Abstract:
:Stem cell research has been a popular topic in the past few decades. This review aims to discuss factors that help regulate, induce, and enhance mesenchymal stem cell (MSC) differentiation into osteoblasts for bone regeneration. The factors analyzed include bone morphogenic protein (BMP), transforming growth factor β (TGF-β), stromal cell-derived factor 1 (SDF-1), insulin-like growth factor type 1 (IGF-1), histone demethylase JMJD3, cyclin dependent kinase 1 (CDK1), fucoidan, Runx2 transcription factor, and TAZ transcriptional coactivator. Methods promoting bone healing are also evaluated in this review that have shown promise in previous studies. Methods tested using animal models include low intensity pulsed ultrasound (LIPUS) with MSC, micro motion, AMD3100 injections, BMP delivery, MSC transplantation, tissue engineering utilizing scaffolds, anti-IL-20 monoclonal antibody, low dose photodynamic therapy, and bone marrow stromal cell transplants. Human clinical trial methods analyzed include osteoblast injections, bone marrow grafts, bone marrow and platelet rich plasma transplantation, tissue engineering using scaffolds, and recombinant human BMP-2. These methods have been shown to promote and accelerate new bone formation. These various methods for enhanced bone regeneration have the potential to be used, following further research, in clinical practice.
journal_name
Orthop Surgjournal_title
Orthopaedic surgeryauthors
Garg P,Mazur MM,Buck AC,Wandtke ME,Liu J,Ebraheim NAdoi
10.1111/os.12304subject
Has Abstractpub_date
2017-02-01 00:00:00pages
13-19issue
1eissn
1757-7853issn
1757-7861journal_volume
9pub_type
杂志文章,评审abstract:OBJECTIVE:To investigate the utility and medium-term results of a new intra-operative classification system for distal tibiofibular syndesmosis injury in ankle fractures. METHODS:Between January 2010 and January 2015, 116 patients diagnosed with displaced closed Weber B and C ankle fractures were treated in our depart...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12355
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Although contributions to sagittal alignment have been characterized for anterior, posterior and transforaminal lumbar interbody fusion, sagittal alignment after lateral transpsoas interbody fusion (LTIF) has not yet been characterized. This study examined the ability of LTIF to restore lumbar lordosis and id...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/j.1757-7861.2012.00175.x
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To describe the technique of primary repair of medial collateral ligament (MCL) insufficiency using a screw and rectangular spiked washer in a case series of 14 patients. METHODS:Fourteen patients undergoing MCL repair by a screw and rectangular spiked washer during TKA between March 2018 and March 2019 were...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12818
更新日期:2020-12-01 00:00:00
abstract::The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of i.v. tranexamic acid (TXA) in simultaneous bilateral total knee arthroplasty (TKA). Potentially relevant published reports were identified from the following electronic databases: Medline, PubMed, Embase, ScienceDirect...
journal_title:Orthopaedic surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1111/os.12256
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To investigate the changes of inflammatory factors and bone metabolism markers in postmenopausal women with H-type hypertension and to assess the relationship between them. METHODS:Postmenopausal women who were diagnosed with osteoporosis were selected as observation objects. Participants were divided into t...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12567
更新日期:2019-12-01 00:00:00
abstract::Pure tibiotalar dislocation without an associated fracture is an extremely rare injury. We present three cases of closed posteromedial tibiotalar dislocation without any associated fractures to the foot, ankle, or leg. All patients were treated conservatively with immediate closed reduction under general or local anae...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12049
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To compare the biomechanical properties of single- and two-segment fusion for Denis type B spinal fracture. METHODS:Two female patients with Denis type B L1 vertebral fractures were studied. Both patients had achieved intervertebral fusion by 1 year postoperatively, at which time CT data were collected, incl...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12068
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To investigate delay in diagnosis by both patients and doctors, and to evaluate its effect on outcomes of high-grade sarcoma of bone in a single-referral oncological center. METHODS:Fifty-four patients with osteosarcoma, 29 with Ewing sarcoma and 19 with chondrosarcoma were enrolled in this retrospective stu...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12239
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To analyze the approach and feasibility of one-stage anterior release and reduction with posterior fusion for irreducible atlantoaxial dislocation. METHODS:Ten male and 6 female patients, with an average age of 36 years, including 13 patients with old trauma, 2 with rheumatoid disease, and 1 with os odontoid...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/j.1757-7861.2009.00049.x
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To assess the difference between drainage and non-drainage after total hip arthroplasty (THA) in Chinese subjects by evaluating post-operative complications and joint function. METHODS:One hundred and sixty-eight patients undergoing THA were randomly allocated into drainage (83 patients) and non-drainage gro...
