Alternative mechanisms of action of cationic antimicrobial peptides on bacteria.

abstract：INTRODUCTION:Rapid molecular diagnostic methods help in the detection of TB and Rifampicin resistance. These methods detect TB early, are accurate and play a crucial role in reducing the burden of drug resistant tuberculosis. Areas covered: This review analyses rapid molecular diagnostic tools used in the diagnosis of ...

journal_title：Expert review of anti-infective therapy

authors： Ramachandran R,Muniyandi M

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Pneumocystis jirovecii is a ubiquitous fungus, which causes pneumonia in humans. Diagnosis was hampered by the inability to culture the organism, and based on microscopic examination of respiratory samples or clinical presentation. New assays can assist in the diagnosis and even aid with the emergence of r...

journal_title：Expert review of anti-infective therapy

authors： White PL,Backx M,Barnes RA

更新日期：2017-05-01 00:00:00

abstract：:Chagas disease affects 7.7 million people and 28 million people are at risk of acquiring the disease in 15 endemic countries of Latin America. Benznidazole and nifurtimox are drugs that have been used to treat the disease. However, both drugs induce severe side effects. Treatment with benznidazole has been recommended...

journal_title：Expert review of anti-infective therapy

authors： Guedes PM,Silva GK,Gutierrez FR,Silva JS

更新日期：2011-05-01 00:00:00

abstract：:Telaprevir is an NS3/4A protease inhibitor that has recently received US FDA approval for the treatment of chronic HCV infection. Telaprevir is given in combination with peg-IFN-α and ribavirin and is indicated for both treatment-naive and treatment-experienced patients with genotype 1 infection. Along with the other ...

journal_title：Expert review of anti-infective therapy

authors： Muir AJ

更新日期：2011-12-01 00:00:00

abstract：:The 49th Annual Spring Meeting of the British Society of Parasitology was held at Nottingham University, UK, on 11-14 April 2011. Although a meeting of a national parasitological society, the meeting attracted approximately 375 delegates from 30 countries worldwide. Of the various themes at this meeting, two were focu...

journal_title：Expert review of anti-infective therapy

authors： Staines HM,Croft SL,Horrocks PD

更新日期：2011-07-01 00:00:00

abstract：:Despite significant advances in the day-to-day management of patients receiving hematopoietic stem cell transplantations, including the introduction of new antiviral drugs, cytomegalovirus (CMV) infection continues to be a major cause of morbidity and mortality. The aim of this article is to undertake a literature-bas...

journal_title：Expert review of anti-infective therapy

authors： Bacigalupo A,Boyd A,Slipper J,Curtis J,Clissold S

更新日期：2012-11-01 00:00:00

abstract：:Ticks can transmit a variety of viruses, bacteria or parasites that can cause serious infections or conditions in humans and animals. While tick-borne diseases are becoming an increasing and serious problem in Europe, tick-borne diseases are also responsible for major depressions in livestock production and mortality ...

journal_title：Expert review of anti-infective therapy

authors： Heyman P,Cochez C,Hofhuis A,van der Giessen J,Sprong H,Porter SR,Losson B,Saegerman C,Donoso-Mantke O,Niedrig M,Papa A

更新日期：2010-01-01 00:00:00

abstract：:Intracellular pathogens present a major health risk because of their innate ability to evade clearance. Their location within host cells and ability to react to the host environment by mutation or transcriptional changes often enables survival mechanisms to resist standard therapies. Host-directed drugs do not target ...

journal_title：Expert review of anti-infective therapy

authors： Collier MA,Gallovic MD,Peine KJ,Duong AD,Bachelder EM,Gunn JS,Schlesinger LS,Ainslie KM

更新日期：2013-11-01 00:00:00

abstract：:Management of anaerobic infections encompasses surgical procedures, antibacterial therapy and adjuncts. At present, metronidazole, penems, beta-lactam/beta-lactamase inhibitor combinations and chloramphenicol have the highest activity against obligate anaerobes. Tigecycline is a promising new agent. Other antibacteria...

journal_title：Expert review of anti-infective therapy

authors： Boyanova L,Kolarov R,Mitov I

更新日期：2007-08-01 00:00:00

abstract：:Chronic infection with the hepatitis B virus remains a serious and life-threatening disease for approximately 5% of the world's population, despite the availability of effective vaccines. Although prognoses can be improved by chemotherapy, treatment options are limited and none has been consistently successful. Interf...

