Abstract:
:Reversing the spread of HIV infection and the incidence of malaria constitute two of the Millenium Development Goals. However, despite recent achievements, both diseases still entail global heath problems. Furthermore, their overlapping geographical distribution raises concerns and challenges for potential immunological, clinical and therapeutic interactions. It has been reported that HIV infection increases malaria susceptibility and reduces the efficacy of antimalarial drugs. On the other hand, the effect of malaria on HIV-infected individuals has also been explored, with the parasitic infection increasing the risk of HIV disease progression and mother-to-child transmission of HIV. The spread of malaria and parasite resistance to antimalarials could also be accelerated by HIV-associated immunosuppresion. Current knowledge of the epidemiological, clinical, immunological and therapeutic interactions of the two diseases is reviewed in this article. We focus on the latest available data, pointing out key future research areas and challenges of the field.
journal_name
Expert Rev Anti Infect Therjournal_title
Expert review of anti-infective therapyauthors
González R,Ataíde R,Naniche D,Menéndez C,Mayor Adoi
10.1586/eri.11.167subject
Has Abstractpub_date
2012-02-01 00:00:00pages
153-65issue
2eissn
1478-7210issn
1744-8336journal_volume
10pub_type
杂志文章,评审abstract::In clinical practice, a significant proportion of HIV-infected patients receive lopinavir/ritonavir (LPV/r) as a component of highly active antiretroviral therapy (HAART). The study by Israr et al. was designed to evaluate the effects of the HIV protease inhibitor LPV/r on gingival epithelium growth and differentiatio...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
doi:10.1586/eri.10.138
更新日期:2010-12-01 00:00:00
abstract::In this article we focus on the pathogenesis and clinical characteristics of schistosomiasis infection on the lung vasculature. Overall, the basic biology and understanding of Schistosoma immune responses and their effect on the cardiopulmonary system is limited in both animal and human models, which hinders clinical ...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.10.124
更新日期:2010-12-01 00:00:00
abstract:INTRODUCTION:Patients with C. difficile infection (CDI) experience intestinal microflora changes that can promote the overgrowth and subsequent translocation of gut resident pathogens into the blood. Consistently, CDI due to PCR-ribotype 027 strain, severe or relapsing CDI, and treatment with high-dosage vancomycin are...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1080/14787210.2016.1197118
更新日期:2016-07-01 00:00:00
abstract:INTRODUCTION:Listeriosis is an uncommon foodborne infection that may cause moderate maternal illness, but can be extremely serious for the fetus and the newborn. Several guidelines have been elaborated in order to help clinicians on the care of pregnant women with known or suspected exposure to Listeria monocytogenes. ...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1080/14787210.2018.1417837
更新日期:2018-01-01 00:00:00
abstract::Lymphogranuloma venereum (LGV) is a sexually transmitted infection, previously only seen in tropical regions. This changed in 2003 when the first endemically acquired LGV cases were reported in Rotterdam, the Netherlands, among predominantly HIV positive men who have sex with men (MSM). Early diagnosis is important to...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.2014.901169
更新日期:2014-06-01 00:00:00
abstract::Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans.Areas covered: This review assessed the scientific literature on phage therapy published between 1 Janu...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1080/14787210.2019.1694905
更新日期:2019-12-01 00:00:00
abstract:INTRODUCTION:Monkeypox is a re-emerging viral zoonosis that occurs naturally in heavily forested regions of West and Central Africa. Inter-human transmission of monkeypox virus, although limited, drives outbreaks, particularly in household and health-care settings. But the available evidence suggests that without repea...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1080/14787210.2019.1567330
更新日期:2019-02-01 00:00:00
abstract::TB is typically caused by Mycobacterium tuberculosis, a symbiotic bacterium present in one-third of the world's population. There any many factors triggering overt clinical disease in a small proportion of humans. In our view the major role in the process is played by the host's immune response, especially self-direct...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.12.1
更新日期:2012-03-01 00:00:00
abstract::Accidents or violence can result in penetrating trauma in the adult population. Contaminated penetrating foreign bodies introduced at the time of wounding cause infection, especially high velocity projectiles, which result in cavitation. Surgical debridement reduces potential infection; however, perioperative antibiot...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.10.155
更新日期:2011-01-01 00:00:00
abstract::Malaria is a curable disease, provided timely access to efficacious drugs is sought. Poor quality and, in particular, falsified antimalarial drugs harm the population of malaria endemic areas; they put lives in peril, cause economic losses to patients, families, industry, and generally undermine the trust in health sy...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.2015.1015990
更新日期:2015-04-01 00:00:00
abstract::Hepatitis C virus infection is the leading cause of chronic liver disease in the western world. Chronic liver diseases may cause, through portal hypertension, the development of gastroesophageal varices, which can then bleed. We assess the findings of a study aimed at identifying the incidence of de novo varix develop...
