Efficiency of Zoledronic Acid in Inhibiting Accelerated Periprosthetic Bone Loss After Cementless Total Hip Arthroplasty in Osteoporotic Patients: A Prospective, Cohort Study.

Abstract:

OBJECTIVE:To investigate the influence of preoperative osteopenia/osteoporosis on periprosthetic bone loss after total hip arthroplasty (THA) and the efficiency of zoledronate (ZOL) treatment in periprosthetic bone preservation. METHODS:This multicenter, prospective cohort study was conducted in four centers between April 2015 and October 2017. Patients were assigned to Normal BMD, Osteopenia, and Osteoporosis+ZOL groups. Patients with osteopenia received daily oral calcium (600 mg/d) and vitamin D (0.5 μg/d), while patients in the Osteoporosis+ZOL group received additional ZOL annually (5 mg/year). Periprosthetic bone mineral density (BMD) in seven Gruen zones, radiographic parameters, Harris hip score, EuroQol 5-Dimensions (EQ-5D) score, and BMD in hip and spine were measured within 7 days, 3 months, 12 months postoperation and annually thereafter. RESULTS:A total of 266 patients were enrolled, while 81 patients that completed the first year follow-up were involved in the statistical analysis. The mean follow-up time was 1.3 years. There were significant decreases of mean BMD in total Gruen zones (-4.55%, P < 0.05) and Gruen zone 1 (-10.22%, P < 0.01) in patients with osteopenia during the first postoperative year. Patients in the Osteoporosis+ZOL group experienced a marked increase in BMD in Gruen zone 1 (+16%) at the first postoperative year, which had a significant difference when compared with the Normal BMD group (P < 0.05) and the Osteopenia Group (P < 0.001). Low preoperative BMD in hip and spine was predictive of bone loss in Gruen zone 1 at 12 months after THA in patients with normal BMD (R2 = 0.40, P < 0.05). CONCLUSIONS:Patients with osteopenia are prone to higher bone loss in the proximal femur after cementless total hip arthroplasty (THA). ZOL, not solely calcium and vitamin D, could prevent the accelerated periprosthetic bone loss after THA in patients with osteopenia and osteoporosis.

journal_name

Orthop Surg

journal_title

Orthopaedic surgery

authors

Fu GT,Lin LJ,Sheng PY,Li CC,Zhang JX,Shen J,Liu S,Xue YL,Lin SP,Wang K,Zheng QJ,Ding Y

doi

10.1111/os.12513

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

653-663

issue

4

eissn

1757-7853

issn

1757-7861

journal_volume

11

pub_type

杂志文章,多中心研究
  • Evaluation of Anterior Decompression Surgical Outcomes of Proximal-Type Cervical Spondylotic Amyotrophy: A Retrospective Study.

    abstract:OBJECTIVE:To investigate the efficiency of anterior decompression on the proximal-type cervical spondylotic amyotrophy patients. METHODS:This was a retrospective analysis. From January 2014 to November 2017, 21 patients with proximal-type cervical spondylotic amyotrophy (CSA) underwent anterior decompression. There we...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12654

    authors: Lu CB,Ma ZS,Hu JB,Yang XJ,Wei W,Zhang Y,Lei W

    更新日期:2020-06-01 00:00:00

  • Clinical Evaluation and Gait Characteristics before and after Total Knee Arthroplasty Based on a Portable Gait Analyzer.

    abstract:OBJECTIVE:To evaluate the effects of surgery and rehabilitation on patients undergoing total knee arthroplasty (TKA). METHODS:Twelve patients and 12 healthy controls were enrolled and their clinical scores evaluated by a doctor. Gait data, including walking velocity, stride length, single support time, foot fall and s...

    journal_title:Orthopaedic surgery

    pub_type: 临床试验,杂志文章

    doi:10.1111/os.12270

    authors: Zhang HH,Yan SH,Fang C,Guo XY,Zhang K

    更新日期:2016-08-01 00:00:00

  • Loss of Reduction after Cephalomedullary Nail Fixation of Intertrochanteric Femoral Fracture: A Brief Report.