journal_title：Expert review of anti-infective therapy

authors： Shaw T,Locarnini S

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:The identification of factors that can predispose to the development of severe influenza is essential to enable the implementation of optimal prevention and control measures for vulnerable populations. AREAS COVERED:Unfortunately, data in the pediatric age group remain difficult to interpret. However, epi...

journal_title：Expert review of anti-infective therapy

authors： Principi N,Esposito S

更新日期：2016-10-01 00:00:00

abstract：:Meningococcal disease is a life-threatening condition and a major cause of bacterial meningitis and sepsis worldwide. In many fatal cases, meningococcal disease is rapidly progressive and death occurs within hours of the initial symptoms. The early identification of patients at high risk of death would be useful in or...

journal_title：Expert review of anti-infective therapy

authors： Montero-Martín M,Inwald DP,Carrol ED,Martinón-Torres F

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:We performed a meta-analysis to determine diagnostic accuracy of Xpert MTB/RIF for diagnosis of abdominal (intestinal or peritoneal) tuberculosis (TB) in various tissues (intestinal, omental/peritoneal tissue or ascitic fluid). METHODS:Electronic databases were searched for observational studies on use of X...

journal_title：Expert review of anti-infective therapy

authors： Sharma V,Soni H,Kumar-M P,Dawra S,Mishra S,Mandavdhare HS,Singh H,Dutta U

更新日期：2020-08-26 00:00:00

abstract：:Rodent-borne hantaviruses (family Bunyaviridae, genus Hantavirus) cause hantavirus pulmonary syndrome in the Americas and hemorrhagic fever with renal syndrome in Europe and Asia. The viruses are transmitted to humans mainly by inhalation of virus-contaminated aerosols of rodent excreta and secreta. Classic clinical h...

journal_title：Expert review of anti-infective therapy

authors： Mattar S,Guzmán C,Figueiredo LT

更新日期：2015-08-01 00:00:00

abstract：:Preterm prelabor rupture of membranes (pPROM) is the precursor of up to 40% of preterm deliveries and an independent risk factor for neonatal disease, death and long-term pulmonary and neurodevelopmental deficits. A significant proportion of cases of pPROM are infection driven, although these are difficult to delineat...

journal_title：Expert review of anti-infective therapy

authors： Ugwumadu A

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an important emerging respiratory pathogen. MERS-CoV resulted in multiple hospital outbreaks within and outside the Arabian Peninsula. The disease has a high case fatality rate, with the need for a therapeutic option. Areas covered: In this rev...

journal_title：Expert review of anti-infective therapy

authors： Al-Tawfiq JA,Memish ZA

更新日期：2017-03-01 00:00:00

abstract：:Ebola and Marburg viruses are emerging/re-emerging pathogens that pose a significant threat to human health. These naturally occurring viral infections frequently cause a lethal hemorrhagic fever in humans and nonhuman primates. The disastrous consequences of infection with these viruses have been pursued as potential...

journal_title：Expert review of anti-infective therapy

authors： Paragas J,Geisbert TW

更新日期：2006-02-01 00:00:00

abstract：:bla NDM is a major mechanism of resistance of Gram-negative bacteria to β-lactam antibiotics including the carbapenems. bla NDM has been acquired by a large range of Gram-negative bacilli, especially by the Enterobacteriaceae and Acinetobacter spp. The combination of human factors (suboptimal antibiotic stewardship an...

journal_title：Expert review of anti-infective therapy

authors： Wailan AM,Paterson DL

更新日期：2014-01-01 00:00:00

abstract：:Tuberculosis continues to be a major health problem worldwide, affecting millions of people each year. Accurate and rapid diagnosis is key to controlling the disease, yet the traditional tests for TB produce results that are either inaccurate or take too long to be definitive. A fast and reliable diagnostic method tha...

journal_title：Expert review of anti-infective therapy

authors： Al-Zamel FA

更新日期：2009-11-01 00:00:00

abstract：:The prodrug isavuconazonium sulfate (BAL8557) is an extended-spectrum water-soluble triazole, developed for the treatment of severe invasive and life-threatening fungal diseases. Its active moiety, BAL4815, is a potent inhibitor of ergosterol biosynthesis, resulting in the disruption of fungal membrane structure and f...

