Keloid Management: A Retrospective Case Review on a New Approach Using Surgical Excision, Platelet-Rich Plasma, and In-office Superficial Photon X-ray Radiation Therapy.

Abstract:

OBJECTIVE:The objective of this retrospective study was to evaluate the efficacy of the authors' combination therapy protocol for keloid treatment. DESIGN:Retrospective. SETTING:Plastic surgery office-based outpatient setting in New York City. PATIENTS:Forty patients with 44 keloid scars requiring surgical excision. INTERVENTIONS:Keloid scars were treated using surgical excision, platelet-rich plasma, and postoperative in-office superficial photon X-ray radiation therapy. Intralesional triamcinolone injections were administered once to 4 patients with poor results on scar scale assessment. Patient follow-up visits ranged from 3 to 11 months to assess for evidence of recurrence and adverse effects. MAIN OUTCOME MEASURE(S):For the purpose of this study, recurrence was defined as any sign of extraordinary erythema, induration, and hypertrophy beyond the site of excision. MAIN RESULTS:In the 16 keloids treated with 2 fractions, there was no evidence of recurrence. One of 25 keloids treated with 3 fractions demonstrated evidence of recurrence. One of 3 keloids treated with a single fraction displayed signs of recurrence. Postirradiation hyperpigmentation was noted in all patients. CONCLUSIONS:Surgical excision combined with platelet-rich plasma and postoperative in-office superficial radiation therapy achieved a 95.5% nonrecurrence rate at 1- to 3-month follow-up. This protocol appears to be a safe and viable option in the management of keloids and merits further randomized controlled study of its comparative efficacy.

journal_name

Adv Skin Wound Care

authors

Jones ME,Hardy C,Ridgway J

doi

10.1097/01.ASW.0000482993.64811.74

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

303-7

issue

7

eissn

1527-7941

issn

1538-8654

pii

00129334-201607000-00005

journal_volume

29

pub_type

杂志文章
  • Stereologic study of the effects of prostaglandin E2 on the induction of angiogenesis in full-thickness skin autografts.

    abstract:OBJECTIVE:To determine whether prostaglandin E2 improves angiogenesis in full-thickness skin grafts. DESIGN:Randomized study SUBJECTS:20 male rabbits, divided into 2 experimental and 2 control groups. METHODOLOGY:Prostaglandin E2 (experimental groups) or prostaglandin E2 vehicle (control groups) was injected locally...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/00129334-200405000-00020

    authors: Khozani TT,Noorafshan A,Nikeghbalian S,Panjeh-Shahin MR,Dehghani F,Azizi M,Tanideh N

    更新日期:2004-05-01 00:00:00

  • Incidence and Variables Predictive of Pressure Injuries in Patients Undergoing Ventricular Assist Device and Total Artificial Heart Surgeries: An 8-Year Retrospective Cohort Study.

    abstract:OBJECTIVE:To investigate the incidence and risk factors of pressure injury (PI) development after ventricular assist device (VAD) or total artificial heart (TAH) surgery. METHODS:The investigator reviewed all VAD-TAH surgeries performed between 2010 and 2018 in a large academic health system. The PIs were reported by ...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000717236.91761.78

    authors: Brindle T

    更新日期:2020-12-01 00:00:00

  • Suspected deep tissue injury profile: a pilot study.

    abstract:PURPOSE:To enhance the learner's competence with knowledge of the results of research examining suspected deep tissue injury profiles. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES:After participating in this educational ac...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000443267.25288.87

    authors: Honaker J,Brockopp D,Moe K

    更新日期:2014-03-01 00:00:00

  • A Quantitative Analysis of Microcirculation in Skin Defects Covered with Topical Wound Dressings or a Newly Developed Collagen Matrix.

    abstract:OBJECTIVE:Innovative skin substitutes and temporary wound dressings are frequently used in the treatment of superficial and partial-thickness wounds. The aim of this study was to compare 2 commonly used temporary skin dressings with a newly developed collagen matrix to determine changes in microcirculation as measured ...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000525848.21221.b8

    authors: Held M,Medved F,Petersen W,Tolzmann DS,Rahmanian-Schwarz A,Schaller HE,Rothenberger J

    更新日期:2017-11-01 00:00:00

  • Physical assessment of the diabetic foot.

    abstract:PURPOSE:To provide physicians and nurses with an overview of diabetic foot assessment. TARGET AUDIENCE:This continuing-education activity is intended for physicians and nurses with an interest in learning about proper diabetic foot assessment. OBJECTIVES:After reading the article and taking the test, the participant ...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章,评审

    doi:10.1097/00129334-200303000-00007

    authors: Kravitz SR,McGuire J,Shanahan SD

    更新日期:2003-03-01 00:00:00

  • A Comparison of Three Dressing Methods for Pilonidal Sinus Surgery Wound Healing.