journal_title:Expert review of anti-infective therapy
pub_type: 评论,杂志文章
doi:10.1586/eri.10.71
更新日期:2010-08-01 00:00:00
abstract::Nitazoxanide (Alinia, Romark Laboratories) was synthesized based on the structure of niclosamide. In vitro studies have demonstrated activity against a broad range of parasites as well as some bacteria. Three controlled trials demonstrated efficacy in cryptosporidiosis, however, the efficacy in advanced AIDS patients ...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.2.1.43
更新日期:2004-02-01 00:00:00
abstract::Tuberculosis is responsible for more then 2 million deaths worldwide each year and vies with HIV as the world's most fatal infectious disease. In many developing countries, attempts to control the spread of infection rely solely on identification and treatment of those with active disease, ignoring subclinical infecti...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.3.6.981
更新日期:2005-12-01 00:00:00
abstract::Sertaconazole is an imidazole-type antifungal agent that has shown considerable in vitro activity against pathogenic fungi. Various studies carried out in animal models, clinical and toxicologic trials have confirmed the value of sertaconazole in the topical treatment of superficial mycoses in dermatology and gynecolo...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.3.3.333
更新日期:2005-06-01 00:00:00
abstract::The prodrug isavuconazonium sulfate (BAL8557) is an extended-spectrum water-soluble triazole, developed for the treatment of severe invasive and life-threatening fungal diseases. Its active moiety, BAL4815, is a potent inhibitor of ergosterol biosynthesis, resulting in the disruption of fungal membrane structure and f...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.2015.990382
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Invasive fungal diseases (IFDs) have received attention as an emerging public health threat, are difficult to diagnose and to treat, and are associated with substantial morbidity and mortality. The standard of care in IFD management requires an early and targeted antifungal treatment, hence covers - amongs...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
doi:10.1080/14787210.2020.1760841
更新日期:2020-08-01 00:00:00
abstract::The acyclic nucleoside phosphonates [HPMPC: cidofovir, Vistide; PMEA: adefovir dipivoxil, Hepsera; and PMPA: tenofovir, Viread] have proven to be effective in vitro (cell culture systems) and in vivo (animal models and clinical studies) against a wide variety of DNA virus and retrovirus infections, for example, cidofo...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.1.1.21
更新日期:2003-06-01 00:00:00
abstract:INTRODUCTION:Sepsis-associated encephalopathy (SAE) and septic encephalitis (SE) are associated with increased mortality, long-term cognitive impairment, and focal neurological deficits. AREAS COVERED:The PUBMED database was searched 2016-2020. The clinical manifestation of SAE is delirium, SE additionally is characte...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
doi:10.1080/14787210.2020.1812384
更新日期:2020-09-14 00:00:00
abstract::Influenza is a ubiquitous infection with a spectrum ranging from mild to severe. The mystery regarding such variability in the clinical spectrum has not been fully unravelled, although a role for the complex interplay among virus characteristics, host immune response and environmental factors has been suggested. Antiv...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.2016.1155450
更新日期:2016-01-01 00:00:00
abstract::Pre- and neonatal screening for congenital toxoplasmosis rests upon the assumption that treatment is beneficial on either acute symptoms or in preventing later reactivation. Postpartum treatment of congenital toxoplasmosis with sulfadiazine and pyrimethamine has remained almost unchanged for 50 years. More recently, s...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.1.1.175
更新日期:2003-06-01 00:00:00