journal_title：Expert review of anti-infective therapy

authors： Seyedmousavi S,Verweij PE,Mouton JW

更新日期：2015-01-01 00:00:00

abstract：:Malaria is a curable disease, provided timely access to efficacious drugs is sought. Poor quality and, in particular, falsified antimalarial drugs harm the population of malaria endemic areas; they put lives in peril, cause economic losses to patients, families, industry, and generally undermine the trust in health sy...

journal_title：Expert review of anti-infective therapy

authors： Chaccour C,Kaur H,Del Pozo JL

更新日期：2015-04-01 00:00:00

abstract：:The authors sought to study whether extended or continuous infusion of cephalosporins is associated with better clinical outcomes than short-term infusion. PubMed and Scopus databases were systematically searched. Studies reporting the clinical outcomes of patients receiving extended or continuous infusion (≥3 or 24 h...

journal_title：Expert review of anti-infective therapy

authors： Korbila IP,Tansarli GS,Karageorgopoulos DE,Vardakas KZ,Falagas ME

更新日期：2013-06-01 00:00:00

abstract：:The emergence of multidrug-resistant tuberculosis strains and the coinfection with HIV, together with advances in immunology, have led to renewed interest regarding ways to exploit the immune responses against Mycobacterium tuberculosis therapeutically. Here we review the fundamentals of tuberculosis therapy in view o...

journal_title：Expert review of anti-infective therapy

authors： Achkar JM,Casadevall A,Glatman-Freedman A

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:Septic arthritis (SA) is an orthopedic emergency in childhood. It is uncommon in high resource settings. However, an incidence of 5-20 per 100,000 children has been reported in low-income countries. Area covered: The predictive value of serum markers is still under debate and the proposed diagnostic algori...

journal_title：Expert review of anti-infective therapy

authors： Chiappini E,Mastrolia MV,Galli L,De Martino M,Lazzeri S

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:In December 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak occurred and caused the coronavirus disease of 2019 (COVID-19), which affected ~ 190 countries. The World Health Organization (WHO) has declared COVID-19 a pandemic on 11 March 2020. AREA COVERED:In the review, a com...

journal_title：Expert review of anti-infective therapy

authors： Bhagat S,Yadav N,Shah J,Dave H,Swaraj S,Tripathi S,Singh S

更新日期：2020-12-07 00:00:00

abstract：:Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of I...

journal_title：Expert review of anti-infective therapy

authors： Berardi A,Spada C,Vaccina E,Boncompagni A,Bedetti L,Lucaccioni L

更新日期：2020-01-01 00:00:00

abstract：:Sepsis in older adults has many challenges that affect rate of septic diagnosis, treatment, and monitoring parameters. Numerous age-related changes and comorbidities contribute to increased risk of infections in older adults, but also atypical symptomatology that delays diagnosis. Due to various pharmacokinetic/pharma...

journal_title：Expert review of anti-infective therapy

authors： Clifford KM,Dy-Boarman EA,Haase KK,Maxvill K,Pass SE,Alvarez CA

更新日期：2016-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is of particular concern in immunodeficient individuals notably transplant recipients, leading to increased morbidity and mortality. HCMV is predicted to encode multiple microRNAs (miRNAs) and several have been characterized in vitro. Furthermore, these miRNAs have been shown to ...

journal_title：Expert review of anti-infective therapy

authors： Ng KR,Li JY,Gleadle JM

更新日期：2015-01-01 00:00:00

abstract：:Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans.Areas covered: This review assessed the scientific literature on phage therapy published between 1 Janu...

journal_title：Expert review of anti-infective therapy

authors： Caflisch KM,Suh GA,Patel R

更新日期：2019-12-01 00:00:00

abstract：:In this article we focus on the pathogenesis and clinical characteristics of schistosomiasis infection on the lung vasculature. Overall, the basic biology and understanding of Schistosoma immune responses and their effect on the cardiopulmonary system is limited in both animal and human models, which hinders clinical ...

journal_title：Expert review of anti-infective therapy

authors： Kolosionek E,Crosby A,Harhay MO,Morrell N,Butrous G

更新日期：2010-12-01 00:00:00