A collection system for dry solid residues from exhaled breath for analysis via atomic force microscopy.

abstract：:Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) represents an attractive tool for the real-time analysis of VOC profiles in human breath. Quantification of breath VOCs by means of direct MS may be affected by the matrix, as human breath not only contains several hundred VOCs at the ppbV-pptV lev...

journal_title：Journal of breath research

authors： Trefz P,Schubert JK,Miekisch W

更新日期：2018-03-01 00:00:00

abstract：:Robust methods for breath sampling and analysis are required for potential clinical applications. We have evaluated an improved sampling and experimental design, assessing instrumental and biological variability within and across breath measurements. Calibration curves for selected relevant volatile organic compounds...

journal_title：Journal of breath research

authors： Basanta M,Ibrahim B,Douce D,Morris M,Woodcock A,Fowler SJ

更新日期：2012-06-01 00:00:00

abstract：:While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles, and our vision of ...

journal_title：Journal of breath research

authors： Singh KD,Del Miguel GV,Gaugg MT,Ibañez AJ,Zenobi R,Kohler M,Frey U,Sinues PM

更新日期：2018-02-07 00:00:00

abstract：:In this study, the effects of aerobic exercise on the upper airways and their defense mechanisms were investigated in athletes. The athletes ran in two different environments: the downtown streets of the city of São Paulo (Street), more polluted, and an urban forest (Forest), less polluted. Thirty-eight young healthy ...

journal_title：Journal of breath research

authors： Cavalcante de Sá M,Nakagawa NK,Saldiva de André CD,Carvalho-Oliveira R,de Santana Carvalho T,Nicola ML,de André PA,Nascimento Saldiva PH,Vaisberg M

更新日期：2016-12-21 00:00:00

abstract：:A point-of-care, non-invasive, low-cost and sensitive nano-biodiagnostic is needed in today's age for rapid and accurate self-diagnosis as well as for the management of asthma, which is advantageous for low resource areas where asthma is prevalent. The objective of this research work was to prepare the miniature, nano...

journal_title：Journal of breath research

authors： Shende P,Vaidya J,Kulkarni YA

更新日期：2019-06-25 00:00:00

abstract：:The discovery of nitric oxide (NO) as a signalling and regulatory molecule and its subsequent detection in the exhaled breath has not only yielded new mechanistic insights but also diagnostic opportunities and therapeutic targets in several important medical conditions. In diseases involving chronic pulmonary inflamma...

journal_title：Journal of breath research

authors： Boshier PR,Hanna GB,Marczin N

更新日期：2013-03-01 00:00:00

abstract：:Reactive oxygen species are associated with tissue inflammation and injury. Our laboratory has demonstrated that ethane, a stable product of lipid peroxidation, in exhaled breath can be used to measure total body oxidative stress. Herein patients were studied who underwent outpatient surgery, laproscopic bilateral tub...

journal_title：Journal of breath research

authors： Brown RH,Risby TH

更新日期：2009-03-01 00:00:00

abstract：:Despite growing interest and considerable progress in breath research over the last decade, standardized practices for the sampling and analysis of breath gas volatiles remain elusive. The primary reasons for this are (a) the rich chemical diversity of exhaled breath that covers an extensive range of volatile organic ...

journal_title：Journal of breath research

authors： Herbig J,Beauchamp J

更新日期：2014-09-01 00:00:00

abstract：:Exhaled NO (FE(NO)) measurements have been utilized as a marker to diagnose asthma as well as a non-invasive tool for monitoring airway inflammation and the response to anti-inflammatory medications. One area where this non-invasive monitoring may be helpful is for asthmatic athletes as they train for competitive even...

journal_title：Journal of breath research

authors： Grob NM,Laskowski D,Dweik RA

更新日期：2008-09-01 00:00:00

abstract：:Cancer cells prefer hyperglycolysis versus oxidative phosphorylation, even in the presence of oxygen. This phenomenon is used through the FDG-PET scans, and may affect the exhaled volatile signature. This study investigates the volatile signature in lung cancer (LC) before and after an oral glucose tolerance test (OGT...

journal_title：Journal of breath research

authors： Feinberg T,Alkoby-Meshulam L,Herbig J,Cancilla JC,Torrecilla JS,Gai Mor N,Bar J,Ilouze M,Haick H,Peled N

更新日期：2016-06-07 00:00:00

abstract：:The objective of this study is to evaluate tonsil odor as a contributor to halitosis and to study the reduction of oral malodor by mouth rinsing, without tonsil treatment. In 48 halitosis patients, tonsil odor and oral malodor were assessed through the 0-5 scale. In tonsil odor assessment, a dental burnisher was inser...

