Abstract:
OBJECTIVE:Bitter melon is a plant fruit that has been shown to exert a hypoglycemic effect when used systemically in patients with diabetes. This study was designed to investigate the topical effect of bitter melon on diabetic wounds using the wound chamber model in rats. DESIGN:Two bilateral wound chambers were implanted subcutaneously in the thoracic-lumbar region of male Sprague-Dawley rats. Diabetes was induced with streptozotocin 7 days after implantation of wound chambers. After 24 hours of induction of diabetes, aqueous extract of bitter melon was injected into 1 wound chamber, and saline (0.9% sodium chloride solution) was injected into the contralateral chamber once daily for 3 days. Wound fluid was collected on day 4 for analysis, following which rats were euthanized. The granulation tissue encapsulating the wound chamber was removed and processed for histology. Controls included diabetic rats with wound chambers injected with saline (instead of bitter melon) and nondiabetic rats with wound chambers injected with bitter melon. RESULTS:In rats with diabetes, wound granulation tissue treated with bitter melon was well formed, with distinct cellular layers, whereas the saline-treated granulation tissue showed a severe loss of tissue organization and blood vessels. Moreover, the bitter melon treatment increased angiogenesis in the diabetic granulation tissue, marked by abundant microvessels and large blood vessels. In nondiabetic rats, no differences in wound granulation tissues were observed between saline- and bitter melon-treated groups. Bitter melon treatment had no effect on systemic blood glucose levels or insulin receptor substrate 1, suggesting that its stimulatory effect on diabetic granulation tissue was not due to alteration of systemic blood glucose levels. CONCLUSIONS:When applied locally to diabetic wounds, bitter melon extract prevents regression of granulation tissue and blood vessels, thus accelerating and improving wound healing.
journal_name
Adv Skin Wound Carejournal_title
Advances in skin & wound careauthors
Singh R,Garcia-Gomez I,Gudehithlu KP,Singh AKdoi
10.1097/01.ASW.0000504758.86737.76subject
Has Abstractpub_date
2017-01-01 00:00:00pages
16-26issue
1eissn
1527-7941issn
1538-8654pii
00129334-201701000-00004journal_volume
30pub_type
杂志文章abstract:GENERAL PURPOSE:To present an evaluation of a surfactant-containing polymeric membrane foam wound dressing for use on patients with chronic pilonidal sinus disease. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in s...
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journal_title:Advances in skin & wound care
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journal_title:Advances in skin & wound care
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pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVE:To describe venous ulcer care and wound care practices in Gauteng, a province of South Africa, according to the Donabedian structure-process-outcome quality improvement model. METHODS:Forty-eight facilities were selected randomly from public and private wound care practices in Gauteng. Structured interviews ...
journal_title:Advances in skin & wound care
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journal_title:Advances in skin & wound care
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doi:10.1097/01.ASW.0000358639.45784.cd
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doi:10.1097/01.ASW.0000414707.33267.92
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journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
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journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
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更新日期:2004-06-01 00:00:00
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更新日期:2016-04-01 00:00:00
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doi:10.1097/01.ASW.0000415343.45178.91
更新日期:2012-06-01 00:00:00
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doi:10.1097/01.ASW.0000557830.01516.6b
更新日期:2019-06-01 00:00:00
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journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/00129334-200405000-00020
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journal_title:Advances in skin & wound care
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
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更新日期:2003-03-01 00:00:00
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journal_title:Advances in skin & wound care
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更新日期:2016-09-01 00:00:00
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更新日期:2019-01-01 00:00:00
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更新日期:2011-11-01 00:00:00
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更新日期:2019-09-01 00:00:00
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journal_title:Advances in skin & wound care
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更新日期:2015-12-01 00:00:00
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更新日期:2016-07-01 00:00:00