    abstract:OBJECTIVE:At present, cephalomedullary nail is the most frequently used implant in the management of intertrochanteric fractures around the world. The implant design and fixation techniques of the cephalomedullary nail have been continuously improved to ensure uncomplicated bone union during the past decade. However, a...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12828

    authors: Pang Y,He QF,Zhu LL,Bian ZY,Li MQ

    更新日期:2020-12-01 00:00:00

  • Anatomy, definition, and treatment of the "terrible triad of the elbow" and contemplation of the rationality of this designation.

    abstract::In the realm of orthopaedics, the terrible triad of the elbow is infamous, not simply because the prognosis is poor for most patients, but also, maybe to a greater extent, because the unique name of this malady attracts considerable attention and interest in both doctors and patients. The adjective terrible is bestowe...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章,评审

    doi:10.1111/os.12149

    authors: Xiao K,Zhang J,Li T,Dong YL,Weng XS

    更新日期:2015-02-01 00:00:00

  • Effect of Patellar Denervation on Anterior Knee Pain and Knee Function in Total Knee Arthroplasty without Patellar Resurfacing: A Meta-Analysis of Randomized Controlled Trials.

    abstract:OBJECTIVE:The aim of the present study was to evaluate the effect of patellar denervation (PD) in preventing anterior knee pain (AKP) and improving knee function after total knee arthroplasty (TKA) without patellar resurfacing, and to help surgeons decide whether or not to use PD in TKA. METHODS:The electronic databas...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12815

    authors: Wang Y,Feng W,Zang J,Gao H

    更新日期:2020-12-01 00:00:00

  • Comparison of biomechanical properties of single- and two-segment fusion for Denis type B spinal fractures.

    abstract:OBJECTIVE:To compare the biomechanical properties of single- and two-segment fusion for Denis type B spinal fracture. METHODS:Two female patients with Denis type B L1 vertebral fractures were studied. Both patients had achieved intervertebral fusion by 1 year postoperatively, at which time CT data were collected, incl...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12068

    authors: Su YS,Ren D,Wang PC

    更新日期:2013-11-01 00:00:00

  • Three-dimensional computerized preoperative planning of total hip arthroplasty with high-riding dislocation developmental dysplasia of the hip.

    abstract:OBJECTIVE:To assess whether computed tomography (CT)-based 3-dimensional (3D) computerized pre-operative planning is accurate and reliable in patients with high-riding dislocation developmental dysplasia of the hip (DDH) undergoing total hip arthroplasty (THA). METHODS:Between September 2009 and February 2011, a prosp...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12099

    authors: Zeng Y,Lai OJ,Shen B,Yang J,Zhou ZK,Kang PD,Pei FX,Zhou X

    更新日期:2014-05-01 00:00:00

  • Cerebrospinal fluid leakage during anterior approach cervical spine surgery for severe ossification of the posterior longitudinal ligament: prevention and treatment.

    abstract:OBJECTIVE:The prevention and treatment of the common complication of cerebrospinal fluid leakage (CSFL) during anterior approach cervical spine surgery for severe ossification of the posterior longitudinal ligament (OPLL) is documented. METHOD:A retrospective analysis of 47 patients with severe cervical OPLL aged 39 t...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12007

    authors: Lei T,Shen Y,Wang LF,Cao JM,Ding WY,Ma QH

    更新日期:2012-11-01 00:00:00

  • Rare Occurrence of Acute Hematogenous Periprosthetic Joint Infection Due to Fusobacterium Nucleatum in the Background of a Dental Procedure: A Case Report.

    abstract:OBJECTIVE:Fusobacterium nucleatum is an anaerobic gram-negative bacilli that is one of the oral and other mucosal surface microbiota. It involves a wide range of human diseases and was first found in periodontal diseases, but reports of bone-related infections caused by F. nucleatum are rare, especially periprosthetic ...

    journal_title:Orthopaedic surgery

    pub_type:

    doi:10.1111/os.12844

    authors: Shi TB,Fang XY,Wang CX,Cai YQ,Li WB,Zhang WM

    更新日期:2020-12-01 00:00:00

  • Mini-invasive Transforaminal Lumbar Interbody Fusion through Wiltse Approach to Treating Lumbar Spondylolytic Spondylolisthesis.