journal_title：Journal of breath research

authors： Talebian A,Tazhibi M,Iranpoor R,Semyari H,Taherzadeh M

更新日期：2008-03-01 00:00:00

abstract：:Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FE(NO)) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared enviro...

journal_title：Journal of breath research

authors： Tarnoki DL,Tarnoki AD,Medda E,Littvay L,Lazar Z,Toccaceli V,Fagnani C,Stazi MA,Nisticó L,Brescianini S,Penna L,Lucatelli P,Boatta E,Zini C,Fanelli F,Baracchini C,Meneghetti G,Koller A,Osztovits J,Jermendy G,Preda

更新日期：2013-06-01 00:00:00

abstract：:Breath contains hundreds of volatile organic compounds (VOCs), the composition of which is altered in a wide variety of diseases. Bacteria are implicated in the formation of VOCs, but the biochemical mechanisms that lead to the formation of breath VOCs remain largely hypothetical. We hypothesized that bacterial DNA fr...

journal_title：Journal of breath research

authors： Bos LD,Meinardi S,Blake D,Whiteson K

更新日期：2016-12-17 00:00:00

abstract：:Bronchiectasis, bronchiolectasis, and bronchiolisation of alveolar regions are salient features of idiopathic pulmonary fibrosis (IPF). We asked whether IPF was associated with physiological changes consistent with increases in the volume of conducting airways, and whether airway volume was related to the severity of ...

journal_title：Journal of breath research

authors： Plantier L,Debray MP,Estellat C,Flamant M,Roy C,Bancal C,Borie R,Israël-Biet D,Mal H,Crestani B,Delclaux C

更新日期：2016-02-01 00:00:00

abstract：:Breath gas analysis provides insight into human metabolism of healthy and ill individuals. As an innovative and non-invasive method, it opens up options to improve diagnostics, monitoring and treatment decisions. Mid-infrared laser absorption spectroscopy is utilized to detect CH(4), H(2)O, CO(2), NH(3) and CH(3)OH in...

journal_title：Journal of breath research

authors： Hannemann M,Antufjew A,Borgmann K,Hempel F,Ittermann T,Welzel S,Weltmann KD,Völzke H,Röpcke J

更新日期：2011-06-01 00:00:00

abstract：:The analysis of volatile organic compounds (VOCs) by an electronic nose (e-nose) is a groundbreaking method that provides distinct exhaled molecular patterns in several respiratory and systemic diseases. It has been shown that an e-nose can detect obstructive sleep apnea (OSA) as well as chronic obstructive pulmonary ...

journal_title：Journal of breath research

authors： Dragonieri S,Quaranta VN,Carratu P,Ranieri T,Resta O

更新日期：2016-11-03 00:00:00

abstract：:Breath analysis represents a new frontier in medical diagnosis and a powerful tool for cancer biomarker discovery due to the recent development of analytical platforms for the detection and identification of human exhaled volatile compounds. Statistical and bioinformatic tools may represent an effective complement to ...

journal_title：Journal of breath research

authors： Martinez-Lozano Sinues P,Landoni E,Miceli R,Dibari VF,Dugo M,Agresti R,Tagliabue E,Cristoni S,Orlandi R

更新日期：2015-09-21 00:00:00

abstract：:Blood ammonia is routinely used in clinical settings to assess systemic ammonia in hepatic encephalopathy and urea cycle disorders. Despite its drawbacks, blood measurement is often used as a comparator in breath studies because it is a standard clinical test. We sought to evaluate sources of measurement error and pot...

journal_title：Journal of breath research

authors： Spacek LA,Mudalel M,Tittel F,Risby TH,Solga SF

更新日期：2015-12-14 00:00:00

abstract：:Breath tests have been used to investigate many physiological functions. Recently, we have developed a breath test system by using a non-invasive technique in conscious rats. In this study, we investigated the effect of atropine sulfate on the gastric emptying and gastrocecal transit time using [1-(13)C]acetic acid an...

journal_title：Journal of breath research

authors： Uchida M,Yoshida K,Shimizu K

更新日期：2009-12-01 00:00:00

abstract：:Based on the adsorption of analytes in the sampling loop, a time-resolved dynamic dilution introduction method was developed for negative ion mobility spectrometry to continuously monitor end-tidal propofol without other sample pre-separation. The dynamic dilution characteristics of propofol and moisture in the Teflon...

journal_title：Journal of breath research

authors： Zhou Q,Li E,Wang Z,Gong Y,Wang C,Guo L,Li H

更新日期：2015-01-05 00:00:00

abstract：:The results of experiments are described in which a known quantity of sterile deuterated water is injected directly into the pulmonary circulation via the right internal jugular vein of several haemodialysis patients and the deuterium to hydrogen ratio, D/H, in the exhaled lung water was measured using the flowing aft...