abstract::Chronic hepatitis C (CHC) virus infection affects more than 170 million people globally. The aim of treatment of CHC is to affect sustained elimination of the virus (a sustained virological response [SVR]). The success and duration of therapy with interferon is dependent on HCV genotype. The current standard of care c...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.12.8
更新日期:2012-03-01 00:00:00
abstract::Chronic hepatitis C is a major worldwide health problem with an estimated prevalence of 1.6-2%. The prognosis of chronic hepatitis C depends on the rate of fibrosis progression which, over a 20-30-year time span, may determine the risk of developing cirrhosis and its complications, namely hepatocellular carcinoma, liv...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.09.70
更新日期:2009-10-01 00:00:00
abstract::Ticks can transmit a variety of viruses, bacteria or parasites that can cause serious infections or conditions in humans and animals. While tick-borne diseases are becoming an increasing and serious problem in Europe, tick-borne diseases are also responsible for major depressions in livestock production and mortality ...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.09.118
更新日期:2010-01-01 00:00:00
abstract::Human enteritis resulting from the consumption of poultry products contaminated with serovars of Salmonella enterica remains a major public-health concern. Reducing food contamination by preventing or controlling infection in the chicken during rearing is an attractive solution. An accurate understanding of the mechan...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.5.5.873
更新日期:2007-10-01 00:00:00
abstract::Neurocysticercosis is the most common parasitic disease of the CNS. Intracranial neurocysticercosis is classified into cerebral parenchymal and extraparenchymal forms (subarachnoidal and intraventricular). Current medical therapy for parenchymal and extraparenchymal neurocysticercosis invovles the use of anticysticerc...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
doi:10.1586/14787210.6.4.435
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:We performed a meta-analysis to determine diagnostic accuracy of Xpert MTB/RIF for diagnosis of abdominal (intestinal or peritoneal) tuberculosis (TB) in various tissues (intestinal, omental/peritoneal tissue or ascitic fluid). METHODS:Electronic databases were searched for observational studies on use of X...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
doi:10.1080/14787210.2020.1816169
更新日期:2020-08-26 00:00:00
abstract::Diarrhoea is one of the most commonly occurring diseases. This article presents a review of the current state of the treatment of acute infectious diarrhoea, as well as of the most important pathogens. The general principles of the therapy of diarrhoea are exemplified, followed by a description of the targeted antimic...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.2016.1128824
更新日期:2016-01-01 00:00:00
abstract::Ventilator-associated pneumonia (VAP) remains a major burden to the healthcare system and intubated patients in intensive care units. In fact, VAP is responsible for at least 50% of prescribed antibiotics to patients who need mechanical ventilation. One of the factors contributing to VAP pathogenesis is believed to be...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/14787210.2015.1007045
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:Microorganisms of clinical importance frequently develop resistance to drug therapy, now a growing problem. The experience with Mycobacterium tuberculosis is a representative example of increasing multi-drug resistance. To avoid reaching a crisis in which patients could be left without adequate treatment, ...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章
doi:10.1080/14787210.2021.1839418
更新日期:2020-10-26 00:00:00
abstract::The aim of this article is to review the current literature examining the use of procalcitonin-guided antibiotic therapy for management of chronic obstructive pulmonary disease (COPD) exacerbations. Procalcitonin is a serum marker that rises in response to bacterial infections, but remains low in nonbacterial infectio...
journal_title:Expert review of anti-infective therapy
pub_type: 杂志文章,评审
doi:10.1586/eri.11.45
更新日期:2011-06-01 00:00:00