    abstract:OBJECTIVE:To assess the clinical efficacy of mini-invasive transforaminal lumbar interbody fusion (TLIF) through the Wiltse approach for treating lumbar spondylolytic spondylolisthesis. METHODS:In this retrospective controlled study, 69 cases with lumbar spondylolytic spondylolisthesis treated in Qilu hospital from Ap...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/os.12224

    authors: Zhou C,Tian YH,Zheng YP,Liu XY,Wang HH

    更新日期:2016-02-01 00:00:00

  • Treatment of lumbar and lumbosacral spinal tuberculosis with minimally invasive surgery.

    abstract:OBJECTIVE:To evaluate the outcome of computed tomography (CT)-guided percutaneous puncture and local chemotherapy for tuberculosis (TB) of the lumbar or lumbosacral spine. METHODS:From January 2002 to August 2006, 49 patients with lumbar or lumbosacral spinal TB in whom conservative treatment had failed were treated b...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/j.1757-7861.2009.00060.x

    authors: Zhang XF,Wang Y,Xiao SH,Liu ZS,Zhang YG,Liu BW,Xia ZM

    更新日期:2010-02-01 00:00:00

  • Intramedullary Nail Fixation Assisted by Orthopaedic Robot Navigation for Intertrochanteric Fractures in Elderly Patients.

    abstract:OBJECTIVE:To compare the clinical efficacy of intramedullary nail fixation for intertrochanteric fractures assisted by orthopaedic robot navigation and the traditional intramedullary nail fixation in elderly patients, and to investigate the application advantages of intramedullary nail fixation for femoral intertrochan...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12447

    authors: Lan H,Tan Z,Li KN,Gao JH,Liu TH

    更新日期:2019-04-01 00:00:00

  • A Radiographic Measurement of the Anterior Epidural Space at L4-5 Disc Level.

    abstract::To observe the morphology character of the anterior epidural space at the L4-5 disc level and to provide an anatomical basis for safely and accurately performing a percutaneous endoscopic lumbar discectomy (PELD). Fifty-five cases with L5 S1 lumbar disc herniation were included in this study, and cases with L4-5 disea...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12325

    authors: Xu RS,Wu JS,Lu HD,Zhu HG,Li X,Dong J,Yuan FL

    更新日期:2017-05-01 00:00:00

  • Relationship between the location of ligamentum flavum hypertrophy and its stress in finite element analysis.

    abstract:OBJECTIVE:To quantitatively describe the stress of the ligamentum flavum (LF) using the finite element method and to compare the stress at different parts of the healthy LF. METHODS:Based on the high resolution computed tomography imaging data of a healthy 22-year-old man, three-dimensional nonlinear L4-5 lumbar finit...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12675

    authors: Peng YX,Zheng ZY,Wang Md WG,Liu L,Chen Md F,Xu Md HT,Zhang ZM

    更新日期:2020-06-01 00:00:00

  • Surgical treatment of thoracolumbar fracture through an approach via the paravertebral muscle.

    abstract:OBJECTIVE:To investigate the methods for, and clinical outcome of, the operative treatment of thoracolumbar fractures through an approach via the paravertebral muscle (PVM). METHODS:From June 2005 to August 2006, 62 patients, comprising 48 men and 14 women with an average age of 45.2 years (range, 21-58) with thoracol...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1757-7861.2009.00032.x

    authors: Pang W,Zhang GL,Tian W,Sun D,Li N,Yuan Q,Zhang B,Wang YQ,Liu W

    更新日期:2009-08-01 00:00:00

  • Pure closed posteromedial dislocation of the tibiotalar joint without fracture.

    abstract::Pure tibiotalar dislocation without an associated fracture is an extremely rare injury. We present three cases of closed posteromedial tibiotalar dislocation without any associated fractures to the foot, ankle, or leg. All patients were treated conservatively with immediate closed reduction under general or local anae...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12049

    authors: Wang YT,Wu XT,Chen H

    更新日期:2013-08-01 00:00:00

  • Morphometric Trajectory Analysis for Occipital Condyle Screws.