journal_title：Journal of breath research

authors： Tan BK,Davies SJ,Spaněl P,Smith D

更新日期：2012-09-01 00:00:00

abstract：:Radiation dose is important in radiotherapy. Too little, and the treatment is not effective, too much causes radiation toxicity. A biochemical measurement of the effect of radiotherapy would be useful in personalisation of this treatment. This study evaluated changes in exhaled breath volatile organic compounds (VOC) ...

journal_title：Journal of breath research

authors： Salman D,Eddleston M,Darnley K,Nailon WH,McLaren DB,Hadjithelki A,Ruszkiewicz D,Langejuergen J,Alkhalifa Y,Phillips I,Thomas CLP

更新日期：2020-10-24 00:00:00

abstract：:The data obtained for the concentration distributions of the most abundant volatile metabolites in exhaled breath determined in two independent studies are reviewed, the first limited study involving five healthy volunteers providing daily breath samples over a month, and the subsequent study involving 30 healthy volu...

journal_title：Journal of breath research

authors： Smith D,Turner C,Spaněl P

更新日期：2007-09-01 00:00:00

abstract：:Methods for breath sampling and analysis require robust quality assessment to minimise the risk of false discoveries. Planning large-scale multi-site breath metabolite profiling studies also requires careful consideration of systematic and random variation as a result of sampling and analysis techniques. In this study...

journal_title：Journal of breath research

authors： Ahmed WM,Brinkman P,Weda H,Knobel HH,Xu Y,Nijsen TM,Goodacre R,Rattray N,Vink TJ,Santonico M,Pennazza G,Montuschi P,Sterk PJ,Fowler SJ

更新日期：2018-10-30 00:00:00

abstract：:Exhaled nitric oxide (eNO) has been suggested to be a marker of small airway injury. We investigated the effects of different ventilation strategies on eNO. Sixty-nine patients who received elective open abdominal surgery under general anesthesia with more than 2 h of surgery duration were randomly divided into three ...

journal_title：Journal of breath research

authors： Cui Y,Pi X,Wang C,Liu S,Gong Y,Wang Y,Zhang F,Shi J,Lin Z,Zhang X,Li E

更新日期：2015-02-26 00:00:00

abstract：:The measurement of the peak exhaled breath temperature (EBT) during multiple tidal breaths offers an easy, non-invasive tool for monitoring airway inflammation. Chronic obstructive pulmonary disease (COPD) is linked to airway inflammation, which is further aggravated by exacerbations of the disease. However, the peak ...

journal_title：Journal of breath research

authors： Lázár Z,Bikov A,Martinovszky F,Gálffy G,Losonczy G,Horváth I

更新日期：2014-09-18 00:00:00

abstract：:This study investigated whether oral malodour with plaque-related periodontal disease was associated with the prevalence of periodontopathic bacteria in saliva and tongue debris. The subjects were 30 patients who visited the Breath Odour Clinic. An oral examination was performed at baseline and two months after period...

journal_title：Journal of breath research

authors： Kurata H,Awano S,Yoshida A,Ansai T,Takehara T

更新日期：2008-03-01 00:00:00

abstract：:The human genome is the counterpart to the human exposome with respect to the gene × environment interaction that describes health state and outcome. The genome has already been sequenced and is in the process of being assessed for specific functionality; to similarly decode the exposome will require the measurement a...

journal_title：Journal of breath research

authors： Pleil JD,Stiegel MA,Sobus JR

更新日期：2011-12-01 00:00:00

abstract：:Exhaled breath is coming to the forefront of non-invasive biomarker discovery efforts. Concentration of exhaled breath volatile organic compounds (VOCs) on thermal desorption (TD) tubes with subsequent analysis by gas chromatography-mass spectrometry (GC-MS) has dominated this field. As discovery experimentation incre...

journal_title：Journal of breath research

authors： Harshman SW,Mani N,Geier BA,Kwak J,Shepard P,Fan M,Sudberry GL,Mayes RS,Ott DK,Martin JA,Grigsby CC

更新日期：2016-10-12 00:00:00

abstract：:In this article, a database of blood:air and fat:air partition coefficients (λ b:a and λ f:a) is reported for estimating 1678 volatile organic compounds recently reported to appear in the volatilome of the healthy human. For this purpose, a quantitative structure-property relationship (QSPR) approach was applied and a...

journal_title：Journal of breath research

authors： Kramer C,Mochalski P,Unterkofler K,Agapiou A,Ruzsanyi V,Liedl KR

更新日期：2016-01-27 00:00:00