journal_title:Orthopaedic surgery
pub_type: 杂志文章,随机对照试验
doi:10.1111/os.12092
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to identify the common microorganisms causing PJI as well as the drug-resistant spectrum for each microorganism, to help orthopaedic surgeons to choose appropriate antibiotics. METHOD:One hundred and sixty patients who suffered from failure of primary or revision total hip or knee ar...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12394
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:To analyze the curative effect of TiRobot surgical robotic navigation and location system-assisted percutaneous sacroiliac screw fixation and percutaneous sacroiliac screw by traditional fluoroscopy, and to summarize the safety and benefits of TiRobot. METHODS:A total of 91 patients with pelvic posterior ri...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12461
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To investigate a stem-adjusted preparation of the femur with a kinked reamer and to determine whether this approach results in higher primary stability of a kinked stem than straight reaming of the intramedullary canal. METHODS:Ten cementless stems with a kinked design were implanted in synthetic femurs afte...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12490
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:The present retrospective study was performed to assess the anatomical features of the pedicle in isthmic spondylolisthesis and to correlate this with degree of slip. METHODS:Twenty-six patients with isthmic spondylolytic spondylolisthesis were studied. Relevant patient variables, length, width, height of th...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12173
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To compare the superior-level facet joint violations (FJV) between robot-assisted (RA) percutaneous pedicle screw placement and conventional open fluoroscopic-guided (FG) pedicle screw placement in a prospective cohort study. METHODS:This was a prospective cohort study without randomization. One-hundred pati...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12534
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Acute hematogenous infection is a devastating complication that can occur after total knee arthroplasty (TKA). The best strategies for management of this infection remain controversial. Two-stage revision has been well described as the gold standard for the management of chronic late infections. However, ther...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12297
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:A series of constant anatomical structures were used as guide targets for screw placement to improve the accuracy of cortical screw placement and reduce surgical injury and fluoroscopy radiation. The most commonly used angles and distances between the cortical bone screw insertion point and the lateral margi...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12775
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:Occipitocervical fusion (OCF) is an effective treatment for instability of occipitocervical junction (OCJ). The occipital condyle screw serves as a novel surgical technique for occipitocervical fixation. However, the intraoperative procedures for the occipital condyle screw technique have relied on surgeons'...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12700
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To assess the clinical efficacy of mini-invasive transforaminal lumbar interbody fusion (TLIF) through the Wiltse approach for treating lumbar spondylolytic spondylolisthesis. METHODS:In this retrospective controlled study, 69 cases with lumbar spondylolytic spondylolisthesis treated in Qilu hospital from Ap...
journal_title:Orthopaedic surgery
pub_type: 杂志文章,随机对照试验
doi:10.1111/os.12224
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To investigate the influence of preoperative osteopenia/osteoporosis on periprosthetic bone loss after total hip arthroplasty (THA) and the efficiency of zoledronate (ZOL) treatment in periprosthetic bone preservation. METHODS:This multicenter, prospective cohort study was conducted in four centers between A...
journal_title:Orthopaedic surgery
pub_type: 杂志文章,多中心研究
doi:10.1111/os.12513
更新日期:2019-08-01 00:00:00
abstract::Herein is described cortical bone trajectory (CBT), a new path for pedicle screw insertion for lumbar vertebral fusion. Because the points of insertion are under the end of the inferior articular process, and because the screws are inserted toward the lateral side, there is less soft tissue development than with the c...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12122
更新日期:2014-08-01 00:00:00
abstract::Gouty arthritis is an extremely painful condition that causes functional impairment. Gouty arthritis has become increasingly complex because of multiple comorbidities, iatrogenic factors and hyperuricemia that is refractory to treatment. In this review, we present a general overview of gouty arthritis including its pa...
journal_title:Orthopaedic surgery
pub_type: 杂志文章,评审
doi:10.1111/os.12024
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:This research aimed to investigate the relative level of Runt-related transcription factor 2 (RUNX2) in giant cell tumor of bone (GCTB). Through the histopathological similarities between osteoporosis and GCTB, the biological functions of exogenous RUNXS were demonstrated in GCTB cell lines. This generated a...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12568
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To establish a three-dimensional finite element model of the L(5)/S(1) motion segment with percutaneous axial lumbosacral screw and analyze the biomechanical stress on the screw. METHODS:With the help of related software and the Mechanical Virtual Human of China, a three-dimensional finite element model was ...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/j.1757-7861.2010.00088.x
更新日期:2010-08-01 00:00:00
abstract::A 66-year-old woman had sustained crush injury 3 hours prior to her presentation to our hospital. The diagnosis was defined as lateral tibial plateau fracture of the right knee (Schatzker III). Supine position was set up and a pad was put under the affected hip. After sterilization of the surgical field the sterilized...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12205
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Femoral avulsion fracture of the posterior cruciate ligament (PCL) in association with meniscus tear is extremely rare in children, and similar cases are not available in the existing literature. CASE PRESENTATION:In this paper, we present a case of a 9-year-old boy treated by an arthroscopic repair techniq...
journal_title:Orthopaedic surgery
pub_type:
doi:10.1111/os.12636
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To assess whether computed tomography (CT)-based 3-dimensional (3D) computerized pre-operative planning is accurate and reliable in patients with high-riding dislocation developmental dysplasia of the hip (DDH) undergoing total hip arthroplasty (THA). METHODS:Between September 2009 and February 2011, a prosp...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12099
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To explore the effect of kartogenin (KGN) on proliferation and chondrogenic differentiation of human umbilical cord mesenchymal stem cells (hUCMSC) in vitro, and the synergistic effects of KGN and transforming growth factor (TGF)-β3 on hUCMSC. METHODS:Human umbilical cord mesenchymal stem cells were isolated...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12691
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of residual varus and valgus deformity on the stress distribution of the knee joint after tibial fracture malunion. METHODS:Fourteen adult cadaver specimens were selected to establish the models of tibial fractures, which were fixed subsequently at neutral position (anatomical reduc...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12668
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Relatively few studies have reported on the morphology of the supracondylar femur, which is a fundamental factor affecting prosthetic reconstruction. The objectives of the present study were to measure the morphological parameters of the supracondylar femur, to classify the supracondylar femur, and to provide...
journal_title:Orthopaedic surgery
pub_type: 杂志文章
doi:10.1111/os.12443
更新日期:2019-04-01 00:00:00