    abstract:OBJECTIVE:To evaluate the effect of different dressing methods on the wound healing process after pilonidal sinus surgery. METHODS:In this clinical trial, 60 patients undergoing pilonidal sinus surgery were randomly assigned to one of three groups. In the first group, hydrogel or alginate and hydrocolloid compounds we...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.ASW.0000558268.59745.d2

    authors: Sadati L,Froozesh R,Beyrami A,Khaneghah ZN,Elahi SA,Asl MF,Salehi T

    更新日期:2019-07-01 00:00:00

  • Role of Vacuum-Assisted Closure in the Management of Crohn Anal Fistulas.

    abstract:BACKGROUND:Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods. OBJECTIVE:To compare NCS with vacuum-assisted clos...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000547411.16017.58

    authors: Hermann J,Banasiewicz T,Kołodziejczak B

    更新日期:2019-01-01 00:00:00

  • Gene Expression of Angiotensin-Converting Enzyme 2 Receptor in Skin and the Implications for COVID-19.

    abstract:BACKGROUND:Binding to the angiotensin-converting enzyme 2 (ACE2) receptor is a critical step for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter target cells. This enzyme is expressed in many human tissues including the lungs, but no research has demonstrated that SARS-CoV-2 can infect human skin ...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000722748.73437.7d

    authors: Al-Benna S

    更新日期:2021-01-01 00:00:00

  • Susceptibility of Trichopyton mentagrophytes to Visible Light Wavelengths.

    abstract:OBJECTIVE:To determine whether a blue light (405 nm) could inhibit the growth of Trichopyton mentagrophytes without using a photosensitizing material as part of the treatment protocol. DESIGN:Basic physiologic randomized trial using laboratory specimens (T mentagrophytes). INTERVENTIONS/METHODS:Plated on a growth med...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000512271.19164.ef

    authors: Guffey JS,Payne W,Buchanan B,Daugherty J,Meurer L,Hensley P

    更新日期:2017-05-01 00:00:00

  • Comparison of forefoot ulcer healing using alternative off-loading methods in patients with diabetes mellitus.

    abstract:OBJECTIVE:To compare the healing rate of forefoot ulcers in patients with diabetes treated using a total contact cast with those treated using alternative off-loading methods. DESIGN Retrospective analysis of healing rates of forefoot ulcers. SETTING:Louisiana State University Health Sciences Center Diabetes Foot Prog...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/00129334-200209000-00006

    authors: Birke JA,Pavich MA,Patout CA Jr,Horswell R

    更新日期:2002-09-01 00:00:00

  • Improved Clinical Efficacy with Wound Support Network Between Hospital and Home Care Service.

    abstract:OBJECTIVE:The aim of this study was to test the efficacy of a wound support network model between the primary home care service and the hospital. The impact on wound healing rate, cost benefit, and transfer of knowledge was investigated. INTERVENTION:The intervention group was exposed to a wound support network (n = 3...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000499714.97688.4b

    authors: Bergersen TK,Storheim E,Gundersen S,Kleven L,Johnson M,Sandvik L,Kvaerner KJ,Ørjasæter NO

    更新日期:2016-11-01 00:00:00

  • Efficacy of Monitoring Devices in Support of Prevention of Pressure Injuries: Systematic Review and Meta-analysis.

    abstract:GENERAL PURPOSE:To present a systematic review of the literature assessing the efficacy of monitoring devices for reducing the risk of developing pressure injuries. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in s...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/01.ASW.0000504579.83707.f6

    authors: Walia GS,Wong AL,Lo AY,Mackert GA,Carl HM,Pedreira RA,Bello R,Aquino CS,Padula WV,Sacks JM

    更新日期:2016-12-01 00:00:00

  • Treatment options for venous leg ulcers: effectiveness of vascular surgery, bioengineered tissue, and electrical stimulation.

    abstract:OBJECTIVE:To evaluate the peer-reviewed literature that compares advanced venous leg ulcer therapies to standard of care with compression dressings. METHODS:A MEDLINE search for venous ulcer treatment with electrical stimulation, surgical vein correction, and bioengineered tissues was conducted. Randomized clinical tr...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章,评审

    doi:10.1097/01.ASW.0000462328.60670.c3

    authors: Thakral G,La Fontaine J,Kim P,Najafi B,Nichols A,Lavery LA

    更新日期:2015-04-01 00:00:00

  • Epidermal micrografts produced via an automated and minimally invasive tool form at the dermal/epidermal junction and contain proliferative cells that secrete wound healing growth factors.

