Abstract:
INTRODUCTION:Drug concentrations in tuberculosis patients on standard regimens vary widely with clinically important consequences. Areas covered: We review the available literature identifying factors correlated with pharmacokinetic variability of antituberculosis drugs. Based on population pharmacokinetic models and the weight, height, and sex distributions in a large data base of African tuberculosis patients, we propose simplified weight-based doses of the available fixed dose combination(FDC) for adults with drug susceptible tuberculosis. Emerging studies will support optimized weight-based dosing for children. Other sources of important pharmacokinetic variability include genetic variants, drug-drug interactions, formulation quality, and methods of preparation and administration. Expert commentary: Optimized weight band-based dosing will result in more equitable distribution of drug exposures by weight. The use of high doses of isoniazid in patients with drug-resistant tuberculosis would be safer and more effective if a feasible test was developed to allow stratified dosing according to acetylator type. There is an urgent need for more suitable formulations of many second-line drugs for children. The adoption of new technologies and efficient FDC design may allow further advances for patients and treatment programs. Lastly, current efforts to ensure adequate quality of antituberculosis drug products are not preventing the use of substandard products to treat patients with tuberculosis.
journal_name
Expert Rev Anti Infect Therjournal_title
Expert review of anti-infective therapyauthors
McIlleron H,Chirehwa MTdoi
10.1080/14787210.2019.1555031subject
Has Abstractpub_date
2019-01-01 00:00:00pages
27-38issue
1eissn
1478-7210issn
1744-8336journal_volume
17pub_type
杂志文章,评审abstract::Despite significant advances in the day-to-day management of patients receiving hematopoietic stem cell transplantations, including the introduction of new antiviral drugs, cytomegalovirus (CMV) infection continues to be a major cause of morbidity and mortality. The aim of this article is to undertake a literature-bas...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.12.115
更新日期:2012-11-01 00:00:00
abstract::The management of anaerobic infection needs to be prompt and appropriate in order to ensure recovery. Management includes the use of hyperbaric oxygen, surgical methods and antimicrobial therapy. Various factors, such as efficacy, bacterial antimicrobial resistance, ability to reach appropriate antimicrobial levels at...
journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
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更新日期:2011-01-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.1.1.175
更新日期:2003-06-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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更新日期:2016-01-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
doi:10.1080/14787210.2020.1697233
更新日期:2020-01-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.4.4.601
更新日期:2006-08-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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更新日期:2012-02-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.4.5.853
更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00
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journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00
abstract::Although efforts to combat the HIV epidemic have focused on the perinatal reduction of HIV transmission, many children are still being infected with HIV in resource-limited settings. Access to HIV care, cotrimoxazole and antiretroviral therapy (ART) for HIV-infected children has greatly improved in recent years, and h...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00