamin C in the setting of COVID-19 in a series of patients. METHODS:We sequentially identified a series of patients who were requiring at least 30% of FiO2 or more who received IV vitamin C as part of the COVID-19 treatment and analyzed their demographic and clinical characteristics. We compared inflammatory markers pre and post treatment including D-dimer and ferritin. RESULTS:We identified a total of 17 patients who received IV vitamin C for COVID-19. The inpatient mortality rate in this series was 12% with 17.6% rates of intubation and mechanical ventilation. We noted a significant decrease in inflammatory markers, including ferritin and D-dimer, and a trend to decreasing FiO2 requirements, after vitamin C administration. CONCLUSION:The use of IV vitamin C in patients with moderate to severe COVID-19 disease may be feasible.
journal_name
Expert Rev Anti Infect Therjournal_title
Expert review of anti-infective therapyauthors
Hiedra R,Lo KB,Elbashabsheh M,Gul F,Wright RM,Albano J,Azmaiparashvili Z,Patarroyo Aponte Gdoi
10.1080/14787210.2020.1794819subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1259-1261issue
12eissn
1478-7210issn
1744-8336journal_volume
18pub_type
杂志文章abstract::Healthy children are high transmitters of influenza and can experience poor influenza outcomes. Many questions remain about the efficacy and impect of preventive measures because most existing studies report imprecise proxies of influenza incidence, do not follow subjects throughout the entire influenza season and acr...
journal_title:Expert review of anti-infective therapy
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abstract::Post-exposure prophylaxis (PEP) with antiretrovirals is now widely used worldwide after either occupational contact (with blood or another blood-containing fluid), or nonoccupational contact (mainly sexual or injection-drug use). It is assumed to reduce the risk of HIV transmission by at least 80%, although its effica...
journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2005-04-01 00:00:00
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journal_title:Expert review of anti-infective therapy
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更新日期:2010-03-01 00:00:00
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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更新日期:2018-04-01 00:00:00
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pub_type: 评论,杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
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