    abstract:OBJECTIVES:Occipitocervical fusion (OCF) is an effective treatment for instability of occipitocervical junction (OCJ). The occipital condyle screw serves as a novel surgical technique for occipitocervical fixation. However, the intraoperative procedures for the occipital condyle screw technique have relied on surgeons'...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12700

    authors: Du YK,Li SY,Yang WJ,Wang XY,Bi YF,Dong J,Huang H,Gao F,Li GZ,Wei HW,Yang JK,Xi YM

    更新日期:2020-06-01 00:00:00

  • Surgical Technique of Anterolateral Approach for Tibial Plateau Fracture.

    abstract::A 66-year-old woman had sustained crush injury 3 hours prior to her presentation to our hospital. The diagnosis was defined as lateral tibial plateau fracture of the right knee (Schatzker III). Supine position was set up and a pad was put under the affected hip. After sterilization of the surgical field the sterilized...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12205

    authors: Wang PC,Ren D,Zhou B

    更新日期:2015-11-01 00:00:00

  • Pedicle length and degree of slip in lumbosacral isthmic spondylolisthesis.

    abstract:OBJECTIVE:The present retrospective study was performed to assess the anatomical features of the pedicle in isthmic spondylolisthesis and to correlate this with degree of slip. METHODS:Twenty-six patients with isthmic spondylolytic spondylolisthesis were studied. Relevant patient variables, length, width, height of th...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12173

    authors: Matthews PG,Phan K,Rao PJ,Ball JR

    更新日期:2015-05-01 00:00:00

  • F-Shaped Osteotomy Combined with Basal Opening Wedge Osteotomy for Severe Hallux Valgus.

    abstract:OBJECTIVE:To evaluate the safety and effectiveness of osteotomy adjacent to the articular surface of the metatarsal head combined with basal opening wedge osteotomy for severe hallux valgus. METHODS:The double osteotomy procedure was carried out in 56 patients (72 feet) with severe hallux valgus deformity, with an ave...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12505

    authors: Li C,Lu L,Zhang Y,Ai-Xin-Jue-Luo QC,Wang ZT,Wang JF

    更新日期:2019-08-01 00:00:00

  • Guideline for Posterior Atlantoaxial Internal Fixation Assisted by Orthopaedic Surgical Robot.

    abstract::Atlantoaxial transarticular facet screw fixation (Magerl technique) and C1 lateral mass screws combined with C2 pedicle screws fixation (Harms technique) are the most commonly used techniques for posterior internal fixation in the upper cervical spine. Upper cervical spinal surgery is a technically demanding and chall...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章,实务指引

    doi:10.1111/os.12454

    authors: Tian W,Liu YJ,Liu B,He D,Wu JY,Han XG,Zhao JW,Fan MX,Technical Committee on Medical Robot Engineering of Chinese Society of Biomedical Engineering.,Technical Consulting Committee of National Robotic Orthopaedic Surgery Application Cent

    更新日期:2019-04-01 00:00:00

  • Anchoring of a Kinked Uncemented Femoral Stem after Preparation with a Straight or a Kinked Reamer.

    abstract:OBJECTIVE:To investigate a stem-adjusted preparation of the femur with a kinked reamer and to determine whether this approach results in higher primary stability of a kinked stem than straight reaming of the intramedullary canal. METHODS:Ten cementless stems with a kinked design were implanted in synthetic femurs afte...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12490

    authors: Heinecke M,Layher F,Matziolis G

    更新日期:2019-08-01 00:00:00

  • Surgical treatment of open pilon fractures.

    abstract:OBJECTIVE:To discuss the methods, timing and clinical outcomes of surgical treatment for open pilon fractures. METHODS:From April 2003 to July 2008, 28 patients with open pilon fractures were treated. All had type C fractures according to the Arbeitsgemeinschaft für osteosynthesefragen-Association for the Study of Int...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/j.1757-7861.2010.00113.x

    authors: Zeng XT,Pang GG,Ma BT,Mei XL,Sun X,Wang J,Jia P

    更新日期:2011-02-01 00:00:00

  • Compensatory Mechanism of Maintaining the Sagittal Balance in Degenerative Lumbar Scoliosis Patients with Different Pelvic Incidence.