    abstract:OBJECTIVE:The aim of this scientific study was to assess epidermal micrografts for formation at the dermal-epidermal (DE) junction, cellular outgrowth, and growth factor secretion. Epidermal harvesting is an autologous option that removes only the superficial epidermal layer of the skin, considerably limiting donor sit...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000470024.81711.b8

    authors: Osborne SN,Schmidt MA,Derrick K,Harper JR

    更新日期:2015-09-01 00:00:00

  • The Use of a Novel Canister-free Negative-Pressure Device in Chronic Wounds: A Retrospective Analysis.

    abstract:OBJECTIVE:Negative-pressure wound therapy (NPWT) is a mainstay in the treatment of acute and chronic wounds. Following the success of the Vacuum-Assisted Closure system (Kinetic Concepts Inc [KCI], an Acelity Company, San Antonio, Texas), many similar systems were developed with minor variations. However, these systems...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000481188.31032.52

    authors: Serena TE,Buan JS

    更新日期:2016-04-01 00:00:00

  • Comparison of the cytotoxicities and wound healing effects of hyaluronan, carbomer, and alginate on skin cells in vitro.

    abstract:OBJECTIVE:To compare the cytotoxicities and efficacy of hyaluronan (HA), carbomer, and sodium alginate on repairing thermal-injured cells and promoting cell migration. DESIGN:The 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetra-zoliumromide method was used to evaluate the cytotoxicities of HA, carbomer, and sodium a...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000467303.39079.59

    authors: Guo X,Huang S,Sun J,Wang F

    更新日期:2015-09-01 00:00:00

  • Evaluation of the incidence of pressure ulcers using hill-rom versacare surfaces.

    abstract:OBJECTIVE:This study was conducted to: (1) determine the clinical effectiveness of a low-air-loss surface, VersaCare P500, in the prevention of pressure ulcers in surgical patients; (2) determine differences in the adjusted Braden scores between those using VersaCare and VersaCare P500 mattress surfaces; and (3) explor...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000396303.13582.70

    authors: Korniewicz DM,Siegel J,Fajardo V,El-Masri M

    更新日期:2011-04-01 00:00:00

  • The relationship between hemoglobin A(1c) values and healing time for lower extremity ulcers in individuals with diabetes.

    abstract:PROBLEM:The diabetic population is at an increased risk, up to 15% over a lifetime, to develop leg and foot ulcers due to such factors as neuropathy, ischemia, and infection. The tight control of glucose levels as possible is necessary to prevent the diabetic complications by preventing microvascular changes that predi...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000358639.45784.cd

    authors: Markuson M,Hanson D,Anderson J,Langemo D,Hunter S,Thompson P,Paulson R,Rustvang D

    更新日期:2009-08-01 00:00:00

  • Incidence and risk factors associated with pressure ulcers among patients with HIV infection.

    abstract:OBJECTIVE:To assess the incidence of and risk factors for pressure ulcers among patients with advanced human immunodeficiency virus type 1 (HIV-1) infection. DESIGN:Multicenter trial that included 1258 consecutive patients infected with HIV-1 who had 1815 admissions to 16 acute care infectious disease units in Italy. ...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00129334-200406000-00011

    authors: Nicastri E,Viale P,Lyder CH,Cristini F,Martini L,Preziosi G,Dodi F,Irato L,Pan A,Petrosillo N,Gruppo HIV ed Infezioni Ospedaliere.

    更新日期:2004-06-01 00:00:00

  • 2015: "key word" for wound care business success.

    abstract::Wound care professionals should consider all this attention to the key word documentation as your 2015 "heads-up." You should conduct a self-audit and request an external audit of your own documentation against all the regulations, LCDs, Policy Articles, newsletters, and educational programs that CMS and your MACs are...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000459113.03360.09

    authors: Schaum KD

    更新日期:2015-01-01 00:00:00

  • Proxy study on minimizing risk of sacral pressure ulcers while complying with ventilator-associated pneumonia risk reduction guidelines.

    abstract::Bed positioning poses a subtle, yet important, tradeoff in the competing needs of hospitalized patients, particularly those susceptible to lower respiratory tract infections and/or pressure ulcers. Although it is widely held that a minimum 30° incline is necessary to mitigate risk of ventilator-acquired pneumonia, it ...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000471877.19459.85

    authors: Crane BA,Wininger M,Kunsman M

    更新日期:2015-12-01 00:00:00

  • Shoelace Technique Plus Negative-Pressure Wound Therapy Closure in Fasciotomy Wounds.