    abstract:OBJECTIVE:To investigate the compensatory mechanism of maintaining the sagittal balance in degenerative lumbar scoliosis patients with different pelvic incidence (PI). METHODS:This was a retrospective imaging observation study. Patients in our department with degenerative lumbar scoliosis between 2017 and 2019 were re...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12805

    authors: Liu C,Hu FQ,Hu WH,Song K,Jiao GL,Zheng GQ,Zhang XS,Li ZZ

    更新日期:2020-12-01 00:00:00

  • Comparison of complications and results of early versus delayed surgery for Gartland type III supracondylar humeral fractures in pediatric patients.

    abstract:OBJECTIVE:To investigate the effect of timing of surgery on clinical results and perioperative complications in pediatric patients with Gartland III type supracondylar humeral fractures without neurovascular compromise. METHODS:Eighty-six consecutive children treated surgically at our hospital from April 2005 to June ...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/j.1757-7861.2011.00153.x

    authors: Han QL,Wang YH,Liu F

    更新日期:2011-11-01 00:00:00

  • Hybrid technique for posterior lumbar interbody fusion: a combination of open decompression and percutaneous pedicle screw fixation.

    abstract::The authors describe a hybrid technique that involves a combination of open decompression and posterior lumbar interbody fusion (PLIF) and percutaneously inserted pedicle screws. This technique allows performance of PLIF and decompression via a midline incision and approach without compromising operative time and visu...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12042

    authors: Mobbs RJ,Sivabalan P,Li J,Wilson P,Rao PJ

    更新日期:2013-05-01 00:00:00

  • Simultaneous intra-operative repair for inadvertent dural tear under posterior lumbar disk scope.

    abstract:OBJECTIVE:To introduce a microsurgical suture technique for repair of dural tear under posterior lumbar disk scope. METHODS:Micro endoscopic discectomy was performed on a 26-year-old male under local anesthesia. During the operation, an irregular tear of about 1.0 cm was inadvertently made in the dura.The cauda equina...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/j.1757-7861.2011.00135.x

    authors: Sun MJ,Gao SM,Wang YH

    更新日期:2011-08-01 00:00:00

  • Diagnosis of bursal-side partial-thickness rotator cuff tears.

    abstract:OBJECTIVE:To study the clinical features and diagnosis of bursal-side partial-thickness rotator cuff tears. METHODS:From August 1999 to June 2006, 38 patients with bursal-side partial-thickness rotator cuff tear were evaluated. Twenty-eight men and ten women of average age 45.7 years (range, 18-69 years) with 11 left ...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/j.1757-7861.2010.00097.x

    authors: Xiao J,Cui GQ,Wang JQ

    更新日期:2010-11-01 00:00:00

  • Comparison of Superior-Level Facet Joint Violations Between Robot-Assisted Percutaneous Pedicle Screw Placement and Conventional Open Fluoroscopic-Guided Pedicle Screw Placement.

    abstract:OBJECTIVE:To compare the superior-level facet joint violations (FJV) between robot-assisted (RA) percutaneous pedicle screw placement and conventional open fluoroscopic-guided (FG) pedicle screw placement in a prospective cohort study. METHODS:This was a prospective cohort study without randomization. One-hundred pati...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12534

    authors: Zhang Q,Xu YF,Tian W,Le XF,Liu B,Liu YJ,He D,Sun YQ,Yuan Q,Lang Z,Han XG

    更新日期:2019-10-01 00:00:00

  • Joint-Preserving Surgery for Talar Malunions or Nonuions.

    abstract:OBJECTIVE:To describe the technique and analyze the outcomes of joint-preserving surgical treatments which included anatomical reconstruction or alignment correction for talar malunions or nonunions, and avoid development of degenerative changes in the adjacent joints. METHODS:Eight patients who had painful talar malu...

    journal_title:Orthopaedic surgery

    pub_type: 杂志文章

    doi:10.1111/os.12301

    authors: Chen G,Hu M,Xu Y,Zhen YH,Hong Y,Xu XY

    更新日期:2017-02-01 00:00:00