    abstract:BACKGROUND:Fasciotomy incision closure is often performed with skin grafts that can lead to cosmetic and functional complications after surgical intervention. Because fasciotomy incisions do not result in skin loss, the authors hypothesized that better closure can be achieved by reducing tissue edema with negative-pres...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000672492.38463.58

    authors: Eceviz E,Çevik HB

    更新日期:2020-09-01 00:00:00

  • Validation of the Healthy Foot Screen: A Novel Assessment Tool for Common Clinical Abnormalities.

    abstract:GENERAL PURPOSE:The purpose of this learning activity is to provide information about the Healthy Foot Screen, a new tool for assessment of common foot abnormalities. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000530686.16243.d5

    authors: Persaud R,Coutts PM,Brandon A,Verma L,Elliott JA,Sibbald RG

    更新日期:2018-04-01 00:00:00

  • Improvement of periulcer skin condition in venous leg ulcer patients: prospective, randomized, controlled, single-blinded clinical trial comparing a biosynthetic cellulose dressing with a foam dressing.

    abstract:OBJECTIVES:The aim of this study was to investigate the influence of a biosynthetic cellulose wound dressing (BWD) to stimulate wound healing in patients with a venous leg ulcer on periulcer skin condition when compared with standard care using a foam dressing. METHODS:Each patient with a venous ulcer received compres...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.ASW.0000431237.22658.15

    authors: Dini V,Romanelli M,Andriessen A,Barbanera S,Bertone MS,Brilli C,Abel M

    更新日期:2013-08-01 00:00:00

  • Bitter Melon Extract Promotes Granulation Tissue Growth and Angiogenesis in the Diabetic Wound.

    abstract:OBJECTIVE:Bitter melon is a plant fruit that has been shown to exert a hypoglycemic effect when used systemically in patients with diabetes. This study was designed to investigate the topical effect of bitter melon on diabetic wounds using the wound chamber model in rats. DESIGN:Two bilateral wound chambers were impla...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000504758.86737.76

    authors: Singh R,Garcia-Gomez I,Gudehithlu KP,Singh AK

    更新日期:2017-01-01 00:00:00

  • Common nail disorders and fungal infections.

    abstract:PURPOSE:To provide the practitioner with current information on the most common nail disorders. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in wound care and related disorders. OBJECTIVES:After reading this article and taking this test, the reader should b...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章,评审

    doi:10.1097/01.ASW.0000276409.53632.42

    authors: Alavi A,Woo K,Sibbald RG

    更新日期:2007-06-01 00:00:00

  • Cultured keratinocytes on urinary bladder matrix scaffolds increase angiogenesis and help in rapid healing of wounds.

    abstract:INTRODUCTION:Urinary Bladder Matrix (UBM) is an extracellular matrix (ECM) scaffold. It is now used in wound care management of partial and full-thickness wounds where conventional methods for wound care usually fail to give satisfactory results. OBJECTIVE:In this study, the authors are comparing the healing of full-t...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000398665.51283.44

    authors: Eweida A,Saad M,Gabr E,Marei M,Khalil MR

    更新日期:2011-06-01 00:00:00

  • Anthropometric, Biochemical, and Food Consumption Parameters are Associated with Venous Leg Ulcer Area and Duration.

    abstract:OBJECTIVE:To describe the dietary habits and anthropometric and biochemical parameters of patients with active venous leg ulcers and to verify the association of these variables with wound duration and area. DESIGN, SETTING, AND PARTICIPANTS:A cross-sectional study conducted with 33 participants diagnosed with venous ...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000694160.19845.1b

    authors: Melo PG,Mota JF,Nunes CAB,Amaral KVA,Coelho ASG,Bachion MM

    更新日期:2020-09-01 00:00:00

  • What is the best method for assessing the rate of wound healing? A comparison of 3 mathematical formulas.

    abstract:OBJECTIVE:To identify and evaluate current mathematical formulas used to assess the rate of wound healing. DATA SOURCES:MEDLINE, CINAHL, and Cochrane Systematic Review databases, from 1965 to 2004. STUDY SELECTION:Papers selected for the study met the following inclusion criteria: (1) participants had chronic venous,...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章,评审

    doi:10.1097/00129334-200604000-00009

    authors: Jessup RL

    更新日期:2006-04-01 00:00:00

  • The Ears of a Hippopotamus: Quality of Venous Leg Ulcer Care in Gauteng, South Africa.

    abstract:OBJECTIVE:To describe venous ulcer care and wound care practices in Gauteng, a province of South Africa, according to the Donabedian structure-process-outcome quality improvement model. METHODS:Forty-eight facilities were selected randomly from public and private wound care practices in Gauteng. Structured interviews ...

    journal_title:Advances in skin & wound care

    pub_type: 杂志文章

    doi:10.1097/01.ASW.0000617848.46377.ae

    authors: Bruwer FA,Botma Y,Mulder M

    更新日期:2020-02-01 00:00:00